Patents Examined by Melanie Brown
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Patent number: 11747330Abstract: Electrochemical impedance-based label-free and rapid biosensor for select bodily fluid biomolecule levels. Monoclonal antibodies to of biomolecule such as cortisol were covalently attached to a 16-mercaptohexadecanoic acid functionalized gold working electrode using zero-length crosslinkers N-(3-dimethylaminopropyl)-N-ethylcarbodiimide and 10 mM N-hydroxysulfosuccinimide. Cortisol was detected in phosphate buffered saline (simulated tear fluid) using a simple ferrocyanide reagent with a lower limit of detection of 18.73 pM and less than 10% relative standard deviation.Type: GrantFiled: August 16, 2019Date of Patent: September 5, 2023Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITYInventors: Jeffrey LaBelle, Tina Hakimi, Brittney Cardinell
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Patent number: 11726086Abstract: A graphene-based sandwich immunoassay for detecting whether a target biological substance is present in a sample, generally comprising contacting said sample with a plurality of particles coated with graphene nanosheets, each particle having at least one targeting receptor, such that the target biological substance, if present, associates with the targeting receptor, and detecting the presence of the target biological substance in the sample by subsequently contacting the sample with a detection antibody, wherein the detection antibody is capable of targeting and binding with the target biological substance if bound to the targeting receptor to yield a detectable complex. The targeting receptor can be an antibody or fragment thereof. The target biological substance can be an exosome.Type: GrantFiled: September 25, 2020Date of Patent: August 15, 2023Assignees: The University of Kansas, Kansas State University Research FoundationInventors: Peng Zhang, Yong Zeng, Mei He
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Patent number: 11719632Abstract: Disclosed is a localised surface plasmon resonance (LSPR) nanopillar assembly. The LSPR assembly is for use in sensing the presence of a biomarker when attached to a quantum dot. The LSPR assembly comprises a substrate and an array. The array comprises a LSPR nanopillar and a polymer spacer attached to the nanopillar. The LSPR assembly further comprises an antibody attached to the at least one polymer spacer. In the LSPR assembly, a combined height of the polymer spacer and antibody is selected by varying the number of monomer units of the polymer spacer, so that, when in use with the biomarker and the quantum dot, the quantum dot is at a predetermined distance from the nanopillar.Type: GrantFiled: July 21, 2017Date of Patent: August 8, 2023Assignees: Temasek Polytechnic, Agency for Science, Technology and Research, Tan Tock Seng Hospital Pte. Ltd.Inventors: Ling Ling Sun, Willie Ng, Xiaodong Zhou, Ten It Wong, Yee Sin Leo
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Patent number: 11719693Abstract: Chromonic azo dyes are particular types of chromonic molecules that are alignable homeotropically (aggregated molecules stack perpendicularly to the surface) on different types of substrates, often without the need of any special surface treatment. This feature enables the optimization of a detection device with increased sensitivity based of the alignment distortion created by a biological immune complex.Type: GrantFiled: June 1, 2018Date of Patent: August 8, 2023Assignee: Pathogen Systems, Inc.Inventor: Luana Tortora
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Patent number: 11714083Abstract: The presence of analytes can be detected in the bodily fluid using Electrochemical Impedance Spectroscopy (EIS) or Electrochemical Capacitance Spectroscopy (ECS) in devices, such as handheld point-of-care devices. The devices, as well as systems and methods, utilize using Electrochemical Impedance Spectroscopy (EIS) or Electrochemical Capacitance Spectroscopy (EIS) in combination with an antibody or other target-capturing molecule on a working electrode. Imaginary impedance or phase shift, as well as background subtraction, also may be utilized.Type: GrantFiled: May 4, 2018Date of Patent: August 1, 2023Assignees: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY, MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH, AXIM BIOTECHNOLOGIES. INC.Inventors: Jeffrey LaBelle, Garrett Repp, Chi Lin, Mark Spano, Jennifer Blain Christen, Hongwu Jiang, Marcus Smith, Andrew Penman, Pierce Youngbar, Mackenzie Honikel, Curtiss Cook
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Patent number: 11703506Abstract: The present invention provides self-contained systems for performing an assay for determining a chemical state, the system including a stationary cartridge for performing the assay therein, at least one reagent adapted to react with a sample; and at least one reporter functionality adapted to report a reaction of the at least one reagent with said sample to report a result of the assay, wherein the at least one reagent, the sample and the at least one reporter functionality are contained within the cartridge.Type: GrantFiled: August 23, 2020Date of Patent: July 18, 2023Assignee: Accellix Ltd.Inventors: Harvey Lee Kasdan, Julien Meissonnier, Yoav Zuta, Micha Rosen, Yael Himmel, Yehoshua Broder, Bruce Davis, Bruce Goldman, Boaz Giron, Zion Botesazan, Eliezer Blasberg, Ilan Semmel, Jacques Aschkenasy
