Patents Examined by Mark Navarro
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Patent number: 10094830Abstract: The present invention relates to novel peptides that may be used in whole or in combination for the detection of Mycobacterium tuberculosis infection. In particular, the present invention relates to compositions and methods involving detection of antibodies contained in the blood of non-human primates that arise from an infection from M. tuberculosis or vaccination using an epitope specific inoculation. More particularly, the present invention provides a means to distinguish early, active, and latent M. tuberculosis infection. More particularly, the present invention describes an immunological diagnostic mechanism for the detection of M. tuberculosis infection.Type: GrantFiled: July 18, 2016Date of Patent: October 9, 2018Assignee: INTUITIVE BIOSCIENCES, INC.Inventor: Kimberly Luke
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Patent number: 10080790Abstract: The disclosure generally relates to the field of prevention and treatment of Staphylococcus aureus infections. In particular, the disclosure relates to immunogens comprising Staphylococcus aureus antigens and methods for generating immune responses to immunogens, and to antibody products specific for the Staphylococcus aureus epitopes and methods for treating Staphylococcus aureus infection with the antibody products.Type: GrantFiled: September 17, 2015Date of Patent: September 25, 2018Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Jon Oscherwitz, Kemp Cease
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Patent number: 10073105Abstract: A method and apparatus for locating and selecting a colony of microorganisms on a culture dish and identifying microorganisms in said selected colony using MALDI. The method comprises the automated steps of locating and selecting a colony of microorganisms on a culture dish; obtaining a sample of said selected colony of microorganisms; depositing at least some of said sample of said selected colony of microorganisms on a target plate; and transferring said target plate with said sample in an apparatus for performing MALDI for identification of said sample of said selected colony of microorganisms. A sample of a colony of microorganisms is automatically deposited on a depositing spot such that the sample covers at most approximately half of said one of the depositing spots of the target plate.Type: GrantFiled: July 28, 2017Date of Patent: September 11, 2018Assignee: BD Kiestra B.V.Inventors: Jetze Botma, Martijn Kleefstra, Tino Walter Van der Zee
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Patent number: 10064901Abstract: Disclosed herein are therapeutic compositions containing non-pathogenic, germination-competent bacterial spores, for the prevention, control, and treatment of gastrointestinal diseases, disorders and conditions and for general nutritional health.Type: GrantFiled: December 19, 2017Date of Patent: September 4, 2018Assignee: Seres Therapeutics, Inc.Inventors: Gregory McKenzie, Mary-Jane Lombardo McKenzie, David N. Cook, Marin Vulic, Geoffrey von Maltzahn, Brian Goodman, John Grant Aunins, Matthew R. Henn, David Arthur Berry, Jonathan Winkler
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Patent number: 10052465Abstract: Methods and systems for delivering toxin and toxin fragments to a patient's nasal cavity provide for both release of the toxin and delivery of energy which selectively porates target cells to enhance uptake of the toxin. The use of energy-mediated delivery is particularly advantageous with light chain fragment toxins which lack cell binding capacity.Type: GrantFiled: June 6, 2017Date of Patent: August 21, 2018Assignee: The Foundry, LLCInventors: Mark E. Deem, Hanson Gifford
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Patent number: 10017806Abstract: The present invention relates to determination of the microorganism content in material comprising cellulose within the pulp and paper industry. The material comprising cellulose is enzymatically pretreated and microorganisms are determined using PCR based technology.Type: GrantFiled: October 27, 2015Date of Patent: July 10, 2018Assignee: Stora Enso OYJInventors: Kirsi Partti-Pellinen, Jari Räsänen, Kielo Härmälä, Anu Kettunen, Kalle-Juhani Riihinen
