Patents Examined by Michael A. Williamson
  • Methods and apparatus for improved administration of pharmaceutically active compounds
    Patent number: 6245347
    Abstract: Methods and apparatus for improving administration of drugs through the use of heat and other physical means. The present invention relates to the use of heat and other physical means in conjunction with specially designed dermal drug delivery systems, conventional commercial dermal drug delivery systems, or drugs delivered into a sub-skin depot site via injection and other methods to alter, mainly increase, the drug release rate from the dermal drug delivery systems or the depot sites to accommodate certain clinical needs.
    Type: Grant
    Filed: September 29, 1998
    Date of Patent: June 12, 2001
    Assignee: Zars, Inc.
    Inventors: Jie Zhang, Hao Zhang
  • Enhanced antiperspirant salts stabilized with calcium and concentrated aqueous solutions of such salts
    Patent number: 6245325
    Abstract: The present invention relates to enhanced efficacy antiperspirant salts containing calcium and an amino acid or a hydroxy acid and particularly to stabilized aqueous solutions of such salts. The present invention also embraces methods of making these antiperspirant salts and solutions and compositions containing same.
    Type: Grant
    Filed: November 5, 1999
    Date of Patent: June 12, 2001
    Assignee: The Gillette Company
    Inventor: Yan-Fei Shen
  • Transdermal administration of fenoldopam
    Patent number: 6238693
    Abstract: Transdermal administration of fenoldopam, both the racemic mixture and the active R-fenoldopam enantiomer, is described. Also described are transdermal patches for therapeutically effective transdermal administration of racemic fenoldopam and its active R-fenoldopam enantiomer to a subject in need of treatment for impaired renal function or hypertension.
    Type: Grant
    Filed: April 27, 1999
    Date of Patent: May 29, 2001
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Robert R. Luther, Dawn McGuire, Vandana Mathur, David J. Ellis
  • Composition for controlled and sustained transdermal administration
    Patent number: 6231885
    Abstract: A patch for transdermal administration of drugs through controlled release system, consisting essentially of: A) a flexible backing layer; B) an adhesive layer comprising: an adhesive pressure sensitive adhesive polymeric matrix, a cohesion improver, a tackifier agent, a combination of permeation enhancers consisting of a first component which is a saturated fatty acid or fatty alcohol represented by the formula CH3—(CH2)n—COOH or CH3—(CH2)n—CH2OH respectively, in which n is an integer from 6 to 16, and of a second component which is a monounsaturated fatty acid or fatty alcohol represented by the formula CH3—(CnH2(n−1))—COOH or CH3—(CnH2(n−1))—CH2OH respectively, in which n is an integer from 8 to 22, with the provision that the chain lenght of the first component is different from that of the second component, C) a protective liner, which is removed at the moment of use.
    Type: Grant
    Filed: September 15, 1998
    Date of Patent: May 15, 2001
    Assignee: Permatec Technologie AG
    Inventor: Dario Carrara
  • Solubility parameter based drug delivery system and method for altering drug saturation concentration
    Patent number: 6221383
    Abstract: A blend of at least two polymers, or at least one polymer and a soluble polyvinylpyrrolidone, in combination with a drug provides a pressure-sensitive adhesive composition for a transdermal drug delivery system in which the drug is delivered from the pressure-sensitive adhesive composition and through dermis when the pressure-sensitive adhesive composition is in contact with human skin. According to the invention, soluble polyvinylpyrrolidone can be used to prevent crystallization of the drug, without affecting the rate of drug delivery from the pressure-sensitive adhesive composition.
    Type: Grant
    Filed: May 25, 1999
    Date of Patent: April 24, 2001
    Assignee: Noven Pharmaceuticals, Inc.
    Inventors: Jesus Miranda, Steven Sablotsky
  • Sheet pack
    Patent number: 6221382
    Abstract: A sheet pack having a multi-layer moisture-permeable support including a hydrophobic layer and a hydrophilic layer, and a cosmetic substance, and a method for applying the sheet pack, including the steps of supplying moisture to skin and applying the sheet pack to the moisture-supplied skin.
    Type: Grant
    Filed: November 30, 1999
    Date of Patent: April 24, 2001
    Assignee: Kao Corporation
    Inventors: Koichi Ishida, Manabu Kaneda, Yasuhiro Komori
  • Decorative sheet for exterior wall surface
    Patent number: 6214453
    Abstract: A decorative sheet for an exterior wall surface is provided which comprises a flexible nonwoven fabric which is permeable to air and moisture, and a coating layer formed on a front surface of the nonwoven fabric, the coating layer being also flexible and permeable to air and moisture after drying. The coating layer may be releasably covered by a stretchable plastic film. Further, the nonwoven fabric may have a rear surface formed with an air- and moisture-permeable adhesive layer which is covered by a releasable paper.
