Abstract: The invention provides a syringe for detecting pressure change. The syringe includes a barrel defining a reservoir for receiving a constituent, a piston movable within the reservoir and a plunger. The barrel further includes a proximal end and a distal end with an outlet, an engaging member with a pair of fingers formed on an outer periphery of the barrel and a rib extending from the outer periphery of the barrel and disposed proximally to the engaging member. The plunger includes a first plunger part, a second plunger part and a baseplate supporting the first and second plunger parts. The first plunger part is partially received by the reservoir and slidably engaged with the piston. The second plunger part further includes at least one stop ledge to which the fingers of the engaging member releasably latch, and the stop ledge formed on a periphery of the second plunger part, and a compartment for accommodating a first biasing member with first and second ends.

Abstract: Infusion devices and related medical devices, patient data management systems, and methods are provided for monitoring a physiological condition of a patient. An exemplary infusion device includes an actuation arrangement operable to deliver fluid to a user, a communications interface to receive measurement data indicative of a physiological condition of the user, a sensing arrangement to obtain contextual measurement data, and a control system coupled to the actuation arrangement, the communications interface and the sensing arrangement to determine a command for autonomously operating the actuation arrangement in a manner that is influenced by the measurement data and the contextual measurement data and autonomously operate the actuation arrangement in accordance with the command to deliver the fluid to the user.

Abstract: Some embodiments include burden-free insulin delivery systems and methods. Some embodiments include a method comprising: receiving previous insulin delivery data at a user device from an insulin pump; receiving estimated glucose data at the user device from a continuous glucose monitor; determining that the estimated glucose value is approaching or has passed a threshold; and in response to determining that the estimated glucose value is approaching or has surpassed the threshold, not providing an indication to the user through a user interface that the estimated glucose value is approaching or surpassed the threshold.

Abstract: A non-compliant medical balloon comprises a base balloon including a pair of spaced-apart, generally conical end sections and a generally cylindrical center section connected therebetween. A braided fabric sleeve surrounds at least a portion of the base balloon, wherein the sleeve is formed of at least three substantially inelastic fibers intertwined in such a way that no two of the three fibers are twisted exclusively around one another. The sleeve is permanently affixed to the outer surface of the base balloon so as to prevent excessive expansion of the base balloon when the base balloon is internally pressurized.

Abstract: An infusion pump is configured to provide one or more context cues to a user while the user programs the infusion pump to deliver an infusion therapy. In some embodiments, the infusion pump includes a display configured to display a keypad and to receive input from a user, a processor in communication with the display, and a memory in communication with the processor. The memory stores instructions that cause a keypad sequence monitor to receive context parameters, the context parameters corresponding to a drug selection, a drug concentration selection, or a clinical care area in which the drug is to be infused. The keypad sequence monitor accesses a drug library using the context parameter to determine a valid parameter range corresponding to a range of values between lower and upper soft limit values stored in the drug library.

Abstract: Disclosed herein are techniques related to dynamic forecasts. The techniques may involve obtaining, from a medical device, measurement data for a patient; forecasting a plurality of values for a condition of the patient based on a forecasting model and the obtained measurement data; providing a graphical user interface depicting the plurality of forecasted values and comprising a plurality of adjustable graphical user interface elements, each associated with a time period and an activity or event likely to influence the condition; obtaining an adjustment to a first adjustable graphical user interface element; in response to obtaining the adjustment to the first adjustable graphical user interface element, updating at least one of the forecasted values based on the adjustment to the first adjustable graphical user interface element, the obtained measurement data, and the forecasting model; and dynamically updating the graphical user interface to reflect the updated at least one forecasted value.

Abstract: The application relates to an applicator (1) for oral administration of a swallowable object (2), in particular a solid dosage form, to a patient, wherein the applicator comprises a housing (3) having a first opening (4) and a second opening (5), the first opening of the housing being configured to be coupled with a liquid reservoir, in particular a drinking vessel, and the second opening of the housing being configured such that the patient can drink therefrom, and a holder (6) disposed within the housing and configured to accommodate the swallowable object, the holder being further configured to allow the swallowable object to be conveyed towards the second opening of the housing when liquid is flowing through the housing from the first opening to the second opening of the housing.

Abstract: A device for delivery of medicament is presented that has an elongated housing, a container mounted within the housing and adapted to contain liquid medicament, a stopper slidably arranged within said container, and a delivery mechanism comprising a resilient member, a plunger assembly having one end connected to the stopper and a second end being operably connected to the resilient member, a rotatable latch for releasably retaining the plunger assembly in a first position where the resilient member has an accumulated energy, where rotation of the latch releases the plunger assembly such that the accumulated energy is transferred to the plunger assembly for driving the stopper within the container whereby the medicament within said container is delivered to an injection site. After delivery of the medicament a rotator having a hard stop feature aligns with a rib on the protective shield to prevent retraction of the protective shield.

Abstract: A medicament delivery device includes a generally elongated tubular housing having opposite proximal and distal parts; a needle shield sleeve slidably and coaxially arranged inside the housing with a proximal part of the sleeve protruding a distance outside the proximal part of the housing; a syringe carrier mechanism having a syringe carrier slidably and coaxially arranged within the needle shield sleeve, a syringe having a stopper, a medicament, and a needle, the syringe being coaxially arranged within the syringe carrier; and a holding member connected to the syringe carrier; a first activator member an a second activator member; a drive mechanism adapted to accumulate a drive force for moving the syringe carrier mechanism in a first step and a second step. The second activator member is arranged within an information device for producing audible, visual, and/or tactile feedback to a user about a completed injection.

