Patents Examined by Mary Lyons
  • Patent number: 9933425
    Abstract: Method and kits are provided determining the presence or absence of parasitic helminth eggs in environmental samples, particularly fecal samples. The methods incorporate egg capture methods and the use of N-acetyl-D-glucosamine specific ligands for egg detection.
    Type: Grant
    Filed: December 5, 2014
    Date of Patent: April 3, 2018
    Assignee: MEP Equine Solutions LLC
    Inventors: Pawel Slusarewicz, Eric W. Hauck
  • Patent number: 9931361
    Abstract: The invention relates to a field of tissue repair and regeneration. More particularly, the invention relates to a composition for promoting cutaneous wound healing. In one embodiment, the composition is composed of one or more metazoan parasites or a mimic thereof sufficient to promote helminth-induced type-2 immune response. Preferably, the composition contains N. brasiliensis excretory/secretory antigen (NES) or an immune triggering portion thereof. The invention also relates to a method of accelerating wound healing in a subject in need of such treatment.
    Type: Grant
    Filed: March 18, 2014
    Date of Patent: April 3, 2018
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: William C. Gause, Fei Chen, Zhugong Liu, Pankaj Mishra
  • Patent number: 9925259
    Abstract: Provided is a gene for expressing an immunogenic polypeptide on the cell surface of a bifidobacterium, and the gene includes a gene encoding the immunogenic polypeptide, the immunogenic polypeptide includes a predetermined base domain and at least one antigenic peptide, and the at least one antigenic peptide is linked on any of the N-terminal side and the C-terminal side of the base domain. The gene for expressing an immunogenic polypeptide on a cell surface of a bifidobacterium of the present invention can further include a gene encoding a bifidobacterium-derived GNB/LNB substrate-binding membrane protein.
    Type: Grant
    Filed: February 14, 2014
    Date of Patent: March 27, 2018
    Assignee: National University Corporation Kobe University
    Inventors: Toshiro Shirakawa, Hak Hotta, Takane Katayama
  • Patent number: 9927438
    Abstract: The subject invention provides point-of-care assays for assessing the topographical distribution of microbial biofilm and/or specific microorganisms in wounds.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: March 27, 2018
    Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED
    Inventors: Gregory S. Schultz, Edith Marion Sampson, Priscilla Lorraine Phillips
  • Patent number: 9926568
    Abstract: The invention provides compositions and methods for clostridial bacteria that have been engineered to produce and/or to improve efficiency of production of industrial bioproducts.
    Type: Grant
    Filed: June 20, 2014
    Date of Patent: March 27, 2018
    Assignee: Danisco US Inc.
    Inventors: Miles C. Scotcher, Derek H. Wells
  • Patent number: 9926586
    Abstract: The present specification discloses methods of detecting a pathogen of interest, components useful in carrying out these methods, including a pre-enrichment media, and enrichment media and a detection solution and kits thereof.
    Type: Grant
    Filed: March 16, 2016
    Date of Patent: March 27, 2018
    Inventors: Cristina Perez Girona, Pablo Lozano Sánchez, Gemma Freixes Prous, Sergio Martinez Montequín, Anna Pallares Lleo, Bruno Teixeira Dias, Katia Uliaque Cugat
  • Patent number: 9926363
    Abstract: Campylobacter jejuni is a leading cause of bacterial food-borne diseases in humans, ranging from acute diarrheal disease to neurological disorders. An isolated or purified antibody or fragment thereof specific to C. jejuni is described. The antibody or fragment thereof binds to a flagellar protein and reduces motility of C. jejuni. The antibody or fragment thereof is derived from a heavy chain IgG variable domain fragment (VHH) of a camelid animal immunized with C. jejuni flagellar protein. A multivalent form, as well as a phage format, of the antibody or fragment thereof is described. Methods of reducing presence of C. jejuni in an animal or an animal environment, methods and formulations for treating C. jejuni infection, and method of detecting C. jejuni are also described.
    Type: Grant
    Filed: October 24, 2013
    Date of Patent: March 27, 2018
    Assignee: National Research Council of Canada
    Inventors: Mehdi Arbabi Ghahroudi, Ali Riazi, Christine M. Szymanski, Greg Hussack, Jamshid Tanha, Roger MacKenzie
  • Patent number: 9926344
    Abstract: Elimination of disulphide bond formation of cysteine-containing S. aureus antigens enhances antigen stability. The invention provides variant forms of cysteine-containing S. aureus antigen with a point mutation that replaces, deletes or modifies the cysteine residue.
