Patents Examined by Mark F. Colosimo
  • Patent number: 4986256
    Abstract: Water-soluble paramagnetic metalloporphyrins are used as contrast enhancing agents for magnetic resonance imaging. These agents exhibit excellent localization, non-toxicity and suprisingly high contrast enhancement in magnetic resonance imaging applications.
    Type: Grant
    Filed: February 28, 1985
    Date of Patent: January 22, 1991
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Jack S. Cohen, Chi-Wan Chen, Charles E. Myers, Miriam Sohn
  • Patent number: 4917685
    Abstract: The present invention relates to a delivery device designed to be implanted in an animal and for the administration of a stabilized growth promoting formulation. This device has a wall formed at least in part by a porous membrane which surrounds and defines a reservoir. The reservoir contains a growth promoting hormone and a stabilizer. Examples of such stabilizers include certain polyols, amino acids, polymers of amino acids having a charged side group at physiological pH, and choline salts.
    Type: Grant
    Filed: May 16, 1986
    Date of Patent: April 17, 1990
    Assignee: International Minerals & Chem. Corp.
    Inventors: Ravi Viswanathan, Randolph B. DePrince
  • Patent number: 4886487
    Abstract: Autotransfusion apparatus is disclosed for employing a patient's blood as a source for providing a transfusion, and which can also supply anticoagulant and diluting solution to the blood collected from a patient. The apparatus including a cardiotomy reservoir for collecting the patient's blood, a blood filter for separating a filtrate from the blood, a blood retention bag for retaining the treated blood and from which the blood can be returned to the patient by gravity.
    Type: Grant
    Filed: November 18, 1986
    Date of Patent: December 12, 1989
    Assignee: Gambro AB
    Inventors: Jan O. Solem, Olev Pilman
  • Patent number: 4883048
    Abstract: Apparatus and methods for use in performing surgical operations such as anterior or posterior cruciate ligament reconstructions wherein the apparatus has means for positioning a target area at the center of an arc of a circle so that when the target area is positioned at a location relative to the anatomical center of the original attachment of the cruciate ligaments on the tibia and femur bones, kirschner wires may be pushed through guide means having a longitudinal axis coinciding with a ray emanating from the center of the circle and indicate the proper location for holes in the tibia and femur for the proper attachment of a cruciate ligament graft substitute. The apparatus is also used in the placement of kirschner wires to serve as guide wires in the performance of an osteotomy.
    Type: Grant
    Filed: August 15, 1988
    Date of Patent: November 28, 1989
    Inventors: Mark L. Purnell, Robert R. Oden, William L. McCune, Michael E. Berkeley
  • Patent number: 4883479
    Abstract: An absorbent article comprising a base sheet of fluid impervious material, a top sheet of fluid pervious non-woven material, and an absorbent pad disposed between the top sheet and the base sheet. The top sheet is secured to the base sheet along the periphery thereof. The absorbent pad has a central portion and two side panels folded under the top sheet and over the central panel. A binder secures the side panels to the central panel to render the central panel more absorbent.
    Type: Grant
    Filed: September 26, 1986
    Date of Patent: November 28, 1989
    Assignee: Colgate-Palmolive Company
    Inventors: Jean P. Piron, Jean C. Daugan
  • Patent number: 4877028
    Abstract: Apparatus for accomplishing the permanent placement of a lockable clip around a target vessel to interrupt the continuity of the same in a rapid, safe and minimally invasive manner. The apparatus includes a trocar obturator and a hollow member in which the open locking clip is enclosed for delivery to a position proximate to the vas whereupon the trocar obturator is retracted such that the clip is locked onto the vessel to effect occlusion.
    Type: Grant
    Filed: July 25, 1988
    Date of Patent: October 31, 1989
    Assignee: Vastech Medical Products Inc.
    Inventor: Jeffrey Sandhaus
  • Patent number: 4872865
    Abstract: A physiologically conforming solution for use in invasive medical procedures which is hypertonic with respect to blood serum and may, in fact, have a higher osmolality than synovial fluid. The solution is of particular utility as an irrigant in arthroscopic surgery in order to reduce the risk of swelling and injury of the synovial tissues and as a therapeutic treatment for swelling and subsequent inflammation of joints and soft tissue which occurs in certain traumatized and pathological states.
