Patents Examined by Melanie Y Brown
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Patent number: 9778251Abstract: The invention is to devices and methods for rapid determination of analytes in liquid samples. The devices and methods incorporate a sample dilution feature and multiple immunosensors for performing a ratiometric immunoassay on a first analyte and a second analyte, for example, hemoglobin and hemoglobin Alc or albumin and glycosylated albumin. The devices are preferably capable of being used in the point-of-care diagnostic field.Type: GrantFiled: May 1, 2015Date of Patent: October 3, 2017Assignee: Abbott Point of Care Inc.Inventor: Cary James Miller
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Patent number: 9778271Abstract: The invention is to devices and methods for rapid determination of analytes in liquid samples. The devices and methods incorporate a sample dilution feature and multiple immunosensors for performing a ratiometric immunoassay on a first analyte and a second analyte, for example, hemoglobin and hemoglobin A1c or albumin and glycosylated albumin. The devices are preferably capable of being used in the point-of-care diagnostic field.Type: GrantFiled: May 1, 2015Date of Patent: October 3, 2017Assignee: Abbott Point of Care Inc.Inventor: Cary James Miller
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Patent number: 9772284Abstract: A miniature optical biosensor and biosensor array where high sensitivity for detection of biomolecular interaction does not require a fluorescent label. Non-linear frequency-shifts of optical resonators (‘nanobeams’) provide a digital all-or-nothing response to equilibrium binding of a biomarker to surface-immobilized bio-recognition elements, a signal suitable to identify active components in genetic and proteomic circuits, as well as toxic substances. The threshold level for the digital response is adjustable to accommodate for varying receptor affinities. A bistable cavity sensing (BCS) method can be used to track the shift of the resonance induced by the analyte more precisely than the conventional cavity sensing method, where the resolution is limited by the cavity linewidth. BCS method can be used to quantitate the concentration of the analyte, and their binding kinetics, affinities and etc.Type: GrantFiled: April 20, 2011Date of Patent: September 26, 2017Assignee: President and Fellows of Harvard CollegeInventors: Qimin Quan, Marko Loncar, Frank Vollmer
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Patent number: 9772329Abstract: Described herein are systems and methods for detecting a target analyte in a sample with electrodes, comprising a linker and an antibody attached to the linker, and measuring an electrocatalytic signal changes generated by binding of an analyte in the sample to the antibody. Also disclosed herein are kits for electrochemical detection of protein analytes.Type: GrantFiled: January 11, 2012Date of Patent: September 26, 2017Assignee: The Governing Council of the University of TorontoInventors: Jagotamoy Das, Shana O. Kelley
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Patent number: 9765395Abstract: A DNA sequencing and blood chemistry analysis device is provided including one or more sensor chips and one or more sample wells, wherein each sample well is configured to form a seal with one of the sensors. The one or more sensor chips may comprise Graphene transistors, and each transistor having an associated sequencing probe. The sensor chips interact with a biological sample introduced into the sample well, wherein changes in the current, transconductance, and resistance of the Graphene transistors are indicative of a DNA binding process. Based on the associated sequencing probes, the DNA sequence present in a biological sample can be identified.Type: GrantFiled: April 10, 2015Date of Patent: September 19, 2017Assignee: Nanomedical Diagnostics, Inc.Inventor: Brett Goldsmith
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Patent number: 9766243Abstract: The invention relates to a test kit for better carrying out a method for detecting biomarkers in human or animal stool, which can serve as an indication of a pathological, particularly a malignant event in the gastrointestinal tract (esophagus, stomach, small bowel, biliary tract, pancreas, and bowel). The invention teaches a novel and more efficient methods, uses and embodiments of a combined rapid test. The combined rapid test cassette used for implementing the test kit and the optimally coordinated reagents thereof contains two lateral flow test strips for the synchronous—in the technical meaning—detection of the biomarkers M2-PK and the biomarker hemoglobin. The test serves as a “dual filter” for diagnosing probands as part of a colon cancer screening program. The test is very cost-efficient and cuts costs in the health system by the examination at an early stage of colon cancer and the consequences thereof.Type: GrantFiled: July 9, 2013Date of Patent: September 19, 2017Assignee: SCHEBO BIOTECH AGInventors: Hans Scheefers, Ursula Scheefers-Borchel
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Patent number: 9766232Abstract: The invention is to devices and method for rapid determination of analytes in liquid samples by various assays including immunoassays incorporating a sample dilution feature for forming a diluted sample for analysis. The devices and methods also include a dilution verification feature for verifying the degree of dilution of the diluted sample. The devices preferably are capable of being used in the point-of-care diagnostic field is provided.Type: GrantFiled: May 1, 2015Date of Patent: September 19, 2017Assignee: Abbott Point of Care Inc.Inventors: Cary James Miller, Graham Davis, Michael Zelin