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Patent number: 9968098Abstract: The present invention generally relates to the use of synergistic amounts of Bacillus thuringiensis subsp. aizawai, Bacillus thuringiensis subsp. kurstaki and cyantraniliprole for the control of diamondback moth, beet armyworm, southwestern corn borer, and corn earworm wherein the ratio of Bacillus thuringiensis subsp. kurstaki to Bacillus thuringiensis subsp. aizawai is from about 1:0.47 to about 1:0.92, and the ratio of the total amount of Bacillus thuringiensis to cyantraniliprole is from about 1:0.025 to about 1:150.Type: GrantFiled: April 27, 2017Date of Patent: May 15, 2018Assignee: VALENT BIOSCIENCES LLCInventors: Deanna D. Branscome, Roger D. Storey, James Russell Eldridge, Emily E. Brazil
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Patent number: 9970931Abstract: The invention generally relates to methods of using compositions that include sets of magnetic particles, members of each set being conjugated to an antibody specific for a pathogen, and magnets to isolate a pathogen from a body fluid sample.Type: GrantFiled: October 24, 2016Date of Patent: May 15, 2018Assignee: DNAE Group Holdings LimitedInventors: Sergey A. Dryga, Victor C. Esch, Lisa-Jo Ann Clarizia, Eddie W. Adams, Thearith H. Ung, Ravil A. Sitdikov
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Patent number: 9943590Abstract: This invention relates to methods of using a Listeria vaccine vector to induce a Th1 immune response in subjects having persistent Th2 immune response profiles.Type: GrantFiled: October 7, 2015Date of Patent: April 17, 2018Assignees: The Trustees of the University of Pennsylvania, University of Georgia Research Foundation, Inc.Inventors: Donald A. Harn, Jr., Yvonne Paterson, Lisa McEwen
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Patent number: 9873870Abstract: Methods and compositions for identifying antigens of human lymphocytes are provided herein.Type: GrantFiled: April 30, 2015Date of Patent: January 23, 2018Assignee: Genocea Biosciences, Inc.Inventors: Jessica Flechtner, Todd Gierahn
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Patent number: 9713637Abstract: The invention provides an isolated Bacillus cereus sensu lato strain, selected from Bacillus anthracis, Bacillus cereus and Bacillus thuringiensis, in which the htrA gene or any part thereof is silenced, and vaccines comprising the same.Type: GrantFiled: July 18, 2012Date of Patent: July 25, 2017Assignee: State of Israel Prime Minister's Office Israel Institute for Biological ResearchInventors: Ofer Cohen, Theodor Chitlaru, Avigdor Shafferman
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Patent number: 9624529Abstract: A cell based assay for detection for protease activity is disclosed. In the assay a cell is engineered to express a protease substrate with at least one label, preferably on its C-terminus. Cleavage of the substrate by the protease that recognizes it results in a C-terminal fragment and a N-terminal fragment, where the fragment having the label is subject to ubiquitin proteasome degradation. The assay measures the disappearance of the label due to degradation of the fragment to which it is attached. A cell free assay is also described for detection of protease activity. In the cell free assay, the protease substrate is expressed in a solution that includes the elements of the ubiquitin proteasome pathway for degradation of the fragment. The assay measures the disappearance of the label attached to the fragment that results from cleavage by the protease.Type: GrantFiled: January 27, 2015Date of Patent: April 18, 2017Assignee: SYNAPTIC RESEARCH, LLCInventors: George A. Oyler, Yien Che Tsai
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Patent number: 9585949Abstract: Strains of Sarcocystidae selected from Toxoplasma spp or Neospora spp isolated from their natural environment and having an immunostimulant effect, for the use thereof in the prevention or the treatment, in a mammal, of a pathology associated with an apicomplexan of the family Cryptosporidiidae.Type: GrantFiled: February 4, 2016Date of Patent: March 7, 2017Assignees: VITAMFERO, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, UNIVERSITE FRANCOIS RABELAIS DE TOURSInventors: Audrey Gnahoui-David, Fabrice Laurent, Marie-Noelle Mevelec, Edouard Seche
