Patents Examined by Md. Younus Meah
  • Polypeptide
    Patent number: 8663966
    Abstract: We disclose a food additive comprising a PS4 variant polypeptide, in which the PS4 variant polypeptide is derivable from a parent polypeptide having non-maltogenic exoamylase activity, in which the PS4 variant polypeptide comprises substitutions at the following positions: G121D, 134, 141, 157, 223, 307 and 334 with reference to the position numbering of a Pseudomonas saccharophilia exoamylase sequence shown as SEQ ID NO: 1.
    Type: Grant
    Filed: September 19, 2007
    Date of Patent: March 4, 2014
    Assignee: Dupont Nutrition Biosciences APS
    Inventors: Karsten Matthias Kragh, Bo Spange Sørensen
  • Gluconacetobacter strain having cellulose producing activity
    Patent number: 8658399
    Abstract: Disclosed herein is a novel gluconacetobacter strain having cellulose producing activity. Specifically, the present invention relates to a novel gluconacetobacter strain producing nano-structured cellulose in a highly efficient manner. The cellulose produced by the strain, due to its superb thermodynamic properties, can be characterized as nano-structured bacterial cellulose and therefore utilized as a bio-nano-fiber. Particularly, the cellulose can be impregnated with a resin to form a cellulose-based resin which can be effectively adapted for a substrate for a liquid crystal display (LCD).
    Type: Grant
    Filed: October 29, 2012
    Date of Patent: February 25, 2014
    Assignee: Samsung Display Co., Ltd.
    Inventors: Jong-Seong Kim, Woo-jae Lee, Nam-Seok Roh, Sang-Il Kim, Min-Ho Yoon, Young Tak Song, Tae Jin Kang, Suk Heung Oh, Seung-Jae Lee, Hye Jin Kim, Jin Ju Yu, Dong Hyun Yu, Young Sik Yoon, Jong Hwan Lee
  • Polypeptide having esterase activity and recombinant esterase and use thereof
    Patent number: 8642312
    Abstract: Polypeptide and recombinant protein having esterase activity which exhibit the amino acid sequence SEQ. ID. No. 1 and the use thereof.
    Type: Grant
    Filed: March 12, 2012
    Date of Patent: February 4, 2014
    Assignee: DSM Fine Chemicals Austria NFG GmbH & Co KG
    Inventors: Gerhard Steinbauer, Micheal Stanek, Peter Pojarliev, Wolfgang Skranc, Helmut Schwab, Joannes Kierkels, Marcel Wubbolts, Harald Pichler, Manuela Hermann, Christoph Zenzmaier
  • Production of L-ribose and other rare sugars
    Patent number: 8642297
    Abstract: The invention provides methods and compositions for the production of L-ribitol and other rare sugars using a mannitol-1-dehydrogenase.
    Type: Grant
    Filed: August 10, 2006
    Date of Patent: February 4, 2014
    Assignee: ZuChem, Inc.
    Inventors: Nathan Wymer, Paul Taylor
  • Thermostabilization of proteins
    Patent number: 8637009
    Abstract: Provided are compositions comprising a cocaine esterase (CocE) and a compound that thermostabilizes the CocE. Also provided are methods of thermostabilizing a cocaine esterase. Additionally provided are methods of treating a mammal undergoing a cocaine-induced condition. Methods of determining whether a compound is a thermostabilizing agent for a protein are also provided. Uses of the above-described compositions for the treatment of a cocaine-induced condition is additionally provided. Additionally provided is an isolated nucleic acid encoding a CocE polypeptide having the substitutions L169K and G173Q, and the CocE polypeptide encoded by that nucleic acid, and pharmaceutical compositions thereof. Further provided is the use of that composition for the manufacture of a medicament for the treatment of a cocaine-induced condition and for the treatment of a cocaine-induced condition.
    Type: Grant
    Filed: July 10, 2008
    Date of Patent: January 28, 2014
    Assignees: The Trustees of Columbia University in the City of New York, The Regents of the University of Michigan
    Inventors: Donald W. Landry, James H. Woods, Roger K. Sunahara, Diwahar L. Narasimhan, Joanne MacDonald, Milan N. Stojanovich, John J. Tesmer, Remy L. Brim
  • Nucleic acid molecules conferring enhanced ethanol tolerance and microorganisms having enhanced tolerance to ethanol
    Patent number: 8629255
    Abstract: The present invention provides isolated nucleic acid molecules which encode a mutant acetaldehyde-CoA/alcohol dehydrogenase or mutant alcohol dehydrogenase and confer enhanced tolerance to ethanol. The invention also provides related expression vectors, genetically engineered microorganisms having enhanced tolerance to ethanol, as well as methods of making and using such genetically modified microorganisms for production of biofuels based on fermentation of biomass materials.
