Patents Examined by Maria Leavitt
  • Compositions and methods for treating and preventing heart tissue degeneration and uses thereof
    Patent number: 9132167
    Abstract: The present invention provides compositions useful for cardiac therapy comprising a cyclin-associated agent. The present invention also provides kits for use in delivering a cyclin-associated agent to cardiac cells in a subject, comprising the composition of the present invention and a catheter. The present invention additionally provides a methods for enhancing cardiac function; promoting regeneration of cardiac tissue; inducing endogenous myocardial regeneration; and preventing or treating heart failure in a subject in need thereof by augmenting cyclin in cells.
    Type: Grant
    Filed: December 18, 2009
    Date of Patent: September 15, 2015
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Hina Chaudhry, Debra Wolgemuth
  • Compositions for regenerating defective or absent myocardium
    Patent number: 9125972
    Abstract: Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function.
    Type: Grant
    Filed: May 1, 2013
    Date of Patent: September 8, 2015
    Assignee: CORMATRIX CARDIOVASCULAR, INC.
    Inventor: Robert G Matheny
  • Method and system for treatment of cardiovascular disorders
    Patent number: 9119899
    Abstract: Methods for treating a cardiovascular disorder comprising concomitant administration of one or more extracellular matrix (ECM) based compositions directly to damaged or diseased cardiovascular tissue associated with the cardiovascular disorder, and provision of ventricular assistance. In a preferred embodiment, the ECM based compositions include an ECM material derived from a mammalian source.
    Type: Grant
    Filed: March 1, 2013
    Date of Patent: September 1, 2015
    Assignee: CORMATRIX CARDIOVASCULAR, INC.
    Inventor: Robert Matheny
  • Polymerase chain reaction product-cloning vector suitable to its easy production and method for producing the same
    Patent number: 9121023
    Abstract: The present invention relates to a PCR product cloning vector applicable directly to the cloning of a PCR product. More precisely, the present invention relates to a PCR product cloning vector designed to be effective in use for blue/white colony selection and produced based on the restriction enzyme treatment process to generate non-complementary unpaired single overhang and a method for producing the same. According to the method of the present invention, the PCR product cloning vector designed to be advantageous for blue/white cloning selection can be produced with improved efficiency compared with the convention method.
    Type: Grant
    Filed: October 29, 2008
    Date of Patent: September 1, 2015
    Assignee: INTRON BIOTECHNOLOGY, INC.
    Inventors: Seongjun Yoon, SooYoun Jun, SangHyeon Kang
  • Nucleic acid sample preparation methods and compositions
    Patent number: 9109222
    Abstract: The present invention provides compositions and methods for preparing a nucleic acid library in a multi-purpose buffer (e.g., employing whole genome amplification), where nucleic acid purification is not required between or during steps. In certain embodiments, small amounts of starting nucleic acid (e.g., genomic DNA) are employed and the steps are accomplished in a single container. In some embodiments, the nucleic acid library is subjected to sequencing methodologies or rolling circle amplification.
    Type: Grant
    Filed: December 27, 2011
    Date of Patent: August 18, 2015
    Assignee: IBIS BIOSCIENCES, INC.
    Inventors: Mark Eshoo, John Picuri, Stanley Motley
  • Method for screening toxin neutralizing peptide, STX2 inhibiting peptide and verotoxin neutralizing agent
    Patent number: 9103820
    Abstract: A screening method directed towards; (1) specifying a receptor binding site by introduction of mutation, and (2) specifying a binding site-specific peptide motif on the basis of an amino acid selection ratio by contrast between a peptide motif bound to a wild-type subunit and a peptide motif bound to a mutant functionally deficient in the binding site according to a peptide library method. A peptide which inhibits a toxin whose receptor binding portion has a subunit structure is screened. Accordingly, an STX2 inhibitor in which an STX2 inhibiting peptide is incorporated in a molecular nuclear structure portion having three molecules of lysine (Lys) peptide-linked thereto and which is easy to synthesize and can inhibit verotoxin is provided.
    Type: Grant
    Filed: June 28, 2005
    Date of Patent: August 11, 2015
    Assignee: JAPAN SCIENCE AND TECHNOLOGY AGENCY
    Inventor: Kiyotaka Nishikawa
  • Method for producing virus vector
    Patent number: 9102943
    Abstract: The present invention provides a method for producing a virus vector, which comprises a step wherein cells that are capable of producing a virus vector are cultured in a culture medium that contains, as active components, a retinoic acid and a histone deacetylase inhibiting substance; and a culture medium for the production of a virus vector, which is characterized by containing, as active components, a retinoic acid and a histone deacetylase inhibiting substance.
