Abstract: A living body function measurement method comprises separating a light from a low coherence light source into a signal light and a reference light, modulating a frequency of at least one of the signal light and the reference light, irradiating the signal light to an observation area of a living body sample, giving a stimulation to the living body sample from an outside of the living body sample, synthesizing the signal light via the observation area and the reference light and detecting a heterodyne interference signal, and measuring a living body function of the observation area by measuring a change in the heterodyne interference signal when the stimulation is changed.

Abstract: A hand held ultrasound system comprises a balance body, a transducer assembly connected to said balance body via a communication means and a plurality of control elements arranged in an ergonomic fashion on said balance body, such that a user may hold said system and operate at least one of said control elements with the same hand. In particular a medical ultrasound system comprising a balance body incorporating system electronics, a power supply and a user interface wherein the user interface comprises a D-controller and a touch screen and a transducer assembly attached to the balanced body by a cable.

Abstract: The present invention provides a power operated instrument stand for use, for example during eye examinations. The instrument stand has a motorized arm to aid in precise placement of instrumentation. The instrument stand also has control circuitry for room lighting levels, patient chair positioning and slit lamp operation. The instrument stand may be controlled through an attached control pad, or a remote control.

Abstract: A device for the optical spectroscopic examination of interior surfaces (2, 2′) of a body, e.g. of blood vessels (1), comprising an optical spectrometer and an endoscope (3) with a light guide for illuminating the surfaces, wherein at the proximal end of the light guide it is supplied with light and at the distal of the light guide the light can be launched to the surfaces to be examined, wherein at the distal end of this endoscope there is provided a device for receiving the light reflected by the surfaces to be examined, is characterized in that the distal end of the light guide is arranged within an inflatable balloon (4) with an elastic exterior, and that the light decoupled from the light guide and the light reflected by the surfaces to be examined to the receiving device penetrates in each case the exterior of the balloon. In this way, the light launched by the light guide and also the light directed to the surface to be examined and the light scattered by them, if e.g.

Abstract: A non-invasive method for analyzing the blood-brain barrier includes obtaining a Raman spectrum of a selected portion of the eye and monitoring the Raman spectrum to ascertain a change to the dynamics of the blood brain barrier. Also, non-invasive methods for determining the brain or blood level of an analyte of interest, such as glucose, drugs, alcohol, poisons, and the like, comprises: generating an excitation laser beam (e.g., at a wavelength of 600 to 900 nanometers); focusing the excitation laser beam into the anterior chamber of an eye of the subject so that aqueous humor, vitreous humor, or one or more conjunctiva vessels in the eye is illuminated; detecting (preferably confocally detecting) a Raman spectrum from the illuminated portion of the eye; and then determining the blood level or brain level (intracranial or cerebral spinal fluid level) of an analyte of interest for the subject from the Raman spectrum.

Abstract: A 3-D ultrasound imaging system acquires partially complete image volumes interspersed with substantially complete image volumes. The partially complete image volumes contain speckle that is processed by a cross-correlation algorithm to track the movement of an ultrasound scanhead. By tracking the movement of the scanhead, the substantially complete image volumes can be properly registered with each other and combined to create a 3-D extended field of view image. The partially complete image volumes contain significantly less data than the substantially complete image volumes. Therefore, the partially complete image volumes can be acquired more quickly than the substantially complete image volumes to allow the scanhead to be scanned at a relatively fast speed.

Abstract: The invention provides a method of magnetic resonance investigation of a sample, said method comprising: (i) reacting para-hydrogen enriched hydrogen with a hydrogenatable MR imaging agent precursor containing a non-hydrogen non-zero nuclear spin nucleus to produce a hydrogenated MR imaging agent; (ii) administering said hydrogenated MR imaging agent to said sample; (iii) exposing said sample to radiation of a frequency selected to excite nuclear spin transitions of said non-zero nuclear spin nucleus in said hydrogenated MR imaging agent; (v) detecting magnetic resonance signals of said non-zero nuclear spin nucleus from said sample; and (vi) optionally, generating an image or biological functional data or dynamic flow data from said detected signals.

Abstract: A method of magnetic resonance investigation of a sample by (i) reacting ortho-deuterium enriched hydrogen with a hydrogenatable MR imaging agent precursor to produce a hydrogenated (i.e. deuterated) MR imaging agent; (ii) optionally, subjecting the hydrogenated MR imaging agent to a low magnetic field;(iii) administering the hydrogenated MR imaging agent to the sample; (iv) exposing the sample to radiation of a frequency selected to excite nuclear spin transitions of selected non-zero nuclear spin nuclei in said hydrogenated MR imaging agent; (v) detecting magnetic resonance signals of the selected non-zero nuclear spin nuclei from the sample; and (vi) optionally, generating an image or biological functional data or dynamic flow data from the detected signals.

Abstract: An improved ophthalmic instrument including an integral wavefront sensor and display device, wherein the wavefront sensor measures phase aberrations in reflections directed thereto to characterize aberrations of the eye and is operably coupled to the display device, which displays a graphical representation of the aberrations of the eye. Such graphical representation may include: two dimensional contour maps that graphically depict contribution of pre-specified terms (such as spherical aberration, astigmatism and coma) for the aberrations of the eye, coefficients corresponding to such pre-specified terms that characterize the aberrations of the eye, or predefined two-dimensional icons that provide a general graphical depiction of such prespecified terms.

