Patents Examined by Matt Mauro
  • Method and composition for treating acne
    Patent number: 9480674
    Abstract: The subject invention provides a method of treating acne in a subject which comprises topically and periodically applying to the subject's acne a composition comprising 3-phenyl-1-benzo[f]chromen-1-one and a pharmaceutically acceptable carrier, wherein the 3-phenyl-1-benzo[f]chromen-1-one is present in an amount effective to treat the subject's acne. The subject invention also provides a method of treating a skin condition associated with abnormal sebum secretion or abnormal sebaceous gland function in a subject, compositions in such methods and a sorting method for identifying agonists of AhR pathway, useful in such methods and compositions.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: November 1, 2016
    Assignee: THESAN PHARMACEUTICALS, INC.
    Inventor: Jean Hilaire Saurat
  • Process for preparation of Darunavir
    Patent number: 9475821
    Abstract: Provided are a process for preparation of darunavir or solvates or a pharmaceutically acceptable salt thereof substantially free of bisfuranyl impurities and a process for preparation of amorphous darunavir using the darunavir propionate solvate.
    Type: Grant
    Filed: July 23, 2013
    Date of Patent: October 25, 2016
    Assignee: Laurus Labs Private Limited
    Inventors: Kameswar R. Chivukula, Venkata R. Murthy, Venkata S. Indukuri, Seeta R. Gorantla
  • Method for synthesising 2,5-di(hydroxymethyl)furan and 2,5-di(hydroxymethyl)tetrahydrofuran by selective hydrogenation of furan-2,5-dialdehyde
    Patent number: 9475786
    Abstract: A method for selective hydrogenation of furan-2,5-dialdehyde (DFF) into 2,5-di(hydroxymethyl)furan (DHMF) and into 2,5-di(hydroxymethyl)tetrahydrofuran (DHMTHF). In relation to the prior art, which uses C6 sugars or 5-hydroxymethyl furaldehyde (5-HMF) as raw materials, the method can be performed at low temperatures (lower than 120° C., preferably 80° C.), while consuming low amounts of catalyst relative to the initial reagent (in particular less than 5%, preferably less than 2% relative to the weight of the reagent). The heterogeneous catalyst used can also be recycled from one reaction to another. Finally, the choice of experimental conditions enables the selective formation of DHMF or DHMTHF.
    Type: Grant
    Filed: September 26, 2013
    Date of Patent: October 25, 2016
    Assignee: ROQUETTE FRERES
    Inventors: Mathias Ibert, Flora Chambon, Laurent Dambrine
  • Preparation method for optically active bicyclic gamma-amino acid compound
    Patent number: 9469623
    Abstract: An object of the present invention is to provide an optically active bicyclic ?-amino acid derivative in a high purity.
    Type: Grant
    Filed: February 6, 2015
    Date of Patent: October 18, 2016
    Assignee: Daiichi Sankyo Company, Limited
    Inventors: Yoshitaka Nakamura, Kazutoshi Ukai, Takafumi Kitawaki, Takumi Nakajima, Yutaka Kitagawa, Yukito Furuya, Makoto Imai, Eiji Numagami, Masakazu Wakayama, Ayako Saito
  • Method of preparing furfural compounds
    Patent number: 9469619
    Abstract: Provided is a two-step method of producing a compound of chemical formula 1 in the presence of an alcohol solvent and a Group 3B metal catalyst or a salt thereof, comprising a first step comprising alkylation or isomerization of an aldohexose-containing substrate to obtain an intermediate, and a second step comprising dehydration of the intermediate to produce a compound of chemical formula 1. Preferably, additional solvent and/or catalyst are not added in the second step.
    Type: Grant
    Filed: October 29, 2013
    Date of Patent: October 18, 2016
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Jong Min Lee, Hyeon Su Heo, Moo Ho Lee, Kyung Hae Lee
  • Method for producing multisubstituted biphenyl compound and solid catalyst to be used therein
    Patent number: 9469621
    Abstract: A method for producing a multisubstituted biphenyl compound is represented by the following formula (2), including a step of coupling a substituted benzene compound represented by the following formula (1) in the presence of a solid catalyst with gold immobilized onto a support.
    Type: Grant
    Filed: October 9, 2013
    Date of Patent: October 18, 2016
    Assignees: KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION, UBE INDUSTRIES, LTD.
