Patents Examined by Michael Bozin
  • Inhibitors of interleukin-1.beta. converting enzyme
    Patent number: 5847135
    Abstract: The present invention relates to novel classes of compounds which are inhibitors of interleukin-1.beta. converting enzyme. The ICE inhibitors of this invention are characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting ICE activity and consequently, may be advantageously used as agents against interleukin-1 mediated diseases, including inflammatory diseases, autoimmune diseases and neurodegenerative diseases. This invention also relates to methods for inhibiting ICE activity and methods for treating interleukin-1 mediated diseases using the compounds and compositions of this invention.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: December 8, 1998
    Assignee: Vertex Pharmaceuticals, Incorporated
    Inventors: Guy W. Bemis, Julian M. C. Golec, David J. Lauffer, Michael D. Mullican, Mark A. Murcko, David J. Livingston
  • Peptides having farnesyl transferase inhibiting properties and strain of genus streptomyces for producing same
    Patent number: 5734013
    Abstract: A Steptomyces No. CBS 154.94 strain, mutants or derivatives thereof, and a method for preparing peptides using said strain, are disclosed. Novel peptides of general formula (1), pharmaceutical compositions containing same, and the use thereof in cancer therapy, are also disclosed.
    Type: Grant
    Filed: September 27, 1996
    Date of Patent: March 31, 1998
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Jean-Jacques Debernard, Thierry Flamant, Didier Van Der Pyl