Abstract: The present invention relates to a quantitative electroencephalogram (QEEG) monitor and system capable of monitoring and displaying simultaneously neuropathological characteristic and activity of both sides of a subject's brain. The methods include various indices and examination of differences in these indices by which neurophysiological conditions or problems can be identified and treated. These methods, and the systems and devices using these methods preferably can be used for identifying these neurophysiological conditions or brain dysfunction with monitors and methods for seizure detection, for sedation monitoring, for anesthesia monitoring, and the like. These bilateral brain monitoring methods and systems, and the devices using these methods can be used by individuals or clinicians with little or no training in signal analysis or processing. These bilateral monitoring methods can also be used in a range of applications.

Abstract: A system for monitoring a patient includes an inflatable cuff configured to at least partially occlude an artery of the patient, and a sensor configured to determine a first parameter associated with the at least partially occluded artery and to generate an output signal indicative of the first parameter. The system also includes a processor configured to receive the output signal and information indicative of an occlusion efficiency of the cuff. The processor is configured to determine a hemodynamic parameter of the patient based on the output signal and the information.

Abstract: The present disclosure presents methods, systems and devices for performing capnography (respiratory CO2) monitoring using a respiratory CO2 sensor and a breath tracking mechanism for tracking and/or detecting phases of the breath wherein the measurements of the CO2 sensor may provide baseline CO2 values, and modulate/quantify the respiratory CO2 levels according to the baseline values.

Abstract: Methods for preserving catalytic activity of a PSA polymer membrane in a humid environment by immobilizing in the membrane an organic acid having a pKa greater than the pKa of the PSA polymer membrane; optical sensors based on the PSA membranes further including an immobilized organic reagent capable of reacting with a target compound in a humid environment to produce a detectable color shifted product; and non-invasive methods for estimating blood glucose concentration by utilizing an optical sensor to detect concentration of acetone in exhaled human breath and correlating it to blood glucose concentration.

Abstract: Novel tools and techniques for assessing, predicting and/or estimating effectiveness of hydration of a patient and/or an amount of fluid needed for effective hydration of the patient, in some cases, noninvasively.

Abstract: The invention relates to a respiratory motion detection apparatus (1) for detecting respiratory motion of a person. An illuminator (3) illuminates the person (2) with an illumination pattern (11), and a detector (4) detects the illumination pattern (11) on the person (2) over time. A temporal respiratory motion signal being indicative of the respiratory motion of the person (2) is determined from the detected illumination pattern by a respiratory motion signal determination unit (5). The illumination pattern deforms significantly with slight movements of the person. Thus, since the respiratory motion signal determination unit (5) is adapted to determine the temporal respiratory motion signal from the detected illumination pattern, even slight respiratory movements of the person can be determined. The sensitivity of detecting respiratory movements of a person can therefore be improved.

Abstract: A method for monitoring pressure of blood in an artery may include contacting a non-invasive sensor of a pressure of blood monitoring device at an area above an artery of a finger, collecting with the sensor one or more pressure data readings, other than readings corresponding to an air pressure reading, from the area after the contacting and after a pressure is exerted at the area on the sensor; and analyzing with a computing device the one or more pressure data readings to generate at least one of a blood pressure reading and a heart pulse reading.

Abstract: A monitor configured to monitor autoregulation includes a memory encoding one or more processor-executable routines and a processor configured to access and execute the one or more routines encoded by the memory. When executed, the routines cause the processor to receive one or more physiological signals from a patient, determine a measure indicative of an autoregulation status of the patient based on the one or more physiological signals, generate an autoregulation alarm indicative of an impaired autoregulation status when the measure exceeds a predetermined threshold for more than a predetermined period of time.

Abstract: A pedestal for a physiological characteristic sensor assembly and a physiological characteristic sensor assembly is provided. The pedestal includes a first side opposite a second side. The pedestal includes a sidewall that interconnects the first side and the second side. The pedestal also includes a first end opposite a second end. The pedestal includes at least one post that extends from the first side adjacent to the first end to couple the pedestal to a physiological characteristic sensor of the physiological characteristic sensor assembly. The pedestal also includes a recess defined in the sidewall at the second end. The recess has a first portion in communication with a second portion. The first portion has a first length that is less than a second length of the second portion along a perimeter of the sidewall, and the second portion is positionable to apply a force to the physiological characteristic sensor.

Abstract: Novel tools and techniques are provided for assessing, predicting and/or estimating a probability that a patient is bleeding, in some cases, noninvasively. In various embodiments, tools and techniques are provided for implementing rapid detection of bleeding of the patient or implementing assessment, prediction, or estimation of a probability of bleeding of the patient following injury, in some instances, in real-time before, during, and after fluid resuscitation. According to some embodiments, one or more sensors might monitor physiological data of the patient before, during, and after resuscitation following injury. A computer system might receive and analyze the physiological data, and might estimate a probability that the patient is bleeding, based at least in part on the analyzed physiological data. An indication of at least one of an assessment, prediction, or estimate of a probability that the patient is bleeding may then be displayed on a display device.

