Patents Examined by Matthew P Coughlin
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Patent number: 12145901Abstract: The present disclosure describes processes and intermediates useful for preparing a compound of Formula (Xa) or Formula (Xb). The processes and intermediates can be used to prepare the compounds of the disclosure at multigram or kilogram scale.Type: GrantFiled: September 16, 2022Date of Patent: November 19, 2024Assignee: Arcus Biosciences, Inc.Inventors: Joel Worley Beatty, Samuel Lawrie Drew, Matthew Epplin, Jeremy Fournier, Balint Gal, Karl T. Haelsig, Clayton Hardman, Jaroslaw Kalisiak, Kenneth Victor Lawson, Manmohan Reddy Leleti, Artur Karenovich Mailyan, Guillaume Mata, Brandon Reid Rosen, Zhang Wang, Kai Yu
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Patent number: 12145938Abstract: Provided is a compound having higher fluorescence quantum yield and higher optical stability than a conventional FLAP and a polymer compound containing the compound. A: seven or eight-membered ring structure, Y1, Y2, Y3: halogen atom or the like, a1: number of Y1, a2: number of Y2, B: number of Y3, 0?m and n?3: when 1?m?3, Y1 may be substituted with a structure portion defined by m, when 1?n?3, Y2 may be substituted with a structure portion defined by n, and B1, B2: Formulas (2-1) to (2-3): C1, C2, C3: structure containing a cyclic hydrocarbon compound, D1, D2, D3: substructure that inhibits aggregation, E1, E2, E3: polymerizable substructure, Z1: hydrogen atom or the like, c: number of substituent groups Z1, Z2, Z3: hydrogen atom or the like, and may form a ring with C2.Type: GrantFiled: December 8, 2022Date of Patent: November 19, 2024Assignee: JAPAN SCIENCE AND TECHNOLOGY AGENCYInventors: Shohei Saito, Hiroshi Yabu, Hiroya Abe
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Patent number: 12145955Abstract: Cyclic azastannanes and cyclic oxostannanes having formulas (I) and (II) where X is an alkoxy or dialkylamino group are a new class of cyclic compounds. These compounds have desirably high vapor pressure and high purity (containing low levels of polyalkyl contaminants after purification), and have particular interest for EUV photoresist applications. Methods for preparing these compounds are described.Type: GrantFiled: September 27, 2023Date of Patent: November 19, 2024Assignees: GELEST, INC., MITSUBISHI CHEMICAL CORPORATIONInventor: Li Yang
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Patent number: 12145929Abstract: Provided are a piperidine derivative compound, a hydrate thereof, a solvate thereof, or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition for the prevention or treatment of diseases related to autotaxin activity, comprising same as an active ingredient, in which the piperidine derivative compound exhibits excellent inhibitory activity against autotaxin, and thus can be effectively used in the treatment and prevention of diseases related to autotaxin inhibition, such as fibrotic diseases, inflammatory diseases, autoimmune diseases, respiratory diseases, cardiovascular diseases, metabolic diseases, cancer and cancer metastasis, ocular diseases, cholestatic form and other forms of chronic pruritus, and acute or chronic organ transplant rejection.Type: GrantFiled: September 30, 2022Date of Patent: November 19, 2024Assignee: NEXTGEN BIOSCIENCE CO., LTD.Inventors: Bong Yong Lee, Young Ah Shin, Mi Ji Lee, Eun Jeong Kim, Shin Ae Kim, Na Ra Han, Soo Sung Kang, Su Jae Yang, Minh Thanh La
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Patent number: 12139487Abstract: The present disclosure features compounds of Formula I, or pharmaceutically acceptable salts thereof, and formulations containing the same. Methods of treating BAF complex-related disorders, such as cancer, are also disclosed.Type: GrantFiled: May 11, 2023Date of Patent: November 12, 2024Assignee: Foghorn Therapeutics Inc.Inventors: Shawn E. R. Schiller, Solymar Negretti, David S. Huang, Kevin J. Wilson, Melek Nihan Ucisik, Richard Caldwell
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Patent number: 12139471Abstract: The present invention relates to novel pyridazin-3-yl phenol compounds of Formula (I): wherein R1, R2, R3, R4, R5 and Z are defined herein, which inhibit NOD-like receptor protein 3 (NLRP3) inflammasome activity. The invention further relates to the processes for their preparation, pharmaceutical compositions and medicaments containing them, and their use in the treatment of diseases and disorders mediated by NLRP3.Type: GrantFiled: January 13, 2022Date of Patent: November 12, 2024Assignee: Novartis AGInventors: Christopher Farady, Nina Gommermann, Philipp Janser, Angela Mackay, Henri Mattes, Nichola Smith, Catherine Fooks Solovay, Nikolaus Johannes Stiefl, Eric Vangrevelinghe, Juraj Velcicky, Anette von Matt
