Patents Examined by Mary C. Lee
  • Patent number: 5470974
    Abstract: A composition of polymer molecules effective to bind, with substantially uniform binding affinity, to a single-stranded polynucleotide containing a target sequence of bases. The polymer molecules are composed of a sequence of base-pairing moieties effective to hydrogen bond to corresponding, complementary bases in the target sequence, under selected binding conditions, and a predominantly uncharged, achiral backbone supporting the base-pairing moieties at positions and in orientations which allow hydrogen bonding between the pairing moieties of the polymer and the corresponding complementary bases in the target sequence. The composition has diagnostic uses, in a solid-support assay system, and therapeutic uses involving inhibition or inactivation of target polynucleotides.
    Type: Grant
    Filed: February 25, 1994
    Date of Patent: November 28, 1995
    Assignee: Neu-Gene Development Group
    Inventors: James Summerton, Dwight Weller, Eugene Stirchak
  • Patent number: 5451683
    Abstract: Methods and compositions are described for immobilizing anti-ligands, such as antibodies or antigens, hormones or hormone receptors, oligonucleotides, and polysaccharides on surfaces of solid substrates for various uses. The methods provide surfaces covered with caged binding members which comprise protecting groups capable of being removed upon application of a suitable energy source. Spatially addressed irradiation of predefined regions on the surface permits immobilization of anti-ligands at the activated regions on the surface. Cycles of irradiation on different regions of the surface and immobilization of different anti-ligands allows formation of an immobilized matrix of anti-ligands at defined sites on the surface. The immobilized matrix of anti-ligands permits simultaneous screenings of a liquid sample for ligands having high affinities for certain anti-ligands of the matrix. A preferred embodiment of the invention involves attaching photoactivatable biotin derivatives to a surface.
    Type: Grant
    Filed: April 23, 1993
    Date of Patent: September 19, 1995
    Assignee: Affymax Technologies N.V.
    Inventors: Ronald W. Barrett, Michael C. Pirrung, Lubert Stryer, Christopher P. Holmes, Steven A. Sundberg
  • Patent number: 5444165
    Abstract: An unsaturated imide compound represented by formula (1): ##STR1## wherein Q is an alicyclic structure-containing hydrocarbon group having 4-20 carbon atoms; each of R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.i and R.sub.j represents a hydrogen atom, a halogen atom, a hydrocarbon group having 1-6 carbon atoms or a halogen-containing hydrocarbon group having 1-6 carbon atoms; each of a, b, c, d, e and f represents an integer of 0 to 4 satisfying a+b.ltoreq.4, c+d.ltoreq.4 and e+f.ltoreq.4 and D represents a divalent organic group having 2-24 carbon atoms and an ethylenically unsaturated double bond, a process for producing the unsaturated imide compound of formula (1) and intermediates for producing the unsaturated imide compound of formula (1). The unsaturated imide compound of formula (1) is well soluble in organic solvents and can give cured products excellent in heat resistance, low water absorption and flexibility.
    Type: Grant
    Filed: February 25, 1994
    Date of Patent: August 22, 1995
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Yasuhiro Hirano, Yasuhiro Endo, Kazuo Takebe, Mitsuhiro Shibata, Shuichi Kanagawa, Yutaka Shiomi, Masatsugu Akiba, Shinichiro Kitayama
  • Patent number: 5442088
    Abstract: Process for the preparation of phosphorus-containing L-amino acids, their derivatives and intermediates for this processL-amino acids of the formula I and salts thereof, ##STR1## in which R.sup.1 to R.sup.5 are defined as in claim 1 and n is 0 or 1, are obtained according to the invention bya) reacting an optically active S-homoserine lactone of the formula II, ##STR2## with hydrogen chloride in the presence of an alcohol of the formula R.sup.5 --OH to give novel compounds of the formula III, ##STR3## in which R.sup.3, R.sup.4 and R.sup.5 are defined as in formula I, except that R.sup.5 =H, andb) reacting the resulting compound of formula III with a compound of formula IV,R.sup.1 (O).sub.n -R(OR.sup.2).sub.2 (IV)and if desired, hydrolyzing the product to give a compound of formula I, in which R.sup.5 =H.
