Abstract: A device, a system and a method for homodyne solid-state biased coherent detection of terahertz pulses in a range between 0.1 and 11 THz, the device comprising a metallic slit between, and parallel to, two longitudinal metallic electrodes, deposited on a surface of a substrate, and covered with a layer of nonlinear material, wherein a width of the metallic slit and a thickness of the nonlinear material layer are selected in relation to a central wavelength of the THz pulses. The method comprises focusing a THz beam and a pulsed laser beam of pulse energies in a range between 10 and 100 nJ onto the metallic slit, the metallic electrodes being biased by a static DC voltage bias selected in a range between 20 VPP and 200 VPP; and retrieving a terahertz pulse waveform using the terahertz pulse repetition rate as synchronism.

Abstract: Systems and methods are described for calibrating an analytical instrument analyzing a plurality of sample matrices in series. A system embodiment can include, but is not limited to, a sample analysis device configured to receive a plurality of samples from a plurality of remote sampling systems and to determine an intensity of one or more species of interest contained in each of the plurality of samples; and a controller configured to generate a primary calibration curve based on analysis of a first standard solution having a first sample matrix by the sample analysis device and generate at least one secondary calibration curve based on analysis of a second standard solution having a second sample matrix by the sample analysis device, the controller configured to associate the at least one secondary calibration curve with the primary calibration curve according to a matrix correction factor.

Abstract: A Fourier-transform hyperspectral imaging system may include an optical imaging system configured to produce an image of an object, and an adjustable birefringent common-path interferometer module comprising a movable birefringent element and configured to produce interfering replicas of an input radiation which are delayed from each other by a phase delay adjustable by the moving birefringent element. The interferometer module may be configured to produce collinear replicas for entering optical rays parallel to said optical axis. The hyperspectral imaging system further comprises a two-dimensional light detector configured to receive the replicas and provide digital images of the object depending on said adjustable phase delay. The system also includes an analysis device configured to perform a Fourier Transform of the digital images to obtain a hyperspectral representation of the object.

Abstract: A freeform concave grating imaging spectrometer includes a slit, a freeform concave grating, and an image surface. The lights incident from the slit is irradiated on the freeform concave grating to be dispersed and reflected, to form a reflected light beam. The reflected light beam is irradiated on the image surface, so that the lights of different wavelengths incident from the slit are separated and imaged on the image surface.

Abstract: A spectrum measurement system includes a laser light source system, an optical signal receiving system and a beam splitting system. The laser light source system is configured to emit a laser output light beam to the object. The laser output light beam includes at least one of a first and a second peak-wavelength laser. After the object is radiated by the laser output light beam, the object generates a conversion beam. The conversion beam includes at least one of a first and a second spectral signals. The optical signal receiving system includes at least a first and a second signal receivers being respectively configured to receive the first and the second spectral signals. The beam splitting system provides a plurality of light exiting paths being configured to respectively transmit the first and the second spectral signals to the first and the second signal receivers.

Abstract: A reflective relay spectrometer design based on reflective optical relay systems, which is more compact in physical size and superior in spectral imaging quality than previous designs, is disclosed.

Abstract: A method of selecting wavelengths of radiation for discriminating a first cell or tissue type from a different cell or tissue type is described. First and second sets of absorption spectra are obtained, each set comprising spectra obtained at a plurality of different spatial regions of the first cell or tissue type and of the different cell or tissue type, respectively. Sets of corresponding metrics are defined for the first and second sets of absorption spectra for each spatial region. Each metric comprises information corresponding to the absorption for at least two different wavelengths. The metrics in each set comprise different combinations of wavelengths. A characteristic value is generated for each metric. Distributions are generated for each metric using corresponding characteristic values for the first cell or tissue type and for the different cell or tissue type and compared to determine an extent of similarity.

Abstract: A method for assessing spectroscopic sensor accuracy, includes building an a priori simulation of generalized etalon drift. A spectroscopic sensor is tested to determine use parameters. A specific drift model is generated by applying the determined use parameters to the built a priori simulation of generalized etalon drift. The specific drift model is analyzed to determine whether the spectroscopic sensor is satisfactory.

Abstract: A spectrometry method used by a spectrometry apparatus including a spectrometry section including a spectrometer and an imaging device that captures a spectroscopic image, a spectroscopic controller that controls the action of the spectrometer, and an image generator that generates the spectroscopic image, the method including generating the spectroscopic image, dividing the range of the spectroscopic image into a plurality of regions including at least a first region, determining a reference value of a color value, generating a first region spectrum based on the spectroscopic image of the first region, calculating first region tristimulus values based on the first region spectrum, calculating a first region color value based on the first region tristimulus values, and calculating a first region color difference that is the color difference between the first region color value and the reference value by using a color difference formula.

Abstract: According to an embodiment of the disclosure, there is provided an electronic device including: an optical element that is fixed and is configured to split incident light reflected from an object into two or more incident light beams traveling along two or more light paths; an optical sensor that is spaced a separation distance from the optical element such that the split incident light beams form an interference area on a light receiving surface and is configured to detect the incident light; and at least one processor configured to determine state information about the object based on similarity between a first spectrum acquired from the detected incident light and at least one reference spectrum.