Abstract: A vascular catheter system comprises a catheter body having a proximal portion with a proximal end, a distal end and work lumen therebetween and a distal portion with a proximal end, a distal end, a work lumen therebetween and a guidewire lumen distal to the work lumen. A first connector is secured to the distal end of the proximal portion and a second connector is secured to the proximal end of the distal portion. The first and second connectors can be selectively connected to each other to join the work lumens of the proximal and distal portions together.

Abstract: A semi-invasive ultrasound imaging system for imaging biological tissue includes a transesophageal probe or a transnasal, transesophageal probe connected to a two-dimensional ultrasound transducer array, a transmit beamformer, a receive beamformer, and an image generator. The two-dimensional transducer array is disposed on a distal portion of the probe's elongated body. The transmit beamformer is connected to the transducer array and is constructed to transmit several ultrasound beams over a selected pattern defined by azimuthal and elevation orientations. The receive beamformer is connected to the transducer array and is constructed to acquire ultrasound data from the echoes reflected over a selected tissue volume. The tissue volume is defined by the azimuthal and elevation orientations and a selected scan range. The receive beamformer is constructed to synthesize image data from the acquired ultrasound data.

Abstract: A method of ultrasound imaging, including the following steps, transmitting ultrasonic beams generated by transducers (20) into an object volume (v) such as an object body or a part thereof, receiving (20) and storing (3) signals reflected from said object volume, processing and receiving signals into image data associated to image dots or lines of a video display (8), and displaying at least a few image data on the display (8) in accordance with parameters set by a user and related to a predetermined section or projection plane of the image of said object volume. According to the invention, scanning is only performed in the region of the object body which coincides with the section plane or the image projection plane (P) of the object volume along which imaging is to be performed.

Abstract: An ultrasonic diagnostic apparatus for observing a detectable object to be ultrasonically diagnosed. The apparatus includes an ultrasonically diagnostic probe unit for probing the object with ultrasonic waves in response to input pulse signals and with an ultrasonic echo from the object, a signal transmitting unit to generate the input pulse signals, a signal receiving unit for receiving the ultrasonic echo and processing output signals to be converted into an image of the object, and a display unit to display the image.

Abstract: Disclosed is a blood vessel detecting apparatus which accurately detects a blood vessel using an image pickup element having a plurality of pixels to pick up an image of a blood vessel, a detector for detecting a pixel output estimated as a blood vessel on the basis of pixel the output from the image pickup elements, and a determination unit for, when the detector detects pixel outputs that are likely to be a plurality of blood vessels, determining a correct number of blood vessels using the pixel output or an area image pickup element.

Abstract: A system and method for controlling an eye movement tracker includes monitoring a plurality of eye positions by following a feature using the tracker. An optical beam is sent into the eye, and an intensity of a reflected beam from the eye is sensed at each position. If the intensity of the reflected beam fluctuates from a predetermined acceptable intensity range, the tracker is returned to a frozen position. The frozen position comprises a most recent position at which the intensity lay within the intensity range. The tracker is also frozen if the noise in the signal exceeds a predetermined acceptable maximum noise level and for counting a number of times the tracker is frozen. The procedure is aborted if the tracker is frozen repeatedly and for a time exceeding a predetermined maximum acceptable time.

Abstract: The accuracy of noninvasive blood analysis methods is limited by the so-called tracking error. The correlation between the component concentration in the probed skin volume and the component concentration in the blood is improved by selecting particular locations on the patient's skin which provide a significantly higher density of capillary vessels than found on average (sweet spots). The higher capillary density causes the component concentration in the probed skin volume to better track the component concentration in the blood and as a useful side effect also improves the signal-to-noise ratio of the noninvasive measurement method itself. Methods for locating sweet spots and controlling the noninvasive measurement to selectively probe sweet spots are described.

Abstract: Herein disclosed is an ultrasonic probe comprising a housing, a driven shaft rotatably supported by the housing, a transducer supported by the driven shaft to be swingable on one side of the driven shaft and operative to transduce an electric signal to and from an ultrasound, a drive shaft rotatably supported by the housing spaced apart from and in parallel relationship with the driven shaft in the predetermined direction; a drive motor supported on the housing and drivably connected to the drive shaft; and a drive belt passed on the driven shaft and the drive shaft to transmit the rotation from the drive motor to the transducer. The transducer has the ultrasound emitted therefrom and reflected thereto through the housing in a predetermined direction.

Abstract: A system records use of a structure deployed in operative association with heart tissue in a patient. An image controller generates an image of the structure while in use in the patient. An input receives data including information identifying the patient. An output processes the image in association with the data as a patient-specific, data base record for storage, retrieval, or manipulation.

Abstract: The method and apparatus of the invention are directed to surgically non-invasively treating skeleto/muscular injuries or of diagnosing bone fractures, involving application of two components of ultrasonic energy, to an external surface of living tissue, wherein the two components are of different frequencies in the range between 10 kHz and 4 MHz, and wherein separate transducers, each uniquely supplied with an excitation signal at a different one of the same two frequencies, are directionally disposed for acoustic propagation on the same directional axis.

Abstract: A system for estimating the volume of fluid in the bladder sequentially scans the bladder with ultrasonic beams that section the bladder into a number of transverse planes. The system determines, from the scan lines associated with a given plane, a plurality of points on each of the front and back walls of the bladder. It then fits a curve to the set of front wall points and another curve to the set of back wall points, to determine an outline of the bladder in the plane. The system next calculates the cross sectional area of the bladder in the plane based on the two curves. After determining the area in each of the planes, the system determines the volume of the bladder by summing weighted version of the planar areas. The system includes a transducer that consists of a plurality of piezo-electric elements held in a relatively thin elastomeric pad and/or substrate that is acoustically impedance matched to skin.