Patents Examined by Mark Navarro
  • Patent number: 10094830
    Abstract: The present invention relates to novel peptides that may be used in whole or in combination for the detection of Mycobacterium tuberculosis infection. In particular, the present invention relates to compositions and methods involving detection of antibodies contained in the blood of non-human primates that arise from an infection from M. tuberculosis or vaccination using an epitope specific inoculation. More particularly, the present invention provides a means to distinguish early, active, and latent M. tuberculosis infection. More particularly, the present invention describes an immunological diagnostic mechanism for the detection of M. tuberculosis infection.
    Type: Grant
    Filed: July 18, 2016
    Date of Patent: October 9, 2018
    Assignee: INTUITIVE BIOSCIENCES, INC.
    Inventor: Kimberly Luke
  • Patent number: 10080790
    Abstract: The disclosure generally relates to the field of prevention and treatment of Staphylococcus aureus infections. In particular, the disclosure relates to immunogens comprising Staphylococcus aureus antigens and methods for generating immune responses to immunogens, and to antibody products specific for the Staphylococcus aureus epitopes and methods for treating Staphylococcus aureus infection with the antibody products.
    Type: Grant
    Filed: September 17, 2015
    Date of Patent: September 25, 2018
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Jon Oscherwitz, Kemp Cease
  • Patent number: 10073105
    Abstract: A method and apparatus for locating and selecting a colony of microorganisms on a culture dish and identifying microorganisms in said selected colony using MALDI. The method comprises the automated steps of locating and selecting a colony of microorganisms on a culture dish; obtaining a sample of said selected colony of microorganisms; depositing at least some of said sample of said selected colony of microorganisms on a target plate; and transferring said target plate with said sample in an apparatus for performing MALDI for identification of said sample of said selected colony of microorganisms. A sample of a colony of microorganisms is automatically deposited on a depositing spot such that the sample covers at most approximately half of said one of the depositing spots of the target plate.
    Type: Grant
    Filed: July 28, 2017
    Date of Patent: September 11, 2018
    Assignee: BD Kiestra B.V.
    Inventors: Jetze Botma, Martijn Kleefstra, Tino Walter Van der Zee
  • Patent number: 10064901
    Abstract: Disclosed herein are therapeutic compositions containing non-pathogenic, germination-competent bacterial spores, for the prevention, control, and treatment of gastrointestinal diseases, disorders and conditions and for general nutritional health.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: September 4, 2018
    Assignee: Seres Therapeutics, Inc.
    Inventors: Gregory McKenzie, Mary-Jane Lombardo McKenzie, David N. Cook, Marin Vulic, Geoffrey von Maltzahn, Brian Goodman, John Grant Aunins, Matthew R. Henn, David Arthur Berry, Jonathan Winkler
  • Patent number: 10052465
    Abstract: Methods and systems for delivering toxin and toxin fragments to a patient's nasal cavity provide for both release of the toxin and delivery of energy which selectively porates target cells to enhance uptake of the toxin. The use of energy-mediated delivery is particularly advantageous with light chain fragment toxins which lack cell binding capacity.
    Type: Grant
    Filed: June 6, 2017
    Date of Patent: August 21, 2018
    Assignee: The Foundry, LLC
    Inventors: Mark E. Deem, Hanson Gifford
  • Patent number: 10017806
    Abstract: The present invention relates to determination of the microorganism content in material comprising cellulose within the pulp and paper industry. The material comprising cellulose is enzymatically pretreated and microorganisms are determined using PCR based technology.
