Abstract: Apparatuses, systems and methods are provided for treating pulmonary tissues via delivery of energy, generally characterized by high voltage pulses, to target tissue using a pulmonary tissue modification system (e.g., an energy delivery catheter system). Example pulmonary tissues include, without cells), lamina propria, submucosa, submucosal glands, basement membrane, smooth muscle, cartilage, nerves, pathogens resident near or within the tissue, or a combination of any of these. The system may be used to treat a variety of pulmonary diseases or disorders such as or associated with COPD (e.g., chronic bronchitis, emphysema), asthma, interstitial pulmonary fibrosis, cystic fibrosis, bronchiectasis, primary ciliary dyskinesia (PCD), acute bronchitis and/or other pulmonary diseases or disorders.

Abstract: The present disclosure relates generally to the field of medical devices. In particular, the present disclosure relates to methods and devices to enhance radial spray from a catheter. Extension devices for a radial spray catheter, including radial cryospray catheters, are disclosed.

Abstract: Described herein is a system including a catheter, an optical circuit, a pulsed field ablation energy source, and a processing device. The catheter includes a proximal section, a distal section, and a shaft coupled between the proximal section and the distal section. The optical circuit is configured to transport light at least partially from the proximal section to the distal section and back. The pulsed field ablation energy source is coupled to the catheter and configured to transmit pulsed electrical signals to a tissue sample. The processing device is configured to analyze one or more optical signals received from the optical circuit to determine changes in polarization or phase retardation of light reflected or scattered by the tissue sample, and determine changes in a birefringence of the tissue sample based on the changes in polarization or phase retardation.

Abstract: Medical catheterization is carried out by introducing a catheter into a heart, sliding the catheter through a sheath that encloses a multi-electrode probe into a chamber of the heart. The sheath is retracted to expose the probe. As the sheath is retracted the exposed probe expands into a spiral configuration, and the electrodes contact the endocardial surface of the chamber at multiple contact points.

Abstract: A catheter is disclosed comprising a catheter shaft including a proximal end and a distal end. A flexible framework can be connected to the distal end of the catheter shaft, wherein the flexible framework includes a plurality of heating electrodes and a temperature sensor. The plurality of heating electrodes can be configured to be heated to a first temperature, the first temperature being lower than which radio frequency ablation is performed. The plurality of heating electrodes can be configured to be heated to a second temperature, the second temperature being a temperature at which radio frequency ablation is performed.

Abstract: The present invention relates to an RF treatment apparatus including micro needles, a method of controlling the same, and a treatment method using the same according to the present invention have effects in that they can prevent damage to a tissue and perform optimized treatment because RF energy can be adjusted and applied based on a current-carrying area that belongs to a portion of the micro needles and that has been inserted into a tissue.

Abstract: A cryoprobe having a working tip formed of two coaxial flexible internal and external tubular lines, wherein the cross-section diameter of the internal line is substantially smaller than the cross-section diameter of the external line, and the length is slightly smaller than the length of the external line. The external line ends with a top closing the working tip of the cryoprobe, while the end of the internal line is open, and there are openings evenly distributed across the circumference on at least half of the section of the internal line. On the section from the handle to the end located under the top, a resistance wire is spirally wound on the internal line, wherein the distance between the wall of the external line and the wall of the internal line is larger than the diameter of the resistance wire. On the external line, no further from the top located on the top of the working tip than ? of the length thereof, there is a temperature sensor connected to the handle by a power line.

Abstract: A screening method for identifying a target nerve to ablate in the treatment of inflammatory lung disease including chronic obstructive pulmonary disease and asthma. The method includes advancing a tool along the airway and into the vicinity of the candidate nerve. The candidate nerve is temporarily blocked or paralyzed. The patient is monitored for an adverse reaction during the step of temporarily blocking. If an adverse reaction is not observed, the candidate nerve is identified as the target nerve. In embodiments, the method further includes the step of ablating the target nerve.

Abstract: A treatment device using a high frequency according to the present invention includes: a plurality of electrodes which transfers high frequency energy to the skin; a plurality of pads each of which is provided on one surface thereof with at least one of the electrodes; and a plurality of elastic members which independently and elastically support the other surfaces of the plurality of pads, respectively, so that plurality of electrodes can be three-dimensionally and closely attached to the curved surface of the skin. Accordingly, even when treating a body region having many curves, the attachment of the electrodes is efficiently maintained. In addition, although a hand piece moves in a state in which the plurality of pads are attached to skin, the plurality of pads can be maintained in the skin attached state while actively coping with the curves.

Abstract: An electrosurgical instrument used in electrosurgery, and includes a handpiece to be gripped by a user and provided with an accommodation space therein; a cable coupled to a rear end of the handpiece so as to transmit electrical energy; a conductive electrode, at least a portion of which protrudes toward a front side of the handpiece and which is configured to move in a front-rear direction relative to the handpiece; and a connecting body provided in the accommodation space and including a conductor electrically connecting the cable and the conductive electrode to each other, and a film formed of a non-conductive material and bonded to opposite sides of the conductor so as to shield the conductor, wherein at least a portion of the connecting body is formed of a Flexible Printed Circuit Board (FPCB) and is formed in a spiral or helical shape such that the total length of the connecting body is variable in the front-rear direction.

