Patents Examined by Mark Navarro
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Patent number: 11633433Abstract: With the aim of proving an antibacterial composition against oral bacteria and the like capable of inducing Th1 cell proliferation or activation in an intestinal tract, the present inventors have found out that bacteria that suppress colonization and the like of the oral bacteria and the like in the intestinal tract are present in an intestinal microbiota. Moreover, the present inventors have succeeded in isolating intestinal bacteria that suppress intestinal colonization and the like of oral bacteria and the like.Type: GrantFiled: July 18, 2018Date of Patent: April 25, 2023Assignee: KEIO UNIVERSITYInventors: Kenya Honda, Koji Atarashi, Seiko Narushima, Wataru Suda, Masahira Hattori, Munehiro Furuichi, Takaaki Kawaguchi, Keiko Mitobe
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Patent number: 11618902Abstract: The disclosure discloses Bacillus subtilis for producing N-acetylneuraminic acid and application thereof, and belongs to the field of genetic engineering. The disclosure optimizes the expression levels of key enzymes in N-acetylneuraminic acid synthesis pathways on genome through promoters of different strength, reduces the protein synthesis pressure caused by the expression of enzymes on cells, and further integrates the three N-acetylneuraminic acids in a same Bacillus subtilis engineering strain. Bacillus subtilis with improved N-acetylneuraminic acid production is obtained, and the production reaches 10.4 g/L at the shake flask level, laying a foundation for further improving the NeuAc production from Bacillus subtilis.Type: GrantFiled: February 16, 2021Date of Patent: April 4, 2023Assignee: Jiangnan UniversityInventors: Yanfeng Liu, Long Liu, Xiaolong Zhang, Guocheng Du, Jianghua Li, Jian Chen
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Patent number: 11609239Abstract: A method and apparatus for locating and selecting a colony of microorganisms on a culture dish and identifying microorganisms in said selected colony using MALDI. The method comprises the automated steps of locating and selecting a colony of microorganisms on a culture dish; obtaining a sample of said selected colony of microorganisms; depositing at least some of said sample of said selected colony of microorganisms on a target plate; and transferring said target plate with said sample in an apparatus for performing MALDI for identification of said sample of said selected colony of microorganisms. A sample of a colony of microorganisms is automatically deposited on a depositing spot such that the sample covers at most approximately half of said one of the depositing spots of the target plate.Type: GrantFiled: November 10, 2020Date of Patent: March 21, 2023Assignee: BD KIESTRA B.V.Inventors: Jetze Botma, Martijn Kleefstra, Tino Walter Van der Zee
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Patent number: 11603391Abstract: The present invention provides new derivatives of CATH2 or CMAP27, one of the cathelicidins. These derivatives comprise N-terminally truncated peptides, cyclic peptides, D-amino acid variants of CATH2 and its truncated derivatives, inverso and retroinverso CATH2 derivatives. These derivatives are useful as anti-infectives, in vaccines, and especially for in ovo applications. Further, for the above derivatives and also for the already known C-terminally truncated derivatives new immunoactivating functions have been described that are particularly advantageous for prophylactic treatments.Type: GrantFiled: October 13, 2020Date of Patent: March 14, 2023Assignee: Universiteit Utrecht Holding B.V.Inventors: Hendrik Peter Haagsman, Albert van Dijk, Edwin Johannes Adrianus Veldhuizen
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Patent number: 11541110Abstract: Provided are vaccine compositions and methods against Streptococcus pneumoniae. The composition comprises liposomes which have polysaccharides from one or more serotypes and have proteins non-covalently attached to the surface and exposed to the exterior.Type: GrantFiled: October 12, 2018Date of Patent: January 3, 2023Assignee: The Research Foundation for The State University of New YorkInventors: Blaine Pfeifer, Charles Jones
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Patent number: 11466057Abstract: It has been found that an extracellular polypeptide derived from Akkermansia municiphila is capable of modulating and/or promoting gut mucosal immune system function and/or maintaining and/or restoring metabolic status and/or increasing the physical integrity of the gut mucosal barrier in a mammal. The polypeptide or host cells comprising such polypeptide may be employed to prevent and/or treat a variety of conditions that benefit from an increased physical integrity of the gut mucosal barrier and/or an improved gut mucosal immune system function and metabolic status.Type: GrantFiled: June 30, 2020Date of Patent: October 11, 2022Assignees: WAGENINGEN UNIVERSITEIT, UNIVERSITÉ CATHOLIQUE DE LOUVAINInventors: Clara Belzer, Willem Meindert De Vos, Patrice Daniel Cani