    Type: Grant
    Filed: January 18, 1995
    Date of Patent: April 10, 2001
    Assignee: Toyokasei Co., Ltd.
    Inventor: Hiromichi Kano
  • Compositions and methods for treatment of attention deficit disorder and attention deficit/hyperactivity disorder with methylphenidate
    Patent number: 6210705
    Abstract: The invention relates to a method of treating Attention Deficit Disorder (ADD) and Attention Deficit/Hyperactivity Disorder (ADHD) and compositions for topical application of methylphenidate comprising methylphenidate in a flexible, finite system wherein the methylphenidate is present in an amount sufficient to achieve substantially zero order kinetics for delivery to the skin or mucosa of a patient in need thereof over a period of time at least 10 hours.
    Type: Grant
    Filed: September 30, 1998
    Date of Patent: April 3, 2001
    Assignee: Noven Pharmaceuticals, NC.
    Inventors: Juan Mantelle, Terese A. Dixon
  • Photoaging inhibitor and skin-care preparation
    Patent number: 6207711
    Abstract: In order to obtain photoaging inhibitor comprising a triterpenoid compound having high safety and excellent photoaging inhibiting effect, a photoaging inhibitor comprises one or more compounds selected from triterpenoid derivatives and salts thereof, wherein the triterpenoid derivatives are derived by substituting a functional group for a hydrogen atom in a carboxyl group at the 28-position and/or a hydrogen atom in a hydroxyl group bonded to a carbon atom at the 3-position of ursolic, oleanolic or betulic acid, wherein at least one of the functional groups is a functional group having an aromatic ring.
    Type: Grant
    Filed: December 22, 1998
    Date of Patent: March 27, 2001
    Assignee: Pola Chemical Industries Inc.
    Inventors: Katsuo Matsumoto, Hiroki Tsuruoka, Norio Fujiwara, Yasutomo Nishimori, Yukiko Kenjo
  • Medical adhesive
    Patent number: 6200595
    Abstract: A medical adhesive which comprises a polyion complex film formed from a polycationic substance and a polyanionic substance. This medical adhesive provides a sufficient gel strength for adhesion of tissues, and it is superior in handling properties and safety for the living body.
    Type: Grant
    Filed: April 22, 1999
    Date of Patent: March 13, 2001
    Assignee: Kuraray Co., Ltd.
    Inventors: Yukiko Motoyashiki, Hideaki Yamada
  • Wet appliable, instant protection sunscreen and makeup and method of use
    Patent number: 6197281
    Abstract: The sunscreen or makeup may be applied to a person who is wet, or even underwater, yet it will provide the fill efficacy which it would have had had it been applied to the person when their skin was dry. In addition, it will be effective from the time that it is first applied, so no waiting period is required, as was the case for the so-called “water resistant” and “waterproof” sunscreens of the prior art. A series of test procedures which illustrate the efficacy of the “wet-appliable” sunscreens of the present invention are disclosed.
    Type: Grant
    Filed: June 4, 1997
    Date of Patent: March 6, 2001
    Inventors: Ernest Glading Stewart, Kenneth Klein
  • Pharmaceutical oral patch for controlled release of pharmaceutical agents in the oral cavity
    Patent number: 6197331
    Abstract: The invention is directed to a controlled-release solid composition for the oral cavity or “pharmaceutical oral patch” that adheres to hard dental surfaces, such as teeth and dentures, and releases an active pharmaceutical agent into the oral cavity. Release of the agent is for a predetermined period of time and at a predetermined sustained concentration. The site of action of the agent is local or systemic.
    Type: Grant
    Filed: July 24, 1997
    Date of Patent: March 6, 2001
    Assignee: Perio Products Ltd.
    Inventors: E. Itzhak Lerner, Vered Rosenberger, Moshe Flashner
  • Hollow reinforcing members and composites containing the same
    Patent number: 6197395
    Abstract: There is disclosed a hollow reinforcing element for casting into composites, which in use defines passageways that may communicate to the exterior of the composite and that can serve as conduit arrays in structures formed from the composite. Benefits include superior strength to weight ratios, reduced thermal stresses, suppression of crack propagation, and improved corrosion protection. The hollow reinforcing elements may also be used to provide antennae, drain systems, leveling devices, containment structures and pneumatic levitation of vehicles.
    Type: Grant
    Filed: December 6, 1993
    Date of Patent: March 6, 2001
    Assignee: Oregon Reinforcing Engineering, LTD
    Inventors: James A. Van Vechten, James R. Lundy, Alan K. Wallace, Chris A. Bell
  • Absorbable E-caprolactone polymers and medical devices
    Patent number: 6197320
    Abstract: Crystalline, low melting -Caprolactone polymers which undergo accelerated hydrolysis, and their use as lubricant coatings and/or as coatings containing bioactive agents, as carriers of viable cells, and as coatings for open-cell microporous template or constucts for tissue regeneration; the polymers bearing basic functionalities can be linked ionically or covalently to the ester chain which induces autocatalyzed hydrolysis.
