Patents Examined by Marianne Allen
  • Platelet derived growth factor antagonists
    Patent number: 5444151
    Abstract: The invention describes antagonists for PDGF. The antagonists contain amino acids, and may be monomers or dimers. Especially preferred are dimers which bind the PDGF receptors, but prevent dimerization of the bound receptors. Dimerization is necessary for PDGF effect, hence the antagonistic effect. Also described are nucleic acid sequences for making the antagonists, as well as cell lines transfected with the material.
    Type: Grant
    Filed: November 16, 1992
    Date of Patent: August 22, 1995
    Assignee: Ludwig Institute for Cancer Research
    Inventors: Flemming S. Vassbotn, Maria Andersson, Gudrun Backstrom, Ulla Engstrom, Carl-Henrik Heldin, Ulf Hellman, Arne stman, Bengt Westermark