    Type: Grant
    Filed: May 20, 2011
    Date of Patent: January 14, 2014
    Assignee: UT-Battelle, LLC
    Inventors: Steven Brown, Adam Guss, Shihui Yang, Tatiana Karpinets, Lee Lynd, Xiongjun Shao
  • Labelling of fusion proteins with synthetic probes
    Patent number: 8623627
    Abstract: The invention relates to new proteins called alkylcytosine transferases (ACTs) derived from O6-alkylguanine-DNA alkyltransferase, and to substrates for ACTs specifically transferring a label to these ACTs and to fusion proteins comprising these. The substrates according of the invention are substituted cytosines of formula (I) wherein R1 is an aromatic or a heteroaromatic group, or an optionally substituted unsaturated alkyl, cycloalkyl or heterocyclyl group with the double bond connected to OCH2—; R2 is a linker; and L is a label or a plurality of same or different labels. The invention further relates to methods of transferring label L from these substrates of formula (I) to ACTs and ACT fusion proteins. The system of ACT-compound of formula (I) is particularly suitable for double labelling studies together with the known system O6-alkylguanine-DNA alkyltransferase (AGT)-benzylguanines.
    Type: Grant
    Filed: May 31, 2012
    Date of Patent: January 7, 2014
    Assignee: New England Biolabs, Inc
    Inventors: Arnaud Gautier, Kai Johnsson, Maik Kindermann, Alexandre Juillerat, Florent Beaufils
  • Method for producing L-phenylephrine using an alcohol dehydrogenase of EBN1 (sp. EBN1)
    Patent number: 8617854
    Abstract: The present invention relates to a multi-stage process for producing substituted, optically active alcohols, comprising an enzyme-catalyzed synthesis step, in particular a synthesis step which is catalyzed by an alcohol dehydrogenase. The inventive method is particularly suitable for producing phenylephrine, i.e. 3-[(1R)-1-hydroxy-2-methylamino-ethyl]-phenol.
    Type: Grant
    Filed: September 15, 2009
    Date of Patent: December 31, 2013
    Assignee: BASF SE
    Inventors: Michael Breuer, Andreas Pletsch, Bernhard Hauer, Wolfgang Siegel
  • Method for producing hydroxylated adamantane using cytochrome P450
    Patent number: 8614080
    Abstract: Disclosed is a method for producing a hydroxylated form of a compound having an adamantane skeleton, which is useful as an intermediate for functional resins and pharmaceutical products, with high yield and at low cost. Specifically, a hydroxylated form of a compound having an adamantane skeleton can be obtained by using cytochrome P450. More specifically, an N-(5-hydroxy-2-adamantyl)-benzamide derivative can be produced by hydroxylating an N-(2-adamantyl)-benzamide derivative.
    Type: Grant
    Filed: November 16, 2012
    Date of Patent: December 24, 2013
    Assignee: Shionogi & Co., Ltd.
    Inventors: Taijiro Tomikawa, Yuuichi Mitsuda
  • Methods for the direct conversion of carbon dioxide into a hydrocarbon using a metabolically engineered photosynthetic microorganism
    Patent number: 8609385
    Abstract: The present invention relates to methods for the production of isoprene by the direct conversion of atmospheric carbon dioxide using metabolically engineered genetically engineered photosynthetic microorganisms. The present invention also relates to genetically engineered photosynthetic microorganisms, such as cyanobacteria, that are capable of producing isoprene from CO2.
    Type: Grant
    Filed: May 1, 2008
    Date of Patent: December 17, 2013
    Assignee: Zuvachem, Inc.
    Inventor: Stephen Anderson
  • Process for the reduction of cinnamaldehyde derivative employing enoate reductases
    Patent number: 8597915
    Abstract: The present invention relates to a novel enzymatically catalyzed method for the production of asymmetric aromatic aldehydes in an aqueous reaction medium containing certain organic co-solvents.
    Type: Grant
    Filed: February 1, 2011
    Date of Patent: December 3, 2013
    Assignee: BASF SE
    Inventors: Bernhard Hauer, Rainer Stürmer, Clemens Stückler, Kurt Faber
  • Nitroreductase enzymatic substrates
    Patent number: 8592175
    Abstract: The invention relates to the use of a compound having formula (I) as an enzymatic substrate for the detection of a nitroreductase activity, wherein: W1, W2, W3 and W4 are independently H, Br, Cl, F, I, alkyl, alkoxy, thiomethyl, perfluoroalkyl, nitro, cyano, carboxyl (including the esters or amides thereof) or any combination of same; n=0, 1 or 2; U is N or N+R and V is CZ6N or N+R or V is N or N+R and U is CZ6, R being H, alkyl, aralkyl, aryl, alkanoic or alkylsulphonic; and Z1, Z2, Z3, Z4, Z5 and Z6 are independently H, Br, Cl, F, I, alkyl, aryl, alkoxy, perfluoroalkyl, nitro, cyano, carboxyl, sulphonyl, including the sulphonyl or carboxyl amides or esters thereof, and the salts of same.
    Type: Grant
    Filed: July 29, 2010
    Date of Patent: November 26, 2013
    Assignee: bioMérieux, S.A.