    Type: Grant
    Filed: June 29, 1998
    Date of Patent: March 6, 2001
    Inventor: Shalaby W. Shalaby
  • Sustained/immediate acting ketoprofen patch and process for manufacturing the same
    Patent number: 6190690
    Abstract: A sustained/immediate acting ketoprofen patch. A moisture permeable backing, a moisture non-permeable primer, a moisture high-permeable drug layer containing ketoprofen and a skin adhesion layer controlling release of a drug solution are piled up. An ethyl acetate soluble acrylic/rubber adhesive is coated onto a silicon coated paper, dried and transfer coated onto the backing to form the primer. The drug layer is formed by coating a drug solution onto a silicon coated paper, drying and transfer coating onto the primer. The skin adhesion layer is formed by coating a mixture of a solution prepared by dissolving an emulsifier in ethyl acetate and acrylic adhesive, drying and transfer coating onto the drug layer. The ketoprofen patch has a drug release controlling function and a good adhesion strength. The drug transferring effect through the skin is good.
    Type: Grant
    Filed: June 27, 1997
    Date of Patent: February 20, 2001
    Assignee: STC Corporation
    Inventors: Chang-Kyu Park, Jae-Keun Choi, Kwang-Ho Lee, Byong-Chul Hyun, Yi-Dan Ha
  • Pharmaceutical compositions containing hydroxycarboxylic acid and/or ketocarboxylic acids and methods of using the same
    Patent number: 6191167
    Abstract: Preventive as well as therapeutic treatment to alleviate cosmetic conditions and symptoms of dermatologic disorders with amphoteric compositions containing alpha hydroxyacids, alpha ketoacids, related compounds or polymeric forms of hydroxyacids is disclosed. The cosmetic conditions and the dermatologic disorders in which the amphoteric compositions and the polymeric compounds may be useful include dry skin, dandruff, acne, keratoses, psoriasis, eczema, pruritus, age spots, lentigines, melasmas, wrinkles, warts, blemished skin, hyperpigmented skin, kyperkeratotic skin, inflammatory dermatoses, skin changes associated with aging, and skin requiring cleansers.
    Type: Grant
    Filed: February 23, 1999
    Date of Patent: February 20, 2001
    Assignee: Tristrata Technology, Inc.
    Inventors: Ruey J. Yu, Eugene J. Van Scott
  • Powdered pharmaceutical formulations having improved dispersibility
    Patent number: 6187344
    Abstract: Dispersibility of a respirable powder, administrable by inhalation, is increased by including a pharmaceutically acceptable water-soluble polypeptide.
    Type: Grant
    Filed: July 31, 1997
    Date of Patent: February 13, 2001
    Assignee: Inhale Therapeutic Systems
    Inventors: Mohammed Eljamal, John S. Patton, Linda C. Foster, Robert M. Platz
  • Stabilized pharmaceutical preparation
    Patent number: 6187340
    Abstract: A stabilized pharmaceutical preparation which is coated with a coating agent comprising an agent for the protection from light, said agent being capable of producing free radicals when exposed to ultraviolet rays, and a free radical scavenger; which is stable to light, especially ultraviolet rays, or heat, and which has excellent storage-stability.
    Type: Grant
    Filed: September 9, 1998
    Date of Patent: February 13, 2001
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Makoto Fukuta, Hiroki Itoh
  • Method of increasing cell renewal rate
    Patent number: 6184247
    Abstract: The present invention relates to a method of enhancing the rate of skin desquamation by incorporating an ascorbic acid derivative into a cosmetic composition suitable for application to mammalian skin. The ascorbic acid derivative is selected from the group consisting of esters of ascorbic acid, salts, and mixtures thereof. The esters are generally selected from fatty acid mono-, di-, tri-, or tetra-esters. The salts are generally selected from ascorbyl phosphates, ascorbyl sulfates, and mixtures thereof.
    Type: Grant
    Filed: May 21, 1999
    Date of Patent: February 6, 2001
    Assignee: Amway Corporation
    Inventor: Louise M. Schneider
  • Hydrogel wound dressing and the method of making and using the same
    Patent number: 6180132
    Abstract: A hydrogel wound dressing which is highly absorptive, contours to a wound site and maintains the wound in a moist state to promote healing thereof.
    Type: Grant
    Filed: September 17, 1998
    Date of Patent: January 30, 2001
    Assignee: Sherwood Services, AG
    Inventors: Yeong Hua Huang, Stephen B. Earhart, William R. Fiehler