    Type: Grant
    Filed: August 29, 2013
    Date of Patent: March 27, 2018
    Assignee: GLAXOSMITHKLINE BIOLOGICALS SA
    Inventors: Fabio Bagnoli, Fabiana Falugi, Guido Grandi, Massimo Mariani, Mikkel Nissum, Michele Pallaoro, Silvana Savino
  • Patent number: 9926346
    Abstract: Recombinant Mycobacteria (rMyc) which contain sequences encoding a heparin-binding hemagglutinin (HBHA) fusion protein are provided, as are methods of making and using the rMyc and the fusion protein. The fusion protein includes an amino terminal mycobacterial antigen Ag85B leader peptide and transcription of the fusion protein is driven by an Ag85B promoter sequence. The recombinant fusion protein is produced in abundance by the rMyc, is post-translationally methylated, and is highly antigenic.
    Type: Grant
    Filed: April 16, 2012
    Date of Patent: March 27, 2018
    Assignees: Aeras, Institut National De La Sante Et De La Recherche Medicale (Inserm)
    Inventors: John Fulkerson, Michael Brennan, Kamalakannan Velmurugan, Camille Locht
  • Patent number: 9921220
    Abstract: Disclosed is a cell wall C-polysaccharide antigen of Streptococcus pneumoniae which contains not more than 10% by weight of protein, and preferably less which has been purified with 0.1N Na OH prior to deproteinizing. Also disclosed are polyvalent antibodies raised against Streptococcus pneumoniae which have been affinity purified by passing them over a chromatographic affinity matrix to which is coupled the purified and at least partially deproteinized antigen to render them antigen-specific.
    Type: Grant
    Filed: March 1, 2016
    Date of Patent: March 20, 2018
    Assignee: Alere Scarborough, Inc.
    Inventors: Norman J. Moore, Mary K. Konstantin, Vladimir A. Koulchin, Elena V. Molokova
  • Patent number: 9920352
    Abstract: Method and system for monitoring for a change in the amount and/or concentration of a pathogen in a pathogenic fluid. The method includes providing a pathogen-impermeable enclosure enclosing the pathogenic fluid, wherein the pathogenic fluid includes a pathogen and a carrier fluid. Additionally, the method includes acoustically monitoring for a change in the amount and/or concentration of the pathogen enclosed in the pathogen-impermeable enclosure.
    Type: Grant
    Filed: April 8, 2013
    Date of Patent: March 20, 2018
    Assignee: Labcyte Inc.
    Inventors: Mitchell W. Mutz, Richard N. Ellson
  • Patent number: 9920113
    Abstract: Methods and reagents for ameliorating biofilm formation on a surface of an indwelling or implanted device in a patient resulting in decreased virulence of microorganisms such as Candida species and/or Staphylococcus species.
    Type: Grant
    Filed: May 26, 2016
    Date of Patent: March 20, 2018
    Assignees: CHILDREN'S HOSPITAL MEDICAL CENTER, UNIVERSITY OF CINCINNATI, YALE UNIVERSITY
    Inventors: Margaret K. Hostetter, Long Lu, Julianne Vernadette Green, Alexey Porollo, Kris I. Orsborn, Khoon Ghee Queenie Tan, Kenneth Greis, David Andes
  • Patent number: 9920297
    Abstract: The present invention relates to an attenuated mutant strain of Salmonella comprising a recombinant DNA molecule encoding Wilms' tumor Protein 1. In particular, the present invention relates to the use of said attenuated mutant strain of Salmonella in cancer immunotherapy.
    Type: Grant
    Filed: April 24, 2014
    Date of Patent: March 20, 2018
    Assignee: VAXIMM AG
    Inventors: Heinz Lubenau, Marco Springer
  • Patent number: 9821048
    Abstract: The present invention is related to a polypeptide comprising an amino acid sequence, whereby the amino acid sequence of the polypeptide is at least 80% identical to a stretch of consecutive amino acids of the region of HPGGT comprising an amino acid sequence corresponding to SEQ.ID.No. 1, whereby such region is defined by (a) amino acid positions 150 to 200 of the amino acid sequence according to SEQ.ID.No.1, or (b) amino acid positions 410 to 480 of the amino acid sequence according to SEQ.ID.No.1, and whereby the polypeptide is suitable to elicit an immune response which is capable of inhibiting the catalytic activity of HPGGT.