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Patent number: 11453883Abstract: Described herein is a protein display selection method which uncouples a protein of interest (POI) library from the display selection system. Display of the POI can be achieved by forming a covalent bond between the POI and the anchor protein post expression either by enzymatic protein ligation (e.g. SpyLigase, SnoopLigase, sortase, butelase, peptiligase etc.) or by spontaneous covalent bond formation (e.g. SpyTag/SpyCatcher, SnoopTag/SnoopCatcher, etc.). The POI library is fused to a tethering sequence, for example SpyTag, at the C-terminus of the POI which then forms a covalent bond to a capture sequence found on an anchor protein, for example, the SpyCatcher-fused anchor protein, e.g., a SpyCatcher-geneIII protein (SpyCatcher-pIII) fusion, for the most common form of phage display. Nucleic acid constructs, host cell systems and methods of producing the protein display systems are also provided.Type: GrantFiled: April 5, 2019Date of Patent: September 27, 2022Assignee: BIO-RAD ABD SEROTEC GMBHInventor: Francisco Ylera
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Patent number: 11389517Abstract: The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles. In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).Type: GrantFiled: June 30, 2021Date of Patent: July 19, 2022Assignee: NORTHWESTERN UNIVERSITYInventors: Lonnie D. Shea, Stephen D. Miller, Jonathan Woon Teck Yap, Daniel R. Getts, Derrick McCarthy
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Patent number: 11360089Abstract: A main controller of an immunological test apparatus counts an elapsed time TP. An information output unit outputs required determination time information regarding a required determination time so as to be associated with information of a determination result. The required determination time information is at least information indicating that the elapsed time TP exceeds a set time TS at which sensitization processing, in which a chemical solution for sensitizing the coloration state of a reagent that is combined with influenza virus to be colored is spread onto a carrier, is started, that is, information indicating that the sensitization processing has been performed.Type: GrantFiled: August 15, 2019Date of Patent: June 14, 2022Assignee: FUJIFILM CorporationInventors: Shigetoshi Ishikawa, Yoshinari Oda
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Patent number: 11318177Abstract: The present invention is directed to a composition of Lactobacillus fermentum for use in the treatment of a fructose-related disease and a related method of treatment.Type: GrantFiled: March 12, 2019Date of Patent: May 3, 2022Assignee: AIXSWISS B.V.Inventors: Jorg Paule, Fabio Oester
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Patent number: 11260081Abstract: Provided are nucleic acid constructs, Toxoplasma comprising same, pharmaceutical compositions comprising same and methods using same for delivering a protein-of-interest to a tissue-of-interest of a subject, such as the CNS and further treating a pathology which is treatable by administration of a therapeutic polypeptide in a central nervous system of the subject.Type: GrantFiled: June 29, 2017Date of Patent: March 1, 2022Assignees: Ramot at Tel-Aviv University Ltd., The Universitv Court of the University of GlasgowInventors: Oded Rechavi, Shahar Bracha, Lilach Sheiner
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Patent number: 11191817Abstract: The present disclosure provides compositions and methods for treating an infection by EV-D68. In particular, the present disclosure provides methods that entail administering agents having an anchoring domain that anchors the compound to the surface of a target cell, and a sialidase domain that can act extracellularly to inhibit infection of a target cell by EV-D68.Type: GrantFiled: April 24, 2020Date of Patent: December 7, 2021Assignee: AnsunBiopharma, Inc.Inventor: Ronald B. Moss
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Patent number: 11137385Abstract: Methods are used for obtaining, cataloguing, and/or storing data derived from a biological source using a flow cell body, electrodes, and an imaging assembly. The data may include DNA and/or RNA obtained from a biological source, such as from the cells of an organism. The methods may be used to obtain, catalog, and/or store data such as DNA or RNA sequence from a pathogen such as a virus and/or a bacteria, human health data over time, and immune system information from an individual. The data obtained using the disclosed methods may be used for a variety of different purposes, including the manufacture of vaccine compositions, and for restoring the immune system of an individual who has undergone an immune system depleting event. The methods may be used for storage of biological cells, which may be used for the screening of compounds, such as small molecules with potential for therapeutic indications.Type: GrantFiled: May 26, 2020Date of Patent: October 5, 2021Assignee: ILLUMINA, INC.Inventors: Tarun Khurana, Ali Agah, Aathavan Karunakaran, Xi-Jun Chen
