Patents Examined by Mary Cebulak
  • Patent number: 5650524
    Abstract: A process for preparing (R)-3-amino-5-methoxychroman is provided. The process comprises the steps of (i) dissolving racemic 3-amino-5-methoxychroman and L(+)tartaric acid in water to form the tartrate salt; (ii) heating the solution until a clear solution is obtained; and (iii) crystallizing the tartrate salt by allowing the solution to cool to room temperature.
    Type: Grant
    Filed: May 26, 1995
    Date of Patent: July 22, 1997
    Assignee: Astra Aktiebolag
    Inventor: Lars-Gunnar Larsson
  • Patent number: 5639443
    Abstract: A microbubble preparation formed of a plurality of microbubbles comprising a first gas and a second gas surrounded by a membrane such as a surfactant, wherein the first gas and the second gas are present in a molar ratio of from about 1:100 to about 1000:1, and wherein the first gas has a vapor pressure of at least about (760-x) mm Hg at 37.degree. C., where x is the vapor pressure of the second gas at 37.degree. C., and wherein the vapor pressure of each of the first and second gases is greater than about 75 mm Hg at 37.degree. C.; also disclosed are methods for preparing microbubble compositions, including compositions that rapidly shrink from a first average diameter to a second average diameter less than about 75% of the first average diameter and are stabilized at the second average diameter; kits for preparing microbubbles; and methods for using such microbubbles as ultrasound contrast agents.
    Type: Grant
    Filed: March 16, 1995
    Date of Patent: June 17, 1997
    Assignee: Alliance Pharmaceutical Corp.
    Inventors: Ernest G. Schutt, David P. Evitts, Rene Alta Kinner, Charles David Anderson, Jeffry G. Weers
  • Patent number: 5571497
    Abstract: Liposomes suitable as ultrasound contrast agents which contain media of various types including gases, gaseous precursors activated by pH, temperature or pressure, as well as other solid or liquid contrast enhancing agents, are described. Methods of using the same as ultrasound contrast agents are also disclosed. The present invention also comprises novel methods for synthesizing liposomes having encapsulated therein gases.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: November 5, 1996
    Assignee: ImaRx Pharmaceutical Corp.
    Inventor: Evan C. Unger
  • Patent number: 5541205
    Abstract: This invention relates to compounds which inhibit lipoxygenase in the metabolism of arachidonic acid and thus inhibits formation of leukotrienes which are implicated in inflammatory processes and bronchoconstriction and inhibits the oxidation of LDL which is implicated in formation of atherosclerotic plaque.The compounds useful in this invention are represented by the formula: ##STR1## wherein: R.sup.2 is hydrogen, halogen or C.sub.1 -C.sub.6 alkyl; Y of O or S;R.sup.5 is hydrogen or methylR.sup.6 is --NH.sub.2, --CH.sub.3 or --OCH.sub.3 ;and R.sup.1 is ##STR2## wherein R.sup.7, R.sup.8 and R.sup.10 are independently halogen, trifluoromethyl, alkyl, alkoxy, methanesulfonyl or trifluoromethanesulfonyl; R.sup.9 is hydrogen or methyl; and Z is O or S,or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: March 24, 1995
    Date of Patent: July 30, 1996
    Assignee: American Home Products Corporation
    Inventors: Michael S. Malamas, Iwan Gunawan
  • Patent number: 5536725
    Abstract: There is provided an insecticidal composition comprising, in admixture with an agriculturally acceptable carrier, an insecticidally effective amount of a tetrahydroquinazoline compound of the formula ##STR1## wherein R, R.sup.1, R.sup.2, R.sup.3, R.sup.5, R.sup.6, R.sup.7, R.sup.8, and R.sup.9 are as defined herein, and methods of using the same. Certain novel substituted-phenyl tetrahydroquinazoline compounds per se are also identified.