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Patent number: 11703505Abstract: The present invention relates to a nano-dynamic biosensor and a fabrication method therefor. A biosensor according to the present invention comprises a substrate having a hollow structure and a graphene layer formed thereon wherein a probe material is bound to the surface of the graphene layer and the resonance vibration of the hollow structure formed in the substrate is modulated as the probe material increases in weight when a target material to be detected is coupled to the probe material without being labeled, whereby the biosensor is expected to take advantage of the modulation to measure the coupling of the target material including vaccinia virus with high sensitivity on a femtogram (10?15 g) level.Type: GrantFiled: May 31, 2018Date of Patent: July 18, 2023Assignee: Korea Research Institute of Standards and ScienceInventors: Seung Hoon Nahm, Nam Hee Lee, Kwon Sang Ryu, Un Bong Baek
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Patent number: 11697117Abstract: Methods for detecting target analytes utilizing an array of wells are advantageous for detection of low concentrations of target analytes. Use of an array of wells requires sealing of the wells. The methods provided herein utilize digital microfluidics to seal wells of an array with a fluid that is immiscible with the aqueous liquid present in the wells to prevent evaporation and contamination of the aqueous fluid during analysis of signals from the wells. The disclosed method include generating a biphasic droplet composed of the immiscible fluid and an aqueous fluid. The immiscible fluid present in the biphasic droplet is moved over the array of wells to seal the wells by electrically actuating the aqueous fluid present in the biphasic droplet which in turn pulls the immiscible fluid.Type: GrantFiled: May 23, 2019Date of Patent: July 11, 2023Assignees: Abbott Laboratories, The Katholieke Universiteit LeuvenInventors: Mark A. Hayden, Karen Leirs, Elena Pérez-Ruiz, Jeroen Lammertyn
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Patent number: 11693001Abstract: The present invention relates to methods and systems for testing for the presence of a material such as one or more analyte types within a sample and more particularly, for improved single enzyme-linked immunosorbent assay (sELISA) testing as well as other variants of single-enzyme linked molecular analysis (SELMA).Type: GrantFiled: June 26, 2020Date of Patent: July 4, 2023Assignee: Selma Diagnostics APSInventor: Andreas Hjarne Kunding
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Patent number: 11673134Abstract: Provided herein are devices that facilitate the magnetic separation of an analyte from a sample, and methods of use thereof. In particular embodiments, devices and methods are provided for the trans-interfacial magnetic separation (TIMS) of analytes from a sample.Type: GrantFiled: June 6, 2018Date of Patent: June 13, 2023Assignee: Northwestern UniversityInventors: David M. Kelso, Abhishek K. Agarwal, Sally M. McFall, Tom Westberg, Matthew Austin Butzler, Jennifer L. Reed
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Patent number: 11668709Abstract: The present disclosure relates to a system for monitoring post-translational modification of protein using a biosensor with a gap, which performs with high reliability a diagnosis of a disease associated with a target protein for which impedance is measured, by measuring an impedance of a sample introduced into a sensor and calculating a change rate of the measured impedance, and to a method of manufacturing the biosensor used for the system.Type: GrantFiled: September 24, 2019Date of Patent: June 6, 2023Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Soo Hyun Lee, Ji Yoon Kang, Hyewhon Rhim, Yi Jae Lee, Hyewon Seo, Yun Kyung Kim
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Patent number: 11668676Abstract: The present disclosure provides methods, microfluidic devices, and systems for isolating target particles from a sample containing or suspected of containing the target particles. The methods, microfluidic devices, and systems disclosed herein facilitate affinity-based isolation of target particles in a microfluidic channel by translating the target particles to the side walls of the microfluidic channel where capture agents that bind to the target particles are immobilized.Type: GrantFiled: May 28, 2020Date of Patent: June 6, 2023Assignee: The Regents of the University of CaliforniaInventors: Ahmet Ali Yanik, Xiangchao Zhu, Evan Peterson, Yixiang Li
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Patent number: 11668711Abstract: A diagnostic assay strip includes a first layer that includes an iron mobile labelled specific binding partner that will bind to and iron biomarker from a sample and produce an iron complex and a vitamin A mobile labelled specific binding partner that will bind to a vitamin A biomarker from the sample and produce a vitamin A complex. A second layer includes iron and vitamin A test regions, and a control region. The iron test region has immobilized specific binding partners that will bind to the iron complex. The vitamin A test region has immobilized vitamin A biomarker that will bind to vitamin A mobile labelled specific binding partner, which is not bound to the vitamin A biomarker, passing from the first layer to the second layer. The control region has a moiety which will non-specifically bind to and immobilize the iron and vitamin A labelled specific binding partners. Methods of using the diagnostic assay strip are also discussed.Type: GrantFiled: November 13, 2018Date of Patent: June 6, 2023Assignee: CORNELL UNIVERISTYInventors: Saurabh Mehta, David Erickson, Zhengda Lu
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Patent number: 11650204Abstract: Provided herein are systems and methods for performing assays. In particular, provided herein are systems and methods for performing sensitive and rapid immunoassays.Type: GrantFiled: April 23, 2018Date of Patent: May 16, 2023Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Young Geun Park, Byunghoon Ryu, Xiaogan Liang, Katsuo Kurabayashi
