Patents Examined by Mark L. Beach
  • Process of enantiomeric separation of carbacephem intermediates
    Patent number: 5142038
    Abstract: Enantiomerically pure .beta.-lactam intermediates of the formula (I) ##STR1## are isolated from a haloalkane solvent through precipitation with methyl-t-butyl ether or methanol. The products thus obtained are key intermediates in the synthesis of antibiotic aagents. The process is appropriate for large scale production.
    Type: Grant
    Filed: July 23, 1991
    Date of Patent: August 25, 1992
    Assignee: Eli Lilly and Company
    Inventors: Christopher W. Doecke, Jeffrey N. Levy, Wayne D. Luke, Michael A. Staszak