    Inventors: Tamao Ishida, Makoto Tokunaga, Akiyuki Hamasaki, Syohei Aikawa, Yoshiyuki Mise, Tetsuro Tsuji, Yasushi Yamamoto, Mitsuru Miyasaka
  • Monomer for binding nano-metal, conductive polymer composite and method of preparing the conductive polymer composite
    Patent number: 9458126
    Abstract: Disclosed herein is a monomer for binding nano-metal, which is useful for the preparation of a conductor having increased conductivity with ensuring flexibility and transparency. Polymerization of the monomer for binding nano-metal provides a conductive polymer composite including a nano-metal rod. A method of preparing the conductive polymer composite is also provided.
    Type: Grant
    Filed: June 26, 2015
    Date of Patent: October 4, 2016
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Byung Hee Sohn, Young Kwan Lee, Yi Yoiung Yun, Won Jae Joo
  • Cage amine ligands for metallo-radiopharmaceuticals
    Patent number: 9457107
    Abstract: The present invention relates to compounds that are useful as metal ligands and which can be bound to a biological entity such as a molecular recognition moiety and methods of making these compounds. Once the compounds that are bound to a biological entity are coordinated with a suitable metallic radionuclide, the coordinated compounds are useful as radiopharmaceuticals in the areas of radiotherapy and diagnostic imaging. The invention therefore also relates to methods of diagnosis and therapy utilizing the radiolabelled compounds of the invention.
    Type: Grant
    Filed: December 6, 2012
    Date of Patent: October 4, 2016
    Assignee: The University of Melbourne
    Inventors: Paul Donnelly, Brett Paterson
  • Polymorphs of darunavir
    Patent number: 9453024
    Abstract: The present invention provides new pseudopolymorphic forms of darunavir as well as a novel amorphous form of darunavir, pharmaceutical compositions comprising these compounds, methods for their preparation and use thereof in treating retroviral infections, in particular, HIV infection.
    Type: Grant
    Filed: November 24, 2014
    Date of Patent: September 27, 2016
    Assignee: Mapi Pharma Ltd.
    Inventor: Ehud Marom
  • Broad spectrum beta-lactamase inhibitors
    Patent number: 9453032
    Abstract: Broad spectrum beta-lactamase inhibitors. Certain inhibitors also exhibit potent antibiotic activity in addition to beta-lactamase inhibition. Compounds of the invention are designed such that on cleavage of the beta-lactam ring reactive moieties are generated which can inactivate beta-lactamase. Also provided are methods of making beta-lactamase inhibitors and beta-lactam antibiotics exhibiting such inhibition. Additionally provided are pharmaceutical compositions for treatment or prevention of bacterial infections and methods of treatment of such infections.
    Type: Grant
    Filed: September 19, 2014
    Date of Patent: September 27, 2016
    Assignee: GLADIUS PHARMACEUTICALS CORPORATION
    Inventors: Larry Sutton, Sophia Yu
  • Method of treatment using substituted pyrazolo[1,5-a]pyrimidine compounds
    Patent number: 9447104
    Abstract: Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.
    Type: Grant
    Filed: September 18, 2014
    Date of Patent: September 20, 2016
    Assignee: Array BioPharma, Inc.
    Inventors: Julia Haas, Steven W. Andrews, Yutong Jiang, Gan Zhang
  • Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
    Patent number: 9446995
    Abstract: Stereoselective and regioselective synthesis of compounds via nucleophilic ring opening reactions of aziridinium ions for use in stereoselective and regioselective synthesis of therapeutic and diagnostic compounds.
    Type: Grant
    Filed: May 17, 2013
    Date of Patent: September 20, 2016
    Assignee: Illinois Institute of Technology
    Inventor: Hyun-Soon Chong
  • Chemical compound for inhibiting the growth and proliferation of human liver cancer cells HepG2 and method for synthesizing it
    Patent number: 9447119
    Abstract: The compound “2-((4-nitrophenyl)amino)-7,8,9,10-tetrahydro cyclohepta[4,5]thieno[2,3-d][1,3,4]thiadiazolo[3,2-a]pyrimidin-11(6H)-one” and method of synthesizing it, wherein the compound is effective to inhibit the growth and proliferation of human liver cancer cells HepG2. The compound has a higher efficiency to inhibit the growth and proliferation of these cells as it has an inhibitory concentration value (IC50) of 0.7 ?g, compared to reference medication Doxorubicin that has an (IC50) value of 1.2 ?g. It further surpasses that reference medication at all tested concentrations.
