Abstract: Device and method for detecting dispersed extracellular vesicles in a liquid dispersion sample, said method using an electronic data processor for classifying the sample as having, or not having, extracellular vesicles present, the method comprising the use of the electronic data processor for pre-training a machine learning classifier with a plurality of extracellular vesicle liquid dispersion specimens comprising the steps of: emitting a laser modulated by a modulation frequency onto each specimen; capturing a temporal signal from laser light backscattered by each specimen for a plurality of temporal periods of a predetermined duration for each specimen; calculating specimen DCT or Wavelet transform coefficients from the captured signal for each of the temporal periods; using the calculated coefficients to pre-train the machine learning classifier; wherein the method further comprises the steps of: using a laser emitter having a focusing optical system coupled to the emitter to emit a laser modulated by a m

Abstract: A sample of an aqueous stream is conducted to an optical measurement device. A hydrophobic dye is added. The sample is fractionated into fractions according to particle size or mass. Fluorescence intensity values and light scattering intensity values for the fractions are measured. Fluorescence intensity values of the fractions are added together thus obtaining a sum of the fluorescence intensity values. Light scattering intensity values of the fractions are added together, thus obtaining a sum of the light scattering intensity values. A hydro-phobicity density of the particles in the sample, is calculated by dividing the sum of the fluorescence intensity values with the sum of the light scattering intensity values. A concentration of hydrophobic contaminants in the aqueous stream is monitored and controlled based on the calculated hydrophobicity density of the particles in the sample.

Abstract: According to an embodiment, a holographic microscope comprises a light source, an optical system splitting light emitted from the light source into an object and a reflective mirror and inducing interference between light reflected by the object or transmitted through the object and light reflected by the reflective mirror, a first image sensor receiving the interference light and sensing interference information for the interference light, a second image sensor receiving the light reflected by the object or transmitted through the object and sensing information for the received light, and an image processor deriving a shape of the object based on the interference information sensed by the first image sensor and the information sensed by the second image sensor.

Abstract: A device may determine a calibration value for a spectrometer using light from a first light source; deactivate the first light source after determining the calibration value; perform measurement with regard to a sample based on the calibration value, wherein the measurement of the sample is performed using light from a second light source; determine that the calibration value is to be updated; and update the calibration value using the light from the first light source.

Abstract: An example system includes a master oscillator that provides a master oscillator beam, a first fiber beam splitter that splits the master oscillator beam into a first branch and a second branch, a second fiber beam splitter that splits the first branch into an imaging branch and an amplified characteristic branch, and a compensation branch mixer that mixes the second branch and the amplified characteristic branch into a compensation branch. The example system includes transmission optics that direct the imaging branch to a target location, an imaging mixer that mixes the compensation branch and a reflected image from the target location into an imaging signal, and an acquisition device that receives the imaging signal as a final image. An example system optionally includes a mode matching lens that applies a selected wavefront characteristic to the compensation branch.

Abstract: Provided is a holographic microscope including an input optical system configured to emit polarized input beam, a first beam splitter configured to emit an object beam by reflecting a portion of the polarized input beam, and emit a reference beam by transmitting a remaining portion of the polarized input beam, a reference optical system configured to separate the reference beam into a first reference beam and a second reference beam, a camera configured to receive the first reference beam and the second reference beam and the object beam that is reflected by an inspection object, the camera including a micro polarizer array, wherein a first polarization axis of the first reference beam is perpendicular to a second polarization axis of the second reference beam.

Abstract: Systems, devices, methods, and computer-readable media for. A method can include receiving, from a laser scan device of a tolling station, a time series of distance measurements, determining, based on the time series of distance measurements, height measurements indicating a height of a vehicle from a surface of a road. generating, based on the height measurements, an image of the height measurements, and classifying, using the image as input to a convolutional neural network (CNN), the vehicle.

Abstract: A method of making a colorimeter colour standard, including determining print parameters required to achieve a desired colour for the colour standard, printing the desired colour on a colour-receiving face of a first transparent piece using the determined print parameters and permanently affixing the printed first piece to a second transparent piece such that the colour-receiving face of the first transparent piece and a joining face of the second transparent piece are positioned at the interface between the first transparent piece and the second transparent piece.

Abstract: The present invention relates to devices for measuring property changes via in-situ micro-viscometry and methods of using same. The aforementioned device is inexpensive and can be used to quickly and accurately measure numerous physical and chemical property changes, including but not limited to the rate of chemical cure, change in tack, and rate of mass loss, for example, rate of moisture, solvent and/or plasticizer change.

Abstract: A photonic device for detecting rotation and a corresponding method for operation thereof are disclosed. The photonic device includes a readout structure coupled to a ring resonator at one or more coupling points. Light is split between a lower waveguide and an upper waveguide of the readout structure in a forward direction at a beam splitter. The light in the waveguides traveling in the forward direction is coupled into the ring resonator and subsequently back into the waveguides in a reverse direction. The light is spatially phase tilted and is combined at the beam splitter. The combined light is detected by a split detector.

