Abstract: A composition for prophylaxis and therapy of dermal aging which comprises a substance having human leukocyte elastase inhibitory activity as an active ingredient.

Abstract: Cosmetic skin compositions containing a weak carboxylic acid and a random copolymer of ethylene oxide and propylene oxide. The copolymer reduces skin irritation that is sometimes caused by the weak acid active without reducing delivery of weak acids to skin tissues.

Abstract: A compound of formula I wherein A is a moiety which provides UV absorbing activity to the compound of formula I that comprises 1 divalent group or 2 monovalent groups, with at least one group having carbonyl (C═O) functionality, and each R is independently linear or branched C1-C8 alkyl. Sunscreen formulations which contain these compounds and methods using these compounds to prepare formulations are also provided.

Abstract: Cosmetic skin care methods and compositions containing methyl-branched esters. The inventive compositions provide control of sebum secretion from sebocytes, improved oil control and improved skin feel, prevent shine and stickiness, while also. providing anti-aging benefits which results in reduced appearance of wrinkles and aged skin, improved skin color, treatment of photoaged skin, improvement in skin's radiance and clarity and finish, and an overall healthy and youthful appearance of the skin.

Abstract: The present invention relates to a preparation process for 2-arylbenzimidazolesulfonic acids of the formula I: Ar is a substituted or unsubstituted phenyl or naphthyl radical and R is a C1-8-alkyl or C1-8-alkoxy radical. n is 1-4, m is 1-3 and o is 0-2. o-phenylenediamine is reacted in the presence of oleum with an arylcarboxylic acid or an arylcarboxylic acid derivative. Compounds prepared in this way can be used as UV filters, and as components in cosmetic compositions.

Abstract: The present invention concerns the food, cosmetic and pharmaceutical compositions including a compound of general formula: alone or in combination, as an ingredient for food, cosmetic, pharmaceutical, and perfume compositions, wherein R1 includes N-Pyrrolidinyl, N-Pyridinyl, N-(amino-diethyl), N-(2-carboxy-pyrrolidinyl), N-(2-Methoxycarbonyl-pyrrolidinyl), or a combination thereof; R2 includes hydrogen, methyl, or a combination thereof; X includes methylene, ethylidene, 1-Propylidene, oxy radical, or a combination thereof; and Y includes methylene, ethylidene, 1-propylidene, oxy radical, ethan-1,2-diyl, ethen-1,2-diyl, propan-1,2-diyl, ethan-1,2-oxy-1,2-yl, or a combination thereof. Food products containing such compositions, as well as methods of imparting a cooling effect on a consumer's skin, are also included.

Abstract: The invention provides methods for diagnosing and treating amyloid-related conditions and compounds useful for the same. The invention provides for detecting, imaging, monitoring, diagnosing, and treating conditions characterized by the binding or aggregation of amyloid fibrils. More particularly, the invention relates to using quinolinehydrazone compounds for diagnosing and treating amyloidotic conditions and also as an antioxidant.

Abstract: There is provided a topical composition for treating and/or preventing skin irritation induced by a retinoid. The composition has comfrey. There is also provided a method for treating and/or preventing skin irritation induced by a retinoid. An effective amount of comfrey is applied to the skin.

Abstract: This invention directs to a method of assessing the concentration of an inhalational compound in the brain of a subject. The method includes administering a gas containing the compound into a subject to fill the pulmonary functional residual capacity, which is defined as the remaining lung volume at the end of an unforced respiration. The method also includes measuring an inspired compound concentration (Cl′) and an expired compound concentration (Ce′) after having filled the functional residual capacity with the gas. Therefore, a mixed venous compound concentration (Cb′) can be assessed based on the formula Cb′=[Ci′(M−1)+Ce′]/M, in which M is an alveolar membrane factor for the compound; and a brain compound concentration (Cb) can be assessed based on the formula Cb=(Ce′+Cb′)/2.

Abstract: The present invention relates to a cosmetic composition which comprises at least one crosslinked, water-soluble or water-dispersible polyurethane formed from A) at least one polyurethane prepolymer having terminal isocyanate groups, and B) at least one polymer having isocyanate-reactive groups selected from hydroxyl, primary and secondary amino and/or carboxyl groups, at least one of components A) and/or B) being soluble or dispersible in water and at least one of components A) and/or B) comprising at least one siloxane group, and the salts thereof.