Abstract: A pull wire assembly for integrating into and anchoring an end of a steerable catheter or introducer sheath used in medical procedures; it has a pull ring made at least in part from a radiopaque material that, when integrated into the end of the steerable catheter or the introducer sheath, allows for visualizing the end of the steerable catheter or the introducer sheath during a medical procedure; and one or more pull wires with a different material composition from that of the pull ring, wherein the one or more pull wires are each fused to the pull ring, wherein the fusion results in an amalgam of the radiopaque material and the pull wire material composition.

Abstract: A system may include a data processor and a memory storing instructions. The instructions may result in operations when executed by the data processor. The operations may include determining, based on location data from a positioning system, a presence of a cartridge at a location. The cartridge may include a substance. A quantity of the substance may be determined based on content data from a content meter at the location. Diversion of the substance may be detected based on the cartridge being present at the location and/or the quantity of the substance. Related methods and articles of manufacture, including apparatuses and computer program products, are also disclosed.

Abstract: Systems and methods for integrating a continuous glucose sensor 12, including a receiver 14, a medicament delivery device 16, a controller module, and optionally a single point glucose monitor 18 are provided. Integration may be manual, semi-automated and/or fully automated.

Abstract: A material includes a metallic, nanoporous structure having a plurality of nanopores having a porosity that allows passage of insulin but not IgG. The metallic nanoporous structure includes titanium, 316L stainless steel and may have a textured nano-sericeous surface. A nanoporous bicontinuous structure can be integrated with nanopores.

Abstract: A system and method for tuning hormone receptors through the dynamic intravenous introduction of a hormone in a manner that mimics a target physiological secretion cadence of that hormone is presented herein. In particular, a dosing model is developed with a desired goal of creating a hormone delivery plan with a dosing waveform that resembles a waveform associated with the target physiological secretion cadence of the hormone. Several bolus delivery specifications, including volume, frequency and pressure, are dynamically defined such that, over a specified period of time, the bolus introductions create the desired dosing waveform. The dosing model is then executed through a plurality of successive and dynamic intravenous exogenous bolus introductions of the hormone according to the plurality of bolus delivery specifications.

Abstract: Some embodiments include burden-free insulin delivery systems and methods. In some embodiments, a method may include receiving previous insulin delivery data at a user device from an insulin pump; receiving estimated glucose data at the user device from a continuous glucose monitor; determining an insulin delivery amount based on the previous insulin delivery data and the estimated glucose data to bring the estimated glucose data closer to a target glucose value without using any user-specific behavioral data physically entered by a user through a user interface of the user device within a previous period of time, the previous period of time being less than six hours; and communicating the insulin delivery amount to the insulin pump.

Abstract: Exemplary embodiments may address the problem of missing blood glucose concentration readings from a glucose monitor that transmits blood glucose concentration readings over a wireless connection due to problems with the wireless connection. In the exemplary embodiments, an automated insulin delivery (AID) device uses an estimate in place of a missing blood glucose concentration reading in determining a predicted future blood glucose concentration reading for a user. Thus, the AID device is able to operate normally in generating insulin delivery settings despite not receiving a current blood glucose concentration reading for a current cycle. There is no need to suspend delivery of insulin to the user due to the missing blood glucose concentration reading.

Abstract: Data collection devices for attachment to injection devices are disclosed. In one embodiment, the data collection device includes: a body attachable to a dial member of the injection device, a sensor arrangement comprising a sensor and a scale, and a processor. The sensor is configured to detect a rotation of the body relative to a trigger of the injection device. The processor is configured to detect a rotation of the body relative to the trigger. One of the sensor and the scale is arranged in or on the body and wherein the other one of the sensor and the scale is located on the trigger or is rotationally lockable to the trigger configured to detect a rotation of the body relative to the trigger.

Abstract: An infusion pump (100) includes a plunger (110) configured to squeeze a section of an infusion tube (150). A proximal valve (120), proximal to the plunger, ascends to allow infusion fluid intake from a reservoir to the infusion tube and descends to inhibit infusion fluid intake from the reservoir to the infusion tube. A distal valve (125), distal to the plunger, ascends to allow infusion fluid flow past the distal valve, and descends to inhibit infusion fluid flow past the distal valve. A controller (141) controls the plunger, proximal valve, and distal valve by initiating descending of the plunger concurrently with or prior to the ascending of the distal valve, such that the descending of the plunger compensates for suction produced by the ascending of the distal valve, thereby reducing backflow of fluid from the subject. Other applications are also described.

Abstract: An injector comprising a housing, a control releasably secured to the housing, and a syringe movably positioned within the housing. When released, the control drives the syringe to expose a portion of the syringe outside of the housing.

Abstract: Systems and methods are described for presenting information for managing a vital sign of a patient. A graphical user interface (GUI) can be presented that displays information concerning a vital sign of a patient, including the most current value of the vital sign received and past values of the vital sign over an elapsed time period. Preferably, the systems and methods are used with a closed-loop system that may automatically adjust a dosage rate of a medication, although manual control is also contemplated. The GUI may comprise one or more visual indicators presented on the historical data that, when selected, present additional information that may be useful to managing the care of the patient.