Patents Examined by Martinell, James
  • Human t-PA production using vectors coding for DHFR protein
    Patent number: 5268291
    Abstract: A method for producing tissue plasminogen activator (t-PA) in eukaryotic host cells is disclosed. Enhanced levels of t-PA production are obtained by co-amplification of the t-PA gene through treatment of cultures transformed with mutant or wild-type DHFR with methotrexate.
    Type: Grant
    Filed: February 28, 1991
    Date of Patent: December 7, 1993
    Assignee: Genentech, Inc.
    Inventors: Arthur D. Levinson, Diane Pennica, William J. Kohr, Gordon A. Vehar, David V. Goeddel, Christian C. Simonsen
  • Hybrid human leukocyte interferons
    Patent number: 4678751
    Abstract: Disclosed herein are methods and means of microbially preparing novel human hybrid leukocyte interferons, useful in the treatment of viral and neoplastic diseases, by DNA recombination of parental interferon genes, taking advantage of common restriction endonuclease cleavage sites therein and in carrier expression plasmids.
    Type: Grant
    Filed: June 20, 1984
    Date of Patent: July 7, 1987
    Assignee: Genentech, Inc.
    Inventor: David V. Goeddel
  • Microbial expression of human influenza hemagglutinin proteins
    Patent number: 4659669
    Abstract: Disclosed herein are methods and means for microbially expressing human influenza hemagglutinin proteins, useful in the preparation of vaccines, by recombination of DNA gene sequences coding for hemagglutinin protein with microbially operable promoter-operator DNA and transformation of microbial host therewith.
    Type: Grant
    Filed: March 2, 1981
    Date of Patent: April 21, 1987
    Assignees: Regents of the Univ. of California, Genentech, Inc.
    Inventors: Dennis G. Kleid, Debi P. Nayak, Alan R. Davis