    Type: Grant
    Filed: October 27, 2015
    Date of Patent: July 10, 2018
    Assignee: Stora Enso OYJ
    Inventors: Kirsi Partti-Pellinen, Jari Räsänen, Kielo Härmälä, Anu Kettunen, Kalle-Juhani Riihinen
  • Patent number: 9968098
    Abstract: The present invention generally relates to the use of synergistic amounts of Bacillus thuringiensis subsp. aizawai, Bacillus thuringiensis subsp. kurstaki and cyantraniliprole for the control of diamondback moth, beet armyworm, southwestern corn borer, and corn earworm wherein the ratio of Bacillus thuringiensis subsp. kurstaki to Bacillus thuringiensis subsp. aizawai is from about 1:0.47 to about 1:0.92, and the ratio of the total amount of Bacillus thuringiensis to cyantraniliprole is from about 1:0.025 to about 1:150.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: May 15, 2018
    Assignee: VALENT BIOSCIENCES LLC
    Inventors: Deanna D. Branscome, Roger D. Storey, James Russell Eldridge, Emily E. Brazil
  • Patent number: 9970931
    Abstract: The invention generally relates to methods of using compositions that include sets of magnetic particles, members of each set being conjugated to an antibody specific for a pathogen, and magnets to isolate a pathogen from a body fluid sample.
    Type: Grant
    Filed: October 24, 2016
    Date of Patent: May 15, 2018
    Assignee: DNAE Group Holdings Limited
    Inventors: Sergey A. Dryga, Victor C. Esch, Lisa-Jo Ann Clarizia, Eddie W. Adams, Thearith H. Ung, Ravil A. Sitdikov
  • Patent number: 9943590
    Abstract: This invention relates to methods of using a Listeria vaccine vector to induce a Th1 immune response in subjects having persistent Th2 immune response profiles.
    Type: Grant
    Filed: October 7, 2015
    Date of Patent: April 17, 2018
    Assignees: The Trustees of the University of Pennsylvania, University of Georgia Research Foundation, Inc.
    Inventors: Donald A. Harn, Jr., Yvonne Paterson, Lisa McEwen
  • Patent number: 9873870
    Abstract: Methods and compositions for identifying antigens of human lymphocytes are provided herein.
    Type: Grant
    Filed: April 30, 2015
    Date of Patent: January 23, 2018
    Assignee: Genocea Biosciences, Inc.
    Inventors: Jessica Flechtner, Todd Gierahn
  • Patent number: 9713637
    Abstract: The invention provides an isolated Bacillus cereus sensu lato strain, selected from Bacillus anthracis, Bacillus cereus and Bacillus thuringiensis, in which the htrA gene or any part thereof is silenced, and vaccines comprising the same.
    Type: Grant
    Filed: July 18, 2012
    Date of Patent: July 25, 2017
    Assignee: State of Israel Prime Minister's Office Israel Institute for Biological Research
    Inventors: Ofer Cohen, Theodor Chitlaru, Avigdor Shafferman
  • Patent number: 9624529
    Abstract: A cell based assay for detection for protease activity is disclosed. In the assay a cell is engineered to express a protease substrate with at least one label, preferably on its C-terminus. Cleavage of the substrate by the protease that recognizes it results in a C-terminal fragment and a N-terminal fragment, where the fragment having the label is subject to ubiquitin proteasome degradation. The assay measures the disappearance of the label due to degradation of the fragment to which it is attached. A cell free assay is also described for detection of protease activity. In the cell free assay, the protease substrate is expressed in a solution that includes the elements of the ubiquitin proteasome pathway for degradation of the fragment. The assay measures the disappearance of the label attached to the fragment that results from cleavage by the protease.
    Type: Grant
    Filed: January 27, 2015
    Date of Patent: April 18, 2017
    Assignee: SYNAPTIC RESEARCH, LLC
    Inventors: George A. Oyler, Yien Che Tsai
  • Patent number: 9585949
    Abstract: Strains of Sarcocystidae selected from Toxoplasma spp or Neospora spp isolated from their natural environment and having an immunostimulant effect, for the use thereof in the prevention or the treatment, in a mammal, of a pathology associated with an apicomplexan of the family Cryptosporidiidae.