Abstract: Characteristics of a standard logic cell, e.g., a random logic cell, are determined using an effective cell approximation. The effective cell approximation is smaller than the standard logic cell and represents the density of lines and spaces of the standard logic cell. The effective cell approximation may be produced based on a selected area from the standard logic cell and include the same non-periodic patterns as the selected area. The effective cell approximation, alternatively, may represent non-periodic patterns in the standard logic cell using periodic patterns having a same density of lines and spaces as found in the standard logic cell. A structure on the sample, such as a logic cell or a metrology target produced based on the effective cell approximation is measured to acquire data, which is compared to the data for the effective cell approximation to determine a characteristic of the standard logic cell.

Abstract: The present disclosure relates to integration of integrated photonics-based optical gyroscopes and fiber-based optical gyroscopes into portable apparatuses that may include compass features. Novel small-footprint modularized fully integrated photonics optical gyroscopes are used for non-critical axes. However, for at least one critical axis, a fiber-optic gyroscope can be used to provide bias stability below 0.1°/Hr, which is directly correlated to predicting positional accuracy in the centimeter range. The positional accuracy results from the compassing ability of the gyroscope (referred to as gyrocompass) to calculate direction of heading using the earth's rotation.

Abstract: An overlay measurement device includes a transmission and receipt part and a processor connecting to the transmission and receipt part electrically. The processor obtains data transmitted from a user terminal through the transmission and receipt part, analyzes a recipe included in the data, and performs optimization of measurement options of a wafer, based on the recipe, after the recipe is analyzed.

Abstract: A system for analysis of a fluid sample has a carrier with a channel. A plug with a sensor can be inserted into a socket arranged on the carrier in such a way that the sensor is in contact with an interior volume of the channel. The sensor can be an optical sensor, in particular based on fluorescence. Optical fibres may be connected to the plug. A camera (8) may be provided to record an image of the plug. The carrier may in particular be a microfluidic chip and the channel a microfluidic channel.

Abstract: A polarization-separated, phase-shifted interferometer can generate interferograms without moving parts. It uses a phase shifter, such as an electro-optic phase modulator, to modulate the relative phase between sample and reference beams. These beams are transformed into orthogonal polarization states (e.g., horizontally and vertically polarized states) and coupled via a common path (e.g., polarization-maintaining fiber) to a polarizing beam splitter (PBS), which sends them into separate sample and reference arms. Quarter-wave plates in the sample and reference arms rotate the polarization states of the sample and reference beams so they are coupled out of the PBS to a detector via a 45° linear polarizer. The polarizer projects the aligned polarization components of the sample and reference beams onto the detector, where they interfere with known relative phase to produce an output that can be used to map surface topography of the test object.

Abstract: A LiDAR sensor unit is configured to detect information of an outside area of a vehicle with sensing light. A cover covers the LiDAR sensor unit so as to allow passage of the sensing light while forming a part of an outer surface of the vehicle. A strain gage is disposed on the cover and configured to output a strain signal corresponding to strain generated in the cover. A processor is configured to detect a foreign substance adhered to the cover based on the strain signal.

Abstract: In some implementations, a Mach-Zehnder interferometer (MZI) includes a delay line arm formed in a chip and a mirrored facet formed in the chip. The delay line arm may be configured to propagate light to the mirrored facet. The mirrored facet may be configured to reflect, to the delay line arm, a percentage of the light propagated to the mirrored facet by the delay line arm.

Abstract: An apparatus and method for aligning two coaxially coupled rotatable shafts. A servo operated multi axis positioning device is movable along a longitudinal axis parallel to the axis of the shafts, and movable vertically to position a laser range (LRF) adjacent to the two shafts, which measures the distance between the LRF and a spot on the shafts. A controller having a processor and memory communicates with the positioning device and the LRF to collect data at two axial positions on each shaft. At each position the LRF measures the distance to the shaft and stores the measurement and location data. The LRF is vertically repositioned and the measurement and storing steps are repeated over a scan distance sufficient to provide enough data to determine the location of the shaft center. The processor then calculates and compares the shafts centerlines and determines the necessary adjustments needed to move the shafts into coaxial alignment.

Abstract: An analyte in water is quantified by mixing an internal standard with a water sample. The sample is analyzed with a Raman spectrometer. The analysis includes mapping the signal from the Raman spectrometer to the quantity of said analyte. The mapping can include using a calibration curve, for example a multivariate calibration curve, that was previously prepared with the internal standard. In other examples, a sample is measured after addition of a known amount of the analyte.

Abstract: A method for determining a contour of a frame groove in a rim of a spectacle frame includes illuminating the rim, capturing a plurality of images of the illuminated rim from different predetermined perspectives, evaluating the captured images, and determining a spatial curve of the frame groove based on the evaluated images. The rim is illuminated along the entire circumference of the rim by directed illumination. Moreover, the evaluation of the captured images includes assigning each portion contained in the captured images to a respective surface element of the frame groove on the basis of at least one of the following properties: shadowing of the respective portion, brightness of the respective portion and phase angle of the illumination of the respective portion. Moreover, an apparatus, a computer program, a method for grinding a spectacle lens, and a computer-implemented method for determining a geometry of a spectacle lens are disclosed.