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Patent number: 11129881Abstract: The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles. In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).Type: GrantFiled: April 13, 2020Date of Patent: September 28, 2021Assignee: NORTHWESTERN UNIVERSITYInventors: Lonnie D. Shea, Stephen D. Miller, Jonathan Woon Teck Yap, Daniel R. Getts, Derrick McCarthy
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Patent number: 11125750Abstract: Methods and kits for the detection of toxic cyanobacteria in a sample by analyzing the sample for the presence antibodies raised in a host, where the presence of antibodies is indicative of toxic cyanobacteria, are described.Type: GrantFiled: June 27, 2019Date of Patent: September 21, 2021Assignee: The University of ToledoInventors: David Kennedy, Steven Haller, R. Mark Wooten, Deepa Mukundan, Apurva Lad, John Presloid, Jason Huntley, Bruce Levison
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Patent number: 11066637Abstract: A live bacteria-containing particulate is provided, wherein the particulate comprises a bacterial strain, a first covering layer, and a second covering layer, and wherein the first covering layer is in-between the cell membrane and cell wall of the bacterial strain and the bacterial strain is dispersed in the second covering layer. A method of preparing a live bacteria-containing particulates is also provided, wherein the method comprises the following steps: (a) subjecting a bacterial strain to a three-stage fermentation to obtain a fermentation broth; (b) concentrating the fermentation broth to provide a concentrated bacterial solution; (c) mixing the concentrated bacterial solution with a protective agent; and (d) drying the mixture to provide live bacteria-containing particulates.Type: GrantFiled: March 23, 2020Date of Patent: July 20, 2021Assignee: TCI CO., LTD.Inventors: Yung-Hsiang Lin, Cheng-Yu Ho, Jin-Jia Wang
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Patent number: 11000581Abstract: This invention relates to the delivery of heterologous peptides or proteins such as therapeutic peptides, therapeutic proteins or antigens to mucosal sites using vesicles derived from the outer membrane of commensal bacteria, recombinant bacteria capable of producing such vesicles, and methods for the production of such vesicles. The invention further relates to an inducible expression system for use in recombinant bacteria.Type: GrantFiled: April 28, 2017Date of Patent: May 11, 2021Assignees: QUADRAM INSTITUTE BIOSCIENCE, UEA ENTERPRISES LIMITEDInventors: Regis Gabriel Stentz, Simon Richard Carding
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Patent number: 10967011Abstract: Disclosed herein are therapeutic compositions containing non-pathogenic, germination-competent bacterial spores, for the prevention, control, and treatment of gastrointestinal diseases, disorders and conditions and for general nutritional health.Type: GrantFiled: August 3, 2018Date of Patent: April 6, 2021Assignee: Seres Therapeutics, Inc.Inventors: Gregory McKenzie, Mary-Jane Lombardo McKenzie, David N. Cook, Marin Vulic, Geoffrey von Maltzahn, Brian Goodman, John Grant Aunins, Matthew R. Henn, David Arthur Berry, Jonathan Winkler
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Patent number: 10920290Abstract: The present disclosure provides engineered modified strains of Enterococcus faecalis (EF) that is able to produce bacteriocin but is inefficient at establishing long-term colonization of the GI track in an animal. Compositions comprising the modified strain and methods of use are also disclosed.Type: GrantFiled: February 14, 2018Date of Patent: February 16, 2021Assignee: The Medical College of Wisconsin, Inc.Inventors: Nita Salzman, Christopher Kristich, Sushma Kommieni
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Patent number: 10906962Abstract: The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to poly-N-acetyl glucosamine (PNAG), such as Staphylococcal PNAG, in acetylated, partially acetylated and/or fully deacetylated form. The invention further provides methods for using these peptides in the diagnosis, prophylaxis and therapy of infections by bacteria that express PNAG such as but not limited to Staphylococci and E. coli. Some antibodies of the invention enhance opsonophagocytic killing and in vivo protection against bacteria that express PNAG such as but not limited to Staphylococci and E. coli. Compositions of these peptides, including pharmaceutical compositions, are also provided, as are functionally equivalent variants of such peptides.Type: GrantFiled: June 11, 2018Date of Patent: February 2, 2021Assignees: The Brigham and Women's Hospital, Inc., Beth Israel Deaconess Medical Center, Inc.Inventors: Gerald B. Pier, Casie Anne Kelly-Quintos, Lisa Cavacini, Marshall R. Posner