Abstract: The invention relates to the calcium complex of [[(4R)-4-[bis[(carboxy-.kappa.O)methyl]amino-.kappa.N]-6,9-bis[(carboxy-.kappa.O)methyl]-1-[(4,4-diphenylcyclohexyl)oxy]-1-hydroxy-2-oxa-6,9-diaza-1-phosphaundecan-11-ylic-acid-.kappa.N6,.kappa. N9,.kappa.011]1-oxidato(6-)]-, tetrahydrogen(MS-325) and its salts, pharmaceutical agents that contain these complexes, for the production of agents for the reduction of effects that are caused by heavy metals as well as processes for their production.

Abstract: The invention relates to a cosmetic product that contains enzymes and has an intensive skin action, especially a regenerative effect The inventive cosmetic product contains 0.01 to 5 wt. % of a concentrate of the coconut milk of Cocos nucifera, containing peroxidase, lipase and protease; 0.1 to 10 wt. % of a plant milkwater, the plants being selected from the following group: banana, dandelion, convolvus, poppy, soya and mixtures thereof; and 0.01 to 5 wt. % of a glycerol extract of a mixture consisting of honey, rice hulls, rice hull oil and/or rice germ oil; with the remainder consisting of cosmetic auxiliary agents, active agents and carrier substances.

Abstract: Indolecarboxylic acid compounds and derivatives thereof are useful for treating seboarhea and the dermatitides associated therewith, especially acne and/or blackheads and/or comedones.

Abstract: A method is provided for inhibiting free radical degradation in the skin of a human or nonhuman animal comprising contacting the skin with a skin treatment composition having a concentration of a 1-(3-methoxybenzyl)-3-substituted thiourea compound effective for inhibiting free radical generation. Skin protecting compositions comprising a free radical inhibiting concentration of a 1-(3-methoxybenzyl)-3-substituted thiourea compound, and optionally a sunscreeen composition, are also provided.

Abstract: Indolecarboxylic acid compounds and derivatives thereof, notably 4,6-dimethoxyindole-2-carboxylic acid and derivatives thereof, are especially useful for inducing/stimulating mammalian hair growth and/or preventing/retarding mammalian hair loss.

Abstract: A controlled release microcapsule pharmaceutical formulation for burst-free, sustained, programmable release of a non-steroidal, antiinflammatory drug over a duration from 24 hours to 2 months, comprising: a non-steroidal, antiinflammatory drug and a blend of biocompatible, biodegradable poly (lactide/glycolide).

Abstract: This invention relates to a novel lipid composition for use in cosmetics capable of increasing moisture-keeping ability or barrier function of the stratum corneum, protecting the skin and improving dry or rough skin, and to products which use the same, such as cosmetics and medicaments. Particularly, it relates to a lipid composition which comprises at least one component (A) selected from the group consisting of a 2-acylaminoalkane-1,3-diol and optically active compounds thereof, at least one component (B) selected from the group consisting of a 2-acylaminoalkane-1,3-diol in which at least one of the &agr;-position and &bgr;-position of the acyl group is substituted with hydroxyl group and optically active compounds thereof and at least one component (C) selected from sterols, wherein the components (A), (B) and (C) are mixed at a ratio that constructs a liquid crystal structure, and to products which contain the lipid composition, such as cosmetics and medicaments.

Abstract: Non-hydroxyalkylated cyclodextrins are disclosed wherein at least one primary alcohol function (CH2OH) is substituted, the —OH portion being replaced by a substituent with formula —O—CO—R or —NR1R2, where: R, R1 and R2 independently represent a linear or cyclic, saturated or unsaturated, hydroxylated or non-hydroxylated alkyl group containing 1 to 30 carbon atoms, preferably 1 to 22 carbon atoms, more preferably a fatty chain containing 2 to 22 carbon atoms. These cyclodextrins are used as vectors for at least one active ingredient, in particular to encourage tissue penetration, in a cosmetic application, or for the production of pharmaceutical compositions, in particular dermopharmaceuticals.

Abstract: The hydroxystilbenes are well suited for reducing or inhibiting the glycation of certain substrates, for example the proteins of nails and/or hair, advantageously to preventatively and/or curatively combat glycation-related aging of the nails/hair.

Abstract: An endermic liniment which characteristically contains an extract from a plant of the Solanaceae family (Solanaceae), genus Withania (Withania). A whitening endermic liniment with a superior whitening effect can be provided.