    Type: Grant
    Filed: October 4, 2011
    Date of Patent: August 11, 2015
    Assignee: TAKARA BIO INC.
    Inventors: Kazuhisa Shinmura, Yoshinori Katayama, Kensuke Sakai, Toshihiro Shodai, Hirofumi Yoshioka, Junichi Mineno
  • Radiopaque implantable collagenous biomaterial device
    Patent number: 9089626
    Abstract: Disclosed is a medical device (5) and more particularly, an implantable biomaterial. The biomaterial comprises a radiopaque (22) collagenous biomaterial (10).
    Type: Grant
    Filed: April 19, 2010
    Date of Patent: July 28, 2015
    Assignee: Cook Biotech Incorporated
    Inventors: Mark W. Bleyer, Michael C. Hiles, Umesh H. Patel
  • Translation enhancer-element dependent vector systems
    Patent number: 9074220
    Abstract: A translation enhancer-driven positive feedback vector system is disclosed which is designed to facilitate identification of a Translational Enhancer Element (TEE) and to provide a means for overexpression of gene products. The system exploits both transcriptional and translational approaches to control the expression levels of genes and/or gene products. Methods are also disclosed for screening libraries of random nucleotide sequences to identify translational elements and for overproduction of proteins, which have uses in both research and industrial environments.
    Type: Grant
    Filed: August 16, 2010
    Date of Patent: July 7, 2015
    Assignee: The Scripps Research Institute
    Inventors: Vincent P. Mauro, Gerald M. Edelman, Wei Zhou
  • Composition for modulating inflammation of cardiovascular tissue
    Patent number: 9072816
    Abstract: A composition for reconstruction, replacement or repair of damaged or diseased biological tissue comprising an extracellular matrix (ECM) composition that includes an ECM scaffold component derived from a mammalian source and at least one additional bioactive component selected from the group consisting of a statin and a chitin derivative.
    Type: Grant
    Filed: September 24, 2012
    Date of Patent: July 7, 2015
    Assignee: CORMATRIX CARDIOVASCULAR, INC.
    Inventor: Robert Matheny
  • CD133 epitopes
    Patent number: 9068020
    Abstract: An immunogen includes an isolated peptide of 800 amino acid residues or fewer having the amino sequence ILSAFSVYV (SEQ ID NO:1) with four or fewer amino acid substitutions, a superagonist variant of SEQ ID NO:1, or an amino acid sequence having the formula: (I/K/T/V/M)-L-(S/L)-(A/E/N/D/Q)-(F/V)-(S/M/V/I)-(V/D/R/G/H)-Y-(V/I/L) (SEQ ID NO:13). The immunogens can be used in compositions and in the treatment of disorders.
    Type: Grant
    Filed: September 2, 2009
    Date of Patent: June 30, 2015
    Assignee: Cedars-Sinai Medical Center
    Inventors: John S. Yu, Keith L. Black, Gentao Liu
  • Translation enhancer-element dependent vector systems
    Patent number: 9068197
    Abstract: A translation enhancer-driven positive feedback vector system is disclosed which is designed to facilitate identification of a Translational Enhancer Element (TEE) and to provide a means for overexpression of gene products. The system exploits both transcriptional and translational approaches to control the expression levels of genes and/or gene products. Methods are also disclosed for screening libraries of random nucleotide sequences to identify translational elements and for overproduction of proteins, which have uses in both research and industrial environments.
    Type: Grant
    Filed: August 23, 2006
    Date of Patent: June 30, 2015
    Assignee: The Scripps Research Institute
    Inventors: Vincent P. Mauro, Gerald M. Edelman, Wei Zhou
  • Generation of capsular polysaccharide A-only producing mutant strain
    Patent number: 9057070
    Abstract: Provided is an isolated B. fragilis bacterial cell producing a native capsular polysaccharide A (PSA), wherein the cell is incapable of producing capsular polysaccharides PSB, PSC, PSD, PSE, PSF, PSG, and PSH because the cell's biosynthetic genes for native capsular polysaccharides PSB, PSC, PSD, PSE, PSF, PSG, and PSH have been deleted from the cell's genome. The isolated or wild type B. fragilis cell, or an extract obtained from said B. fragilis cell, can be used to treat individuals with inflammation.
    Type: Grant
    Filed: October 3, 2012
    Date of Patent: June 16, 2015
    Assignees: California Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Sarkis K. Mazmanian, Sung-Eun Lee, Dennis L. Kasper
  • PSMA-targeting compounds and uses thereof
    Patent number: 9056841
    Abstract: Prostate-specific membrane antigen (PSMA) targeting compounds are described. Uses of the compounds for imaging, therapy, cell sorting, and tumor mapping are also described.