    Type: Grant
    Filed: June 24, 2015
    Date of Patent: November 21, 2017
    Assignee: IMEVAX GMBH
    Inventors: Markus Gerhard, Christian Schmees, Christian Prinz
  • Patent number: 9796744
    Abstract: The present invention generally relates to the field of detecting and preventing infectious diseases caused by Enterococcus faecalis and/or Enterococcus faecium.
    Type: Grant
    Filed: November 13, 2007
    Date of Patent: October 24, 2017
    Assignee: UNIVERSITÄTSKLINIKUM FREIBURG
    Inventors: Johannes Hübner, Otto Holst, Christian Theilacker, Zbigniew Kaczynski
  • Patent number: 9789141
    Abstract: This invention relates to use of probiotics, particularly P acidilactici and S boulardii, for use in conjunction with steroids and other immune suppressor agents to ameliorate symptoms of autoimmune diseases, especially disease symptoms arising from the body's production of antibodies against autologous blood cells. The practice of the invention sustains ameliorative response associated with immune suppressor agents while lowering the amount of immune suppressor agents required for treatment.
    Type: Grant
    Filed: May 6, 2016
    Date of Patent: October 17, 2017
    Assignee: IMAGILIN TECHNOLOGY, LLC
    Inventors: Jhy-Jhu Lin, Gen Kato, Takuo Ishida
  • Patent number: 9778259
    Abstract: The present invention concerns an in vitro method for diagnosing invasive candidiasis (IC) in a subject which comprises detecting the presence of a Candida glycan and detecting the presence of antibody directed against a protein selected from the group consisting of fructose bisphosphate aldolase (Fba1), enolase 1 (Eno1), heat shock protein 90 (Hsp90), hyphal wall protein (Hwp1), and mannoprotein 65 (Mp65) in a blood, plasma or serum sample of the subject. The invention also relates to a method of determining a suitable treatment regimen for a patient and to a kit for implanting the methods described herein.
    Type: Grant
    Filed: March 18, 2013
    Date of Patent: October 3, 2017
    Assignees: Bio-Rad Innovations, Centre Hospitalier Universitaire De Lille, Universite Lille 2 Droit et Sante
    Inventors: Sebastien Damiens, Chantal Fradin, Daniel Poulain, Boualem Sendid, Marc Charles Victor Tabouret
  • Patent number: 9759721
    Abstract: The present specification discloses methods of detecting a pathogen of interest and components useful in carrying out these methods, including a pre-enrichment media, and enrichment media and a detection solution.
    Type: Grant
    Filed: January 22, 2014
    Date of Patent: September 12, 2017
    Assignee: IMICROQ, S.L.
    Inventors: Pablo Lozano Sánchez, Gemma Freixes Prous, Sergio Martinez Montequín, Anna Pallares Lleo, Cristina Perez Girona, Katia Uliaque Cugat
  • Patent number: 9758760
    Abstract: The invention provides methods of producing vaccines directed against microorganisms, with the methods comprising culturing, harvesting and/or suspending the microorganism in the presence of a radiation-protective composition and irradiating the bacteria or viruses with a dose of radiation sufficient to render the microorganism replication-deficient and/or non-infective. The radiation-protective compositions used in the methods of the present invention comprise at least one nucleoside, at least one antioxidant and at least one small peptide. The invention also provides methods of rendering bacteria in culture resistant to ionizing radiation (IR), with these methods comprising culturing the bacteria in the presence of a radiation-protective composition.
    Type: Grant
    Filed: December 8, 2015
    Date of Patent: September 12, 2017
    Assignee: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
    Inventors: Michael J. Daly, Elena K. Gaidamakova
  • Patent number: 9751930
    Abstract: The present invention provides method for purifying a recombinant protein from a gram-negative bacterial host cell sample or extract thereof wherein said host cell expresses a recombinant protein and a recombinant disulphide isomerase DsbC; comprising: a. adjusting the pH of the host cell sample or extract thereof to a pH of 5 or less to precipitate the recombinant disulphide isomerase; and b. separating precipitated recombinant disulphide isomerase DsbC from the recombinant protein to produce a recombinant protein sample.
    Type: Grant
    Filed: July 27, 2011
    Date of Patent: September 5, 2017
    Assignee: UCB PHARMA, S.A.
    Inventor: Gavin Barry Wild