Patents Examined by Marcella M Cordero Garcia
  • Opioid prodrugs with heterocyclic linkers
    Patent number: 8685916
    Abstract: The embodiments provide prodrug compounds of Formulae I-XV. The present disclosure also provides compositions, and their methods of use, where the compositions comprise a prodrug compound of Formulae I-XV that provides controlled release of an opioid. Such compositions can optionally provide a trypsin inhibitor that interacts with the enzyme that mediates the controlled release of an opioid from the prodrug so as to attenuate enzymatic cleavage of the prodrug.
    Type: Grant
    Filed: March 8, 2012
    Date of Patent: April 1, 2014
    Assignee: Signature Therapeutics, Inc.
    Inventors: Thomas E. Jenkins, Craig O. Husfeld
  • Processes for the manufacture of macrocyclic depsipeptides and new intermediates
    Patent number: 8614289
    Abstract: The invention relates to a method or process for the chemical manufacture of depsipeptides of the formula I, wherein the symbols have the meaning defined in the description, to new intermediates and their manufacture, as well as related invention embodiments.
    Type: Grant
    Filed: April 18, 2012
    Date of Patent: December 24, 2013
    Assignee: Novartis AG
    Inventors: Murat Acemoglu, Heribert Hellstern, Felix Kollmer, John Lopez, Robert Schreiber, Christian Sprecher, Hans Stettler