Abstract: According to an aspect, the invention includes a biopsy instrument for retrieving a tissue sample from a patient that may include a tubular member having an aspiration conduit, a distal end effector assembly coupled to the distal end of the tubular member and adapted to detach the tissue sample from the patient, and a proximal actuation handle coupled to the proximal end of the tubular member. The biopsy instrument may further include a sample catch assembly coupled to the aspiration conduit and adapted to receive the tissue sample from the aspiration conduit, the sample catch assembly including a chamber and a sample catch member adapted to separate the tissue sample from the fluid, the sample chamber having a first opening to receive the fluid, a second opening to discharge the fluid from the chamber, and a third opening to removably receive the sample catch member.