Abstract: Methods and systems are provided for making a drug microtablet. The method includes loading a lyophilization capillary channel with a liquid drug solution; lyophilizing the liquid drug solution in the lyophilization capillary channel to produce a lyophilized drug formulation; compressing the lyophilized drug formulation in the lyophilization capillary channel, or in a compression capillary channel, to form a microtablet; and ejecting the microtablet from the lyophilization capillary channel or compression capillary channel. The methods and systems may provide drug microtablets having improved content uniformity and reduced weight variability.
Type:
Grant
Filed:
May 11, 2012
Date of Patent:
November 27, 2012
Assignee:
On Demand Therapeutics, Inc.
Inventors:
Jonathan R. Coppeta, Robert Dyer, Cynthia L. Stevenson