Patents Examined by Michael L. Borin
  • Patent number: 10564146
    Abstract: A method for the early prediction of risk of hypertensive disorders in pregnant women, including for example eclampsia, mild pre-eclampsia, chronic hypertension, EPH gestosis, gestational hypertension, superimposed pre-eclampsia, HELLP syndrome, or nephropathy.
    Type: Grant
    Filed: May 16, 2018
    Date of Patent: February 18, 2020
    Assignee: University College Cork, National University of Ireland, Cork
    Inventors: Louise Kenny, Philip Newton Baker, David Broadhurst
  • Patent number: 10564089
    Abstract: The present invention provides methods and systems to combine the capabilities of a hematology analyzer with those of a flow cytometer to yield a far more powerful analytical system than either device alone. In one embodiment, a method of analyzing a cell sample includes receiving a first data generated by an analysis of a first aliquot of the sample on a first particle analyzer having a fluorescence measurement device such as a flow cytometer, detecting at least one unresolved cell population in the first data, and accessing a second data stored on a storage device wherein the second data was previously generated by interrogating a second aliquot of the sample using at least one of a cell volume measurement device and a cell conductivity measurement device in a second particle analyzer such as a hematology analyzer. The unresolved cell population in the first data is then resolved using the second data. Corresponding system embodiments are also disclosed.
    Type: Grant
    Filed: September 12, 2016
    Date of Patent: February 18, 2020
    Assignee: Beckman Coulter, Inc.
    Inventors: William H. Gutierrez, Cheng Qian, John S. Riley
  • Patent number: 10545076
    Abstract: Determination of Analytes in a Sample Matrix by Solvent Extraction A method for the assay of one or more analytes in a sample matrix comprising the steps of: performing analyte extraction on the sample matrix, said analyte extraction comprising combining the sample matrix with a solvent for an extraction period which is less than that required for reaching equilibrium; and separating the analyte containing solvent from the sample matrix; next measuring a level of analyte present in the separated solvent; and then applying in a computer a calibration by which is established a mathematical relationship between levels of analyte extracted from each of a plurality of reference samples by means of the process employed above in the extraction for the sample matrix and a reference value of the levels of analyte for each reference sample to thereby derive a measure of the level of analyte in the sample matrix.
    Type: Grant
    Filed: October 20, 2014
    Date of Patent: January 28, 2020
    Assignee: Foss Analytical A/S
    Inventors: Claus Holm, Malin Dahl, Christer Zoffmann Bisgaard
  • Patent number: 10535426
    Abstract: A method of administering insulin includes receiving blood glucose measurements of a patient at a data processing device from a glucometer. The blood glucose measurements are separated by a time interval. The method also includes receiving patient information at the data processing device and selecting a subcutaneous insulin treatment from a collection of subcutaneous insulin treatments. The selection is based on the blood glucose measurements and the patient information. The selection includes one or more of a subcutaneous standard program, a subcutaneous program without meal boluses, a meal-by-meal subcutaneous program without carbohydrate counting, a meal-by-meal subcutaneous program with carbohydrate counting, and a subcutaneous program for non-diabetic patients. The method also includes executing, using the data processing device, the selected subcutaneous insulin treatment.
    Type: Grant
    Filed: February 12, 2019
    Date of Patent: January 14, 2020
    Assignee: Aseko, Inc.
    Inventors: Robert C. Booth, Harry Hebblewhite
  • Patent number: 10514657
    Abstract: The invention relates to a method for selecting compounds which can be used as additives in photopolymer formulations for producing light holographic media, and to photopolymer formulations which contain at least one softener which are selected according to the claimed method. The invention also relates to the use of photopolymer formulations for producing holographic media.
    Type: Grant
    Filed: April 23, 2015
    Date of Patent: December 24, 2019
    Assignee: Covestro Deutschland AG
    Inventors: Thomas Roelle, Friedrich-Karl Bruder, Thomas Fäcke, Marc-Stephan Weiser, Dennis Hönel, Christian Diedrich
  • Patent number: 10497466
    Abstract: Protein confidence values are calculated in proteomic analysis. A protein database is searched for proteins matching peptides found from mass spectrometry of a sample producing a set of proteins and a corresponding set of peptides. Peptide confidence values for the set of peptides are determined. Protein confidence values are calculated for the set of proteins based on the peptide confidence values. A protein is selected from the set of proteins with a largest protein confidence value, the largest protein confidence value is saved for the protein, the protein is removed from the set of proteins, and one or more peptides corresponding to the protein are removed from the set of peptides. Protein confidence values are recalculated for the set of proteins based on the peptide confidence values and an effect of removing the one or more peptides from the set of peptides.
    Type: Grant
    Filed: May 12, 2011
    Date of Patent: December 3, 2019
    Assignee: DH Technologies Development Pte. Ltd.