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Patent number: 9759681Abstract: The present invention is intended to provide a method and a device for detecting a biomolecule with high sensitivity and high throughput over a wide dynamic range without requiring concentration adjustments of a sample in advance. The present invention specifically binds charge carriers to a detection target biomolecule, and detects the detection target biomolecule one by one by measuring a current change that occurs as the conjugate of the biomolecule and the charge carriers passes through a micropore. High-throughput detection of a biomolecule sample is possible with an array of detectors.Type: GrantFiled: June 28, 2013Date of Patent: September 12, 2017Assignee: Hitachi High-Technologies CorporationInventors: Toshiro Saito, Kenta Imai, Kyoko Imai, Kazumichi Imai, Itaru Yanagi, Yoshimitsu Yanagawa, Masahiko Ando, Naoshi Itabashi
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Patent number: 9759722Abstract: The present invention provides self-contained systems for performing an assay for determining a chemical state, the system including a stationary cartridge for performing the assay therein, at least one reagent adapted to react with a sample; and at least one reporter functionality adapted to report a reaction of the at least one reagent with said sample to report a result of the assay, wherein the at least one reagent, the sample and the at least one reporter functionality are contained within the cartridge.Type: GrantFiled: December 17, 2013Date of Patent: September 12, 2017Assignee: LEUKODX LTD.Inventors: Harvey Lee Kasdan, Julien Meissonnier, Yoav Zuta, Micha Rosen, Yael Himmel, Yehoshua Broder, Bruce Davis, Bruce Goldman, Boaz Giron, Zion Botesazan, Ellezer Blasberg, Ilan Semmel, Jacques Aschkenasy
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Patent number: 9753030Abstract: The invention relates to carbon nanotube-containing composites as biosensors to detect the presence of target clinical markers, methods of their preparation and uses in the medical field. The invention is particularly suitable for the detection in patient biological specimens of bone markers and tissue markers. The biosensors of the invention include carbon nanotubes deposited on a substrate, gold nanoparticles deposited on the carbon nanotubes and, binder material and biomolecule deposited on the gold-coated carbon nanotubes. The biomolecule is selected to interact with the target clinical markers. The biosensor can be used as an in-situ or an ex-situ device to detect and measure the presence of the target clinical markers.Type: GrantFiled: March 5, 2014Date of Patent: September 5, 2017Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Prashant Nagesh Kumta, Madhumati Ramanathan, Mitali Shirish Patil
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Patent number: 9753029Abstract: The present invention provides a method and microfluidic immunoassay pScreen™ device for detecting and quantifying the concentration of an analyte in a liquid sample by using antigen-specific antibody-coated magnetic-responsive micro-beads. The methods and devices of the present invention have broad applications for point-of-care diagnostics by allowing quantification of a large variety of analytes, such as proteins, protein fragments, antigens, antibodies, antibody fragments, peptides, RNA, RNA fragments, functionalized magnetic micro-beads specific to CD4+, CD8+ cells, malaria-infected red blood cells, cancer cells, cancer biomarkers such as prostate specific antigen and other cancer biomarkers, viruses, bacteria, and other pathogenic agents, with the sensitivity, specificity and accuracy of bench-top laboratory-based assays.Type: GrantFiled: January 6, 2014Date of Patent: September 5, 2017Assignee: Carnegie Mellon UniversityInventors: Alberto Gandini, James F. Antaki, Byron Wang Chuan, Joie N. Marhefka
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Patent number: 9746468Abstract: Methods, systems, devices and materials are disclosed for implementing a bioaffinity sensor having a self-assembled monolayer interface for detection of a target molecule. In one aspect, a sensor device for detecting a target molecule includes a surface capable of attaching a thiol and a molecular monolayer formed on the surface that includes a molecular capture probe having a thiol region, a linear alkanethiol molecule having one thiol region, and a linear alkanedithiol molecule having two thiol regions, in which the molecular capture probe includes a region for receiving a target substance having a complimentary region that couples with the region of the molecular capture probe to generate a detectable signal.Type: GrantFiled: January 27, 2012Date of Patent: August 29, 2017Assignee: The Regents of the University of CaliforniaInventors: Joseph Wang, Susana Campuzano-Ruiz
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Patent number: 9746443Abstract: In at least one illustrative embodiment, a method for in-situ pathogen detection may comprise distributing one or more magnetoelastic measurement sensors on a surface of a test object, wherein each of the one or more magnetoelastic measurement sensors includes a biorecognition element configured to bind with a pathogen to cause a shift in a characteristic frequency of the associated measurement sensor; applying a varying magnetic field, using a test coil, to the one or more magnetoelastic measurement sensors distributed on the surface of the test object, wherein the test object is positioned outside of an inner volume defined by the test coil; detecting a frequency response of the one or more magnetoelastic measurement sensors using the test coil, while applying the varying magnetic field; and determining whether the pathogen is present based on the detected frequency response of the one or more magnetoelastic measurement sensors.Type: GrantFiled: October 28, 2013Date of Patent: August 29, 2017Assignee: AUBURN UNIVERSITYInventors: Bryan A. Chin, Zhongyang Cheng, Suiqiong Li, Mi-Kyung Park, Shin Horikawa, Yating Chai, Kanchana Weerakoon, Stevie R. Best, Martin E. Baltazar-Lopez, Howard C. Wikle
