Patents Examined by Margaret M. Mach
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Patent number: 5972976Abstract: The invention relates to an aminostilbazole derivative of the following formula or a hydrate thereof, and a salt thereof. ##STR1## wherein R.sup.1 and R.sup.2 each represents hydrogen etc.; R.sup.3, R.sup.4, R.sup.13, and R.sup.14 each represents hydrogen, C.sub.1-3 acyl, halogen, hydroxy etc.; R.sup.5 represents hydrogen or hydroxy-substituted C.sub.1-3 alkyl etc.; R.sup.6 represents benzenesulfonyl substituted by C.sub.1-3 alkoxy etc.; ring Y represents phenyl etc.; ring Z represents 4-pyridyl, its oxide etc. The compound is useful or the treatment of various malignant tumors.Type: GrantFiled: October 2, 1996Date of Patent: October 26, 1999Assignee: Nippon Shinyaku Company, LimitedInventors: Hiroyoshi Hidaka, Akira Matsuura, Masato Matsuda
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Patent number: 5968952Abstract: The present invention is concerned with compounds of formula (I), ##STR1## the stereoisomeric forms thereof and the pharmaceutically acceptable acid or base addition salts thereof, wherein the dotted line represents an optional bond; X is oxygen or sulfur; R.sup.1 is hydrogen, C.sub.1-12 alkyl, Ar.sup.1, Ar.sup.2 C.sub.1-6 alkyl, quinolinylC.sub.1-6 alkyl, pyridylC.sub.1-6 alkyl, hydroxyC.sub.1-6 alkyl, C.sub.1-6 alkyloxyC.sub.1-6 alkyl, mono- or di(C.sub.1-6 alkyl)-aminoC.sub.1-6 alkyl, aminoC.sub.1-6 alkyl, or a radical of formula --Alk.sup.1 --C(.dbd.O)--R.sup.9, --Alk.sup.1 --S(O)--R.sup.9 or --Alk.sup.1 --S(O).sub.2 --R.sup.9 ; R.sup.2 and R.sup.3 each independently are hydrogen, hydroxy, halo, cyano, C.sub.1-6 alkyl, C.sub.1-6 alkyloxy, hydroxyC.sub.1-6 alkyloxy, C.sub.1-6 alkyloxy-C.sub.1-6 alkyloxy, aminoC.sub.1-6 alkyloxy, mono- or di(C.sub.1-6 alkyl)aminoC.sub.1-6 alkyloxy, Ar.sup.1, Ar.sup.2 C.sub.1-6 alkyl, Ar.sup.2 oxy, Ar.sup.2 C.sub.1-6 alkyloxy, hydroxycarbonyl, C.sub.Type: GrantFiled: April 29, 1998Date of Patent: October 19, 1999Assignee: Janssen Pharmaceutica, N.V.Inventors: Marc Gaston Venet, Patrick Rene Angibaud, Gerard Charles Sanz, David William End
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Patent number: 5965459Abstract: A planarizing method involves a first polishing step in which a relatively hard, low compressibility pad removes excess material of a first layer and planarizes the first layer. Deep defects emanating from the polishing surface formed during the first polishing step are then enlarged and filled with a second layer. After filling, and optionally annealing, the second layer is planarized by polishing with a relatively soft and high compressibility pad or by anisotropic etching.Type: GrantFiled: October 11, 1996Date of Patent: October 12, 1999Assignee: International Business Machines CorporationInventor: Klaus Dietrich Beyer
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Patent number: 5965619Abstract: Substituted indene derivatives are useful for treating patients having precancerous lesions and for inhibiting the growth of neoplastic cells.Type: GrantFiled: December 23, 1997Date of Patent: October 12, 1999Assignee: Cell Pathways Inc.Inventors: Rifat Pamukcu, Gary A. Piazza, Paul Gross, Gerhard Sperl, Klaus Brendel
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Patent number: 5965491Abstract: 1-Aryl-3-iminopyrazoles of the formula: ##STR1## wherein R.sub.31, R.sub.32, R.sub.33, R.sub.4, R.sub.5, R.sub.12, R.sub.13, R.sub.14, R.sub.15 and Z are as defined in the specification, are useful as pesticides or as intermediates to other pesticides. Compositions comprising the compounds of formula (I) and methods for their use, particularly in agriculture or for animal protection, as pesticides, especially for controlling arthropods, are described.Type: GrantFiled: March 9, 1998Date of Patent: October 12, 1999Assignee: Rhone-Poulenc Inc.Inventors: Tai-Teh Wu, David Treadway Manning
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Patent number: 5962506Abstract: Compounds of Formula I ##STR1## are disclosed as inhibitors having activity against the aspartyl proteases, plasmepsin and cathepsin D. The compounds are therefore useful for treatment of diseases such as malaria and Alzheimer's disease. In preferred compounds of Formula I, Y is an dialkoxyphosphonate, or .alpha.-hydroxyamide group and Z is an acyl or .alpha.-ketocarbamate functionality. Intermediates in the solid phase synthesis of compounds of Formula I, in which compounds are attached to a solid support, are also disclosed.Type: GrantFiled: July 7, 1997Date of Patent: October 5, 1999Assignee: Pharmacopeia, Inc.Inventors: Carolyn DiIanni Carroll, Roland Ellwood Dolle, III, Yvonne Class Shimshock, Timothee Felix Herpin