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Patent number: 12144248Abstract: The present disclosure relates to the technical field of OLED, and provides a compound having TADF property. In an embodiment the compound has a structure according to Formula (1), in which X1-X5 are each independently selected from a carbon atom and a nitrogen atom, and at least one of X1-X5 is a nitrogen atom; R11-R20 are each selected from the group consisting of a hydrogen atom, a fluorine atom, alkyl, alkoxy, cyano, trifluoromethyl, an electron-accepting group, and an electron-donating group; at least one of R11-R15 is an electron-donating group or an electron-accepting group, and at least one of R16-R20 is an electron-donating group or an electron-accepting group; when each of R11-R15 is an electron-accepting group, at least one of R16-R20 is an electron-donating group, and each of R11-R15 is an electron-donating group, at least one of R16-R20 is an electron-accepting group.Type: GrantFiled: December 31, 2019Date of Patent: November 12, 2024Assignees: WUHAN TIANMA MICROELECTRONICS CO., LTD., WUHAN TIANMA MICROELECTRONICS CO., LTD. SHANGHAI BRANCHInventors: Wei Gao, Lei Zhang, Wenpeng Dai, Yang Li, Jinghua Niu
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Patent number: 12139465Abstract: The present invention relates to a non-fullerene acceptor compound containing benzoselenadiazole, and organic optoelectronic devices comprising the same.Type: GrantFiled: November 27, 2020Date of Patent: November 12, 2024Assignee: RAYNERGY TEK INCORPORATIONInventors: Yu-Tang Hsiao, Chia-Hao Lee, Chuang-Yi Liao, Chun-Chieh Lee, Chia-Hua Li, Hsiuan-Ling Ho, Yi-Ming Chang
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Patent number: 12134620Abstract: Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I): or a pharmaceutically acceptable salt, stereoisomer, isotopic form or prodrug thereof, wherein R1, L1, L2, L3, A1, A2, A3, A4, G1, G2, E, W, X, Y, Z, m, and n are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods to modulate the activity of G12C mutant KRAS protein for treatment of disorders, such as cancer, are also provided.Type: GrantFiled: August 1, 2019Date of Patent: November 5, 2024Assignee: ARAXES PHARMA LLCInventors: Liansheng Li, Jun Feng, Tao Wu, Yuan Liu, Yi Wang, Alana K. Borum, Pingda Ren, Yi Liu
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Patent number: 12134602Abstract: The invention provides (1) processes for making substantially-pure (?) huperzine A and substantially-pure (?) huperzine A derivatives; (2) compositions useful in making substantially-pure (?) huperzine A and substantially-pure (?) huperzine A derivatives; and (3) methods of treating or preventing neurological disorders using substantially-pure (?) huperzine A and substantially-pure (?) huperzine A derivatives.Type: GrantFiled: September 23, 2021Date of Patent: November 5, 2024Assignee: YALE UNIVERSITYInventors: Seth Herzon, Maung Kyaw Moe Tun
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Patent number: 12129246Abstract: The disclosure relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof wherein A, Ra to Rd, and R4 to R7, are as described herein, as well as compositions and methods of using such compounds.Type: GrantFiled: February 28, 2024Date of Patent: October 29, 2024Assignee: Novartis AGInventors: Daniela Angst, Philippe Bolduc, Matthew William Carson, Atwood Kim Cheung, Véronique Darsigny, Xiang Gao, Viktor Hornak, Keith Jendza, Rajesh Karki, Ajay Kumar Lal, Gang Liu, Justin Yik Ching Mao, Jeffrey M. McKenna, Erik Meredith, Muneto Mogi, Vivek Rauniyar, Liansheng Su, Ritesh Tichkule, Shuangxi Wang, Chun Zhang, Liang Zhao, Rui Zheng
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Patent number: 12122759Abstract: The present invention relates to a method for the synthesis of cyclic depsipeptides, in particular emodepside, from the open form.Type: GrantFiled: November 6, 2018Date of Patent: October 22, 2024Assignees: ELANCO ANIMAL HEALTH GMBH, THE KITASATO INSTITUTEInventors: Dirk Heimbach, Satoshi Omura, Toshiaki Sunazuka, Tomoyasu Hirose, Yoshihiko Noguchi, Johannes Köbberling, Zhijie Wu, Shuibiao Fu, Wei Wu, Jinfeng Qiu, Liu He, Xudong Wei
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Patent number: 12122758Abstract: The invention provides a material comprising (i) a crown ether of formula (I) and/or (ii) a crown ether of formula (II), or a salt thereof, wherein each m independently is an integer from 1 to 8, each “” designates an optionally present bond and/or structure, each X independently is —N(R1)2, —N*(R1), —N**, —N*(R1)2+Z?, or —N**(R1)+Z?, provided at least one X is —N*(R1), —N**, —N*(R1)2+Z?, or —N**(R1)+Z?, wherein each R1 independently is hydrogen or C1-6 alkyl, each Z is optionally present and independently is a counterion to balance the charge on nitrogen, and * represents a bond to a remainder of the material, a method of making the material, and a method of using the material.Type: GrantFiled: September 5, 2023Date of Patent: October 22, 2024Assignee: Pall CorporationInventors: Andrew Kocen, Rehanah Sejoubsari, Ahmad Arabi Shams Abadi
