Patents Examined by Michael G. Ambrosse
  • Synthesis of optically active cyclohexylphenylglycolate esters
    Patent number: 6140529
    Abstract: A process for the preparation of optically active cyclohexylphenylglycolate esters is described. The process utilizes carboxylic acid activation to couple (R)- or (S)-cyclohexylphenylglycolic acid (CHPGA) with 4-N,N-diethylamino butynol or other propargyl alcohol derivatives. The preparation of the hydrochloride salt is also described. In addition, a resolution process employing tyrosine methyl ester enantiomers for preparing a single enantiomer of CHPGA from racemic CHPGA is disclosed.
    Type: Grant
    Filed: December 15, 1998
    Date of Patent: October 31, 2000
    Assignee: Sepracor Inc.
    Inventors: Roger P. Bakale, Jorge L. Lopez, Francis X. McConville, Charles P. Vandenbossche, Chris Hugh Senanayake