Patents Examined by Margaret D. Seamani
  • Condensed N-heterocyclic compounds and their use as CRF receptor antagonists
    Patent number: 7427630
    Abstract: The present invention provides compounds of formula (I) including stereoisomers, prodrugs and pharmaceutically acceptable salts or solvates thereof to processes for their preparation, to pharmaceutical compositions containing them and to their use in the treatment of conditions mediated by corticotrophin-releasing factor (CRF).
    Type: Grant
    Filed: April 7, 2004
    Date of Patent: September 23, 2008
    Assignees: SB Pharmaco Puerto Rico Inc., Neurocrine Biosciences Inc.
    Inventors: Romano Di Fabio, Fabio Maria Sabbatini, Yves St-Denis
  • 4-substituted imidazoles
    Patent number: 7384954
    Abstract: Compounds of formula I: wherein A and R1 are as defined in the specification, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, especially in the treatment or prophylaxis of psychotic and intellectual impairment disorders.
    Type: Grant
    Filed: November 15, 2004
    Date of Patent: June 10, 2008
    Assignee: AstraZeneca AB
    Inventors: James R. Empfield, Eifion Phillips, Scott Throner
  • 3-substituted quinuclidines and their use
    Patent number: 7332507
    Abstract: This invention relates to novel 3-substituted quinuclidine derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
    Type: Grant
    Filed: May 27, 2003
    Date of Patent: February 19, 2008
    Assignee: Neurosearch A/S
    Inventors: Dan Peters, Gunnar M. Olsen, Elsebet Østergaard Nielsen, Philip K. Ahring, Tino Dyhring Jørgensen
  • 8-Substituted imidazopyridines
    Patent number: 7326718
    Abstract: The present invention relates to 8-substituted imidazopyridines of a certain formula (1) in which the substitutents and symbols have the meanings indicated in the description. The compounds have gastric secretion inhibiting and excellent gastric and intestinal protective action properties.
    Type: Grant
    Filed: November 15, 2003
    Date of Patent: February 5, 2008
    Assignee: Altana Pharma AG
    Inventors: Wilm Buhr, Jörg Senn-Bilfinger, Peter Jan Zimmermann
  • Photo-caged fluorescent molecules
    Patent number: 7304168
    Abstract: A class of photo-caged and cell permeable fluorescent molecules having high uncaging cross sections, robust fluorescence enhancement, and flexible chemistry for bioconjugation. Some of the photo-caged fluorescent molecules are derived from 6-chloro-7-hydroxy-coumarin 3-carboxamide. The fluorescent molecules are useful for cellular imaging applications and particularly for tracing the molecular transfer between cellular gap junctions. The fluorescent molecules also have an emission wavelength that spectrally complements with the emission wavelength of other fluorophores, enabling simultaneous multi-color imaging.
    Type: Grant
    Filed: August 13, 2004
    Date of Patent: December 4, 2007
    Assignee: Board of Regents, University of Texas System
    Inventors: Wen-Hong Li, YuRui Zhao