Patents Examined by Michael C. Chen
  • Polypeptides encoded by DNA sequences derived from the genome of the papillomavirus HPV39, antibodies thereto, and their use in in vitro diagnosis
    Patent number: 5665535
    Abstract: Polypeptides encoded by genes of papillomavirus HPV39 are provided. Also provided are antibodies directed to the polypeptides, and methods for diagnosing genital neoplasias and for detecting infection by HPV39.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: September 9, 1997
    Assignees: Institut National de la Sante et de la Recherche Medicale, Institut Pasteur
    Inventors: Gerard Orth, Christoph Volpers, Rolf E. Streeck
  • Determined DNA sequences derived from a papillomavirus genome, their uses for in vitro diagnostic purposes and the production of antigenic compositions
    Patent number: 5648459
    Abstract: The invention concerns DNA fragments derived from the genomic DNA of HPV-33. These fragments are selected from the group of fragments extending between the nucleotide extremities defined hereafter in relation to the nucleotide-numbering in FIGS. 1a and 1b respectively:76-556543-864867-28112728-38083326-35753842-40794198-56115516-8091.The invention also relates to the use of these fragments as probes for the detection of HPV in tissue cultures.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: July 15, 1997
    Assignee: Institut Pasteur
    Inventors: Stewart Cole, Rolf E. Streeck
  • Chimeric papillomavirus-like particles
    Patent number: 5618536
    Abstract: The present invention provides a papillomavirus-like particle, characterized as having conformational epitopes, comprising a papillomavirus L1 product and a papillomavirus L2 fusion product; and related synthetic DNA molecules, host cells, methods and vaccines.
    Type: Grant
    Filed: October 6, 1994
    Date of Patent: April 8, 1997
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Douglas R. Lowy, John T. Schiller, Heather Greenstone