Patents Examined by Maureen Wallenhorst
  • Patent number: 11221282
    Abstract: Measurement arrangement for determining a constituent substance or quality parameter of water by thermal decomposition in a reaction module, delivery of a reaction product to a detector, and evaluation of a detector signal for deriving a value of the constituent substance or quality parameter, wherein the reaction module is an elongated vessel having internal heating, and has a head section into which the sample is introduced, a reaction zone, as well as a foot section, from which the reaction product is output, wherein the reaction module, the heating, and means for the supply of samples and carrier gas are configured such that during the operation of the measurement arrangement an outer head temperature is TH?80° C., and an outer foot temperature is TF?150° C. at a maximum temperature in the reaction zone of TMAX?1150° C.
    Type: Grant
    Filed: March 12, 2019
    Date of Patent: January 11, 2022
    Inventors: Werner Arts, Wolfgang Genthe
  • Patent number: 11209364
    Abstract: An apparatus and method of measuring free water, also known as undissolved water, in hydrocarbon fuel. A housing defines a chamber and is adapted to receive a fluorescein impregnated filter pad in the chamber between a UV light source and a light sensor. The filter pad is exposed to the fuel causing the free water to react with the fluorescein and is then placed within the chamber between the light source and sensor. The UV light strikes one side surface of the filter pad and excites the reacted fluorescein thereby causing light emitted from the UV light reacted fluorescein filter pad opposite side surface to strike the light sensor. An output from the light sensor is proportional to the fluorescein on the filter pad which reacted with free water and is used for providing an output value representative of the free water present in the hydrocarbon fuel.
    Type: Grant
    Filed: May 11, 2020
    Date of Patent: December 28, 2021
    Assignee: Telectro-Mek, Inc.
    Inventor: James Edward Andrews, Jr.
  • Patent number: 11199548
    Abstract: Methods for determining an in vitro release profile of peanut allergens in a sample are provided. Methods for determining one or more signatures of peanut allergens in a sample are provided.
    Type: Grant
    Filed: September 24, 2019
    Date of Patent: December 14, 2021
    Assignee: SANOFI
    Inventors: Kim Alving, Pierre deMontigny, Bing Huang Wang
  • Patent number: 11186557
    Abstract: The present invention relates to a method for purifying pure thioflavin T in having a step of preparing a thioflavin T solution in which crude thioflavin T is dissolved in a polar solvent, a step of bringing the thioflavin T solution into contact with a non-polar polymeric porous body, and a step of separating the thioflavin T solution after the contact from the non-polar polymeric porous body.
    Type: Grant
    Filed: August 15, 2016
    Date of Patent: November 30, 2021
    Inventors: Akinori Oda, Hiroshi Satozono, Tomomi Shinke, Yohei Takata
  • Patent number: 11181537
    Abstract: The invention relates to the detection of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). In a particular aspect, the invention relates to methods for detecting DHA and EPA by mass spectrometry and kits for carrying out such methods.
    Type: Grant
    Filed: January 13, 2020
    Date of Patent: November 23, 2021
    Assignee: Quest Diagnostics Investments Incoporated
    Inventors: Scott M. Goldman, Julie A. Neidich
  • Patent number: 11182893
    Abstract: A method of pretreating a sample including biological particles, the method including a step of acquiring a fraction (1b) which passes through a sieve (A) having meshes of 250 to 1000 ?m and does not pass through a sieve (B) having meshes of 32 to 63 ?m by sieving a sample including biological particles as a detection target, and a step of adding a colloidal solution having a density of 1.10 to 2.45 g/cm3 to the fraction (1b), subjecting the resultant solution to centrifugation, and acquiring a supernatant fraction (S0) after the centrifugation.
    Type: Grant
    Filed: November 27, 2017
    Date of Patent: November 23, 2021
    Assignee: Japan Agency for Marine-Earth Science and Technology
    Inventors: Tomo Kitahashi, Hiromi Watanabe, Masashi Tsuchiya, Hiroyuki Yamamoto
  • Patent number: 11181525
    Abstract: A system and method for using new biomarkers to assess individual diseases is provided. In one embodiment of the present invention, absolute quantification of annotated metabolites by mass spectrometry is used to identify certain biomarkers and derivatives thereof (i.e., signatures), which are then used to screen for, diagnose, predict, prognose, and treat various diseases, including, but not limited to, breast cancer, ovarian cancer, colorectal cancer, pancreatic cancer, and acute graft-versus-host disease.
    Type: Grant
    Filed: December 16, 2019
    Date of Patent: November 23, 2021
    Assignee: Metabolomyes, Inc.