    Type: Grant
    Filed: October 6, 1994
    Date of Patent: July 16, 1996
    Assignee: FMC Corporation
    Inventors: Thomas G. Cullen, Robert N. Henrie, II, Clinton J. Peake, Brian D. Bennett
  • Patent number: 5442074
    Abstract: Novel herbicidal fluorobenzothiazolyloxyacetamides of the formula ##STR1## in which R.sup.1 represents hydrogen or an optionally substituted radical from the group consisting of alkyl, alkenyl, alkinyl and aralkyl,R.sup.2 represents an optionally substituted radical from the group consisting of alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkenyl, aralkyl, aryl, alkoxy, alkenyloxy or alkinyloxy, orR.sup.1 and R.sup.2, together with the nitrogen atom to which they are bonded, form an optionally substituted, saturated or unsaturated nitrogen heterocycle which can contain further heteroatoms and to which a benzo group can be fused.
    Type: Grant
    Filed: June 9, 1994
    Date of Patent: August 15, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventors: Heinz Forster, Klaus Wagner, Hans-Joachim Santel, Klaus Lurssen, Robert R. Schmidt
  • Patent number: 5428039
    Abstract: While performing cardiopulmonary bypass, the aorta is cross-clamped and the beating heart is stopped by introducing of an ATP-dependent potassium channel opening agent. The infusion into the coronary circulation shortens the cardiac action potential thereby arresting the heart muscle at a hyperpolarized membrane potential. This maintains the heart in a state of minimal metabolic requirement, thereby preserving transmembrane ionic gradients, intercellular energy stores and cellular integrity. Cardiac arrest is reversed simply by flushing the heart by the coronary circulation upon removal of the aortic cross-clamp. This use is also germane to organ preservation during transport for transplantation. For example, the donor heart is arrested using an ATP-dependent potassium channel opening agent, it is then removed and transported to the recipient and transplanted. Cardiac arrest is reversed by reperfusing the orthotropic graft.
    Type: Grant
    Filed: February 20, 1994
    Date of Patent: June 27, 1995
    Assignee: The Center for Innovative Technology
    Inventor: Neri Cohen
  • Patent number: 5403515
    Abstract: The invention relates to surfactant containing, liquid compositions based on the magnesium salt of primary alcohol sulphates and provides and aqueous, liquid, cleaning composition having a pH from 6-8, comprising:a) 2-40% wt surfactant, said surfactant comprising primary alcohol sulphate (i) and nonionic surfactants (ii) wherein at least 50% wt of the surfactant present is primary alcohol sulphate, said surfactant comprising less than 1% on surfactant of nitrogen-containing surfactant speciesb) magnesium, at a Molar ratio of at least 0.3 moles Mg per mole primary alcohol sulphate.
    Type: Grant
    Filed: August 20, 1993
    Date of Patent: April 4, 1995
    Assignee: Lever Brothers Company, Division of Conopco, Inc.
    Inventors: Terry Instone, David P. Jones, David Roscoe, Philip J. Sams, Martin Sharples
  • Patent number: 5403861
    Abstract: Modulators of neurotransmitter release including substituted guanidines, N"-aminoguanidines, and N,N'N",N"'-tetrasubstituted hydrazinedicarboximidamides, and pharmaceutical compositions thereof are disclosed. Also disclosed are methods involving the use of such neurotransmitter release modulators for the treatment or prevention of pathophysiologic conditions characterized by the release of excessive or inappropriate levels of neurotransmitters. Also disclosed are screening assays for compounds which selectively inhibit glutamate release. Also disclosed are methods of blocking voltage sensitive sodium and calcium channels in mammalian nerve cells.
    Type: Grant
    Filed: February 10, 1992
    Date of Patent: April 4, 1995
    Assignee: Cambridge NeuroScience, Inc.
    Inventors: Stanley M. Goldin, Subbarao Katragadda, Lain-Yen Hu, N. Laxma Reddy, James B. Fischer, Andrew G. Knapp, Lee D. Margolin
  • Patent number: 5356864
    Abstract: Novel herbicidal fluorobenzothiazolyloxyacetamides of the formula ##STR1## in which R.sup.1 represents hydrogen or an optionally substituted radical from the group consisting of alkyl, alkenyl, alkinyl and aralkyl,R.sup.2 represents an optionally substituted radical from the group consisting of alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkenyl, aralkyl, aryl, alkoxy, alkenyloxy or alkinyloxy, orR.sup.1 and R.sup.2, together with the nitrogen atom to which they are bonded, form an optionally substituted, saturated or unsaturated nitrogen heterocycle which can contain further heteroatoms and to which a benzo group can be fused.
