Patents Examined by Marianne M. Cintins
  • Patent number: 6339078
    Abstract: The present invention provides methods of conferring protection on a population of cells associated with ischemia in a subject following an ischemic event, comprising: (a) providing an estrogen compound; and (b) administering the effective amount of the compound over a course that includes at least one dose within a time that is effectively proximate to the ischemic event, so as to confer protection on the population of cells. Novel methods are provided for the delivery of an estrogen compound. Examples of ischemic events treatable according to the invention are cerebrovascular disease or stroke, subarachnoid subhemorrhage, myocardial infarct, surgery and trauma. A method of treating ischemic damage utilizing non-sex hormones is also provided.
    Type: Grant
    Filed: July 20, 1999
    Date of Patent: January 15, 2002
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: James W. Simpkins, Katherine D. Gordon, Robert J. Leonard
  • Patent number: 6337333
    Abstract: Fludarabine-5′-monophosphate is useful for the treatment of autoimmune disease, in particular, rheumatoid arthritis.
    Type: Grant
    Filed: October 23, 1992
    Date of Patent: January 8, 2002
    Assignee: Schering Aktiengesellschaft
    Inventor: Martin A. Giedlin
  • Patent number: 6331569
    Abstract: To improve the quantitative and qualitative hair growth, skin structure and/or nail regeneration, a mixture of proline and carrier substances is used, which may additionally contain at least one of the four amino acids valine, leucine, isoleucine and/or glycine. The mixture is prepared for oral administration. The mixture may contain, as additional additives, ATP, biotin, cysteine, lysine, methionine, and others. The preparation may furthermore have a positive effect on the stamina, muscle build-up, brain performance, fat catabolism, blood fat and blood sugar values and the firmness of the connective tissue.
    Type: Grant
    Filed: June 22, 1999
    Date of Patent: December 18, 2001
    Inventors: Friedrich Kisters, Reinhold Nöfer, Günther Kessler
  • Patent number: 6329401
    Abstract: A tachykinin antagonist is useful, alone or in conjunction with other agents, for altering circadian rhythmicity and alleviating circadian rhythm disorders and for enhancing and improving the quality of sleep.
    Type: Grant
    Filed: December 16, 1999
    Date of Patent: December 11, 2001
    Assignee: Merck & Co., Inc.
    Inventors: Carl M. Mendel, Joanne Waldstreicher
  • Patent number: 6323199
    Abstract: This invention describes the use of the compounds of general formula I in which A, B, A, Ar, R1, R2 and R3 have the meaning that is indicated in more detail in the description, for the production of pharmaceutical agents with anti-inflammatory action. The compounds of general formula I show a clear dissociation between anti-inflammatory and metabolic action.
    Type: Grant
    Filed: November 24, 1999
    Date of Patent: November 27, 2001
    Assignee: Schering Aktiengesellschaft
    Inventors: Manfred Lehmann, Konrad Krolikiewicz, Werner Skuballa, Peter Strehlke, Frank Kalkbrenner, Roland Ekerdt, Claudia Giesen
  • Patent number: 6323241
    Abstract: The invention provides methods of treating erectile dysfunction comprising the step of placing within the fossa navicularis of the patient an effective erection-inducing amount of a prostaglandin E1 composition of a semi-solid consistency. The composition comprises prostaglandin E1, a penetration enhancer, a polysaccharide gum, a lipophilic compound, and an acidic buffer system. The penetration enhancer is an alkyl-2-(N,N-disubstituted amino)-alkanoate ester, an (N,N-disubstituted amino)-alkanol alkanoate, or a mixture of these. The lipophilic compound may be an aliphatic C1 to C8 alcohol, an aliphatic C8 to C30 ester, or a mixture of these. The composition includes a buffer system capable of providing a buffered pH value for said composition in the range of about 3 to about 7.4.
    Type: Grant
    Filed: January 10, 2000
    Date of Patent: November 27, 2001
    Assignee: NexMed (Holdings) Inc.
    Inventors: James L. Yeager, Nadir Buyuktimkin, Servet Buyuktimkin
  • Patent number: 6303656
    Abstract: A composition comprising urea and an N-substituted aminosulfonic acid. The composition may be used for the care, treatment and/or protection of human skin, mucous membranes and/or keratin fibers, in particular for moisturizing the skin and for the treatment of dry skin.