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Patent number: 11651866Abstract: A method for initiating a telemedicine conference on a mobile device is provided. The method comprises receiving diagnostic test results in response to a diagnostic test, determining if the diagnostic test results include a positive result, storing the diagnostic test results on a server disposed on a network, presenting, if the diagnostic test results are positive, a telemedicine initiation option on a screen of the mobile device, determining whether the telemedicine initiation option is selected, sending the diagnostic test results from the server to the telemedicine provider, sending additional medical history information to the telemedicine provider, and initiating a telemedicine conference with the telemedicine provider. Some of these aspects also provide healthcare providers the ability to electronically send prescriptions and provide users the ability to use a mobile application to send prescriptions to pharmacies to be filled.Type: GrantFiled: September 20, 2018Date of Patent: May 16, 2023Assignee: RELIANT IMMUNE DIAGNOSTICS, INC.Inventors: Jovan Hutton Pulitzer, Henry Joseph Legere, III
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Patent number: 11639931Abstract: The present disclosure provides apparatuses and methods for analyzing the presence of a target analyte. The apparatuses and methods of the present disclosure can be operated in a multiplexed format to perform various assays of clinical significance.Type: GrantFiled: September 3, 2019Date of Patent: May 2, 2023Assignee: Analog Devices, Inc.Inventors: Kee-Hyun Paik, Kaveh M. Milaninia, Kilian Dill
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Patent number: 11635367Abstract: A contrast-amplifying carrier for observing a sample, includes a transparent substrate bearing at least one absorbent coating suitable for behaving as an antireflection coating when it is illuminated at normal incidence at an illumination wavelength ? through the substrate and when the face of the coating opposite the substrate is in contact with a medium referred to as a transparent ambient medium, the refractive index n3 of which is lower than that of the refractive index n0 of the substrate. The absorbent coating comprises: an absorbent sublayer referred to as the contrast sublayer, deposited on the surface of the transparent substrate; and an absorbent layer referred to as the sensitive layer, distinct from the contrast sublayer and comprising between 1 and 5 sheets of a graphene-type material. Methods for producing and for using such a contrast-amplifying carrier are also provided.Type: GrantFiled: December 16, 2016Date of Patent: April 25, 2023Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE DU MANS, COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVESInventors: Stéphane Campidelli, Renaud Cornut, Vincent Derycke, Dominique Ausserre, Manuel Ausserre
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Patent number: 11633738Abstract: Integrated devices that include a sample preparation component integrated with a detection component are disclosed. The sample preparation component may be a digital microfluidics module or a surface acoustic wave module which modules are used for combing a sample droplet with a reagent droplet and for performing additional sample preparation step leading to a droplet that contains beads/particles/labels that indicate presence or absence of an analyte of interest in the sample. The beads/particles/labels may be detected by moving the droplet to the detection component of the device, which detection component includes an array of wells.Type: GrantFiled: October 3, 2017Date of Patent: April 25, 2023Assignee: ABBOTT LABORATORIESInventors: Jeffrey B. Huff, Mark A. Hayden, Peter J. Karabatsos, Andrew Fischer, John M. Robinson, Shelley R. Holets-McCormack, Sophie Laurenson
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Patent number: 11630106Abstract: There is disclosed herein a device for determining the smoking status of a subject, wherein said device comprises a plurality of different specific binding molecules deposited to a solid phase to detect specifically the presence of two or three tobacco smoke exposure biomarkers in a biological sample, said biomarkers consisting of: (i) cotinine and total 4-(methylnitrosamino)-1-(3-, pyridyl)-1-butanol (NNAL); (ii) cotinine and N-acetyl-S-[2-carboxyethyl]-L-cysteine (CEMA); or (iii) cotinine and NNAL and CEMA.Type: GrantFiled: May 18, 2018Date of Patent: April 18, 2023Assignee: Philip Morris Products S.A.Inventors: Frank Luedicke, Manuel C. Peitsch
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Patent number: 11609229Abstract: The present invention relates to a system capable of performing simple and rapid inspection of an antigen equivalent to the immune chromatographic method with accuracy good as a PCR method. An embodiment relates to a novel fluorescence counting system for quantifying viruses or antibodies in an analyte which comprises an unit of providing an antigen or antibody phase solidified substrate by an aggregation method with quantum crystals, an unit for making a labeling liquor and labeling a virus or an antibody to be measured in the analyte by an antigen-antibody method, an unit of exciting the fluorescently labeled virus or antibody by a surface plasmon excitation method, and an unit of counting fluorescent points in an excited fluorescent screen to quantify the virus or antibody in the analyte.Type: GrantFiled: November 12, 2020Date of Patent: March 21, 2023Assignee: MYTECH CO. LTD.Inventors: Yuki Hasegawa, Katsuyuki Hasegawa