    Type: Grant
    Filed: September 9, 1993
    Date of Patent: October 18, 1994
    Assignee: Bayer Aktiengesellschaft
    Inventors: Heinz Forster, Klaus Wagner, Hans-Joachim Santel, Klaus Lurssen, Robert R. Schmidt
  • Patent number: 5352435
    Abstract: Liposomes suitable as ultrasound contrast agents which contain media of various types including gases, gaseous precursors activated by pH, temperature or pressure, as well as other solid or liquid contrast enhancing agents, are described. Methods of using the same as ultrasound contrast agents are also disclosed. The present invention also comprises novel methods for synthesizing liposomes having encapsulated therein gases.
    Type: Grant
    Filed: October 27, 1992
    Date of Patent: October 4, 1994
    Inventor: Evan C. Unger
  • Patent number: 5347018
    Abstract: A process for producing sulfolane compounds is provided which comprises: (1) contacting a conjugated diene with sulfur dioxide under conditions sufficient to synthesize a sulfolene compound whereby a mixture of the sulfolene compound and impurities comprising unreacted sulfur dioxide is produced; (2) transferring the mixture to an impurities removal vessel containing a freezing point depressant which comprises an aromatic compound; (3) removing the impurities; (4) transferring the impurities-reduced sulfolene compound to a hydrogenation reactor; (5) contacting the impurities-reduced sulfolene compound with hydrogen, in the presence of a hydrogenation catalyst, under conditions sufficient to produce a sulfolane compound; and (6) optionally recovering the sulfolane compound.
    Type: Grant
    Filed: September 28, 1993
    Date of Patent: September 13, 1994
    Assignee: Phillips Petroleum Company
    Inventors: Earl Clark, Jr., Howard F. Efner, Jimmie J. Straw
  • Patent number: 5346895
    Abstract: Novel compounds of the formula ##STR1## where X is S, O; R.sub.1 -R.sub.5 are hydrogen or lower alkyl; R.sub.6 is lower alkyl, lower alkenyl, lower cycloalkyl having 1 to 6 carbons, or halogen; A is lower branched chain alkyl having 2 to 6 carbons, cycloalkyl having 3 to 6 carbons, alkenyl having 2 to 6 carbons and 1 or 2 double bonds, alkynyl having 2 to 6 carbons and 1 or 2 triple bonds, (CH.sub.2).sub.n where n is 0-5; and B is hydrogen, COOH or a pharmaceutically acceptable salt thereof, COOR.sub.8, COONR.sub.9 R.sub.10, --CH.sub.2 OH, CH.sub.2 OR.sub.11, CH.sub.2 OCOR.sub.11, CHO, CH(OR.sub.12).sub.2, CHOR.sub.13 O, --COR", CR"(OR.sub.12).sub.2, or CR"OR.sub.13 O, where R" is an alkyl, cycloalkyl or alkenyl group containing 1 to 5 carbons, R.sub.8 is an alkyl group of 1 to 10 carbons, or a cycloalkyl group of 5 to 10 carbons, or R.sub.8 is phenyl or lower alkylphenyl, R.sub.9 and R.sub.
    Type: Grant
    Filed: January 6, 1993
    Date of Patent: September 13, 1994
    Assignee: Allergan, Inc.
    Inventor: Roshantha A. S. Chandraratna
  • Patent number: 5334381
    Abstract: Liposomes suitable as ultrasound contrast agents which contain media of various types including gases, gaseous precursors activated by pH, temperature or pressure, as well as other solid or liquid contrast enhancing agents, are described. Methods of using the same as ultrasound contrast agents are also disclosed. The present invention also comprises novel methods for synthesizing liposomes having encapsulated therein gases.