    Inventors: Robert Nagourney, Ismael Silva, Paulo D'Amora
  • Patent number: 11181529
    Abstract: The three-dimensional structural analysis of pharmaceutical and/or biological molecules is performed by the reaction of OH radicals on the surfaces of the molecules of interest. Quantitation and/or completeness of the OH radicals are optionally measured using buffers intrinsic to the sample solutions as internal standards. Measurements of the reactions of these buffers with OH radicals provide an internal standard while avoiding the use of prior art internal standards that can have unwanted effects on the three-dimensional structures of interest.
    Type: Grant
    Filed: March 5, 2021
    Date of Patent: November 23, 2021
    Assignee: GenNext Technologies, Inc.
    Inventors: Scot Randy Weinberger, Joshua S. Sharp, Sandeep Misra
  • Patent number: 11169061
    Abstract: A method and system for processing particles contained in a liquid biological sample is presented. The method uses a rotatable vessel for processing particles contained in a liquid biological sample. The rotatable vessel has a longitudinal axis about which the vessel is rotatable, an upper portion having a top opening for receiving the liquid containing the particles, a lower portion for holding the liquid while the rotatable vessel is resting, the lower portion having a bottom, and an intermediate portion located between the upper portion and the lower portion, the intermediate portion having a lateral collection chamber for holding the liquid while the rotatable vessel is rotating. The method employs dedicated acceleration and deceleration profiles for sedimentation and re-suspension of the particles of interest.
    Type: Grant
    Filed: August 16, 2019
    Date of Patent: November 9, 2021
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Claudio Cherubini, Martin Kopp, Nenad Milicevic, Daniel Mueller, Emad Sarofim, Goran Savatic
  • Patent number: 11162920
    Abstract: A method for disrupting a sample of biological material of human, animal, or plant origin for subsequent proteome analysis by a mass spectrometry method is provided. The method involves disrupting the sample by treatment with a certain volume of an organic acid until the sample completely dissolves, incubating the sample for a certain period, and then neutralizing the sample with a neutralizing solution until a pH value between 7 and 9 is reached.
    Type: Grant
    Filed: December 27, 2018
    Date of Patent: November 2, 2021
    Inventors: Andy Schneider, Jörg Döllinger, Peter Lasch
  • Patent number: 11162952
    Abstract: The disclosure concerns methods for identifying amino acids in peptides, including peptides including unnatural amino acids. Various aspects of the present disclosure provide compositions and methods for amino acid-type specific labeling, as well as methods for detecting the labels. Further disclosed herein are strategies for highly multiplexed, high-throughput peptide analysis.
    Type: Grant
    Filed: September 16, 2019
    Date of Patent: November 2, 2021
    Inventors: Edward Marcotte, Eric V. Anslyn, Andrew Ellington, Jagannath Swaminathan, Erik Hernandez, Amber Johnson, Alexander Boulgakov, James L. Bachman, Helen Seifert
  • Patent number: 11150193
    Abstract: A method for detecting an analyte in a blood sample includes dissolving a refractive index adjuster in the blood sample to obtain an analysis sample in which a difference in refractive index between a red blood cell and an extra-red blood cell fluid is reduced and detecting the analyte using the analysis sample.
    Type: Grant
    Filed: February 13, 2019
    Date of Patent: October 19, 2021
    Inventors: Takeyuki Moriuchi, Yusuke Komata, Fumihiko Chai
  • Patent number: 11143593
    Abstract: A method of determining beryllium or a beryllium compound in a sample is disclosed by measuring fluorescence. This method discloses use of highly strong acids to extract beryllium from samples into the acidic medium, and then using these solutions in combination with highly alkaline fluorescent indicating dye solutions to determine the amount of beryllium in the samples.
    Type: Grant
    Filed: December 19, 2019
    Date of Patent: October 12, 2021
    Assignee: AJJER L.L.C.
    Inventors: Anoop Agrawal, Lori Adams, John P. Cronin
  • Patent number: 11143595
    Abstract: A plasma spectroscopy analysis method includes a preliminary addition process in which a bonding agent that is an agent other than DMSA is added to the specimen collected from a living body to which meso-2,3-dimercaptosuccinic acid (DMSA) is administered, a concentration process in which the analyte heavy metal ions in the specimen at a vicinity of one of a pair of electrodes by applying a voltage to the pair of electrodes, and a detection process in which plasma is generated by applying a voltage to the pair of electrodes, and luminescence of the analyte metal ions caused by the plasma is detected.
    Type: Grant
    Filed: April 22, 2019
    Date of Patent: October 12, 2021
    Assignee: ARKRAY, Inc.