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Patent number: 5959107Abstract: New isoquinoline derivatives and pharmaceutically acceptable acid addition salts represented by the following general formula (I) ##STR1## wherein Ar is an aromatic ring which may be substituted, and n shows 0, 1 or 2, have an inhibitory activity against apoptotic neuronal cell death. These compounds are useful for agents of prevention and treatment of neuronal neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, Huntington's chorea and amyotrophic lateral sclerosis, cerebral ischemic injury such as stroke, and peripheral neuropathy in diabetes mellitus.Type: GrantFiled: May 28, 1998Date of Patent: September 28, 1999Assignee: Snow Brand Milk Products Co., Ltd.Inventors: Susumu Ishiguro, Shinichi Shimada, Motohide Seya, Masayuki Okue, Yuzo Yagi, Nobuo Ogane, Yasunari Saitou
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Patent number: 5951966Abstract: This invention relates to a compound toothpaste which includes a housing part and a paste part The paste part is composed of several pastes which are separated by biomacromolecule colloid diaphragm. The housing part may include lubricant membrane covered on inside wall and a cutter which is arranged on exit and towards the paste parts. Because the toothpaste contains several pastes, function can be raised. Since a biomacromolecule colloid diaphragm is adopted, packing system which has simple structure is provided which eliminates remainder from the housing.Type: GrantFiled: March 7, 1997Date of Patent: September 14, 1999Inventor: Haisheng Wang
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Patent number: 5952343Abstract: HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optionally other anti-viral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS.Type: GrantFiled: June 7, 1995Date of Patent: September 14, 1999Assignee: Agouron Pharmaceuticals, Inc.Inventors: Bruce A. Dressman, James E. Fritz, William J. Hornback, Stephen W. Kaldor, Vincent J. Kalish, John E. Munroe, Siegfried Heinz Reich, John H. Tatlock, Timothy A. Shepherd, Michael J. Rodriguez
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Patent number: 5945433Abstract: The present invention relates to hitherto unknown compounds of formula (I) in which R.sub.1 is hydrogen or halogen, preferably fluorine or chlorine, and m is 0, 1 or 2. The present compounds are of value in the human and veterinary practice as leukotriene antagonists.Type: GrantFiled: January 13, 1998Date of Patent: August 31, 1999Assignee: Leo Pharmaceutical Products, Ltd. A/SInventors: Dorte Kirstein, Schneur Rachlin
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Patent number: 5942620Abstract: Novel compounds comprising chemically reactive intermediates which can react with available reactive functionalities on blood components to form covalent linkages, where the resulting covalently-bound conjugates are found to have thrombin inhibition activity are provided. Specifically, the thrombin inhibitor compounds of the present invention are derivatives of the known thrombin inhibitor argatroban, which can be covalently linked to chemically reactive functionalities on various blood components. The conjugated thrombin inhibitors thereby have extended lifetimes in the bloodstream, as compared to the unconjugated parent drug, and are, therefore, capable of maintaining thrombin inhibitory activity for extended periods of time as compared to the unconjugated parent drug. Also provided herein are methods for inhibiting thrombin activity in vivo comprising administering to the bloodstream of a mammalian host the novel compounds of the present invention.Type: GrantFiled: July 1, 1998Date of Patent: August 24, 1999Assignee: ConjuChem, Inc.Inventors: Alexander Krantz, Alan M. Ezrin, Yonghong Song
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Patent number: 5942619Abstract: This invention provides processes for producing quinolone compounds which comprise cultivating Amycoa sp. FERM BP-4785, and then isolating quinolone compounds from the fermentation broth. The compounds produced by these processes include compounds of formula (I) wherein R.sup.1 is H, R.sup.2 is (a) and R.sup.3 is CH.sub.3 ; R.sup.1 is CH.sub.3, R.sup.2 is (a) and R.sup.3 is CH.sub.3 ; or R.sup.1 is CH.sub.3, R.sup.2 is (b) and R.sup.3 is CH.sub.3 ; and the like. The present invention also relates to a pharmaceutical composition comprising the same, which is useful in the treatment of diseases, disorders and adverse conditions caused by Helicobacter pylori and is particularly useful in the treatment of gastroduodenal disorders, diseases and adverse conditions caused thereby.Type: GrantFiled: April 24, 1998Date of Patent: August 24, 1999Assignee: Pfizer Inc.Inventors: Koenraad A. Dekker, Liang H. Huang, Taisuke Inagaki, Nakao Kojima, Yasuhiro Kojima, Yuji Yamauchi
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Patent number: 5935860Abstract: The invention relates to methods for identifying prostatic intraepithelial neoplasia by determining the uteroglobin concentration in a tissue sample.Type: GrantFiled: June 5, 1996Date of Patent: August 10, 1999Assignee: The George Washington UniversityInventors: Steven R. Patierno, Michael J. Manyak
