Patents Examined by Michael C. Henry
  • Patent number: 10420793
    Abstract: Aspects of the invention provide compositions for use in the treatment galectin-dependent diseases. In particular, compositions comprising a selectively depolymerized, branched galactoarabino-rhamnogalacturonate whose backbone is predominantly comprised of 1,4-linked galacturonic acid (GalA) moieties, with a lesser backbone composition of alternating 1,4-linked GalA and 1,2-linked rhamnose (Rha), which in-turn is linked to any number of side chains, including predominantly 1,4-b-D-galactose (Gal) and 1,5-a-L-arabinose (Ara) residues.
    Type: Grant
    Filed: May 8, 2018
    Date of Patent: September 24, 2019
    Assignee: Galectin Therapeutics, Inc.
    Inventors: Eliezer Zomer, Peter G. Traber, Anatole A. Klyosov, Elena Chekhova
  • Patent number: 10307440
    Abstract: A graft composition intended for transplantation into a human patient comprises an injection solution comprising an isolated therapeutic cell transplant, wherein the therapeutic cell transplant is therapeutic to a human patient, and dextran sulfate, or a pharmaceutically acceptable salt thereof, having an average molecular weight of less than 20,000 Da.
    Type: Grant
    Filed: January 20, 2016
    Date of Patent: June 4, 2019
    Assignee: TX Medic AB
    Inventors: Bo Nilsson, Olle Korsgren
  • Patent number: 10292924
    Abstract: The invention relates to a mixture composition comprising rhamnolipids, to a process for its preparation, to its use for producing formulations and to formulations comprising this mixture composition.
    Type: Grant
    Filed: April 2, 2014
    Date of Patent: May 21, 2019
    Assignee: Evonik Industries AG
    Inventors: Martin Schilling, Christian Hartung, Fabien Cabirol, Steffen Schaffer, Petra Allef
  • Patent number: 10287309
    Abstract: The present invention relates to a disaccharide intermediate and a synthesis method thereof, relates to the chemical pharmaceutical field, and more specifically relates to a method for preparing a disaccharide segment of a key intermediate for chemically synthesizing heparin and heparinoid compounds. Disclosed are a new disaccharide intermediate and three methods for synthesizing the disaccharide intermediate, that is, compounds of a formula (4) and glucopyranose protected by different anomeric carbon are made to react in the presence of an active agent, to obtain the disaccharide intermediate. According to the technical solutions of the present invention, synthetic raw materials are easy to obtain, have a mild reaction condition, and are suitable for industrialized production.
    Type: Grant
    Filed: April 28, 2014
    Date of Patent: May 14, 2019
    Assignee: Zhejiang Hisun Pharmaceutical Co., Ltd.
    Inventors: Yanghui Guo, Junhui Zhou, Qingfeng Cai, Hegeng Wei, Hua Bai, Fei Long, Yue Zhang, Yingqiu Wu
  • Patent number: 10278912
    Abstract: Provided herein are microalgal polysaccharide compositions and. Also provided are methods of using polysaccharides for applications such as topical personal care products, cosmetics, and wrinkle reduction compositions. The invention also provides novel microalgal compositions useful for improving the health and appearance of skin. The invention also includes insoluble polysaccharide particles for application to human skin.
    Type: Grant
    Filed: November 25, 2014
    Date of Patent: May 7, 2019
    Assignee: Algenist Holdings, Inc.
    Inventors: Anna Coragliotti, Scott Franklin, Anthony G. Day, Stephen M. Decker
  • Patent number: 10272065
    Abstract: The present document describes a synthesis of a class of gem-difluorinated C-glycoside compounds derived from podophyllotoxin, which may be used, but not exclusively, in oncology for the treatment of cancer. More particularly, the podophyllotoxin gem-difluorinated C-glycoconjugated derivatives display improved conformational and chemical stability, and improved cytotoxicity exhibited against drug-resistant cancer cell lines.
    Type: Grant
    Filed: January 13, 2014
    Date of Patent: April 30, 2019
    Assignee: Benoit & Côté
    Inventor: Steve N. Slilaty
  • Patent number: 10265340
    Abstract: Immune function of an animal can be modulated by administration of a composition that includes beta glucan. The beta glucan can be derived from Euglena, which provides a form of beta glucan that is different from other organisms, where the beta glucan is predominantly unbranched beta-(1,3)-glucan. Beta glucan can also be complexed with a metal, such as zinc, and/or can combined with an animal feed component to form an animal feed composition. Use of such compositions can improve the well being of an animal, and may augment or even replace the use of antibiotics in certain circumstances.
    Type: Grant
    Filed: February 22, 2013
    Date of Patent: April 23, 2019
    Assignee: KEMIN INDUSTRIES, INC.
