Abstract: A hybrid plasminogen activator-like polypeptide comprising a polypeptide region responsible for an affinity to fibrin derived from a tissue plasminogen activator polypeptide and a polypeptide region responsible for an enzyme activity derived from a prourokinase polypeptide; a DNA segment coding for the hybrid polypeptide; plasmid containing the DNA segment; a microorganism transformed with the DNA; and a process for production of the hybrid polypeptide comprising culturing the microorganism and recovering the hybrid polypeptide from the cultured cells.
Type:
Grant
Filed:
July 3, 1991
Date of Patent:
April 20, 1993
Assignees:
Sagami Chemical Research Center, Central Glass Company, Limited, Hodogaya Chemical Co., Ltd., Nippon Soda Company, Limited, Nissan Chemical Industries, Limited, Toyo Soda Manufacturing Co., Ltd.