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Patent number: 9539316Abstract: An immunogenic composition for use as a blood-stage malaria vaccine, a method of producing the immunogenic composition and a method of treatment of malaria are provided. The immunogenic composition includes isolated or purified merozoites, or red blood cells infected with merozoites, treated with centanamycin or tafuramycin A. The immunogenic composition does not include an adjuvant. A single dose of the immunogenic composition is sufficient to protect an animal against subsequent malaria infection by the same isolate, strain or species of Plasmodium used in the immunogenic composition, or by one or more heterologous isolates, strains or species of Plasmodium.Type: GrantFiled: May 28, 2012Date of Patent: January 10, 2017Assignees: Griffth University, La Trobe UniversityInventors: Michael Good, Terry W. Spithill, Moses Lee
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Patent number: 9522180Abstract: The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).Type: GrantFiled: April 3, 2015Date of Patent: December 20, 2016Assignee: NORTHWESTERN UNIVERSITYInventors: Lonnie D. Shea, Stephen D. Miller, Jonathan Woon Teck Yap, Daniel R. Getts, Derrick McCarthy
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Patent number: 9504739Abstract: The subject invention provides materials and methods that effectively support innate immunity and/or disperse pathogenic biofilms using readily available, nontoxic, natural substances, while supporting restoration of normal microbiotic homeostasis. In one embodiment, the subject invention provides anti-biofilm compositions comprising one or more probiotic organisms, anti-microbial honey, and other ingredients such as prebiotic compounds, other hive products, green tea derivatives, other plant derivatives, and vitamin D3.Type: GrantFiled: November 4, 2011Date of Patent: November 29, 2016Assignee: QUORUM INNOVATIONS, LLCInventors: Eva A. Berkes, Nicholas T. Monsul
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Patent number: 9446080Abstract: Disclosed herein are therapeutic compositions containing non-pathogenic, germination-competent bacterial spores, for the prevention, control, and treatment of gastrointestinal diseases, disorders and conditions and for general nutritional health.Type: GrantFiled: March 11, 2016Date of Patent: September 20, 2016Assignee: Seres Therapeutics, Inc.Inventors: Gregory McKenzie, Mary-Jane Lombardo McKenzie, David N. Cook, Marin Vulic, Geoffrey von Maltzahn, Brian Goodman, John Grant Aunins, Matthew R. Henn, David Arthur Berry, Jonathan Winkler
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Patent number: 9416412Abstract: The invention provides novel nucleic acid polymerases from strains GK24 and RQ-1 of Thermus thermophilus, and nucleic acids encoding those polymerases, as well as methods for using the polymerases and nucleic acids.Type: GrantFiled: March 12, 2015Date of Patent: August 16, 2016Assignee: APPLIED BIOSYSTEMS, LLCInventors: James Rozzelle, Elena Bolchakova
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Patent number: 9301984Abstract: Present invention features a method for controlling body weight, comprising Lactobacillus reuteri GMNL-263 with the deposition numbers of BCRC 910452 and CCTCC M 209263. Moreover, the invention also relates to a novel use of the composition or the isolated Lactobacillus strain for controlling body weight, whose mechanism is inhibiting biosynthesis of lipids and reducing formation of lipid droplets so as to control body weight.Type: GrantFiled: April 22, 2015Date of Patent: April 5, 2016Assignee: GenMont Biotech Inc.Inventors: Yi-Hsing Chen, Feng-Ching Hsieh, Po-Yung Chen
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Patent number: 9243198Abstract: The present disclosure identifies methods and compositions for modifying photoautotrophic organisms as hosts, such that the organisms efficiently convert carbon dioxide and light into n-alkanes, and in particular the use of such organisms for the commercial production of n-alkanes and related molecules.Type: GrantFiled: January 9, 2015Date of Patent: January 26, 2016Assignee: Joule Unlimited Technologies, Inc.Inventors: Nikos Basil Reppas, Christian Perry Ridley