    Type: Grant
    Filed: July 7, 1994
    Date of Patent: August 15, 1995
    Assignee: Hoechst Aktiengesellschaft
    Inventor: Michael Hoffmann
  • Patent number: 5441973
    Abstract: The invention is directed to N-acetyl-4-phenyl-pyrrolidin-2-ones, which, because of their pronounced cerebroprotective effect in human medicine, can be used for the prophylaxis and treatment of cerebral functional disorders. Pursuant to the invention, these compounds are synthesized by reacting 4-phenyl-pyrrolidin-2-ones with a reactive derivative of a carboxylic acid, or by cyclizing N-acylaminobutyric acid derivatives.
    Type: Grant
    Filed: January 13, 1994
    Date of Patent: August 15, 1995
    Assignee: Arzneimittelwerk Dresden G.m.b.H.
    Inventors: Lothar Zenker, Helmut Wunderlich, Dieter Lohmann, Angelika Rostock, Christine Siegemund, Artur V. Valdman, Tatjana A. Voronina, Ilmira C. Rachmankulova, Oleg M. Glozman, Taisija L. Garibova, Larisa M. Mescerjakova, Ljudmila A. Zmurenko, Sergej B. Seredenin, Grigorij G. Rozancev
  • Patent number: 5438137
    Abstract: An asymmetric dioxazine compound of the following formula in the free acid form, ##STR1## wherein R is hydrogen, halogen, sulfo or alkoxy, R.sub.1, R.sub.2 and R.sub.3 are each hydrogen or alkyl, X.sub.1 and X.sub.2 are each hydrogen, halogen, alkyl, alkoxy or phenoxy, Y is alkylene, phenylene or naphthylene, Z is --SO.sub.2 CH.dbd.CH.sub.2, --SO.sub.2 CH.sub.2 CH.sub.2 OSO.sub.3 H or the like, V is hydrogen, alkyl, acyl or substituted triazinyl, and Q is halogen, alkoxy, amino or a group similar to that of ##STR2## provided that R is hydrogen, and Q is amino or a group similar to that of ##STR3## when V is substituted triazinyl, which is useful for dyeing or printing fiber materials to give dyed or printed products of a brilliant blue color superior in fastness properties, particularly those such as chlorine fastness with superior build-up property.
    Type: Grant
    Filed: September 30, 1993
    Date of Patent: August 1, 1995
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Tetsuya Miyamoto, Miyao Takahashi, Takahiko Fujisaki, Shinei Ikeou, Takashi Omura, Naoki Harada
  • Patent number: 5436324
    Abstract: Improved reactive dyestuffs of the following formula (I) ##STR1## in which the substituents have the meaning given in the description. The improved reactive dyestuffs are highly suitable for the dyeing and printing of natural or synthetic OH-- and/or amido-containing materials, in particular, those made of cellulose and polyamides.
    Type: Grant
    Filed: July 23, 1992
    Date of Patent: July 25, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventors: Wolfram Reddig, Karl-Josef Herd
  • Patent number: 5436346
    Abstract: The process for the preparation of benzothiazolyl-2-sulphenamides, by reacting a 2-mercaptobenzothiazole or dibenzothiazolyl 2,2'-disulphide with a primary or secondary aliphatic or cycloaliphatic amine in the presence of hydrogen peroxide as oxidizing agent in an aqueous medium is distinguished in that an aqueous hydrogen peroxide solution is metered at a temperature in the range from 30.degree. to 70.degree. C. into an aqueous suspension of the respective amine and the 2-mercaptobenzothiazole or dibenzothiazolyl 2,2'-disulphide in a ratio in the range between 1.0 and 1.5 mol of amine per mole of 2-mercaptobenzothiazole or per equivalent of dibenzothiazolyl 2,2'-disulphide, preferably in a quantity of below 1.35 mol per mole of 2-mercaptobenzothiazole or per equivalent of dibenzothiazolyl 2,2'-disulphide over a period of at least 60 minutes. The total quantity of water in the reaction mixture should not exceed 1500 g per mole of 2-mercaptobenzothiazole.
    Type: Grant
    Filed: June 21, 1994
    Date of Patent: July 25, 1995
    Assignee: Akzo Nobel N.V.
    Inventors: Ludwig Eisenhuth, Manfred Bergfeld
  • Patent number: 5436362
    Abstract: In a method of producing dialkylcarbonate, alcoholic compound and cyclo-carbonate are subjected to a catalytic reaction each other at a reaction temperature of 20.degree. to 200.degree. C. and under a pressure of 0 to 40 kg/cm.sup.2 G, which keeps the reaction system liquid, in the presence of ion exchanged zeolite which is ion-exchanged with alkali metal ion and/or alkaline earth metal ion.