Abstract: Novel tools and techniques are provided for assessing, predicting and/or estimating a physiological state of a patient, based on variance of the patient's compensatory reserve index (“CRI”) before, during, and/or after a physical perturbation. In some embodiments, the system might receive a first set of physiological data from one or more sensors at a first time relative to a physical perturbation of the patient, and might calculate a first set of CRI values of the patient. The system might receive a second set of physiological data at a second time relative to the physical perturbation, calculate a second set of CRI values, analyze the two sets of CRI values against a pre-existing model, estimate a physiological state (e.g., hydration, etc.) of the patient, and display the estimate on a display device. The system might also control an infusion device to infuse fluids into the patient based on estimated hydration state.

Abstract: Novel tools and techniques for assessing, predicting and/or estimating effectiveness of fluid resuscitation of a patient and/or an amount of fluid needed for effective resuscitation of the patient, in some cases, noninvasively.

Abstract: Tools and techniques for estimating a probability that a patient is bleeding or has sustained intravascular volume loss (e.g., due to hemodialysis or dehydration) and/or to estimate a patient's current hemodynamic reserve index, track the patient's hemodynamic reserve index over time, and/or predict a patient's hemodynamic reserve index in the future. Tools and techniques for estimating and/or predicting a patient's dehydration state. Tools and techniques for controlling a hemodialysis machine based on the patient's estimated and/or predicted hemodynamic reserve index.

Abstract: Tools and techniques for estimating and/or predicting a patient's current and/or future blood pressure. In some cases, the tools will analyze physiological data captured from the patient against a model of blood pressure values to estimate/predict the patient's blood pressure value. In particular cases, derived parameters, such as a patient's compensatory reserve index (“CRI”) can be analyzed against such models, while in other cases, data captured from sensors can be directly analyzed against such models.

Abstract: Various embodiments enable calibrating a non-invasive blood pressure measurement device by determining multiple parameters defining a stress-strain relationship of an artery of a patient. The device may obtain output signals from a blood pressure sensor at two or more measurement elevations. The obtained measurement signals may be filtered into AC and quasi-DC components, and results fit to exponential functions to calculate an arterial time constant and a veinous time constant related to vein draining/filling rates. The arterial and veinous time constants may be used to calculate an infinity ratio. The infinity ratio and the obtained sensor output may be used to calculate values for multiple parameters defining a stress-strain relationship of a measured artery. Once defined, this stress-strain relationship may be stored and applied to future sensor output signals (e.g., blood pressure measuring sessions) to infer patient blood pressure.

Abstract: A respiration monitoring system has deformation transducers on a flexible substrate arranged to adhere to a patient's torso. A processor receives signals in channels from the transducers and processes them to eliminate, reduce or compensate for noise arising from patient motion artefacts, to provide an output representative of respiration. The transducers have a size and a mutual location on the substrate so that a first transducer can overlie at least part of the 10th rib and a second transducer can overlie at least part of the 11th rib or the abdomen, and the processor processes data from the first transducer as being primarily representative of rib distending respiration and from the second transducer as being primarily representative of either diaphragm respiration or patient motion artefacts.

Abstract: A system and method of tracking activity includes a motion sensor, a light source and a light detector. The light detector is configured to capture an amount of the light that is reflected back to the light detector, at least a first portion of the light reflected back to the light detector is reflected from a blood vessel disposed under a skin adjacent to the housing. A processor is in communication with the motion sensor and the light detector and can process the reflected light to identify heart beats and produce an indication of a heart rate. The indication of the heart rate can be displayed on the display screen as an option, in addition to the metrics that quantify the motion data.

Abstract: Systems, devices and methods for monitoring analyte levels using a self-powered analyte sensor and associated sensor electronics are provided.

Abstract: The tinnitus testing apparatus of this invention comprises a control part that in turn comprises: an auditory stimulus generation part that can generate a stimulus; and an AEP acquisition and amplitude measurement part that can acquire auditory evoked potential (AEP) brain waves of a examinee due to said stimulus and measure the specific amplitude of said acquired brainwaves; wherein said auditory stimulus is one or more of: a 1st stimulus containing continuous noise and pulse noise; and a 2nd stimulus containing pulse noise and continuous noise with a silent gap.

Abstract: A method and device is provided for the continuous estimation of the blood pressure using a noninvasive technique. The method involves sensing of the displacement signal generated by the palpation of the radial artery. The radial artery is modelled as a cylindrical voight type viscoelastic tissue for the estimation of the personalized blood pressure. The model includes the displacement signal and a set of parameters as an input. The set of parameters include a mean radius of the artery, a radius at zero mmHg, a viscoelastic damping parameter, an elasticity of the artery and a thickness of wall of artery. The method involves the optimization of the set of parameters using heuristic optimization techniques, which helps in the estimation of the systolic and diastolic blood pressure. The method and device can also be personalized for individualized monitoring and estimation of the blood pressure of the person.