Abstract: The invention concerns a gas delivery system (1, 2) for providing gaseous Nitric Oxide (NO) to a patient comprising a medical ventilator (2) providing a respiratory gas, such as air, to a patient breathing circuit (3) having an inspiratory limb (31) with a flow sensor (100) and an NO injection module (110), and a NO-delivery device (1) for providing a NO-containing gas to the NO injection module (110) of the inspiratory limb (31), said NO delivery device (1) including a control unit (130) and a differential pressure sensor (104). The medical ventilator (2) can be a High Frequency Oscillatory (HFO) ventilator.

Abstract: A suction assembly is described. The suction assembly includes a therapy unit with a body that can apply a supplemental therapy to a skin surface. The suction assembly also includes a cup that can be removably connected to the therapy unit and that can interface with a skin surface to define a chamber within the cup. A pump of the therapy unit can reduce a pressure within the chamber to draw the skin surface into the chamber in a cupping therapy. In response to the skin surface being drawn into the chamber, the body can move in a longitudinal direction to maintain contact with the skin surface. A wall of the cup is translucent and the suction assembly is dimensioned to provide a user with a view into the chamber through the wall of the cup that is substantially unobstructed by the housing.

Abstract: A cuff for an air delivery conduit includes a first end portion provided to a tube and a second end portion adapted to engage a tubular connector. The second end portion includes an annular bead for sealing and retention.

Abstract: A method and apparatus for assisting walking of a user is provided. Information related to a motion of a user wearing a walking assistance apparatus is measured by an inertial measurement unit (IMU), a gait phase of the user corresponding to the measured information is predicted using data learned in advance through machine learning, an assistance torque to be provided to the user is determined based on the predicted gait phase, and a driver is controlled to output the assistance torque.

Abstract: An air conditioning assembly for an environmental chamber includes a suspended ceiling below a structural ceiling creating a plenum space. The suspended ceiling is configured to cover a substantially horizontal plane of the environmental chamber while leaving a first perimeter gap adjacent to a wall of the environmental chamber and a second perimeter gap adjacent to an opposing wall of the environmental chamber. A substantially vertical wall covers a vertical plane of the plenum space. At least one fan draws air from one from the environmental chamber into the plenum space through the first perimeter gap and blows air from the plenum space into the environmental chamber through the second perimeter gap. At least one air conditioning means in fluid communication with the at least one fan conditions the air flow passing through the at least one fan. The air conditioning assembly creates substantially laminar air flow.

Abstract: A respiratory treatment device comprising at least one chamber, a chamber inlet configured to receive air into the at least one chamber, at least one chamber outlet configured to permit air to exit the at least one chamber, and a flow path defined between the chamber inlet and the at least one chamber outlet. A restrictor member positioned in the flow path is moveable between a closed position, where a flow of air along the flow path is restricted, and an open position, where the flow of air along the flow path is less restricted. A vane in fluid communication with the flow path is operatively connected to the restrictor member and is configured to reciprocate between a first position and a second position in response to the flow of air along the flow path.

Abstract: An endotracheal tube comprises a main lumen for delivering a breathing gas into a lung of a patient, and a cuff, mounted at a distal end of the endotracheal tube, to be located in the subglottal region of the patient. The endotracheal tube also comprises a cuff inflation lumen for inflating the cuff, and at least three additional lumens, other than the main lumen and the cuff inflation lumen, configured for delivering liquid to the subglottal region, for suctioning liquid from the subglottal region, and for venting the subglottal region.

Abstract: A neuromuscular enhancement system comprising engineered textile structures is worn by a user to increase strength, preserve energy, and increase motion accuracy. The system can be used in surgery and interface with operating room technology, together providing the surgeon with the ability to perform surgery for longer hours and with increased accuracy. The enhancement system is a flexible structure, worn over the user's body, comprising engineered textile materials that apply forces to different areas of the user's body. The engineered materials can be activated in order to apply a force to a particular region of the body to assist in a desired user output. The engineered materials can be embedded with sensors to detect and monitor motion and other physical properties. The engineered materials can also be embedded with a communication system that conveys information between a computer system and the neuromuscular enhancement system and its various sensors and components.

Abstract: An oxygen mask configured for CO2 sampling and oxygen delivery, the oxygen mask having an oxygen inlet, a nasal breath-sampling element and a breath sampling port configured to receive breath samples, sampled by the breath-sampling element, wherein the breath-sampling element is configured to reduce dilution of exhaled breath by the delivered oxygen.

Abstract: A mask apparatus includes a mask body and a mask body cover coupled to the mask body. The mask body includes a front surface, a rear surface, and a pair of air ducts disposed at left and right sides of the front surface. The mask body is configured to mount a pair of fan modules at suction sides of the pair of air ducts. The mask body cover covers the pair of air ducts and the pair of fan modules. The mask body defines a cover coupling groove along an edge of the mask body, and the cover coupling groove is coupled to an edge of the mask body cover.