    Inventor: Ignat V. Shilov
  • Patent number: 10482991
    Abstract: Systems and methods for searching conformation space of a polymer to determine a three-dimensional conformation of the polymer that satisfies a performance metric is provided. The polymer comprises a plurality of domains and at least a first hinge. Initial three-dimensional coordinates of the polymer are altered by pivoting the first domain with respect to the second domain about the first hinge thereby obtaining an altered set of three-dimensional coordinates for the polymer. In this altering, atoms within the first domain are held fixed with respect to each other and atoms within the second domain are also held fixed with respect to each other. The altered set of coordinates is scored against a performance metric. Additional instances of the altering and scoring are performed, if necessary, until the altered set of three-dimensional coordinates satisfy the performance metric.
    Type: Grant
    Filed: August 16, 2013
    Date of Patent: November 19, 2019
    Assignee: ZYMEWORKS INC.
    Inventor: Surjit Bhimarao Dixit
  • Patent number: 10460827
    Abstract: The present invention relates to a method for identifying target regions existing in the interface of monomers constituting the PilT protein with the view to design molecules potentially applicable in impairing the activity of this protein, thus controlling infectious processes. The method is characterized in (i) selecting at least one amino acid sequence constituting the PilT monomer; (ii) developing a three-dimensional computational model of the PilT homo-hexameric structure; (iii) analyzing and determining, with computer aid, the interface-forming residues (IFR) and their physicochemical and structural characteristics for all the chains of the models of hexameric complexes generated; (iv) selecting the regions to be used as therapeutic targets (and preferred therapeutic targets) in the interface between the monomers based on the intensity of determined parameters; (v) computer-aided design of molecules potentially capable of effecting bindings and/or interactions between target regions of the monomers.
    Type: Grant
    Filed: September 8, 2011
    Date of Patent: October 29, 2019
    Inventors: Goran Neshich, Izabella Agostinho Pena Neshich, Jose Gilberto Jardine, Leticia Nishimura, Ivan Mazoni, José Salim
  • Patent number: 10444230
    Abstract: A method of determining kinetic parameters for a reversible molecular interaction between a ligand immobilized to a solid support surface and a binding partner to the ligand in solution, comprises sequentially, without intermediate regeneration or renewal of the immobilized ligand, flowing a plurality of fluid volumes containing different known concentrations of the binding partner over the solid support surface, monitoring the momentary amount of binding partner bound to the solid support surface related to time and solution concentration of binding partner and collecting the binding data, and determining the kinetic parameters by globally fitting a predetermined kinetic model for the interaction between the binding partner and the immobilized ligand to the collected binding data, which model allows for mass transport limitation at the solid support surface.
    Type: Grant
    Filed: April 13, 2016
    Date of Patent: October 15, 2019
    Inventors: Robert Karlsson, Karl Andersson, Christina Wass
  • Patent number: 10437339
    Abstract: The present technology relates to systems, methods and devices for haptically-enabled virtual reality simulation of cerebral aneurysm clipping, wherein a user uses two physical stations during the simulation. The first station is a haptic and augmented reality station, and the second station is a haptic and virtual reality station.
    Type: Grant
    Filed: March 19, 2018
    Date of Patent: October 8, 2019
    Inventors: P. Pat Banerjee, Cristian J. Luciano
  • Patent number: 10431325
    Abstract: The present disclosure relates to methods and computational tools based, at least in part, on computer simulations that identify hot-spot amino acid residues and binding-region amino acid residues of a protein.
    Type: Grant
    Filed: August 2, 2013
    Date of Patent: October 1, 2019
    Inventors: Neeraj J. Agrawal, Bernhard Helk, Bernhardt L. Trout
  • Patent number: 10424398
    Abstract: A computerized procedure for aligning molecules for use in CoMFA or other 3D QSAR methodologies does not rely on fragmentation of the molecules instead, aligning molecules based upon comparison to identified template molecules. Initially an anchor bond is identified in the candidate and template molecule that have similar atoms at each end of the bonds. The anchor bond need not be an acyclic bond. The candidate molecule is overlaid onto the template molecule by aligning the anchor bonds. Starting and working away from the anchor bond, matching atoms or atom types between the candidate and template molecule are identified. Once all matching atoms have been identified, the 3D coordinates of the template atoms are assigned to the corresponding atoms in the candidate molecule to place the candidate molecule into alignment.
    Type: Grant
    Filed: July 22, 2014
    Date of Patent: September 24, 2019
    Inventor: Richard D. Cramer
  • Patent number: 10422803
    Abstract: The present invention provides compositions and methods for light-activated cation channel proteins and their uses within cell membranes and subcellular regions. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-activated cation channels to specific cells or defined cell populations. In particular the invention provides millisecond-timescale temporal control of cation channels using moderate light intensities in cells, cell lines, transgenic animals, and humans. The invention provides for optically generating electrical spikes in nerve cells and other excitable cells useful for driving neuronal networks, drug screening, and therapy.
