Abstract: The present invention provides methods for the assessment of diseases that result from the combined or interactive effects of two or more genetic variants, and in particular for diagnosing risk of developing such diseases in subjects using an analysis of genetic polymorphisms. Methods for the derivation of a net score indicative of a subject's risk of developing a disease are provided.

Abstract: The present invention relates to a method and system for automated correlation of genetic test results. The method includes: receiving a first genetic test result from an individual's genetic history and receiving a second genetic test result for the individual. The method further includes determining based on result criteria if the second genetic test result should be identified as the primary genetic test result for the individual and, if so, identifying said second genetic test result as the primary genetic test result in the individual's genetic history.

Abstract: Disclosed is a visualization method of RNA pseudoknot structures. The method of the invention comprises the steps of setting criteria required for visualizing RNA pseudoknots, setting structural elements and data structures for representing a whole RNA structure containing pseudoknots, determining an input format for visualization and a drawing order of the structure, determining connectivity relations between regular loops and stems in the structure and between pseudoknot loops and stems in the structure, calculating radii of the regular loop and the PK loop, calculating coordinates of bases in the regular loops, setting internal angles of the PK loops, calculating startAngles of the regular loops and angles of the stem, determining positions of the pseudoknots in the PK loops, and drawing the pseudoknots and the whole RNA structure containing the pseudoknots.

Abstract: A method for cell-based combinatorial logic includes the steps of providing at least one genetically engineered cell, the genetically engineered cell having at least one transcriptional unit. The transcriptional unit includes a gene and a promoter, wherein application of a stimulus to the promoter results in the expression of a gene product. An energetic or chemical stimulus is applied to activate the promoter, wherein the detection of an output signal corresponds to the presence of a gene product. The cell can include a plurality of transcriptional units configured to form logic gates. The logic gates of a plurality of cells can be operably interconnected by release of output signals, such as chemical stimuli.

Abstract: A technique for determining events of interest within an output pattern generated from a detected image of an array of detectors where the output pattern comprises signals associated with noise, and signals associated with the events of interest which have intensities both greater and less than intensities of signals associated with noise. Quantum resonance interferometry is utilized to amplify signals associated with the events of interest having an intensity lower than the intensity of signals associated with noise, to an intensity greater than the intensity of the signals associated with noise to generate a modified output pattern. Once the desired signals are amplified, the technique determines which signals within the modified output pattern correlate with events of interest thus permitting a determination to be made whether a certain event of interest has occurred.