    Type: Grant
    Filed: June 30, 1993
    Date of Patent: August 2, 1994
    Inventor: Evan C. Unger
  • Patent number: 5315014
    Abstract: The present invention involves monomeric compounds having the structure: ##STR1## Substituents W and Z are independently --CN, --NO.sub.2, --aryl, --aryl--V, --COX, SO.sub.2 R, --H, or --alkyl. Substituent X is --OR, or --NR,R where R and R.sup.1 are independently --alkyl or --H. Substituent V is --halide, --NO.sub.2, --CN, --SO.sub.2 R, or --COX. At least one of W and Z is --NO.sub.2, --SO.sub.2 R, --CN, --COX or --aryl--V. In one preferred embodiment substituents W and Z are both --CN. In another preferred embodiment, substituent X is --NO.sub.2 or --CN and substituent Z is --C.sub.6 H.sub.4 NO.sub.2. These monomers are polymerized to form low bandgap polymers.
    Type: Grant
    Filed: August 25, 1993
    Date of Patent: May 24, 1994
    Assignee: Board of Regents, The University of Texas System
    Inventors: John P. Ferraris, Tim L. Lambert, Santiago Rodriguez
  • Patent number: 5304656
    Abstract: In a process for preparing alkylene sulfides through the intramolecular dehydration reaction of mercaptoalkanols in a gaseous phase, catalysts are used, which are represented by the formula: M.sub.a X.sub.b Y.sub.c O.sub.d, where M represents at least one element selected from the group of alkali metals, alkaline earth metals and thallium; X represents at least one element selected from the group of Al, B, Si and P; Y represents at least one element selected from the group consisting of lanthanides, IIIA group, IVA group, VA group, IIIB group, IVB group, VB group and VIB group, excluding an element contained in M or X; O represents oxygen; and a and b are numerical values not equal to 0; b=0.2-100 and c=0-50 when a=1; and d is a numerical value determined according to a, b and c.
    Type: Grant
    Filed: November 23, 1992
    Date of Patent: April 19, 1994
    Assignee: Nippon Shokubai Co., Ltd.
    Inventors: Hitoshi Yano, Yoshinari Yamaguchi, Kimio Ariyoshi, Yuuji Shimasaki, Ryuichi Ishikawa, Michio Ueshima
  • Patent number: 5300646
    Abstract: A novel heterocyclic amine derivative of the general formula: ##STR1## wherein a ring A and a ring B stand independently for an optionally substituted benzene ring, Z.sup.o stands for O or S or ##STR2## stands for --CH.sub.2 --, X stands for O, S or NR.sup.1 wherein R.sup.1 stands for hydrogen atom or an alkyl group, Y stands for NH, O or (CH.sub.2).sub.n wherein n denotes 0 to 2, and R.sup.2 stands for an optionally substituted hydrocarbon group, or their salts.
    Type: Grant
    Filed: December 22, 1992
    Date of Patent: April 5, 1994
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Hideaki Natsugari, Hiroyuki Tawada, Hitoshi Ikeda
  • Patent number: 5274122
    Abstract: Homocysteine thiolactone derivatives in which the nitrogen is acylated with groups containing acidic functionalities have been synthesized. These include the succinyl, the carboxymethylglutaryl, the 3-phosphonopropionyl and the 3-sulfopropionyl derivatives. These thiolactones can be used to introduce a thiol functionality into proteins such as the outer membrane protein complex of Neisseria meninioitidis (OMPC) allowing conjugation with electrophilic ligands. This chemistry is similar to known N-acetyl-homocysteine thiolactone chemistry, but the pK.sub.a values are such that at pH 7, concomitant negative charge is introduced into the conjugate. Such negative charge neutralizes excess positive charge introduced when arginine- and lysine-rich peptides are bonded as ligands. In the case of OMPC, introduction of positive charge commonly effects irreversible precipitation of the conjugate. Conjugates prepared with the anionic thiolactones have improved solubility.
    Type: Grant
    Filed: October 15, 1992
    Date of Patent: December 28, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Richard L. Tolman, Stephen Marburg, William J. Leanza