Patents Examined by Margaret E. Jamroz
  • Immunosuppressant target proteins
    Patent number: 6464974
    Abstract: The present invention relates to the discovery of novel proteins of mammalian origin which are immediate downstream targets for FKBP/rapamycin complexes and provides, e.g., isolated polypeptides, nucleic acids encoding such, antibodies, screening methods, and diagnostic and therepeutic methods.
    Type: Grant
    Filed: January 23, 1998
    Date of Patent: October 15, 2002
    Assignee: Ariad Pharmaceuticals
    Inventors: Vivian Berlin, Maria Isabel Chiu, Guillaume Cottarel, Veronique Damagnez
  • Family of immunoregulators designated leukocyte immunoglobulin-like receptor (LIR)
    Patent number: 6448035
    Abstract: A new family of immunoreceptor molecules of the immunoglobulin superfamily, (LIR) polypeptides is described. Disclosed are sequences encoding LIR family members and their deduced amino acid sequences, polypeptides encoded by DNA that hybridize to oligonucleotide probes having defined sequences, processes for producing polypeptides of the LIR family, and antagonistic antibodies to LIR family members. LIR family members can be used to treat autoimmune diseases and disease states associated with suppressed immune function.
    Type: Grant
    Filed: April 24, 1997
    Date of Patent: September 10, 2002
    Assignee: Immunex Corporation
    Inventor: David J. Cosman