    Type: Grant
    Filed: September 3, 1999
    Date of Patent: October 16, 2001
    Assignee: L'Oreal
    Inventor: Veronique Burnier
  • Patent number: 6300373
    Abstract: Neurotrophic and antiproliferative compounds related to the antiepileptic drug valproate are provided. These compounds are useful for promoting neuronal function as in neurodegenerative disorders and for treating neoplastic disease.
    Type: Grant
    Filed: May 22, 1995
    Date of Patent: October 9, 2001
    Assignees: American Biogenetic Sciences, Inc., University College Dublin
    Inventors: Heinz Nau, Ciaran M. Regan
  • Patent number: 6262229
    Abstract: The invention features somatostatin antagonists having a D-amino acid at the second residue.
    Type: Grant
    Filed: May 13, 1997
    Date of Patent: July 17, 2001
    Assignees: Biomeasure Incorporated, The Administration of the Tulane Educational Fund
    Inventors: David H. Coy, Barry Morgan, William Murphy
  • Patent number: 6251428
    Abstract: Compositions for pharmaceutical and other uses for preparing clear aqueous solutions containing bile acids which do not form precipitates over selected ranges of pH values of the aqueous solution and methods of making such solutions. The compositions of the invention comprise water; a bile acid in the form of a bile acid, bile acid salt, or a bile acid conjugated with an amine by an amide linkage; and a high molecular weight aqueous soluble starch conversion product. The composition remains in solution without forming a precipitate over a range of pH values and, according to one embodiment, remains in solution for all pH values obtainable in an aqueous system. The composition, according to some embodiments, may further contain a pharmaceutical compound in a pharmaceutically effective amount.
    Type: Grant
    Filed: July 20, 1999
    Date of Patent: June 26, 2001
    Inventor: Seo Hong Yoo
  • Patent number: 6248869
    Abstract: The present invention relates to an isolated fragment of human cardiac troponin I (TnI) comprising the following sequence X-A-B-Y wherein X comprises any of amino acid residues 1-27 of SEQ ID NO: 2; A comprises amino acid residues 28-69 of SEQ ID NO: 2; B comprises amino acid residues 70-90 of SEQ ID NO: 2; and Y comprises any of amino acid residues 91-170 of SEQ ID NO: 2. The present invention further relates to fragments of TnI wherein the fragment has a greater immunologic reactivity than intact cTnI when the fragment and intact cTnI are reacted with a monoclonal antibody, which has an epitopic site on the fragment.
    Type: Grant
    Filed: May 29, 1997
    Date of Patent: June 19, 2001
    Assignee: Medical Analysis Systems, Inc.
    Inventors: Nihmat A. Morjana, Angela M. Puia
  • Patent number: 6245783
    Abstract: This invention relates to a method of using neurotrophic low molecular weight, small molecule sulfonamide compounds having an affinity for FKBP-type immunophilins, as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity.
    Type: Grant
    Filed: October 18, 1999
    Date of Patent: June 12, 2001
    Assignee: GPI NIL Holdings, Inc.
    Inventors: Gregory S. Hamilton, Jia-He Li, Joseph P. Steiner
  • Patent number: 6239119
    Abstract: The present invention is directed to methods of treating or protecting mucosal tissue from damage associated with radiation and/or chemotherapeutic treatment of cancers, by the topical application of amifostine and related compounds. These methods avoid the side effects of systemically applied radio/chemo protectants. The invention is also directed to treatment and prevention of infections associated with mucositis by topical application of amifostine and related compounds.
    Type: Grant
    Filed: April 26, 1999
    Date of Patent: May 29, 2001
    Assignee: MedImmune Oncology, Inc.
    Inventors: Martin Stogniew, Jean Bourhis
  • Patent number: 6235773
    Abstract: The present invention relates to methods for preventing or treating skin disorders using flavonoid compounds. The present invention also relates to methods for regulating skin condition.
    Type: Grant
    Filed: January 28, 2000
    Date of Patent: May 22, 2001
    Assignee: The Procter & Gamble Company
    Inventor: Donald Lynn Bissett
  • Patent number: 6211336
    Abstract: There is provided a purified amino acid sequence selected from the group of Sequence ID No.: 3 and analogs thereof and mutations of Sequence ID No.: 3 which cause ataxia-telangiectasia. Also provided is a purified amino acid sequence as set forth in Sequence ID No.: 3 and analogs thereof.
