Abstract: Multiplexed transdermal extraction and detection devices and systems for non-invasive monitoring of substances, such as glucose, are disclosed, as are methods of using these devices for substance monitoring in subjects.

Abstract: A method and a device for determining an estimation value of the body weight of a person, in which at least one measurement value typical for a biological impedance measurement is determined and transmitted to an evaluation unit. The evaluation unit processes the measurement value together with individual or several individual data of the person as well as taking into consideration statistical data concerning other persons, in order to determine an estimated value for the weight of the person.

Abstract: A tissue imaging system comprising a computing device, tissue visualization application, image capturing unit, and an illumination unit, is configured to capture measurement data. The visualization application extracts visualizations of tissue health indicators from the measurement data. The application generates an interface with one or more interface elements corresponding to the visualization of tissue health indicators.

Abstract: Introduced here are techniques for digitally characterizing the movement of a subject in order to detect the presence of a disorder or monitor the progression of the disorder. More specifically, one or more angular features can be identified that define how certain part(s) of the human body move relative to other part(s) of the human body. These angular feature(s) can be used, for example, to affirmatively diagnose instances of a disorder, eliminate a disorder as the source of symptoms experienced by a subject, generate confidence scores that can be used to assist in diagnosing a subject, monitor disorder progression due to treatment or lack thereof, etc.

Abstract: Foley type catheter embodiments for sensing physiologic data from a urinary tract of a patient are disclosed. The system includes the catheter and a data processing apparatus and methods for sensing physiologic data from the urinary tract. Embodiments may also include a pressure sensor having a pressure interface at a distal end of the catheter, a pressure transducer at a proximal end, and a fluid column disposed between the pressure interface and transducer. When the distal end is residing in the bladder, the pressure transducer can transduce pressure impinging on it into a chronological pressure profile, which can be processed by the data processing apparatus into one or more distinct physiologic pressure profiles, for example, peritoneal pressure, respiratory rate, and cardiac rate. At a sufficiently high data-sampling rate, these physiologic data may further include relative pulmonary tidal volume, cardiac output, relative cardiac output, and absolute cardiac stroke volume.

Abstract: An information processing apparatus is provided which includes a sensor information acquisition unit that acquires sensor information including at least biological information of a user and a biological information change prediction unit that predicts a change of the biological information from the sensor information in accordance with a framework based on knowledge concerning poor physical condition of the user.

Abstract: Presented are methods and systems for determining, monitoring, and displaying the relative positioning of two rigid bodies during surgery. In particular, the present disclosure relates to methods and systems for positioning a prosthesis relative to a bone during a surgery as well as to systems and methods for verifying resulting relative positioning of adjacent bones.

Abstract: An apparatus for monitoring a surgical procedure includes a MALDI-TOF mass spectrometer comprising a load lock, an ionization chamber, and an ion detector. A first video camera produces an optical image of an operating field of the surgical procedure. A sample extracting device extracts the tissue sample at the location within the optical image of the operating field. A sample preparation system prepares MALID-TOF samples by depositing an extract of the extracted tissue sample on a sample plate together with a MALDI matrix. A sample plate loading mechanism loads the sample plate into the MALDI-TOF mass spectrometer. A second video camera produces an optical image of the sample plate and records a location of the extracted tissue sample.

Abstract: Disclosed is a method and a system implementing the method for determining an optimal time window for sleep of a person. The method includes receiving samples of a distal skin temperature of the person, and detecting a temperature change pattern in the samples of distal skin temperature. The temperature change pattern indicates a reference point within the circadian rhythm. The optimal time window for sleep is determined on the basis of the indicated reference point. The temperature change pattern is in the form of a drop in the distal skin temperature followed an increase in the distal skin temperature, where the drop and the increase occur within a time window of ten minutes or less.

Abstract: An arthrocentesis kit and method for using the kit including a procedure tray having all the necessary contents in one tray to reliably perform an arthrocentesis procedure and deliver the fluid samples to a laboratory for analysis, allowing the physician to order delivery of the tray and perform the procedure at the bedside of the patient by using the tray to simultaneously collect and send the synovial fluid collected to a laboratory for all diagnostic testing, thus enhancing the reliability of proper diagnosis thereby allowing crucial orthopedic surgeons, rheumatologists, internists, emergency room physicians and family practitioners to minimize mistakes caused by delays and mistakes attributable to not having all the arthrocentesis kit tools together and readily available for bedside or emergency room treatment.

Abstract: A targeting set for use with positioning a biopsy device within a patient. The targeting set includes an obturator and an actuator. The actuator includes a housing and a lock array. The lock array extends inwardly within a hollow interior defined by the housing. The obturator is configured for insertion into the housing of the actuator such that at least a portion of the obturator engages the lock array. The lock array is configured to selectively lock the obturator in a plurality of axial positions relative to the housing.