    Type: Grant
    Filed: November 30, 1987
    Date of Patent: October 10, 1989
    Assignee: Harrington Arthritis Research Center
    Inventors: Roy D. Bloebaum, Frank P. Magee
  • Patent number: 4867743
    Abstract: This invention discloses disposable infusion delivery systems, in each of which fluid is drawn into a receiving and retaining housing and a piston is slideable in said housing. As the piston is moved away from a discharge end of the housing, at least one elastomeric member is stretched, with the stored fluid ahead of said piston discharged from said housing by the force developed by said stretched elastomeric member. This stored fluid provides a continuous flow of fluid to a patient. There are three arrangements shown. The first enables additive drugs to be infused into a fluid stream without purging. The second shows a syringe adapted to provide the disposable infusion device, and the third provides a fluid stream to and through a pressure transducer, enabling monitoring of blood pulses with minimum distortion.
    Type: Grant
    Filed: November 24, 1986
    Date of Patent: September 19, 1989
    Inventor: Vincent L. Vaillancourt
  • Patent number: 4865598
    Abstract: A dispensing device is disclosed for delivering a beneficial agent. The device comprises (1) a housing defining an internal space, (2) an expandable composition in the space, (3) an aqueous sensitive beneficial agent formulation in the space, and (4) at least one passageway in the housing for delivering the beneficial agent from the dispensing device.
    Type: Grant
    Filed: February 2, 1988
    Date of Patent: September 12, 1989
    Assignee: ALZA Corporation
    Inventor: James B. Eckenhoff
  • Patent number: 4863432
    Abstract: A catheter assembly is provided to facilitate taping of the emplaced catheter onto the patient's body. The assembly comprises a catheter extending distally from a catheter hub. The hub has a hub axis co-axially aligned with the catheter and provided with a pair of opposed wings integral with the hub. Each of the wings having a proximal edge and a distal edge are such that a portion of at least one of these edges forms an acute angle with the axis of the hub of from about 35.degree. to about 55.degree. whereby the taping operation of the wings to the patient's body may be facilitated.
    Type: Grant
    Filed: June 30, 1988
    Date of Patent: September 5, 1989
    Assignee: Critikon, Inc.
    Inventor: Michael L. Kvalo
  • Patent number: 4863456
    Abstract: A dosage form is disclosed comprising a wall surrounding a compartment housing a first layer comprising a drug formulation, a middle layer comprising a hydrophobic composition, and a third layer comprising a hydrophilic composition.
    Type: Grant
    Filed: February 8, 1988
    Date of Patent: September 5, 1989
    Assignee: ALZA Corporation
    Inventors: Sally I. Stephens, Patrick S. L. Wong
  • Patent number: 4861339
    Abstract: An injection spray gun with a holder comprising: a sheathing adapted to receive a cylindrical ampule; a handle fastened to the gun; an actuating lever pivotally attached to the handle; a plunger guided in the holder and connected with the actuating lever; a piston located in the cylindrical ampule wherein movement of the plunger causes forward thrust of the piston; and a pressure limiting device being provided for acting on at least one of the actuating lever and/or the plunger.
    Type: Grant
    Filed: May 26, 1987
    Date of Patent: August 29, 1989
    Assignee: Henke-Sass, Wolf GmbH
    Inventor: Horst Jonischkeit
  • Patent number: 4858602
    Abstract: A bone nail for the treatment of upper arm fractures comprises a hollow shank adapted to be introduced into the medullary canal and slotted at the distal end, and an expansion screw adapted to be advanced into the shank through rotation of the screw so as to radially expand the slotted end of the shank. An inner thread is formed on the inner wall of the shank outside the slotted region for cooperation with the expansion screw. At least in the slotted region, the cross sectional profile of the shank is provided with alternating elevations and depressions on the inner surface of the wall of the hollow shank.