    Type: Grant
    Filed: March 19, 2010
    Date of Patent: June 16, 2015
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Martin Pomper, Ronnie Charles Mease, Ray Sangeeta, Ying Chen
  • Enrichment of tissue-derived adult stem cells based on retained extracellular matrix material
    Patent number: 9045735
    Abstract: Methods for enriching, detecting, or using adult stem cells through the use of recognition ligands that specifically bind to ECM components retained to the surfaces of adult stem cells are described. An ECM component such as hyaluronan that is retained to the surfaces of adult stem cells when removed from animal tissues can be used to detect a diverse population of adult stem cells based on the nature of the ECM niche region in which the adult stem cells normally reside. For example, a separation method such as magnetic separation can be used to detect and isolate or enrich adult stem cells based on a recognition ligand that is specific for an ECM component that is retained to the surfaces of adult stem cells to a greater degree than to other cells in the population.
    Type: Grant
    Filed: April 3, 2008
    Date of Patent: June 2, 2015
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: George Muschler, Tonya Caralla, Vincent Hascall, Ronald Midura
  • Diagnostic kit and methods for radioimaging myocardial perfusion
    Patent number: 9040016
    Abstract: A method of radioimaging a myocardial perfusion, the method including in sequence: administering to a subject a low dose of a first radiopharmaceutical; subjecting the subject to a physical stress; administering to the subject at a peak of said physical stress a medium or high dose of a second radiopharmaceutical; and immediately radioimaging using a 3D non-coincidence imaging method a heart of the subject, thereby radioimaging a myocardial perfusion.
    Type: Grant
    Filed: July 19, 2007
    Date of Patent: May 26, 2015
    Assignee: Biosensors International Group, Ltd.
    Inventors: Benny Rousso, Dalia Dickman, Shlomo Ben-Haim, Simona Ben Haim
  • Modified rodent parvovirus capable of propagating and spreading through human gliomas
    Patent number: 9029117
    Abstract: Described are (a) parvovirus variants capable of propagating and spreading through human tumor cells which is obtainable by serially passaging a rodent parvovirus as starting strain in semi-permissive human tumor cells, and (b) parvovirus variants capable of propagating and spreading through human tumor cells characterized by particular amino acid deletions and/or substitutions, e.g. a deletion of several amino acids in the C-terminus of NS1/middle exon of NS2. A pharmaceutical composition containing such parvoviruses as well as their use for the treatment of cancer, preferably a glioblastoma, is also described.
    Type: Grant
    Filed: May 9, 2011
    Date of Patent: May 12, 2015
    Assignee: Deutsches Krebsforschungzentrum
    Inventors: Jürg Nüesch, Nadja Thomas, Claudia Plotzky, Jean Rommelaere
  • Nitroimidazole-amino acid hypoxia contrast medium, preparation method and use thereof
    Patent number: 9028799
    Abstract: A hypoxia contrast medium including nitroimidazole-amino acid chelate with a positively charged radioactive nuclide, a preparation method and use thereof. The contrast medium can be used in imaging cerebral thrombosis, tumors or other diseases such as ulceration, thrombosis, and so on.
    Type: Grant
    Filed: April 29, 2011
    Date of Patent: May 12, 2015
    Inventor: Jianping Ruan
  • PKC ligands and polynucleotides encoding PKC ligands
    Patent number: 8999666
    Abstract: The invention relates to kinase ligands and polyligands. In particular, the invention relates to ligands, homopolyligands, and heteropolyligands that modulate PKC activity. The ligands and polyligands are utilized as research tools or as therapeutics. The invention includes linkage of the ligands, homopolyligands, and heteropolyligands to a cellular localization signal, epitope tag and/or a reporter. The invention also includes polynucleotides encoding the ligands and polyligands.
    Type: Grant
    Filed: August 9, 2007
    Date of Patent: April 7, 2015
    Assignee: Intrexon Corporation
    Inventors: Thomas D. Reed, Amy H. Atzel
  • Method of improving salmon meat color
    Patent number: 8999664
    Abstract: The present invention provides a salmon flesh color improving method and a salmon flesh color improving feed which are usable for producing a salmon having a mild reddish orange flesh color close to the flesh color of wild fish, and a salmon and fish flesh thereof produced by such a flesh color improving method. The present invention also provides a method for producing a salmon having a mild reddish orange flesh color, comprising cultivating the salmon with a feed comprising a carotenoid colorant mixed therein, the carotenoid colorant comprising at least astaxanthin, phoenicoxanthin, canthaxanthin and adonixanthin.
    Type: Grant
    Filed: September 14, 2007
    Date of Patent: April 7, 2015
    Assignee: JX Nippon Oil & Energy Corporation
    Inventors: Kazuaki Hirasawa, Akira Tsubokura, Hisashi Yoneda