Abstract: Embodiments of a system including a remotely controlled substance delivery device and associated controller are described. Methods of use and control of the device are also disclosed. According to some embodiments, a delivery device or related device may be placed in an environment in order to pump a material into the environment or into an additional fluid handling structure within the device. Exemplary environments include a body of an organism, a body of water, or an enclosed volume of a fluid. The concentration of a substance in the fluid to be delivered may be modified by a remote control signal. In selected embodiments, an acoustic control signal may be used.

Abstract: An apparatus provides feedback regarding the material in which tip of the apparatus is located as the tip is advance into matter of varying resistances. The apparatus responds to a change in pressure, force, or other parameter such that when the tip reaches matter of a certain resistance, a change in the parameter is sensed. The apparatus provides a driving force to a penetrating medical device, such as a needle, when the apparatus tip encounters material of high resistance. When the apparatus tip encounters a low resistance material, no further driving force is applied to the apparatus. An inner core may be advanced into the low resistance material for deployment of a gas or a liquid as desired.

Abstract: A flow control device (10) includes a connector (12) defining a first receiving formation (14) for receiving a first conduit, a second receiving formation (18) for receiving a second conduit and a cross member (22) separating the first receiving formation (14) and the second receiving formation (16). An orifice plate (24) is received in the cross member to control flow of fluid, in use, through the conduits received in the first and the second receiving formations (14, 18) of the connector (12), the orifice plate (24) defining at least one substantially frustoconical orifice (34).

Abstract: A self attaching injection port has integral moveable fasteners which are moveable from a undeployed state to a deployed state engaging tissue. The fasteners may be disposed radially or tangentially, and rotated to pierce the fascia. The fasteners may be rigid or elastically deformable.

Abstract: A catheter including one or more bidirectional valves is provided. The catheter includes a tubular body having proximal and distal ends, and inner and outer surfaces, and at least one valve formed near the distal end of the tubular body. The valve includes a deformation portion that defines a slit that is openable and closable. The openable/closable slit communicates from the inner surface to the outer surface of the tubular body, wherein the distance between the inner surface and the outer surface of the tubular body progressively becomes thinner approaching the openable/closable slit within the deformation portion.

Abstract: A system for monitoring and/or controlling tissue modification during an electrosurgical procedure is provided. The system includes an electrosurgical apparatus adapted to connect to an electrosurgical generator. The electrosurgical apparatus configured to transmit energy to tissue. The system also includes a control system having one or more electromagnetic wave sources configured to generate the interrogator wave of one or more frequencies adjacent tissue. One or more sensors are configured to transmit and sense a reflected portion of the interrogator wave of at least one frequency to determine dielectric boundary data. A processor operatively coupled to the control system and to the electrosurgical generator configured to control the delivery of electrosurgical energy from the electrosurgical generator to tissue based on dielectric boundary data provided by the one or more sensors.

Abstract: A penis erection stimulation system comprises a fully implantable drug delivery device for delivering a drug in relation to a penis to achieve erection of the penis. The drug delivery device may comprise a catheter adapted to be implanted in the corpora cavernosa of a penis or in close proximity thereto in order to deliver drugs through said catheter. Alternatively, one or more infusion needles may be disposed within and implanted along with one or more housings adjacent the patient's left and right corpora cavernosa. A reservoir and a pump may also be implanted inside the patient's body to supply the infusion needle with infusion liquid.

Abstract: Provided is a pressurized carbon dioxide bathing apparatus for causing even a small amount of carbon dioxide to be efficiently absorbed from skin of a living body with the structure of a cover suit simplified, and the pressurized carbon dioxide bathing apparatus is to bring carbon dioxide with a concentration of a predetermined value or more into contact with skin of the human body and thereby promote the blood circulation, and is characterized by being comprised of a carbon dioxide supply means 1 for supplying a mixed gas of carbon dioxide and water vapor, a compressed air supply means 2, a first cover suit 3A which is connected to the carbon dioxide supply means 1 via a connector 6, is filled with the mixed gas supplied from the carbon dioxide supply means 1, and forms an enclosed layer 4 to bring the mixed gas into direct contact with skin of the human body, and a second cover suit 3B which is connected to the compressed air supply means 2 via a connector 7 and forms an enclosed layer 5 filled with compres

Abstract: Medical devices comprising a syringe barrel and a two-piece plunger rod are provided. According to one or more embodiments, the two-piece plunger rod includes a distal portion and proximal portion slidably mounted to the distal portion. The distal and proximal portions include a tab and plurality of grooves which engage to adjust the overall length of the plunger rod to a plurality of locked lengths. The locked lengths of the plunger rod permit varying amount of fluid to be expelled from the barrel.

Abstract: A mounting pad comprising an adhesive layer (2), said adhesive layer being provided with a removable release liner (3). The release liner being divided into at least two sections (3A, 3B) and each of the at least two said sections of the release liner is provided with one or more score lines (4) thereby defining each section of the release liner as a strip, which renders it possible by a single straight upward pull to peel a release liner in two or more narrow strips, thereby still maintaining an even pull with small force needed to remove the release liner and using only a short pulling distance for removing the release liner from the adhesive surface.