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Patent number: 12122776Abstract: The present disclosure relates generally to certain tetracyclic compounds, pharmaceutical compositions comprising said compounds, and methods of making said compounds and pharmaceutical compositions. The compounds of the disclosure are useful in treating or preventing human immunodeficiency virus (HIV) infection.Type: GrantFiled: May 12, 2023Date of Patent: October 22, 2024Assignee: Gilead Sciences, Inc.Inventors: Lan Jiang, David W. Lin, Michael L. Mitchell, Ezra Roberts, Gregg M. Schwarzwalder
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Patent number: 12116349Abstract: The invention provides a novel compound having the general formula (I) or a pharmaceutically acceptable salt thereof. The compound of formula (I) can be used as a medicament.Type: GrantFiled: June 8, 2022Date of Patent: October 15, 2024Assignee: Hoffmann-La Roche Inc.Inventors: Cosimo Dolente, David Stephen Hewings, Daniel Hunziker, Daniela Krummenacher, Piergiorgio Francesco Tommaso Pettazzoni, Juergen Wichmann
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Patent number: 12110280Abstract: A method for synthesizing cyclic carbonate monomers using carbon dioxide (CO2) is provided. The method also includes combining reagents to synthesize the cyclic carbonate monomer, the reagents including a substrate that is a 1,X-diol, where X is between 2 and 5, a base that is a tertiary amine, a promoter that is a multidentate, bis-tertiary amine base where nitrogens are separated by 2 to 4 carbon atoms, a solvent, and CO2.Type: GrantFiled: June 17, 2021Date of Patent: October 8, 2024Assignee: International Business Machines CorporationInventors: Nathaniel H. Park, Victoria A Piunova, Dmitry Zubarev, Tim Erdmann, Pedro Arrechea, James L. Hedrick
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Patent number: 12110292Abstract: Disclosed are compounds with immunomodulatory activity, methods of making the compounds, pharmaceutical compositions containing the compounds, and methods of using the compounds to treat diseases or disorders characterized or mediated by dysfunctional protein activity.Type: GrantFiled: November 11, 2022Date of Patent: October 8, 2024Assignee: Dana-Farber Cancer Institute, Inc.Inventors: Nathanael Gray, Tinghu Zhang, Eric Fischer, Zhixiang He, Guangyan Du, Katherine Donovan, Radoslaw Nowak, Jing Ting Christine Yuan
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Patent number: 12102608Abstract: A composition of acylethanolamides is obtained from olive oil fatty acids and is used in treating neuroinflammation. The acylethanolamide complex includes (weight percentages): oleoylethanolamide (OEA) C18:1 60-65%? palmitoylethanolamide (PEA) C16:0 5-20% linoleylethanolamide (LEA) C18:2 5-20% stearoylethanolamide (SEA) C18:0 ?1-2% palmitoylethanolamide (POEA) C16:1 0.1-0.8%? myristoylethanolamide (MEA) C14:0 0.02-0.15%?? mixture of glycerides ?4-6% glycerol ?6-8%. A method obtains the acylethanolamide complex and formulations contain the acylethanolamide complex.Type: GrantFiled: May 26, 2022Date of Patent: October 1, 2024Assignee: EPITECH GROUP S.P.A.Inventors: Francesco Della Valle, Maria Federica Della Valle, Gabriele Marcolongo, Chiara Gomiero
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Patent number: 12103904Abstract: Disclosed are compounds of formulae: and pharmaceutically acceptable salts thereof, wherein the variables, R1, R2, R3, R4, R5, R6, R7, R11, R12, R13, R14, R15, R16, R17, n, and m are defined herein. These compounds are useful for treating Gram-negative bacteria infections. Also disclosed are methods of making these compounds.Type: GrantFiled: March 19, 2021Date of Patent: October 1, 2024Assignees: Duke University, The University of North Carolina at Chapel HillInventors: Pei Zhou, Eric J. Toone, Robert A. Nicholas, Ramesh Gopalaswamy, Xiaofei Liang, Frank Navas, III
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Patent number: 12102712Abstract: A topical composition for treating fungal skin infections with associated inflammation may include making or administering to the affected skin area an antifungal and steroid, such as a corticosteroid. Certain compositions may include antifungals such as itraconazole or econazole and corticosteroids such as fluticasone, fluocinonide, or clobetasol. The antifungal and steroid may be within a cream. In one example, a commercially available econazole nitrate cream may be used in conjunction with a commercially available fluocinonide cream or commercially available clobetasol cream to treat the affected skin area.Type: GrantFiled: May 3, 2021Date of Patent: October 1, 2024Assignee: CMPD Licensing LLCInventor: Jay Richard Ray