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Patent number: 5935970Abstract: The imidazo?1,5-a!quinolines (I) are useful in treating neurological diseases/conditions or chronic neurodegenerative diseases/conditions.Type: GrantFiled: June 3, 1996Date of Patent: August 10, 1999Assignee: Pharmacia & Upjohn CompanyInventor: Donald B. Carter
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Patent number: 5932193Abstract: Disclosed are toothpaste compositions and a process for preparing such compositions comprising dental abrasive, humectant, fluidized polymer suspension and a suitable vehicle for the humectant, wherein the fluidized polymer suspension comprises: polyethylene glycol, carboxymethyl cellulose and hydrated thickening silica.Type: GrantFiled: September 23, 1997Date of Patent: August 3, 1999Assignee: Hercules IncorporatedInventors: Jean-Paul Lopez, Mohand Melbouci, Gerhard Dewald
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Patent number: 5932191Abstract: The present invention relates to silicas, in particular precipitated silicas, which can be used in particular as abrasive agents in toothpaste compositions. The silicas according to the invention have, first of all, low specific surfaces. Their BET specific surface is between 20 and 75 m.sup.2 /g, preferably between 35 and 64 m.sup.2 /g. The invention also relates to a process for their preparation and to the toothpaste compositions containing them.Type: GrantFiled: July 31, 1996Date of Patent: August 3, 1999Assignee: Rhone-Poulenc ChimieInventors: Yvonick Chevallier, Adrien Dromard
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Patent number: 5932115Abstract: The present invention is a method of manufacturing crown shape capacitors for use in DRAM semiconductor memory. The method includes the steps of forming a first polysilicon layer, patterning a photoresist on the first polysilicon layer, etching the first polysilicon layer, using oxygen plasma to strip the photoresist, forming a side wall polymer onto the side walls of the first polysilicon layer, using the side wall polymer as a mask to etch back the first polysilicon layer to form a crown shape structure, removing the side wall polymer, depositing a dielectric layer onto the first polysilicon layer, and depositing a second polysilicon layer onto the dielectric layer.Type: GrantFiled: May 3, 1996Date of Patent: August 3, 1999Assignee: Vanguard International Semiconductor CorporationInventors: Yu-Chun Ho, Meng-Chao Cheng, Pei-Wen Li, Hsu-Li Cheng, Yu-Hua Huang, Shing-Huang Wu
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Patent number: 5930584Abstract: A process for fabricating electrodes for the capacitor dielectric of semiconductor memory devices with low leakage current characteristics is disclosed. The process comprises the steps of first depositing a titanium oxide film over a semiconductor silicon substrate. The deposited titanium oxide film is then annealed. A layer of tungsten nitride top electrode is then deposited on the annealed titanium oxide film. A second annealing procedure is then conducted to simulate post electrode high temperature process.Type: GrantFiled: April 30, 1996Date of Patent: July 27, 1999Assignee: United Microelectronics Corp.Inventors: Shi-Chung Sun, Tsai-Fu Chen
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Patent number: 5925760Abstract: A method for preparing N.sup.2 -(3-(a hydrogen atom or a lower alkyl)-8-quinolinesulfonyl)-N.sup.G -nitro-L-arginine which comprises the step of condensing N.sup.G -nitro-L-arginine and 3-(a hydrogen atom or a lower alkyl)-8-quinolinesulfonyl chloride. The method achieves an extremely efficient and high yield preparation of N.sup.2 -arylsulfonyl-L-arginineamides that are useful as active ingredients of medicaments. Also provided is a novel N.sup.2 -(3-(a hydrogen atom or a lower alkyl)-8-quinolinesulfonyl)-N.sup.G -nitro-L-arginine compound which can be used as synthetic intermediate for the manufacture of (2R,4R)-4-methyl-1-?N.sup.2 -(3-methyl-1,2,3,4-tetrahydro-8-quinolinesulfonyl)-L-arginyl!-2-piperidine -carboxylic acid.Type: GrantFiled: August 4, 1997Date of Patent: July 20, 1999Assignee: Mitsubishi Chemical CorporationInventor: Ryoji Kikumoto
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Patent number: 5925335Abstract: An orally absorbable improved dental formulation is provided. The dental formulation includes a base to which an active component is added. The active component comprises, based on the overall weight thereof, Vitamin C in an amount between about 10 and 25 weight percent, and coenzyme Q-10 (or ubiquinone), in an amount between 10 and 25 weight percent, are added.Type: GrantFiled: June 12, 1997Date of Patent: July 20, 1999Assignee: C.S. Bioscience Inc.Inventors: David J. Shuch, Gerald P. Curatola