Patents Examined by Marianne Porter Allen
  • DNA sequences encoding t-PA derivatives with cleavable sites
    Patent number: 5326700
    Abstract: The invention concerns compounds and methods for the recombinant production of a homogeneous population of tissue plasminogen activator molecules and derivatives thereof through the use of heterologous propeptide regions that are uniformly cleaved upon secretion from the host cell.
    Type: Grant
    Filed: November 6, 1990
    Date of Patent: July 5, 1994
    Assignee: Eli Lilly and Company
    Inventors: David T. Berg, Brian W. Grinnell