Abstract: Skin treatment apparatus comprising an energy applicator structure configured to establish heating or ablation at a predetermined and controllable (i.e. selectable) depth below a surface of skin tissue with which it is in contact. The applicator structure may receive a cooling medium and microwave frequency electromagnetic energy, which provide a combined treatment effect that results in heating or ablation in a zone beneath the skin surface. The applicator may be a waveguide (e.g. waveguide horn antenna) with internal shielding configured to provide a substantially uniform heating effect. The applicator may include a thermal camera to monitor treatment.

Abstract: This invention provides a device for mapping and ablating the renal nerves distributed on renal artery, having a guide catheter, a mapping-ablation catheter, a handle and a connector. The guide catheter has at least one lumen and a distal end with adjustable curvature. The mapping-ablation catheter is housed in one of the lumens of the guide catheter and its distal end has one or more electrodes and one or more detecting devices. The distal end of the mapping-ablation catheter is curved, rotatable, and can be extended out of or retracted into the guide catheter. The handle connects the guide catheter and mapping-ablation catheter, and has one or more controlling components for controlling the movement of the guide catheter and mapping-ablation catheter. The connector is designed to supply energy to the electrodes.

Abstract: Cardiac ablation catheters include an outer balloon positioned at a distal end of the catheter and configured to have an inner balloon disposed therein. The outer balloon is inflated with a first fluid that has a temperature less than 100 degrees Celsius, while the inner balloon is inflated with heated vapor. An area of contact between the two balloons, comprising a surface area less than the total surface area of either balloon, creates a hot zone for ablating cardiac tissue through the transfer of thermal energy from the contact area to the cardiac tissue.

Abstract: Embodiments of medical devices and methods are disclosed. The medical devices typically comprises a needle with a rigid proximal shaft, a flexible distal shaft and a distal tip. The distal tip includes an electrode for delivering energy to puncture a tissue. In some embodiments, the distal shaft comprises a superelastic material. In other embodiments, the distal shaft is comprised of both a superelastic material and a non-superelastic material.

Abstract: A device positionable in a cavity of a bodily organ (e.g., a heart) may discriminate between fluid (e.g., blood) and non-fluid tissue (e.g., wall of heart) to provide information or a mapping indicative of a position and/or orientation of the device in the cavity. Discrimination may be based on flow, or some other characteristic, for example electrical permittivity or force. The device may selectively ablate portions of the non-fluid tissue based on the information or mapping. The device may detect characteristics (e.g., electrical potentials) indicative of whether ablation was successful. The device may include a plurality of transducers, intravascularly guided in an unexpanded configuration and positioned proximate the non-fluid tissue in an expanded configuration. Expansion mechanism may include helical member(s) or inflatable member(s).

Abstract: A method is provided, including inserting a catheter into a right atrium of a heart of the subject. A distal portion of the catheter is advanced toward a fossa ovalis of the heart. A flexible longitudinal member is deployed from the catheter, such that a deployed portion of the flexible longitudinal member is loop-shaped. The fossa ovalis is contacted with the deployed portion of the flexible longitudinal member. A needle is deployed from the catheter. A distal end of the needle is brought in contact with a site on a surface of an interatrial septum of the heart outside the fossa ovalis. A hole is formed through the interatrial septum at the site with the needle. The deployed portion of the flexible longitudinal member is withdrawn toward the catheter.

Abstract: A flexible probe has an assembly in its distal end that includes a transmitter and a receiver that receives signals from the transmitter for sensing a position of the receiver relative to the transmitter. A resilient element disposed between the transmitter and the receiver is configured to deform in response to pressure exerted on the distal tip when the distal tip engages a wall of a body cavity.

Abstract: A processor of an electric power source device exercises control over a power output before a control switching time point based on a value related to initial impedance, and determines the control switching time point upon detecting that a value related to impedance of a living tissue is at a minimum. The processor sets a set electric-power value of the power output based on a parameter related to controlling the power output before the control switching time point, and performs constant-electric-power control by controlling the power output using the electric-power value at and after the control switching time point.

Abstract: An electrosurgical instrument is disclosed including an end effector, a shaft assembly, and a link. The end effector includes a first jaw rotatable relative to a second jaw between an open position and a closed position. The shaft assembly includes an outer tube, a jaw tube disposed within the outer tube, an actuation band operably coupled to the jaw tube. The jaw tube is configured to move within the outer tube between a proximal end and a distal end. The link includes a first end and a second end. The first end of the link is pivotably coupled to the actuation band. The second end of the link is pivotably coupled to the first jaw. The jaw tube is configured to rotate the first jaw towards the closed position based on movement of the jaw tube towards the proximal end.

Abstract: Described herein are methods of performing immunotherapy on a subject and/or determining if a subject will be responsive to ablation immunotherapy.