Abstract: The present invention provides variant HSV-1 glycoprotein D and HSV-2 glycoprotein D molecules capable of preventing infection of cells by herpes simplex virus types 1 and/or 2. Also provided are novel purified and isolated polynucleotides encoding the variant gD molecules. HSV gD-1 and gD-2 region IV variants or fragments thereof are specifically contemplated by the invention. The presently preferred variant molecule gD-1(.DELTA.290-299t) is the product of recombinant expression in Sf9 cells of a fusion protein including the signal peptide of honeybee melittin and Patton strain HSV-1 gD wherein (1) the Patton strain amino acid residues 290 through 299 of the mature gD-1 protein have been replaced with the amino acid residues arginine, lysine, isoleucine and phenylalanine, and (2) Patton strain amino acid residues 308 through 369 have been replaced with five histidine residues.
Type:
Grant
Filed:
July 7, 1995
Date of Patent:
August 5, 1997
Assignee:
Competitive Technologies, Inc.
Inventors:
Gary H. Cohen, Roselyn J. Eisenberg, Anthony Nicola
Abstract: The invention describes the isolation for the first time of human papilloma virus (HPV) 57, the partial characterization of its genome and its cloning in pUC 19. This opens up a way of diagnosing those tumors (oral, genital and cutaneous tumors) which are associated with HPV 57.
Type:
Grant
Filed:
June 7, 1995
Date of Patent:
April 8, 1997
Assignee:
Behringwerke Aktiengesellschaft
Inventors:
Ethel-Michele de Villiers, Anja Hirsch-Behnam, Harald zur Hausen
Abstract: The invention relates to seroreactive regions on proteins E1 and E2 of human papillomavirus (HPV) 16.The application also relates to a vaccine which contains such peptides which contain the seroreactive regions.The invention likewise embraces compositions for diagnostic purposes which contain peptides with the seroreactive regions.
© 2023 Justia