    Type: Grant
    Filed: January 9, 2015
    Date of Patent: September 20, 2016
    Inventor: Zainab Saeed Alghamdi
  • Heterocyclic compound preparing
    Patent number: 9447064
    Abstract: Disclosed is a process for selectively producing (D+1)-member heterocyclic compounds from corresponding unactivated dienes or derivatives thereof in the presence of a transition metal or lanthanide catalyst or a precursor thereof, relative to D-member heterocyclic rings.
    Type: Grant
    Filed: April 30, 2014
    Date of Patent: September 20, 2016
    Assignee: THE CHINESE UNIVERSITY OF HONG KONG
    Inventor: Chun Yu Ho
  • Use of macrocyclic picolinamides as fungicides
    Patent number: 9439422
    Abstract: The invention relates to macrocyclic picolinamides of Formula I and their use as fungicides.
    Type: Grant
    Filed: September 29, 2014
    Date of Patent: September 13, 2016
    Assignee: Dow AgroSciences LLC
    Inventors: Timothy P. Martin, Kevin G. Meyer, Benjamin Nugent, Chenglin Yao, W. John Owen, Anne M. Wilson, Ian O'Callaghan, Jeremy Wilmot, Johnathan E. DeLorbe, William Dent, III
  • Method for inhibiting growth of cancer cells
    Patent number: 9433604
    Abstract: A method of inhibiting the growth of cancer cells is disclosed in which cancer cells that contain an enhanced amount relative to non-cancerous cells of one or more of phosphorylated mTOR, Akt1, ERK2 and serine2152-phosphorylated filamin A are contacted with an FLNA-binding effective amount of a compound or a pharmaceutically acceptable salt thereof that binds to the pentapeptide of filamin A (FLNA) of SEQ ID NO: 1 and exhibits at least about 60 percent of the FITC-labeled naloxone binding amount when present at a 10 ?M concentration and using unlabeled naloxone as the control inhibitor at the same concentration. A compound that binds to the FLNA pentapeptide preferably also contains at least four of the six pharmacophores of FIGS. 19-24.
    Type: Grant
    Filed: September 26, 2014
    Date of Patent: September 6, 2016
    Assignee: Pain Therapeutics Inc.
    Inventors: Hoau-Yan Wang, Lindsay Burns Barbier
  • Branched siloxanes and methods for synthesis
    Patent number: 9434750
    Abstract: The present invention describes branched and functionalized siloxanes and methods for making such compounds. The compounds have a variety of uses. One preferred application is as novel planarizing material for lithography, in which case functionalized branched siloxane, such as an epoxy-modified branched siloxane is particularly useful.
    Type: Grant
    Filed: April 8, 2015
    Date of Patent: September 6, 2016
    Assignee: Board of Regents, The University of Texas System
    Inventors: C. Grant Willson, Tsuyoshi Ogawa, Michael B. Jacobsson
  • Lipids and compositions for intracellular delivery of biologically active compounds
    Patent number: 9433681
    Abstract: The present invention provides novel amino-lipids, compositions comprising such amino-lipids and methods of producing them. In addition, lipid nanoparticles comprising the novel amino-lipids and a biologically active compound are provided, as well as methods of production and their use for intracellular drug delivery.
    Type: Grant
    Filed: February 12, 2014
    Date of Patent: September 6, 2016
    Assignee: AXOLABS GMBH
    Inventors: Rainer Constien, Anke Geick, Philipp Hadwiger, Torsten Haneke, Ludger Markus Ickenstein, Carla Alexandra Hernandez Prata, Andrea Schuster, Timo Weide
  • Prodrug of fluorine-containing amino acid
    Patent number: 9428483
    Abstract: Provided are a fluorine-containing amino acid prodrug represented by general formula (I) that makes a fluorine-containing amino acid which is a group 2 metabotropic glutamate receptor agonist into a prodrug, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: May 31, 2013
    Date of Patent: August 30, 2016
    Assignee: TAISHO PHARMACEUTICAL CO., LTD.
    Inventors: Takashi Hashihayata, Norikazu Otake, Naoki Miyakoshi, Kazunari Sakagami
  • Conjugated side-strapped phthalocyanines and methods for producing and using the same
    Patent number: 9425413
    Abstract: The present invention provides conjugated side-strapped phthalocyanines and methods for producing and using the same. In one particular embodiment, the conjugated side-strapped phthalocyanine is of the formula: where each of the substituents are defined herein.
    Type: Grant
    Filed: March 28, 2015
    Date of Patent: August 23, 2016
    Assignee: The Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: Dominic V. McGrath, Neal R. Armstrong