Abstract: Provided is a pressurized carbon dioxide bathing apparatus for bringing carbon dioxide into contact with skin of a living body by a predetermined pressure value or more using compressed air, and thereby enabling carbon dioxide to be absorbed efficiently from the skin, and the pressurized carbon dioxide bathing apparatus is comprised of a carbon dioxide supply means 1 for supplying a mixed gas of carbon dioxide and water vapor containing one or a plurality of chemical agents, a compressed air supply means 2, and a cover suit 3 of a two-layer structure having an enclosed layer 4 that is connected to the carbon dioxide supply means 1 via a connector 6 to confine the mixed gas supplied from the carbon dioxide supply means 1 so as to bring the mixed gas into direct contact with skin of the human body and an enclosed layer 5 that is connected to the compressed air supply means 2 via a connector 7 to confine compressed air supplied from the compressed air supply means 2, where the carbon dioxide is brought into cont

Abstract: An infusion system, which may be a closed loop, or “semi-closed-loop”, infusion system, uses state variable feedback to control the rate at which fluid is infused into a user's body. The closed loop system includes a sensor system, a controller, and a delivery system. The “semi-closed-loop” system further includes prompts that provide indications to the user prior to fluid delivery. The sensor system includes a sensor for monitoring a condition of the user and produces a sensor signal which is representative of the user's condition. The delivery system infuses a fluid into the user at a rate dictated by the commands from the controller. The system may use three state variables, e.g., subcutaneous insulin concentration, plasma insulin concentration, and insulin effect, and corresponding gains, to calculate an additional amount of fluid to be infused with a bolus and to be removed from the basal delivery of the fluid.

Abstract: A system for engaging heart tissue includes an engagement catheter defining a first lumen therethrough and having a suction port at or near a distal end and a vacuum port at or near a proximal end, a delivery catheter defining a delivery catheter lumen therethrough and configured for slidable insertion into the first lumen of the engagement catheter, and an implantable device capable of insertion into the delivery catheter lumen such that at least part of the implantable device extends from a delivery catheter distal end upon implantation into a patient, where the suction port is operable to removably attach to a targeted tissue on an interior wall of a heart of the patient after the engagement catheter has been advanced through a blood vessel and into the heart, thereby forming a reversible seal with the targeted tissue when a vacuum source is operatively coupled to the vacuum port.

Abstract: A method of repositioning an injection port comprises positioning the injection port at a first location in a patient's body and extending fasteners of the injection port to substantially secure the injection port at the first location. The fasteners are then retracted to substantially unsecure the injection port from the first location in the patient's body. The injection port is then moved to a second location in the patient's body. The fasteners are then re-extended to substantially secure the injection port at the second location in the patient's body. The injection port includes a port body. The fasteners are integral with the port body. The fasteners may be selectively extended and retracted relative to the port body. For instance, the fasteners may be pivoted relative to the port body to transition between extended and retracted positions. The extension and retraction of fasteners may be provided through a port applier.

Abstract: An injection port system comprises an injection port and an applier. The port comprises a body and a plurality of fasteners. The fasteners are integral with the body and are movable from a non-deployed position to a deployed position. The applier comprises a port engagement portion and an actuator. The port engagement portion is configured to selectively engage the port body to selectively retain the port relative to the applier. The actuator is operable to move the fasteners to the deployed position. The applier is also configured to disengage the port engagement portion from the port body to release the port from the applier when the actuator moves the fasteners to the deployed position. The actuator may release the port from the applier by moving a resilient member away from the port body as the actuator also moves the fasteners from the non-deployed position to the deployed position.

Abstract: Devices and methods for balloon delivery of rapamycin and other hydrophobic compounds to the wall of blood vessels. Balloon catheters, such as those used for balloon angioplasty, are modified with the addition of a reservoir of dry micelles, disposed at a suitable location within the balloon or catheter. The reservoir may be installed within the angioplasty balloon, within a lumen in communication with the angioplasty balloon, either as a loose or packed powder or as a film coating. The micelle preparation is reconstituted and the micelles are mobilized when the aqueous solution used to inflate the balloons is injected into the catheter. The micelles are infused into tissue surrounding the balloon when pressurized fluid within the balloon leaks through the wall of the balloon.

Abstract: An injection port applier is configured to engage an injection port that has integral fasteners that are movable from a non-deployed position to a deployed position. The applier comprises a shaft, a port engagement portion, and a handle. The port engagement portion is includes a fastener deployment member that is operable to move the fasteners to the deployed position. The handle comprises a first handle portion and a second handle portion. The second handle portion is movable distally relative to the first handle portion in order to actuate the fastener deployment member, to thereby move the fasteners to the deployed position. An elongate actuating member couples the second handle portion with the fastener deployment member. One part of the elongate actuating member translates longitudinally in response to the second handle being moved distally; while another part of the elongate actuating member rotates in response to the first portion translating.

Abstract: Engraftment of therapeutic cells and agents to a target site in an organism is enhanced by mechanical, chemical and biological methods and systems.

Abstract: The disclosure is directed toward an infusion catheter epidural system comprising a portable infusion pump configured to administer a combination of anesthetics and corticosteroid at a predetermined rate over a predetermined time. A catheter is fluidly coupled to the portable infusion pump. The catheter is configured to be maneuvered into a site of inflammation of a patient to deliver the combination of anesthetics and corticosteroid. The portable pump and the catheter are configured for attachment to the patient.

Abstract: Microneedle devices are provided for transport of molecules across tissue barriers and for use as microflameholders. In a preferred embodiment for transport across tissue, the microneedles are formed of a biodegradable polymer. Methods of making these devices, which can include hollow and/or porous microneedles, are also provided. A preferred method for making a microneedle includes forming a micromold having sidewalls which define the outer surface of the microneedle, electroplating the sidewalls to form the hollow microneedle, and then removing the micromold from the microneedle. In a preferred method of use, the microneedle device is used to deliver material into or across a biological barrier from chambers in connection with at least one of the microneedles. The device preferably further includes a means for controlling the flow of material through the microneedles. Representative examples of these means include the use of permeable membranes, fracturable impermeable membranes, valves, and pumps.