Patents Examined by Maurie Garcia
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Patent number: 6897305Abstract: Novel multibinding compounds are disclosed. The compounds of this invention comprise 2-10 ligands covalently connected, each of the ligands being capable of binding to a ligand binding site in a Ca++ channel , thereby modulating the biological activities thereof.Type: GrantFiled: December 8, 1999Date of Patent: May 24, 2005Assignee: Theravance, Inc.Inventors: Yu-Hua Ji, Maya Natarajan, John H. Griffin, Thomas E. Jenkins
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Patent number: 6864201Abstract: Methods and apparatus for the preparation and use of a substrate having an array of diverse materials in predefined regions thereon. A substrate having an array of diverse materials thereon is generally prepared by delivering components of materials to predefined regions on a substrate, and simultaneously reacting the components to form at least two materials. Materials which can be prepared using the methods and apparatus of the present invention include, for example, covalent network solids, ionic solids and molecular solids. More particularly, materials which can be prepared using the methods and apparatus of the present invention include, for example, inorganic materials, intermetallic materials, metal alloys, ceramic materials, organic materials, organometallic materials, non-biological organic polymers, composite materials (e.g., inorganic composites, organic composites, or combinations thereof), etc.Type: GrantFiled: June 13, 2001Date of Patent: March 8, 2005Assignees: The Regents of the University of California, Symyx Technologies, Inc.Inventors: Peter G. Schultz, Xiaodong Xiang, Isy Goldwasser, Gabriel Briceno, Xiao-Dong Sun, Kai-An Wang
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Patent number: 6790965Abstract: Combinatorial libraries are disclosed which are represented by Formula I: (T′—L)q—Ŝ—C(O)—L′—II′ I wherein: Ŝ is a solid support; T′—L— is an identifier residue; and —L′—II′ is a ligand/linker residue. These libraries contain dihydrobenzopyrans of the formula: which interact (i.e., as agonists or antagonists) with &agr; adrenergic receptors, dopamine receptors, &dgr;-opiate receptors, and K+ channels and are inhibitors of carbonic anhydrase isozymes. They are useful in the treatement of ocular diseases such as glaucoma.Type: GrantFiled: September 8, 1999Date of Patent: September 14, 2004Assignee: Pharmacopeia Drug Discovery, Inc.Inventors: John J. Baldwin, John C. Reader, Lawrence W. Dillard, Ge Li, Wenguang Zeng
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Patent number: 6770754Abstract: Universal supports for oligonucleotide synthesis include a support material represented by the following formula: In this formula, substituent A is selected from H, alkyl, aryl, or a polymeric or silica base material; substituent B is selected from acyl, aroyl, or a polymeric or silica base material; and substituent C is selected from a dimethoxytrityl group or a protecting group removable under acidic or neutral conditions. For the supports, one of substituents A or B constitutes the polymeric or silica base material. In use, an oligonucleotide is attached to the support at substituent C.Type: GrantFiled: November 29, 2001Date of Patent: August 3, 2004Assignee: Glen Research CoporationInventors: Alex Azhayev, Maxim Antopolskii
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Patent number: 6764858Abstract: A method for developing a library of compounds, the compound library, a method for identifying ligands for target molecules, and a method for identifying lead chemical templates, which, for example, can be used in drug discovery and design are provided. Certain embodiments of these methods include the use of NMR spectroscopy.Type: GrantFiled: November 19, 2001Date of Patent: July 20, 2004Assignee: Pharmacia & Upjohn CompanyInventor: Brian J. Stockman
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Patent number: 6749756Abstract: A method of separating compounds that includes the steps of: tagging at least a first organic compound with a first tagging moiety to result in a first tagged compound; tagging at least a second organic compound with a second tagging moiety different from the first tagging moiety to result in a second tagged compound; and separating the first tagged compound from a mixture including the second tagged compound using a separation technique based upon differences between the first tagging moiety and the second tagging moiety. The present invention also provides a method for carrying out a chemical reaction including the steps of: tagging a plurality of compounds with different tagging moieties to create tagged compounds, conducting at least one chemical reaction on a mixture of the tagged compounds to produce a mixture of tagged products, and separating the mixture of tagged products by a separation technique based upon differences in the tagging moieties.Type: GrantFiled: February 18, 2000Date of Patent: June 15, 2004Assignee: University of PittsburghInventors: Dennis P. Curran, Oscar de Frutos Garcia, Yoji Oderaotoshi
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Patent number: 6746104Abstract: The present invention provides a unique and highly accurate method for generating molecular arrays of very high density on porous surfaces. The method involves the application of focused acoustic energy to each of a plurality of fluid-containing reservoirs to eject a small fluid droplet—on the order of 1 picoliter or less—from each reservoir to a site on a porous substrate surface. High density molecular arrays are provided as well, in which greater than about 62,500 molecular moieties, serving as array elements, are present on a porous surface. Biomolecular arrays that can be generated using focused acoustic ejection include oligonucleotide arrays and peptidic arrays.Type: GrantFiled: September 25, 2001Date of Patent: June 8, 2004Assignee: Picoliter Inc.Inventors: Richard N. Ellson, Mitchell W. Mutz, James K. Foote
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Patent number: 6727368Abstract: Disclosed are cyclic imino oligomers and polymers comprised of subunits of the formula: Also disclosed are combinatorial libraries and arrays of the cyclic imino compounds.Type: GrantFiled: June 13, 2000Date of Patent: April 27, 2004Assignee: Wisconsin Alumni Research FoundationInventors: Samuel H. Gellman, Bayard R. Huck, Michele R. Richards