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Patent number: 9744532Abstract: Microfluidic devices and methods for using the same are provided. Aspects of the invention include microfluidic devices that include a separation medium and a pan-capture binding medium. The microfluidic devices are configured to subject a sample to two or more directionally distinct electric fields. Also provided are methods of using the devices as well as systems and kits that include the devices. The devices, systems and methods find use in a variety of different applications, including diagnostic and validation assays.Type: GrantFiled: November 7, 2014Date of Patent: August 29, 2017Assignee: The Regents of the University of CaliforniaInventors: Amy E. Herr, Dohyun Kim
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Patent number: 9739718Abstract: A system for detecting concentration of a target in a solution where sample fluid is passed into a microchannel with wall coated with the receptor that reacts and crosslinks with the target to constrict the channel and slow or stop sample flow through the microchannel. Concentration of the target is determined by measuring length of the sample filled channel.Type: GrantFiled: February 3, 2014Date of Patent: August 22, 2017Assignee: Brigham Young UniversityInventors: Adam T. Woolley, Debolina Chatterjee, Danielle Scarlet Mansfield
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Patent number: 9720003Abstract: The present invention relates to a method for measuring Troponin I in a sample comprising the steps of providing a sample, contacting the sample with a monoclonal anti-Troponin I antibody coupled to a magnetic label, contacting the sample with a polyclonal anti-Troponin I antibody coupled to a sensor surface and detecting the magnetic label on the sensor surface. The invention further relates to a device and a cartridge for measuring Troponin I in a sample.Type: GrantFiled: December 15, 2009Date of Patent: August 1, 2017Assignee: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Wendy Uyen Dittmer, Toon Hendrik Evers, Peggy De Kievit, Ricky Kamps, Joost Lambert Max Vissers, Michael Franciscus Wilhelmus Cornelis Martens, David Walterus Cornelis Dekkers
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Patent number: 9708599Abstract: A method of processing a sample may include introducing a sample into a vessel, the vessel having proximal and distal ends, the sample being introduced into the proximal end of the vessel; incubating the sample in the vessel with a substance capable of specific binding to a preselected component of the sample; propelling components of the incubated sample, other than the preselected component, toward the proximal end of the vessel by clamping the vessel distal to the incubated sample and compressing the vessel where the incubated sample is contained; propelling the preselected component toward a distal segment of the vessel by clamping the vessel proximal to the preselected component and compressing the vessel where the preselected component is contained; and mixing the preselected component with a reagent in the distal segment of the vessel.Type: GrantFiled: December 17, 2014Date of Patent: July 18, 2017Assignee: Roche Molecular Systems, Inc.Inventors: Shuqi Chen, Lingjun Chen
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Patent number: 9700889Abstract: A method of flowing a fluid with a tracer in a microfluidic channel of an assay device and detecting the tracer for determining the channel location or condition of the channel.Type: GrantFiled: September 6, 2014Date of Patent: July 11, 2017Assignee: CyVek, Inc.Inventors: Martin A. Putnam, Jeffrey T. Branciforte, Charles O. Stanwood
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Patent number: 9702846Abstract: A device includes a biosensor, a sensing circuit electrically connected to the biosensor, a quantizer electrically connected to the sensing circuit, a digital filter electrically connected to the quantizer, a selective window electrically connected to the digital filter, and a decision unit electrically connected to the selective window.Type: GrantFiled: November 8, 2013Date of Patent: July 11, 2017Assignee: Taiwan Semiconductor Manufacturing Company, Ltd.Inventors: Jui-Cheng Huang, Yi-Shao Liu, Chun-Wen Cheng, Tung-Tsun Chen, Chin-Hua Wen
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Patent number: 9695390Abstract: Various aspects of the present invention relate to the control and manipulation of fluidic species, for example, in microfluidic systems. In one set of embodiments, droplets may be sorted using surface acoustic waves. The droplets may contain cells or other species. In some cases, the surface acoustic waves may be created using a surface acoustic wave generator such as an interdigitated transducer, and/or a material such as a piezoelectric substrate. The piezoelectric substrate may be isolated from the microfluidic substrate except at or proximate the location where the droplets are sorted, e.g., into first or second microfluidic channels. At such locations, the microfluidic substrate may be coupled to the piezoelectric substrate (or other material) by one or more coupling regions. In some cases, relatively high sorting rates may be achieved, e.g., at rates of at least about 1,000 Hz, at least about 10,000 Hz, or at least about 100,000 Hz, and in some embodiments, with high cell viability after sorting.Type: GrantFiled: August 23, 2011Date of Patent: July 4, 2017Assignees: President and Fellows of Harvard College, Universität AugsburgInventors: David A. Weitz, Thomas Franke, Achim Wixforth, Lothar Schmid, Jeremy Agresti, Adam R. Abate