Patents Examined by Mathew L. Fedowitz
  • Efficient synthesis of pyropheophorbide a and its derivatives
    Patent number: 7053210
    Abstract: A process for the preparation of pyropheophorbide a and its derivatives, including 3-devinyl-3-(1?-hexyloxy)ethyl-pyropheophorbide-a, otherwise known as HPPH, is provided. The process involves treating chlorin e6, in the form of its trimethyl ester, with a base, followed by heating to give pyropheophorbide a, which is converted to HPPH by treatment with acid, followed by hexyl alcohol under basic conditions.
    Type: Grant
    Filed: July 2, 2003
    Date of Patent: May 30, 2006
    Assignee: Health Research, Inc.
    Inventors: Ravindra K. Pandey, Thomas J. Dougherty, Alexander J. Pallenberg
  • Photosensitizer and method for production thereof
    Patent number: 6969765
    Abstract: The invention relates to medicine and concerns a photosensitizer for detecting and curing tumors. The inventive photosensitizer is embodied in the form of a composition containing chlorin in the form of salt and alkali metals. The chlorin is composed of 80-90% of chlorin e6, 5-20 of purpurin 5 and the rest being purpurin 18 -chlorin p6. Said photosensitizer is produced by extracting Spirulina biomass with the aid of acetone. Afterwards said biomass is exposed to acid treatment, neutralization, hydrolysis, extraction of pheophorbide a, dissolution in acetone, addition of a strong base, neutralization and reprecipitation of chlorin e6.
    Type: Grant
    Filed: October 4, 2001
    Date of Patent: November 29, 2005
    Assignee: Obschestvo s Ogranichennoi Otvetstvennostiju “Rada-Pharma”
    Inventors: Andrei Valentinovich Reshetnikov, Igor Dmitrievich Zalevsky, Jury Viktorovich Kemov, Andrei Valentinovich Ivanov, Artashes Vacheevich Karmenyan, Alexandr Tikhonovich Gradjushko, Vladimir Petrovich Laptev, Nataliya Petrovna Neugodova, Olga Yurievna Abakumova, Valery Alexeevich Privalov, Alexandr Vladimirovich Lappa, Vladimir Alexandrovich Romanov