Abstract: The present disclosure provides system and method for monitoring of at least one physiological parameter of a person engaged in a physical activity, for example, an impact received by a player engaged in a contact sport such as football. The system includes a monitoring unit that actively monitors the physiological parameter of the person, wherein the monitoring unit generates an alert event when the monitored physiological parameter exceeds a threshold of the parameter. The monitoring unit determines whether the parameter exceeds an over-exposure threshold, wherein said threshold is based upon both a single incidence or cumulative incidences.

Abstract: A transmission apparatus for the transmission of brain parameter sensor data includes, a receiving unit with an antenna, which can be wirelessly connected to a transmitting unit of a brain parameter sensor for data transmission, a data processing device which is in signaling connection to the receiving unit, a high frequency source for generating a data transmission carrier frequency, wherein the high frequency source is integrated in a housing of the data processing device. The result is a transmission apparatus which is designed for use in a domestic patient environment.

Abstract: Blood sample optimization systems and methods are described that reduce or eliminate contaminates in collected blood samples, which in turn reduces or eliminates false positive readings in blood cultures or other testing of collected blood samples. A blood sample optimization system can include a blood sequestration device located between a patient needle and a sample needle. The blood sequestration device can include a sequestration chamber for sequestering an initial, potentially contaminated aliquot of blood, and may further include a sampling channel that bypasses the sequestration chamber to convey likely uncontaminated blood between the patient needle and the sample needle after the initial aliquot of blood is sequestered in the sequestration chamber.

Abstract: A wearable band configured to fit human limbs receives muscle tension data via sensors housed within the device. The processing circuitry generates statistical models for each physical state of a user and compares the received data with the statistical model. The user is alerted when the processing circuitry detects a change in the data that is outside the predetermined range. The sampling rate of measurements increases when a change is detected to confirm the abnormal data.

Abstract: A system and method to screen for malignant gliomas, other brain tumors, and brain injuries use disturbance coefficient, differential impedances, and artificial neural networks. The system uses prescribed excitation signals with several system configurations to measure the differential impedances, calculate harmonic responses and nonlinearity of brain tissue, and estimate the disturbance coefficient that indicates the likelihood of malignant gliomas, other brain tumors, and brain injuries. The disturbance coefficient is a weighted sum of many parameters such as receiving differential impedances, transmission differential impedances, harmonic responses, frequency dispersion, and nonlinear responses using different system configurations and different excitation signals. The method includes arranging the transmitters, receivers, and transmission lines to maximize the sensitivity of detecting brain tissue condition.

Abstract: The technology disclosed herein relates to, in part, a gas sampling device. According to some aspects, the gas sampling device has a housing defining an airflow aperture, a gas testing chamber and an airflow pathway extending from the airflow aperture to the gas testing chamber. The housing also defines a sensor receptacle configured to removably hold a disposable sensor test strip within the gas testing chamber and a docking structure configured to be received by a docking station.

Abstract: A non-invasive method of estimating intra-cranial pressure (ICP). The method including the steps of: a. non-invasively measuring pressure pulses in an upper body artery; b. determining central aortic pressure (CAP) pulses that correspond to these measured pressure pulses; c. identifying features of the ICP wave which denote cardiac ejection and wave reflection from the cranium, including Ejection Duration (ED) and Augmentation Index of Pressure (PAIx); d. non-invasively measuring flow pulses in a central artery which supplies blood to the brain within the cranium; e. identifying features of the measured cerebral flow waves which denote cardiac ejection and wave reflection from the cranium as Flow Augmentation Index (FAIx); f. calculating an ICP flow augmentation index from the measured central flow pulses; g.

Abstract: A biopsy tool includes an elongated flexible body, a sensor assembly, and a screw member. The sensor assembly is disposed within the elongated flexible body towards the distal end thereof. The sensor assembly includes a location sensor(s) configured to enable detection of a location of the sensor assembly. The screw member is coupled to the distal end of elongated flexible body, extends distally from the elongated flexible body, and is positioned distally of the sensor assembly. The screw member defines a helical configuration having a hollow interior and is configured for simultaneous rotation relative to tissue and advancement into tissue to obtain a tissue sample.

Abstract: A biopsy needle assembly configured for use with a tissue biopsy device is disclosed. The biopsy needle assembly may be configured to be advanced to a predetermined tissue sample, sever the tissue sample, and extract the tissue sample from a body tissue of a patient. The biopsy needle assembly may be further configured with two or more cooperating members configured to sever a sample.