    Type: Grant
    Filed: December 16, 1993
    Date of Patent: July 25, 1995
    Assignee: Chiyoda Corporation
    Inventors: Tadami Kondoh, Yoshimi Okada, Fumiaki Tanaka, Sachio Asaoka, Susumu Yamamoto
  • Patent number: 5434269
    Abstract: A process for the asymmetric hydrogenation of furoimidazole derivatives of the general formula: ##STR1## with hydrogen in the presence of a homogeneous catalyst to give the corresponding diastereomeric dihydrofuroimidazole derivatives of the general formula: ##STR2## R.sub.1 and R.sub.2 are protective groups, although R.sub.2 can be hydrogen. The dihydrofuroimidazole derivatives of the general formula II are intermediates for the preparation of (+)-biotin.
    Type: Grant
    Filed: August 3, 1994
    Date of Patent: July 18, 1995
    Assignee: Lonza Ltd.
    Inventors: Martin Eyer, Ronald E. Merrill
  • Patent number: 5434143
    Abstract: The phosphite-borane compounds of the present invention correspond to the formula ##STR1## where R.sub.1 is independently selected from H, C.sub.1 -C.sub.20 alkyl, alkylaryl, aryl, trialkylsilyl, with the proviso that both R.sub.1 groups cannot simultaneously be H.sub.1, andR.sub.2 is selected from H, a monovalent cation such as Li.sup.+, Na.sup.+, K.sup.+, NH.sub.4.sup.+, N(R.sub.3.sup.+).sub.4, where R.sub.3 is independently selected from H, C.sub.1 -C.sub.20 alkyl.The phosphite-borane compounds of the present invention are bioactive in character, variously exhibiting anti-tumor, anti-inflammatory, and hypolipidemic activity. Also disclosed are various synthetic methods for making such phosphite-borane compounds, and for formulating same in unit dosage forms as well as other pharmaceutically and pharmacologically acceptable formulations.
    Type: Grant
    Filed: October 19, 1994
    Date of Patent: July 18, 1995
    Assignee: Boron Biologicals, Inc.
    Inventors: Bernard F. Spielvogel, Anup Sood
  • Patent number: 5434251
    Abstract: Symmetric azo dyestuffs of the formula ##STR1## wherein the substituents have the meaning given in the description, produce improved dyeings or prints on wool and cellulose materials.
    Type: Grant
    Filed: April 2, 1993
    Date of Patent: July 18, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventor: Karl-Josef Herd
  • Patent number: 5434252
    Abstract: Reactive dyes of the formula ##STR1## in which D, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as defined in claim 1, are particularly suitable for dyeing or printing cellulosic fiber materials or naturally occurring or synthetic polyamide fiber materials with a high tinctorial yield, and produce dyeings and prints having good fastness properties.
    Type: Grant
    Filed: October 25, 1994
    Date of Patent: July 18, 1995
    Assignee: Ciba-Geigy Corporation
    Inventors: Paul Herzig, Athanassios Tzikas, Anton Andreoli, Claudia Carisch
  • Patent number: 5432288
    Abstract: Novel O.sub.10eq -derivatives of ryanodine and dehydroryanodine characterized as binding strongly to ryanodine receptor, useful in affecting Ca.sup.++ efflux in tissue and also in isolating ryanodine receptor from sarcoplasmic reticulum. Also described are novel radio-iodinated alanine derivatives useful to radio label ryanodine and dehydroryanodine derivatives.
    Type: Grant
    Filed: March 2, 1993
    Date of Patent: July 11, 1995
    Assignee: Indiana University Foundation
    Inventors: Koert Gerzon, Rod A. Humerickhouse, Henry R. Bensch, Jr., Keshore R. Bidasee
  • Patent number: 5430169
    Abstract: The present invention provides a series of non-toxic compounds which function to inhibit the activity of S-1-P aldolase in respect to its cleavage of S-1-P. These inhibitors are described by the compounds of formula I ##STR1## wherein R is a radical containing 1 to 15 carbon atoms, a halogen, or hydrocarbon, R' is an organic radical or hydrogen, and R" is --NH.sub.3.sup.+ or --NH--NH .sup.+, with the proviso that, when R is CH.sub.3 (CH).sub.12 (CH.dbd.CH) and R' is hydrogen, R" is --NH--NH.sub.3.sup.+.A method for preparing such compounds, which may generally be described as 1-phosphate derivatives of compounds which include a 2-amino-1,3-alcohol radical is also disclosed.