Abstract: The present invention relates to a target gene-detecting device and a method for detecting a target gene. According to an aspect, a target gene-detecting device can be conveniently fabricated at low cost by employing a porous substrate or a method for detecting a target gene allows the pretreatment of a sample, the extraction of a nucleic acid, the amplification of a nucleic acid, and the detection of a target gene to be conducted at high accuracy and specificity in an integral system, with no contamination plausibility and can be thus useful for gene inspection.

Abstract: An optical characteristic measurement device has a measurement opening, includes a first optical measurement unit and a second optical measurement unit that measure different optical characteristics with different geometries with respect to a measurement target facing the measurement opening, and further includes a processing unit that corrects a measurement value obtained in the second optical measurement unit based on a measurement value obtained in the first optical measurement unit.

Abstract: A hand-held point of care monitoring system that includes a plurality of assay modules configured to receive different assay devices that perform assays on one or more samples. At least two of the assay modules or at least two of the assay devices have different identifiers that identify the assays. The system also includes an apparatus having a portable frame configured to interchangeably receive the plurality of assay modules in a same port; a means for decoding the different identifiers when received by the frame; and a means for reading assay results.

Abstract: An optical scanning device includes: an optical scanning unit configured to repeatedly scan an irradiation destination of irradiation light to a predetermined trajectory; a light emission control unit configured to control light emission of the irradiation light to irradiate irradiation points to the predetermined trajectory; and a driving signal generation unit configured to generate a driving signal for driving the optical scanning unit, wherein the light emission control unit irradiates the irradiation points to the predetermined trajectory so that the irradiation points are substantially uniformly dispersed in a region in which a density of the irradiation points is relatively low in a region in which the irradiation light is irradiated.

Abstract: The capabilities of using gold nanoparticle as surface-enhanced Raman scattering (SERS) substrate to obtain cervical smear harvested cells biochemical information for non-invasive cervical precancerous detection were presented in this patent document. A SERS reagent and a platform has been developed and optimized for the generation of a differential spectral fingerprinting for cervical cancer detection. SERS measurements were performed on three group's cervical exfoliated cell samples: one group from patients (n=36) with pathologically confirmed cervical cancer and another group with high-grade squamous intraepithelial lesion (HSIL) (n=41) and the last group from healthy volunteers (control subjects, n=47).

Abstract: A body fluid analysis device includes a light source, a detector, a normalization part, and a calculation part. The light source is configured to emit light at a first wavelength and light at a second wavelength different from each other to a body fluid. The detector is configured to receive light emitted from the light source and transmitted through the body fluid or light reflected by the body fluid, and is configured to detect intensity of the light. The normalization part is configured to calculate a ratio of an intensity of light emitted at the second wavelength to an intensity of light emitted at the first wavelength, both of which are detected by the detector. The calculation part is configured to calculate a concentration of a predetermined component included in the body fluid on the basis of the ratio calculated by the normalization part.

Abstract: Provided is a hyperspectral sensor including a spectral angle converting unit configured to convert an angle of incident light differently according to a wavelength, a diffraction unit configured to selectively diffract the incident light according to an incident angle and a wavelength, a focusing optics including at least one lens, and configured to collect diffracted light passing through the diffraction unit, and an image sensor configured to acquire an image passing through the focusing optics and formed on a focal plane, wherein the diffraction unit includes a volume Bragg grating having a periodic refractive index distribution therein.

Abstract: Disclosed is a system for detecting contaminants in a sample fluid. The system has a colloidal dispersion circuit with a reservoir containing a colloidal dispersion with colloidal particles capable of exhibiting localized surface plasmon resonance (“LSPR particles”), a Raman spectrometer/flow cell and a pump for circulating the colloidal dispersion through the colloidal dispersion circuit. A colloidal dispersion level sensor measures the extent of colloidal dispersion in the colloidal dispersion circuit. A permeation valve diverts the colloidal dispersion in the colloidal dispersion circuit through an ultra-filtration membrane with a pore size smaller than the LSPR particles, thus preventing the LSPR particles from passing through. The sample may be introduced into the colloidal dispersion circuit through a fluid sample injection valve. A processor is connected to the Raman spectrometer/flow cell, the pump, the permeation valve, the colloidal dispersion level sensor, and the fluid sample injection port.

Abstract: A biological detection device for a toilet water solution includes a mounting portion, a main system, an adjustable support portion and a detection portion. The main system is connected to the mounting portion. The adjustable support portion can be adjusted for its movement in both horizontal and vertical directions and is connected to the mounting portion. The detection portion is connected and linked to the adjustable support portion and includes a light emitting source and an optical sensor. The biological detection device for a toilet water solution is a home healthcare device capable of automatically detecting whether there is blood in stool or urine without adding any chemical reagent or collecting any stool or urine specimen.

Abstract: An optical detection system, a blood cell analyzer and a platelet detection method are provided. The optical detection system includes: an optical subsystem, a flow chamber and a first detector; the optical subsystem includes a laser, a front optical assembly including an optical isolator, and a rear optical assembly including a blocking diaphragm. The laser is configured to emit a laser beam; the front optical assembly is configured to perform front optical treatment; the rear optical assembly is disposed downstream of the flow chamber in the propagation direction of the laser beam, and is configured to perform rear optical treatment on the scattered light and the laser beam converged at the blocking diaphragm; and the optical isolator is configured to isolate reflected light that is generated when the laser beam passes through the flow chamber.