    Inventors: Olivier Fabrega, Arthur James, Sylvain Orenga, John Perry, Vindhya Salwatura, Stephen Stanforth
  • Method of producing a polypeptide or virus of interest in a continuous cell culture
    Patent number: 8580554
    Abstract: Described herein is a chemostat-like continuous cell culture system that combines certain advantages of perfusion open systems and chemostat open systems to improve the culturing of mammalian cells, e.g., genetically modified cells, particularly in serum-free or chemically-defined media. The continuous culture system described herein involves culturing mammalian cells in a continuous cell culture system, which comprises a cell retention device, wherein the cell culture system has a dilution rate (D) of less than about 2 d?1, and a cell density of less than about 2×107 cell/mL.
    Type: Grant
    Filed: July 30, 2010
    Date of Patent: November 12, 2013
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Leopold Grillberger, Manfred Reiter, Daniel Fleischanderl
  • Method of enzyme cleavage of polysaccharides derived from algae
    Patent number: 8563276
    Abstract: The invention relates to a method for enzyme cleavage of polysaccharides comprising a first sequence [?4)-?-D-GlcpA-(1?4)-?-L-Rhap3 sulphate-(1?]n and a second sequence [?4)-?-L-IdopA-(1?4)-?-L-Rhap3 sulphate-(1?]m, the first and second sequences respectively comprising two monosaccharide units connected by an osidic bond, wherein said method is such that: said polysaccharide sequences are provided; a microorganism capable of producing an enzyme substance of the lyase class is provided; and said enzyme substance is brought into contact with said polysaccharide sequences in such a way as to bring about cleavage of the osidic bond according to a ?-elimination reaction. The invention is characterized in that a microorganism belonging to the bacteria of the Ochrobactrum genus is chosen for producing said enzyme substance.
    Type: Grant
    Filed: June 23, 2008
    Date of Patent: October 22, 2013
    Assignee: Universite de Picardie Jules Verne
    Inventors: Redouan El Boutachfaiti, Patrice Pheulpin, Bernard Courtois, Josiane Courtois-Sambourg
  • Perhydrolase variant providing improved specific activity
    Patent number: 8557556
    Abstract: An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error-prone PCR and site-directed mutagenesis to create an enzyme catalyst characterized by an increase in specific activity. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.
    Type: Grant
    Filed: October 22, 2012
    Date of Patent: October 15, 2013
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Robert Dicosimo, Mark Scott Payne, John Edward Gavagan
  • Cellulose degradable yeast and method for production thereof
    Patent number: 8557586
    Abstract: The present invention provides a method for producing a cellulose degradable yeast, comprising the step of co-introducing genes coding for at least two cellulose-degrading enzymes into a yeast host via integration with a yeast ? sequence. According to the invention, a yeast having an improved cellulose degradation ability are provided.
    Type: Grant
    Filed: December 10, 2010
    Date of Patent: October 15, 2013
    Assignees: National University Corporation Kobe University, Kansai Chemical Engineering Co., Ltd., Bio-Energy Corporation
    Inventors: Akihiko Kondo, Ryosuke Yamada, Hideo Noda
  • Perhydrolase variant providing improved specific activity
    Patent number: 8546119
    Abstract: An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error-prone PCR and site-directed mutagenesis to create an enzyme catalyst characterized by an increase in specific activity. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.
    Type: Grant
    Filed: October 22, 2012
    Date of Patent: October 1, 2013
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Robert DiCosimo, Mark Scott Payne, John Edward Gavagan
  • Perhydrolase variant providing improved specific activity
    Patent number: 8546120
    Abstract: An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error-prone PCR and site-directed mutagenesis to create an enzyme catalyst characterized by an increase in specific activity. The variant acetyl xylan esterase may be used to produce peroxycarboxylic acids suitable for use in a variety of applications such as cleaning, disinfecting, sanitizing, bleaching, wood pulp processing, and paper pulp processing applications.
    Type: Grant
    Filed: October 22, 2012
    Date of Patent: October 1, 2013
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Robert Dicosimo, Mark Scott Payne, John Edward Gavagan
  • Fluorescent proteins and uses thereof
    Patent number: 8541558
    Abstract: A fluorescent sensor and methods for producing and using the fluorescent sensor. Such fluorescent sensors have broad applicability in characterizing cells and organisms, in detecting or measuring various cellular parameters, and in detecting or measuring protein-protein/peptide interactions.
    Type: Grant
    Filed: May 3, 2006
    Date of Patent: September 24, 2013
    Assignee: Georgia State University Research Foundation, Inc.
    Inventor: Jenny J. Yang
  • Endometriosis-related markers and uses thereof
    Patent number: 8541173
    Abstract: The present invention relates to markers of endometriosis which are differentially expressed in the endometrial cells of females with endometriosis compared to endometriosis-free females. The invention also relates to methods for determining likelihood of endometriosis in female subjects, to methods for grading endometriosis in females suffering from endometriosis and to methods for treating this disease. The invention is also concerned with polynucleotides, probes, primers and kits useful for reducing into practice the above-mentioned methods which are more rapid, non invasive, much less complicated and much less costly than laparoscopy.
    Type: Grant
    Filed: February 23, 2012
    Date of Patent: September 24, 2013
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Soheyl Baban, Monique Bernard, Elana Cherry, Diane Gosselin, Patrice Hugo, Brigitte Malette, Pierre Miron, Charles Privé, Kamran Shazand