    Type: Grant
    Filed: March 2, 2016
    Date of Patent: September 24, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Karl Deisseroth, Edward S. Boyden
  • Patent number: 10405762
    Abstract: A system for non-invasively measuring cardiac output, stroke volume, or both comprises a pulse oximeter, a data processor, and means for generating an output reporting measured one or more CO or SV values to a user. A method for non-invasively measuring cardiac output, stroke volume, or both comprises collecting plethysmographic waveform data of a patient, providing the plethysmographic waveform to a data processor, and calculating measured values for CO or SV. The data processor comprises a mathematical model of the cardiovascular system integrated in a dynamic state space model (DSSM).
    Type: Grant
    Filed: August 1, 2016
    Date of Patent: September 10, 2019
    Assignee: Vital Metrix, Inc.
    Inventor: Rodrigo E. Teixeira
  • Patent number: 10386371
    Abstract: Provided herein are methods for measuring molecular flux rates of molecules of interest in a tissue sample in spatially-organized manner and generating output (e.g., an image, a heat map, a contour map, a table or a database) representing the molecular flux rates of each spatially-defined location of the sample. Provided herein are also the output, as well as systems and computer-readable medium with computer-executable instructions for determining molecular flux rates of molecules of interest in the sample.
    Type: Grant
    Filed: September 7, 2012
    Date of Patent: August 20, 2019
    Inventors: Benjamin P. Bowen, Katherine B. Louie, Trent R. Northen, Marc K. Hellerstein
  • Patent number: 10381110
    Abstract: A method for computational drug design using an evolutionary algorithm, comprises evaluating virtual molecules according to vector distance (VD) to at least one achievement objective that defines a desired ideal molecule. In one method the invention comprises defining a set of n achievement objectives (OA1-n), where n is at least one; defining a population (PG=0) of at least one molecule; selecting an initial population (Pparent) of at least one molecule (I1-In) from the population (PG=0); and evaluating members (I1-In) of the initial population (Pparent) against at least one of the n achievement objectives (OA1-x), where x is from 1 to n.
    Type: Grant
    Filed: December 31, 2015
    Date of Patent: August 13, 2019
    Inventors: Andrew Lee Hopkins, Jérémy Besnard
  • Patent number: 10373702
    Abstract: The present invention is directed to a computer implemented method for executing a procedure to select a water-soluble variant of a G Protein-Coupled Receptor (GPCR).
    Type: Grant
    Filed: May 27, 2015
    Date of Patent: August 6, 2019
    Assignee: Massachusetts Institute of Technology
    Inventors: Shuguang Zhang, Fei Tao
  • Patent number: 10360994
    Abstract: The method according to the invention allows modelling of oil and the retention phenomenon in the source rock. Organic matter characterization experiments are used to establish the molecular model (MM) of the initial sample. The thermal cracking reaction of this molecular model is reproduced by dynamic molecular simulation computations with a reactive force field and validated by comparison with experimental data. The reaction mechanism permits a kinetic study by variation of the temperature parameter. The successive phase equilibrium assessments at various progress stages of the cracking reaction allow following the physicochemical evolution of the thermal maturation of the organic sample. The free hydrocarbons are not retained in the solid residue can be quantified throughout numerical modelling of the sample maturation.
    Type: Grant
    Filed: October 6, 2015
    Date of Patent: July 23, 2019
    Inventors: Elodie Salmon, Francois Lorant, Francoise Behar
  • Patent number: 10351970
    Abstract: The present invention relates to screening methods and, in particular, to methods of screening anti-ligand libraries for identifying anti-ligands specific for differentially and/or infrequently expressed ligands. The method comprises the steps of providing a library of anti-ligands: providing a first subtractor ligand; providing a second target ligand; determining the amount of the first and second target ligands using one or more equations derived from the universal law of mass action; providing the determined amount of a first subtractor ligand; providing the determined amount of a second target ligand; providing separation means capable of use to isolate anti-ligand bound to the second target ligand from anti-ligand bound to the first subtractor ligand; exposing the library of to the first and second target ligands to permit binding of anti-ligands to ligands; and using the separation means to isolate the anti-ligand bound to second target ligand.
    Type: Grant
    Filed: February 29, 2016
    Date of Patent: July 16, 2019
    Assignee: BioInvent International AB
    Inventor: Björn Frendéus
  • Patent number: 10335238
    Abstract: A method and system for patient-specific simulation of cardiac electrophysiology is disclosed. A patient-specific anatomical heart model is generated from medical image data of a patient. A patient-specific cardiac electrophysiology model is generated based on simulated torso potentials and body surface potential measurements of the patient. Cardiac electrophysiology of the patient is simulated over time for the patient-specific anatomical heart model using the patient-specific electrophysiology model. One or more electrophysiology maps are generated based on the cardiac electrophysiology simulated using the patient-specific cardiac electrophysiology model.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: July 2, 2019
    Assignee: Siemens Healthcare GmbH
    Inventors: Ali Kamen, Tommaso Mansi, Tiziano Passerini, Bogdan Georgescu, Saikiran Rapaka, Dorin Comaniciu, Gabriel Haras