    Type: Grant
    Filed: February 4, 2016
    Date of Patent: March 7, 2017
    Assignees: VITAMFERO, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, UNIVERSITE FRANCOIS RABELAIS DE TOURS
    Inventors: Audrey Gnahoui-David, Fabrice Laurent, Marie-Noelle Mevelec, Edouard Seche
  • Patent number: 9539316
    Abstract: An immunogenic composition for use as a blood-stage malaria vaccine, a method of producing the immunogenic composition and a method of treatment of malaria are provided. The immunogenic composition includes isolated or purified merozoites, or red blood cells infected with merozoites, treated with centanamycin or tafuramycin A. The immunogenic composition does not include an adjuvant. A single dose of the immunogenic composition is sufficient to protect an animal against subsequent malaria infection by the same isolate, strain or species of Plasmodium used in the immunogenic composition, or by one or more heterologous isolates, strains or species of Plasmodium.
    Type: Grant
    Filed: May 28, 2012
    Date of Patent: January 10, 2017
    Assignees: Griffth University, La Trobe University
    Inventors: Michael Good, Terry W. Spithill, Moses Lee
  • Patent number: 9522180
    Abstract: The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).
    Type: Grant
    Filed: April 3, 2015
    Date of Patent: December 20, 2016
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Lonnie D. Shea, Stephen D. Miller, Jonathan Woon Teck Yap, Daniel R. Getts, Derrick McCarthy
  • Patent number: 9504739
    Abstract: The subject invention provides materials and methods that effectively support innate immunity and/or disperse pathogenic biofilms using readily available, nontoxic, natural substances, while supporting restoration of normal microbiotic homeostasis. In one embodiment, the subject invention provides anti-biofilm compositions comprising one or more probiotic organisms, anti-microbial honey, and other ingredients such as prebiotic compounds, other hive products, green tea derivatives, other plant derivatives, and vitamin D3.
    Type: Grant
    Filed: November 4, 2011
    Date of Patent: November 29, 2016
    Assignee: QUORUM INNOVATIONS, LLC
    Inventors: Eva A. Berkes, Nicholas T. Monsul
  • Patent number: 9446080
    Abstract: Disclosed herein are therapeutic compositions containing non-pathogenic, germination-competent bacterial spores, for the prevention, control, and treatment of gastrointestinal diseases, disorders and conditions and for general nutritional health.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: September 20, 2016
    Assignee: Seres Therapeutics, Inc.
    Inventors: Gregory McKenzie, Mary-Jane Lombardo McKenzie, David N. Cook, Marin Vulic, Geoffrey von Maltzahn, Brian Goodman, John Grant Aunins, Matthew R. Henn, David Arthur Berry, Jonathan Winkler
  • Patent number: 9416412
    Abstract: The invention provides novel nucleic acid polymerases from strains GK24 and RQ-1 of Thermus thermophilus, and nucleic acids encoding those polymerases, as well as methods for using the polymerases and nucleic acids.
    Type: Grant
    Filed: March 12, 2015
    Date of Patent: August 16, 2016
    Assignee: APPLIED BIOSYSTEMS, LLC
    Inventors: James Rozzelle, Elena Bolchakova
  • Patent number: 9301984
    Abstract: Present invention features a method for controlling body weight, comprising Lactobacillus reuteri GMNL-263 with the deposition numbers of BCRC 910452 and CCTCC M 209263. Moreover, the invention also relates to a novel use of the composition or the isolated Lactobacillus strain for controlling body weight, whose mechanism is inhibiting biosynthesis of lipids and reducing formation of lipid droplets so as to control body weight.
    Type: Grant
    Filed: April 22, 2015
    Date of Patent: April 5, 2016
    Assignee: GenMont Biotech Inc.
    Inventors: Yi-Hsing Chen, Feng-Ching Hsieh, Po-Yung Chen
  • Patent number: 9243198
    Abstract: The present disclosure identifies methods and compositions for modifying photoautotrophic organisms as hosts, such that the organisms efficiently convert carbon dioxide and light into n-alkanes, and in particular the use of such organisms for the commercial production of n-alkanes and related molecules.
    Type: Grant
    Filed: January 9, 2015
    Date of Patent: January 26, 2016
    Assignee: Joule Unlimited Technologies, Inc.
    Inventors: Nikos Basil Reppas, Christian Perry Ridley