Abstract: A patient interface includes a seal-forming structure constructed and arranged to form a seal with a region of the patients face surrounding an entrance to the patients airways. The seal-forming structure comprises a first section and a second section. The first section is constructed from a first material. The first section is configured to sealingly engage against a first region of the patients face. The second section is constructed from a second material that is different than the first material. The second section is configured to sealingly engage against a second region of the patients face. The second material is foam. The patient interface also includes a positioning and stabilising structure to provide a force to hold a seal-forming structure in a therapeutically effective position on a patient's head.

Abstract: An ambulatory assist ventilation (AAV) apparatus and system are disclosed for the delivery of a respiratory gas to assist the spontaneous breathing effort of a patient with a breathing disorder. The AAV system includes a compressed respiratory gas source, a respiratory assist device for controlling respiratory gas flow to the patient, a patient circuit tubing and a low profile nasal interface device, which does not have a dead space or hollow area where CO2 can collect, for delivering the respiratory gas to the patient, wherein the nasal interface device is fluidly connected to the respiratory assist device via tubing for receiving the respiratory gas therefrom. In some cases, the nasal interface device may be used in combination with other gas sources, such as oxygen concentrators, to provide dual therapy capability suitable for some applications.

Abstract: A respirator system is disclosed that includes a foldable head cover assembly including a face seal portion. The respirator assembly further includes a visor assembly attached to the head cover assembly and a head suspension system removably attached to the visor assembly. The visor assembly and the head cover assembly on one hand, and the suspension system on the other, are separable and foldable to enable storing and/or shipping the same separately. A head suspension system is also disclosed.

Abstract: Provided herein are methods of treatment, including methods of treating subjects having or at risk of having or having a viral infection, and specifically a SARS-CoV-2 viral infection. The methods provided include the administration of 4-methylumbelliferone (4-MU), palmitoylethanolamide (PEA), resveratrol, fisetin, H2, nebulized hyaluronidase or combinations thereof. Also provided herein are a respiratory assistance device, methods of generating a customized respiratory assistance device, methods of treating a coronavirus infection, and methods of inhibiting a coronavirus infectivity, virulence and/or spread.

Abstract: A nozzle for use in delivering a mixture of aerosol propellant and drug formulation. The nozzle includes a drug product inlet configured to receive a mixture of aerosolized propellant and an intranasal dosage form. The inlet is disposed at the proximal end. A nozzle body is secured to the drug product inlet. Two or more channels are disposed within the body. Two or more orifice apertures are disposed at the distal end of the nozzle.

Abstract: A cradle style cushion includes a central sealing body portion including a front wall, a rear wall, a top wall and a bottom wall. The top wall includes a central sealing surface, a first stabilizing surface and a second stabilizing surface, the first and second stabilizing surfaces each extending upwardly and outwardly with respect to the central sealing surface and a top edge of the front wall and being structured to wrap around and engage an outside of the nostrils when the patient interface device is donned by the patient, wherein the first stabilizing surface includes a first front side edge portion and the second stabilizing surface includes a second front side edge portion, and wherein the top edge of the front wall, the first front side edge portion and the second front side edge portion together define a front opening of the central sealing body portion.

Abstract: A respiratory assembly is provided. The assembly includes at least one post having a nasal engaging portion on about a first end thereof for delivering treatment gases to the nasal cavity of a patient. A pair of tubes capable of receiving gas from a hose or fluid source are selectively engaged with the pair of posts for delivering treatment gases from the inlet through the receptacle and into the nasal cavity of the patient. A splitter may be positioned between the hose or fluid source and the pair of tubes. Ball and socket joints may provide enhanced flexibility of the assembly while in use.

Abstract: The present disclosure relates to a method for identifying a user interface. Flow data associated with air flowing in a respiratory therapy system is received. Acoustic data associated with the respiratory therapy system is received. The received flow data and the received acoustic data are analyzed. Based at least in part on the analysis, a mask type for the user interface is determined.

Abstract: The present invention relates to improved protective pleated facial masks or respirators that comprise a pleating spacer that is adapted to enter into, and stably separate the folds of one or more of pleats of a pre-pleated mask or respirator filter, or a pre-pleated filter layer thereof. The present invention also relates to improved protective pleated facial masks or respirators that comprise a pleating spacer that is adapted to stably form one or more pleats in an initially unpleated filter of a facial mask or respirator, or a filter layer thereof. The pleating spacers of the present invention thus act to increase the effective surface area of the filters of such masks or respirators, and thereby improve airflow while preserving the ability of the mask or respirator to protect the wearer from hazardous agents.

Abstract: A flow regulating valve for a respiratory treatment system is disclosed, as well as a vent arrangement comprising the flow regulating valve. The flow regulating valve may include an inlet, an outlet, and a variable conduit in fluid communication with the inlet and the outlet. The variable conduit may include a movable portion that may move to vary an impedance of the variable conduit, thereby regulating a flow rate of the air travelling through the variable conduit. Advantageously, the flow regulating valve may thus reduce wastage of air (e.g. humidified air) that is exhausted from a respiratory treatment system, while maintaining sufficient washout of air.