    Type: Grant
    Filed: February 14, 1994
    Date of Patent: July 4, 1995
    Assignee: The United States of America represented by the Department of Health and Human Services
    Inventors: Ahcene Boumendjel, Stephen P. F. Miller
  • Patent number: 5430170
    Abstract: A industrially advantageous process for preparing dialkyl carbonates is provided. The process is characterized in that an alkylene carbonate and an alcohol are subjected to an transesterification in the presence of a catalyst which contains, as the catalytically active component, at least one rare-earth oxide. According to this process, the transesterification progresses rapidly due to the excellent activity of the catalyst, and the catalyst can be readily separated after termination of the reaction, allowing high efficiency isolation and purification of dialkyl carbonate.
    Type: Grant
    Filed: November 23, 1993
    Date of Patent: July 4, 1995
    Assignee: Nippon Shokubai Co., Ltd.
    Inventors: Yoshiaki Urano, Masaru Kirishiki, Yoshiyuki Onda, Hideaki Tsuneki
  • Patent number: 5428052
    Abstract: Aromatic heterocyclic derivatives have the formula ##STR1## wherein R.sub.1 represents (i)--CH.sub.3, (ii)--CH.sub.2 OH or (iii) ##STR2## wherein R.sub.3 represents hydrogen, --OR.sub.4 wherein R.sub.4 represents hydrogen, alkyl having 1-20 carbon atoms or mono- or polyhydroxyalkyl or R.sub.3 represents ##STR3## wherein r' and r" represent hydrogen, lower alkyl or together form a heterocycle, R.sub.2 represents hydrogen or --CH.sub.3 and Ar represents ##STR4## wherein R.sub.6 is hydrogen or alkyl having 1-10 carbon atoms and R.sub.7 represents alkyl having 4-12 carbon atoms or cycoalkyl, Y is CH or a nitrogen atom and X represents oxygen, sulfur or --N--R.sub.8 when R.sub.8 represents hydrogen, lower alkyl or lower alkoxycarbonyl, with the proviso that (i) when Y is CH and X is oxygen or sulfur Ar is other than C and (ii) when Y is nitrogen and X is oxygen, Ar is other than (C) or (D) in which R.sub.6 is alkyl having 1-4 carbon atoms and R.sub.7 is branched alkyl having 4-12 atoms.
    Type: Grant
    Filed: December 2, 1993
    Date of Patent: June 27, 1995
    Assignee: Centre Internationale de Recherches Dermatologiques (C.I.R.D.)
    Inventors: Braham Shroot, Jacques Eustache, Jean-Michel Bernardon
  • Patent number: 5428137
    Abstract: The monoazo compound represented by formula I is excellent in compatibility with, solubility in, and coloring power for, almost all water-immiscible organic liquids, has a low melting point, and is suitable for use to color molten plastics, synthetic fiber spinning solutions, etc., and to color thermal transfer ink. ##STR1## wherein R represents sec-butyl; Cp represents a coupling component residue.The dense solution of at least one kind of said monoazo compound in a hydrocarbon solvent diffuses and dissolves quickly and uniformly in coloring subjects such as petroleum products, and is capable of coloring fuel oil etc. to a desired distinguishable color density with small amounts.
    Type: Grant
    Filed: January 28, 1993
    Date of Patent: June 27, 1995
    Assignee: Orient Chemical Industries, Ltd.
    Inventors: Masahiro Otsuka, Toru Tsuruhara
  • Patent number: 5428163
    Abstract: A broad class of pharmaceutical agents which react directly with electron carriers or with reactive species produced by electron transport to release a pharmacologically active molecule to effect a therapeutic functional change in the organism by a receptor or nonrecepter mediated action.
    Type: Grant
    Filed: December 4, 1989
    Date of Patent: June 27, 1995
    Inventor: Randell L. Mills
  • Patent number: RE35009
    Abstract: Organic pigments selected from the diketopyrrolopyrrole, azo, isoindolinone and isoindoline series, which pigments consist of .Iadd.at least .Iaddend.50% by weight of platelets which are from 5 to 50 .mu.m long, 2 to 50 .mu.m wide and 0.01 to 5 .mu.m thick, with the proviso that the ratios of length:thickness and width:thickness must be at least 3.The pigments in platelet form are excellently suited to producing effect colorations in high molecular weight organic material and in cosmetic products.
    Type: Grant
    Filed: October 28, 1993
    Date of Patent: August 1, 1995
    Assignee: Ciba-Geigy Corporation
    Inventors: Philippe Bugnon, Fritz Herren, Bernhard Medinger