    Type: Grant
    Filed: February 26, 1998
    Date of Patent: April 3, 2001
    Assignees: The United States of America as represented by the Department of Health and Human Services, Ramot University Authority for Applied Research and Industrial Dev.
    Inventors: Yosef Shiloh, Danilo A. Tagle, Francis Collins
  • Patent number: 6211169
    Abstract: The invention provides a therapeutic calcitriol solution which is suitable for packaging into pharmaceutical vials without producing discoloration of the antioxidant component of the solution.
    Type: Grant
    Filed: September 29, 1999
    Date of Patent: April 3, 2001
    Assignee: Aesgen, Inc.
    Inventor: Edward C. Shinal
  • Patent number: 6194628
    Abstract: An apparatus for preventing particulate matter and residue build-up within a vacuum exhaust line of a semiconductor processing device. The apparatus uses RF energy to form excite the constituents of particulate matter exhausted from a semiconductor processing chamber into a plasma state such that the constituents react to form gaseous products that may be pumped through the vacuum line. The apparatus may include a collection chamber structured and arranged to collect particulate matter flowing through the apparatus and inhibiting egress of the particulate matter from the apparatus. The apparatus may further include an electrostatic collector to enhance particle collection in the collection chamber and to further inhibit egress of the particulate matter.
    Type: Grant
    Filed: September 25, 1995
    Date of Patent: February 27, 2001
    Assignee: Applied Materials, Inc.
    Inventors: Ben Pang, David Cheung, William N. Taylor, Jr., Sebastien Raoux, Mark Fodor
  • Patent number: 6194455
    Abstract: A composition and method of treating skin ulcers utilizes a combination of sucralfate and a topical anesthetic such as lidocaine. The composition finds utility in treating the symptoms of d from herpes, acne, psoriasis, eczema, diabetic ulcers, bed sores, shingles, jock itch, athlete's foot, ringworm, and other dermal conditions. The composition also finds utility in preventing the development of nascent herpes outbreaks into herpes ulcers, in addition to providing long-lasting relief from such symptoms.
    Type: Grant
    Filed: May 28, 1999
    Date of Patent: February 27, 2001
    Inventor: Marie Madeline Wharton
  • Patent number: 6184199
    Abstract: The invention concerns a synergetic complex designed in particular for being incorporated in a cosmetic and/or pharmaceutical preparation for topical use on the skin and/or superficial body growth this complex is characterized in that it contains at least an extract of Pisum Sativum seeds rich in peptides, an extract of a plant of the Meliaceae family, rich in tannin and/or coumarin derivatives and, if required, at least an amino acid in the form of complex salt(s).
    Type: Grant
    Filed: September 2, 1999
    Date of Patent: February 6, 2001
    Assignee: Laboratoires Serobiologiques (Societe Anonyme)
    Inventor: Gilles Pauly
  • Patent number: 6184208
    Abstract: A peptide of the formula I X-Tyr-Y-Phe-Z-A  I wherein X is hydrogen, arginine, D-arginine, ornithine, D-ornithine, lysine, D-lysine, homoarginine, D-homoarginine, citrulline, D-citrulline; Tyr is tyrosine; Y is D-alanine, D-valine, D-leucine, D-isoleucine, D-phenylalanine, D-asparagine, D-tryptophan, D-proline, D-serine, D-threonine, D-tyrosine, D-hydroxyproline, D-cysteine, D-cysteyl-cysteine, D-methionine, D-lysine, D-homoarginine, D-arginine, D-histidine, D-aspartic acid, D-glutamic acid, D-&bgr;-alanine, or D-ornithine; Phe is phenylalanine; Z is alanine, D-alanine, valine, D-valine, leucine, D-leucine, isoleucine, D-isoleucine, phenylalanine, D-phenylalanine, asparagine, D-asparagine, glycine, glutamine, D-glutamine, tryptophan, D-tryptophan, proline, D-proline, serine, D-serine, threonine, D-threonine, tyrosine, D-tyrosine, hydroxyproline, D-hydroxyproline, cysteine, D-cysteine, cysteyl-cysteine, cysteine-D-cysteine, D-cysteyl-cysteine, D-cysteine-D-cysteine, methionine, D-methionine, lysin
    Type: Grant
    Filed: July 22, 1996
    Date of Patent: February 6, 2001
    Assignee: Immunotech Developments Inc.
    Inventors: Vladislav I. Deigin, Yelena Yarova