    Inventors: Jeffrey Richard LeBrun, Robert Levine, Geoffrey Paul Horst
  • Patent number: 10258579
    Abstract: A process for the preparation of nanoparticles from polysaccharides and derivatives thereof, by their specific partial oxidation to produce aldehyde groups and attachment of compounds with amino or other group with the R—NH2 bond which react with aldehyde groups, and a nanoparticle produced by such process.
    Type: Grant
    Filed: September 12, 2014
    Date of Patent: April 16, 2019
    Assignee: NANOVELOS SP. Z O.O.
    Inventors: Tomasz Ciach, Iga Wasiak
  • Patent number: 10253140
    Abstract: The present invention aims to provide a polyrotaxane-containing composition having excellent transparency. The present invention relates to a polyrotaxane-containing composition including: a polyrotaxane that has a cyclic molecule, a linear molecule threading through a cavity of the cyclic molecule in a skewered manner, and capping groups capping both ends of the linear molecule; and an alkyl (meth) acrylate that has a C4-C18 alkyl group, the polyrotaxane having at least one cyclic molecule that has a C4-C18 alkyl group.
    Type: Grant
    Filed: October 6, 2014
    Date of Patent: April 9, 2019
    Assignees: Sumitomo Seika Chemicals Co., Ltd., Advanced Softmaterials Inc.
    Inventors: Yusaku Masuhara, Naoki Sainou, Naoyuki Hashimoto
  • Patent number: 10174128
    Abstract: Provided is a method for producing low-substituted hydroxypropyl cellulose with less yellowing. More specifically, the method for producing purified low-substituted hydroxypropyl cellulose includes the steps of: reacting alkali cellulose and an etherifying agent to obtain a reaction mixture; dispersing the reaction mixture in water containing a portion of acetic acid necessary for neutralizing the total amount of the reaction mixture to neutralize a portion of the reaction mixture, and then completely neutralizing with the remaining acetic acid to cause precipitation, to obtain a slurry containing crude low-substituted hydroxypropyl cellulose; disintegrating a solid component in the slurry through a cutter pump, the solid component containing the crude low-substituted hydroxypropyl cellulose, and discharging the slurry containing the disintegrated solid component; washing the discharged slurry with water to obtain a cake of purified low-substituted hydroxypropyl cellulose; and drying the cake.
    Type: Grant
    Filed: November 14, 2013
    Date of Patent: January 8, 2019
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Akira Kitamura, Atsuhiko Yonemochi, Mitsuo Narita
  • Patent number: 10125016
    Abstract: Disclosed are cyclodextrin-based metal organic frameworks comprising a metal cation and cyclodextrin or a cyclodextrin derivative. These metal organic frameworks are permanently porous and capable of molecule storage.
    Type: Grant
    Filed: July 20, 2015
    Date of Patent: November 13, 2018
    Assignee: Northwestern University
    Inventors: J. Fraser Stoddart, Ronald A. Smaldone, Ross S. Forgan, Jeremiah J. Gassensmith
  • Patent number: 10098948
    Abstract: Objective of the present invention is to provide polysaccharides which modulate immune response, and which can be used as ingredients in edible products or pharmaceutical compositions. The present invention provides such polysaccharides obtained from the species Camellia sinensis, which comprise a rhamnogalacturonan-I core, and wherein the molar ratio of galacturonyl acid residues to rhamnosyl residues in the backbone of the polysaccharide is close to 1:1. The present invention also provides edible products or pharmaceutical compositions containing such polysaccharides, in order to modulate immune response.
    Type: Grant
    Filed: February 8, 2016
    Date of Patent: October 16, 2018
    Assignee: NUTRILEADS B.V.
    Inventors: Ruud Albers, Jari Helin, Werner Klaffke, Jean Hypolites Koek, Petronella Anna Kreijveld, Jari Natunen, Erwin Werner Tareilus, Richardus Paulus Anton Oranje
  • Patent number: 10076534
    Abstract: The inventors have determined, contrary to the prior art and experience, how to successfully use triciribine to treat ovarian cancer by one or a combination of (i) administering triciribine only to patients which according to a diagnostic test described below, exhibit enhanced sensitivity to the drug; (ii) use of a described dosage level that minimizes the toxicity of the drug but yet still exhibits efficacy; or (iii) use of a described dosage regimen that minimizes the toxicity of the drug.
    Type: Grant
    Filed: July 25, 2016
    Date of Patent: September 18, 2018
    Assignee: University of South Florida
    Inventor: Jin Q. Cheng
  • Patent number: 10053483
    Abstract: Provided in the present invention are novel key intermediates of selamectin and the preparation method thereof. Also provided is a new synthesis process, using doramectin as a starting material, and obtaining selamectin via hydrogenation, oxidation, oximation and desugaring. The new process of the present invention has few steps, and is simple to operate, high in yield, low in cost and causes little pollution, and is more suitable for large scale industrial production.