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Patent number: 6720190Abstract: Disclosed are methods for screening compound libraries using frontal chromatography in combination with mass spectrometry to identify and rank those members of the library that bind to a target receptor. Methods are also disclosed which permit a compound library to be rapidly screened to determine if any member of the library has an affinity for the target receptor as measured by a pre-selected indicator compound.Type: GrantFiled: March 25, 1999Date of Patent: April 13, 2004Inventors: Ole Hindsgaul, David C. Schriemer
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Patent number: 6720186Abstract: A method and system for researching and developing and/or optimizing new catalysts and products in a combinatorial manner is disclosed. The method begins with starting components or a ligand library and provides methods of creating catalyst or product libraries, which are then tested in a reaction of interest. The system uses methods of robotic handling for moving libraries from station to station. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial catalyst libraries, but also offer significant advantages over conventional experimental methods as well.Type: GrantFiled: January 8, 1999Date of Patent: April 13, 2004Assignee: Symyx Technologies, Inc.Inventors: Howard W. Turner, Adam Safir, Ralph B. Nielsen
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Patent number: 6713651Abstract: Disclosed are multibinding compounds which are &bgr;2-adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, and bronchitis. They are also useful in the treatment of nervous system injury and premature labor.Type: GrantFiled: November 1, 2000Date of Patent: March 30, 2004Assignee: Theravance, Inc.Inventors: Edmund J. Moran, Seok-Ki Choi
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Patent number: 6710186Abstract: Disclosed are cyclic imino oligomers and polymers comprised of subunits of the formula: Also disclosed are combinatorial libraries and arrays of the cyclic imino compounds.Type: GrantFiled: June 18, 2001Date of Patent: March 23, 2004Assignee: Wisconsin Alumni Research FoundationInventors: Samuel H. Gellman, Bayard R. Huck
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Patent number: 6709821Abstract: Novel polypeptides having functional domains of interest are described, along with DNA sequences that encode the same. A method of identifying these polypeptides by means of a sequence-independent (that is, independent of the primary sequence of the polypeptide sought), recognition unit-based functional screen is also disclosed. Various applications of the method and of the polypeptides identified are described, including their use in assay kits for drug discovery, modification, and refinement.Type: GrantFiled: June 13, 2001Date of Patent: March 23, 2004Assignees: University of North Carolina at Chapel Hill, Cytogen Corp.Inventors: Andrew B. Sparks, Noah Hoffman, Brian K. Kay, Dana M. Fowlkes, Stephen J. McConnell
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Patent number: 6693168Abstract: Methods for preparing chiral non-racemic cyanoamines are provided. The methods are useful, e.g., for preparing chiral amino acids.Type: GrantFiled: September 14, 1999Date of Patent: February 17, 2004Assignee: The Trustees of Boston CollegeInventors: Amir Hoyeyda, Marc L. Snapper, Kevin Kuntz, Clinton A. Krueger, Carolyn Dzierba
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Patent number: 6693202Abstract: Disclosed are multibinding compounds which are muscarinic receptor antagonists. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is, independently of each other, a muscarinic receptor antagonist or an allosteric modulator provided that at least one of said ligand is a muscarinic receptor antagonist. The multibinding compounds of this invention are useful in the treatment and prevention of diseases such as chronic obstructive pulmonary disease, chronic bronchitis, irritable bowel syndrome, urinary incontinence, and the like.Type: GrantFiled: August 25, 2000Date of Patent: February 17, 2004Assignee: Theravance, Inc.Inventors: James Aggen, John H. Griffin, Mathai Mammen, Daniel Marquess, Edmund J. Moran, David Oare
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Patent number: 6689613Abstract: A combinatorial method is provided for the preparation and screening of heterogeneous catalysts. The method comprises the steps of: (I) providing a library of elemental catalysts; (II) reacting the catalysts with a carbon source to form product directly on the catalyst; and (III) screening the products to evaluate the catalysts.Type: GrantFiled: March 28, 2000Date of Patent: February 10, 2004Assignee: General Electric CompanyInventors: Xiao-Dong Sun, Navjot Singh
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Patent number: 6686503Abstract: The invention relates to methods of synthesizing libraries of diverse and complex highly substituted 2,4-dioxopiperidine compounds of the general formula: wherein R1, R2 and R3 are as herein described, novel intermediates useful for synthesizing such 2,4-dioxopiperidine compounds and methods for identifying and isolating the compounds.Type: GrantFiled: June 13, 2001Date of Patent: February 3, 2004Assignee: Ortho-McNeil Pharmaceutical, Inc.Inventors: Wenying Chai, William V. Murray
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Patent number: 6683115Abstract: Disclosed are multibinding compounds which are &bgr;2 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and premature labor.Type: GrantFiled: August 21, 2001Date of Patent: January 27, 2004Assignee: Theravance, Inc.Inventors: Edmund J. Moran, Seok-Ki Choi
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Patent number: 6683154Abstract: Disclosed are antimicrobial compositions containing &bgr;-peptides and methods of inhibiting microbial growth in mammals using the compositions. The &bgr;-peptides present in the compositions contain ring structures in the peptide backbone which limit the conformational flexibility of the peptide backbone.Type: GrantFiled: February 11, 2000Date of Patent: January 27, 2004Assignee: Wisconsin Alumni Research FoundationInventors: Samuel Helmer Gellman, Bernard Weisblum, Emilie Ann Porter, Xifang Wang
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Patent number: 6677160Abstract: A method for developing a library of compounds, the compound library, a method for identifying ligands for target molecules, and a method for identifying lead chemical templates, which, for example, can be used in drug discovery and design are provided. Certain embodiments of these methods include the use of NMR spectroscopy.Type: GrantFiled: September 29, 2000Date of Patent: January 13, 2004Assignee: Pharmacia & Upjohn CompanyInventors: Brian J. Stockman, Kathleen A. Farley, Claudio Dalvit