    Type: Grant
    Filed: November 28, 1986
    Date of Patent: August 22, 1989
    Assignee: Howmedica GmbH Werk Schonkirchen
    Inventors: Hartmut R. A. Seidel, Hans E. Harder, Klaus F. A. Behrens
  • Patent number: 4856533
    Abstract: A vacuum blood-collection tube comprising a tube-shaped vessel having an opening through which air can be removed, and a plug that makes the opening air-tight to maintain low-pressure conditions inside the said vessel, the raw materials of the said vessel being polyethyleneterephthalate, a copolymer of polyethyleneterephthalate, or an acrylonitrile resin, and the inner walls of said vessel incorporating a hydrophilic substance that is either difficult or impossible to dissolve in water and that prevent blood clots from adhering to the inner walls of said tube, a water-soluble substance, and a adsorptive inorganic substance.
    Type: Grant
    Filed: January 28, 1986
    Date of Patent: August 15, 1989
    Assignee: Sekisui Kagaku Kogyo Kabushiki Kaisha
    Inventors: Hideo Anraku, Yoshikata Shoji
  • Patent number: 4857052
    Abstract: A formulation chamber is disclosed comprising a wall surrounding a lumen containing a device for delivering a beneficial agent. The chamber has an inlet for admitting a fluid into the chamber and an outlet for letting an agent formulation leave the chamber. The chamber is adapted for use in an intravenous delivery system for delivering an agent formulation to a patient.
    Type: Grant
    Filed: May 4, 1987
    Date of Patent: August 15, 1989
    Assignee: Alza Corporation
    Inventor: Felix Theeuwes
  • Patent number: 4850993
    Abstract: A method and system is disclosed for introducing anti-bacterial agents, for example, quinolone carboxylic acid derivatives into blood bag systems for preventing massive bacteria growth in stored blood and blood components. The quinolone carboxylic acid derivative can be added to a collection container before, during or after the collection of blood and blood components. The addition of a quinolone carboxylic acid derivative to blood bag systems allows for increase in storage time for blood and blood components without the threat of massive bacterial contamination.
    Type: Grant
    Filed: December 22, 1986
    Date of Patent: July 25, 1989
    Assignee: Miles Laboratories, Inc.
    Inventors: Alexander B. Champion, Michael S. Collins
  • Patent number: 4846782
    Abstract: Radiation sensitive human cancers are treated with combined interferon and radiation therapy.
    Type: Grant
    Filed: November 25, 1987
    Date of Patent: July 11, 1989
    Assignee: Schering Corporation
    Inventor: Eric Bonnem
  • Patent number: 4842586
    Abstract: A protective device and method for the removal and disposal of spinal needles. The protective device is comprised of a needle pulling assembly upon which is slidably mounted an external housing. In operation, a needle to be removed from a patient is engaged in the needle cradle portion of the needle pulling assembly. The external housing is moved into contact with the patient's skin and the needle is withdrawn by pulling on the pulling rod portion of the needle pulling assembly in a direction away from the patient. The needle is withdrawn into the interior of the external housing, thereby covering the entire length of the needle. The pulling assembly is then locked into place and the entire assembly including the withdrawn needle can be disposed of, thereby avoiding the possibility of needle pricks by contaminated spinal needles.
    Type: Grant
    Filed: March 18, 1987
    Date of Patent: June 27, 1989
    Assignee: City of Hope National Medical Center
    Inventor: John M. Hogan
  • Patent number: 4840190
    Abstract: Described herein is an improved injection reservoir of the type which is employed to permit subcutaneous inflation of inflatable, implantable prostheses such as tissue expanders. The improved injection reservoir has a lozenge shape when viewed from above which permits this injection reservoir to be more easily inserted and removed subcutaneously. In a more preferred embodiment, the injection reservoir has a low profile shape such that its height is no more than forth percent of its width.
    Type: Grant
    Filed: April 14, 1988
    Date of Patent: June 20, 1989
    Assignee: Dow Corning Wright
    Inventor: Gordon H. Sasaki
  • Patent number: 4838876
    Abstract: Silicone rubber catheters possessing improved surface morphology, at least the surface of the catheter to be inserted in the body having bonded thereto the reaction product of a composition comprising:(1) at least one crosslinkable polysiloxane;(2) an innocuous lubricating agent; and(3) a crosslinking agentPreferably, the lubricating agent is a medical grade lubricating oil.
    Type: Grant
    Filed: February 11, 1988
    Date of Patent: June 13, 1989
    Assignee: The Kendall Company
    Inventors: Edward W. Wong, Daniel G. Ballan