    Type: Grant
    Filed: April 2, 2013
    Date of Patent: August 21, 2018
    Assignee: Zhejiang Hisun Pharmaceutical Co., Ltd.
    Inventors: Mingxing Yin, Jianchao Wu, Jian Chai
  • Patent number: 10052373
    Abstract: The present invention provides a protein- and peptide-free conjugate comprising a synthetic carbohydrate and a carrier molecule, wherein the synthetic carbohydrate is a Streptococcus pneumoniae type 3 capsular polysaccharide related carbohydrate and the carrier molecule is a glycosphingolipid. Said conjugate and pharmaceutical composition thereof are useful for immunization against diseases associated with Streptococcus pneumoniae, and more specifically against diseases associated with Streptococcus pneumoniae type 3.
    Type: Grant
    Filed: September 18, 2014
    Date of Patent: August 21, 2018
    Assignee: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
    Inventors: Dominea Rathwell, Sharavathi Guddehalli Parameswarappa, Subramanian Govindan, Chakkumkal Anish, Claney Lebev Pereira, Peter H. Seeberger, Felix Bröcker
  • Patent number: 10047170
    Abstract: There is provided a process for the preparation of purified ?-(1,3)-D-glucans, comprising the steps of providing an aqueous ?-(1,3)-D-glucan initial solution having a pH of above 11.0, filtering the aqueous ?-(1,3)-D-glucan initial solution to obtain a ?-(1,3)-D-glucan containing filtrate, adjusting the pH of the ?-(1,3)-D-glucan containing filtrate with an acid to a pH of below 5.0 to obtain an acidic ?-(1,3)-D-glucan solution, and heating the acidic ?-(1,3)-D-glucan solution to a temperature in the range of 60 to 160° C.
    Type: Grant
    Filed: October 16, 2014
    Date of Patent: August 14, 2018
    Assignee: Cargill, Incorporated
    Inventors: Jacques André Christian Mazoyer, Jean-Pierre Lhonneur
  • Patent number: 10047168
    Abstract: There is provided a process for the preparation of purified ?-(1,3)-D-glucans, comprising the steps of providing an aqueous ?-(1,3)-D-glucan initial solution having a pH of above 11.0, filtering the aqueous ?-(1,3)-D-glucan initial solution to obtain a ?-(1,3)-D-glucan containing filtrate, adjusting the pH of the ?-(1,3)-D-glucan containing filtrate with an acid to a pH of below 5.0 to obtain an acidic ?-(1,3)-D-glucan solution, and heating the acidic ?-(1,3)-D-glucan solution to a temperature in the range of 60 to 160° C.
    Type: Grant
    Filed: October 16, 2014
    Date of Patent: August 14, 2018
    Assignee: Cargill. Incorporated
    Inventors: Jacques André Christian Mazoyer, Jean-Pierre Lhonneur
  • Patent number: 10047169
    Abstract: There is provided a process for the preparation of purified ?-(1,3)-D-glucans, comprising the steps of providing an aqueous ?-(1,3)-D-glucan initial solution having a pH of above 11.0, filtering the aqueous ?-(1,3)-D-glucan initial solution to obtain a ?-(1,3)-D-glucan containing filtrate, adjusting the pH of the ?-(1,3)-D-glucan containing filtrate with an acid to a pH of below 5.0 to obtain an acidic ?-(1,3)-D-glucan solution, and heating the acidic ?-(1,3)-D-glucan solution to a temperature in the range of 60 to 160°C.
    Type: Grant
    Filed: October 16, 2014
    Date of Patent: August 14, 2018
    Assignee: Cargill, Incorporated
    Inventors: Jacques André Christian Mazoyer, Jean-Pierre Lhonneur
  • Patent number: 10035863
    Abstract: There is provided a process for the preparation of purified ?-(1,3)-D-glucans, comprising the steps of providing an aqueous ?-(1,3)-D-glucan initial solution having a to pH of above 11.0, filtering the aqueous ?-(1,3)-D-glucan initial solution to obtain a ?-(1,3)-D-glucan containing filtrate, adjusting the pH of the ?-(1,3)-D-glucan containing filtrate with an acid to a pH of below 5.0 to obtain an acidic ?-(1,3)-D-glucan solution, and heating the acidic ?-(1,3)-D-glucan solution to a temperature in the range of 60 to 160° C.
    Type: Grant
    Filed: October 16, 2014
    Date of Patent: July 31, 2018
    Assignee: Cargill, Incorporated
    Inventors: Jacques André Christian Mazoyer, Jean-Pierre Lhonneur
  • Patent number: 10030078
    Abstract: Processes for making reduced molecular weight ethersuccinylated polysaccharides, for example ethersuccinylated starches are provided.
    Type: Grant
    Filed: February 18, 2016
    Date of Patent: July 24, 2018
    Assignee: The Procter & Gamble Company
    Inventor: Stephen Wayne Heinzman