    Inventors: Tsuyoshi Takasu, Kojiro Honma
  • Patent number: 11131681
    Abstract: Disclosed herein is a method for predicting or diagnosing psychiatric disorders through analyzing skin tissues samples minimally invasive or non-invasively collected. The method disclosed herein makes it possible to diagnose psychiatric disorders through objective biomarkers at a very early age, without giving pain to subjects because of noninvasive or minimally invasive feature of skin sample collection method.
    Type: Grant
    Filed: May 16, 2018
    Date of Patent: September 28, 2021
    Inventors: Byeong Deog Park, Se Kyoo Jeong, Kyungho Park, Chae Hyeong Park, Kyong Oh Shin
  • Patent number: 11131634
    Abstract: The subject invention provides colorimetric test strips and fast screening field test kits for differentiating between cannabinoids in cannabis samples, preferably, for differentiating marijuana from other cannabis plants, e.g., hemp. The fast screening field test kit can also be used for confirming the presence of marijuana in a complex cannabis sample. The colorimetric test strips use a solid substrate (e.g., capillary microextraction of volatiles (CMV) device) for the colorimetric reaction. The non-polar nature of the CMV sorbent does not allow the reaction of FBBB and THC to spread, producing an intense red color in the presence of a plant with high concentration of THC (e.g., marijuana) or an orange color in the presence of a plant with a high concentration of CBD (e.g., hemp).
    Type: Grant
    Filed: November 17, 2020
    Date of Patent: September 28, 2021
    Inventors: Jose Almirall, Alexander Acosta
  • Patent number: 11131633
    Abstract: Color quantification of chemical test pads and titration of analytes can be performed under different lighting conditions. In one embodiment, the lighting condition is estimated under which a digital image is captured and utilized to select a set of reference colors from which the quantified color is compared to determine the titration. In another embodiment, a plurality of comparisons are made with different lighting conditions with the result having the highest confidence level being selected to determine the titration.
    Type: Grant
    Filed: March 9, 2019
    Date of Patent: September 28, 2021
    Assignee: HEALTHY.IO LTD.
    Inventors: Bernard Burg, Martin Zizi, Aaron Alexander Rowe, Anthony Smart, Walter De Brouwer
  • Patent number: 11131658
    Abstract: An analysis method and device including detecting at least one particle of matter in a fluid inside in a reaction chamber and correlating a change in the particle to a physicochemical property of the matter.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: September 28, 2021
    Assignee: The Solubility Company Oy
    Inventors: Sami Svanbäck, Jouko Yliruusi, Henrik Ehlers, Osmo Antikainen, Heikki Räikkönen
  • Patent number: 11119084
    Abstract: The invention provides a method and device for measuring mercury isotopes in natural gas. The method includes the following steps: (1) primary enrichment: subjecting natural gas to a three-stage cascading absorption with an acidic potassium permanganate aqueous solution, and collecting all of the acidic potassium permanganate aqueous solutions in which natural gas is absorbed in step (1); (2) mercury purification and enrichment: reducing the mercury absorbed in the step (1) to mercury vapor with a stannous chloride solution, and then purifying and enriching the mercury vapor by using an acidic potassium permanganate aqueous solution; (3) detecting the acidic potassium permanganate solution in which the mercury vapor is enriched in step (2) to determine the total mercury content therein; and (4) detecting the acidic potassium permanganate solution in which the mercury vapor is enriched in step (2) to determine the composition/content of stable mercury isotopes therein.
    Type: Grant
    Filed: April 19, 2019
    Date of Patent: September 14, 2021
    Assignee: PetroChina Company Limited
    Inventors: Guangyou Zhu, Shunlin Tang
  • Patent number: 11119087
    Abstract: The invention provides a method for establishing a separable regeneration system for verifying regeneration effect between two antioxidants, which belongs to the field of regeneration effect of antioxidants. According to different solubilities of two antioxidants, lipid-soluble antioxidant is first combined into PE film, and water-soluble antioxidant is dissolved into deionized water and a separable regeneration system where antioxidants can contact with other but not dissolve in each other is formed. This method compares the differences of change of antioxidant capacity in aqueous phase with and without lipid-soluble antioxidant so that to judge whether the added lipid-soluble antioxidant has regeneration effect on aqueous-soluble antioxidant. The present invention effectively verifies the regeneration effect between different antioxidants, and has advantages of simple operation, less interference factors, intuitive and high efficiency.
    Type: Grant
    Filed: July 2, 2019
    Date of Patent: September 14, 2021
    Assignee: Jiangnan University
    Inventors: Hang Yu, Yaxin He, Yunfei Xie, Yahui Guo, Yuliang Cheng, Weirong Yao