Patents Examined by Michael L Hobbs
  • Patent number: 11325130
    Abstract: A multiwell instrument includes a vessel having an inside; a plurality of culture plates arranged in the inside of the vessel, each individual one of the plurality of culture plates having an inside in which material to be examined can be stored; and filters disposed inside the respective culture plates to partition the insides of the respective culture plates into at least two wells which are horizontally adjacent.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: May 10, 2022
    Inventors: Takeo Shimasaki, Yumiko Kitano, Hideki Yamada
  • Patent number: 11325129
    Abstract: A collection system including a storage tray and a swab positioned in the storage tray, wherein the swab is configured to collect a sample comprising one or more microorganisms. The system further includes a generally elongate storage device positioned in the tray. The storage device is configured to contain a culture medium therein and configured to receive therein at least part of the one or more microorganisms collected by the swab. The storage tray includes a first recess configured to receive the storage device in a longitudinal configuration, and a second recess configured to receive the storage device in an axial configuration oriented generally perpendicular to the longitudinal configuration.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: May 10, 2022
    Assignee: OXOID LIMITED
    Inventor: John Marshall Staton
  • Patent number: 11319523
    Abstract: Aspects relate to an automated cell culture incubator and to methods for using such an incubator. In one aspect, the cell culture incubator includes an incubator cabinet having a transfer chamber and an internal chamber that are arranged to form an airlock configuration. In some embodiments, objects placed into the incubator cabinet are sterilized using ozone produced by an ozone generator. The incubator may include one or more transfer devices that move objects between the transfer chamber and the internal chamber.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: May 3, 2022
    Assignee: Thrive Bioscience, Inc.
    Inventor: Alan Blanchard
  • Patent number: 11318463
    Abstract: A cell transfer apparatus transfers cells from a dish in which the cells are held to a microplate where a plurality of wells are classified into a plurality of groups. The cell transfer apparatus includes a camera unit that captures an image of the dish with the cells being held in the dish, an evaluation unit that gives evaluation levels to the plurality of cells held in the dish, respectively, based on the image of the dish with reference to predetermined multiple-step evaluation level for the cells, an allocation processor that sets transfer destinations of the cells on the dish so that the cells equal in evaluation level are distributed evenly to the groups in the microplate, and a shaft controller that transfers the cells in accordance with the transfer destinations set by the allocation processor.
    Type: Grant
    Filed: October 17, 2016
    Date of Patent: May 3, 2022
    Inventor: Saburo Ito
  • Patent number: 11319525
    Abstract: The disclosure provides systems and methods for producing a cannabinoid product, which comprises contacting a cannabinoid precursor in a first phase with a cannabinoid synthase in a second phase, wherein the first phase and the second phase are substantially immiscible or immiscible. The disclosure also provides a composition comprising the cannabinoid precursor in a first phase and a cannabinoid synthase in a second phase, wherein the first phase and the second phase are substantially immiscible or immiscible.
    Type: Grant
    Filed: June 26, 2019
    Date of Patent: May 3, 2022
    Inventors: Richard Peet, Malcolm J. Kavarana, Mingyang Sun, Peter C. Michels, John D. Rabenstein, C. Seth Pearson, Geoffrey M. Fox
  • Patent number: 11319520
    Abstract: Provided herein are filter cake-based systems and methods for cultivating cells and cell biomass therefrom. Provided herein is a system for cultivating cells and cell biomass comprising a filter chamber comprising at least one inlet and at least one outlet, at least one filter support located within the filter chamber, and a filter cake located on the filter support, wherein the filter cake comprises at least one filter aid and a plurality of cells. Provided herein is a method for optimizing the cultivation of cells and cell biomass, comprising providing a filter support, adding at least one filter aid to the filter support, adding a plurality of cells to the filter aid, wherein the cells and the filter aid together comprise a filter cake, growing the cells into a cell biomass in the filter cake, wherein the filter cake is at least partially compressible.
    Type: Grant
    Filed: September 21, 2021
    Date of Patent: May 3, 2022
    Assignee: Upside Foods, Inc.
    Inventor: Konrad Mueller-Auffermann
  • Patent number: 11319524
    Abstract: This disclosure describes an improved heat transfer system for use in reaction vessels used in chemical and biological processes. In one embodiment, a heat transfer baffle comprising two sub-assemblies adjoined to one another is provided.
    Type: Grant
    Filed: October 7, 2019
    Date of Patent: May 3, 2022
    Assignee: ABEC, Inc.
    Inventor: Cameron Knight
  • Patent number: 11319519
    Abstract: The microfluidic chip can comprise at least one multichamber flow assembly that can comprise a plurality of microchannels. The plurality of microchannels can comprise a first microchannel that includes: a first inlet; a first outlet; and a first chamber fluidly connected to the first inlet and the first outlet. The plurality of microchannels can comprise a second microchannel that includes: a second inlet; a second outlet; and a second chamber fluidly connected to the second inlet and the second outlet. The multichamber flow assembly can comprise a porous biocompatible membrane oriented along a longitudinal interface between the first microchannel and the second microchannel, wherein the porous biocompatible membrane is permeable for movement of biomolecules from the first chamber to the second chamber through the porous biocompatible membrane.
    Type: Grant
    Filed: December 12, 2019
    Date of Patent: May 3, 2022
    Assignees: MACAU GLCAO Biotechnology Research Center Limited, Calroy Health Sciences, LLC
    Inventors: Yong Luo, Jinhua Wei, Zhou Wang, Ming Sun, Chen Chen, Yuguang Du
  • Patent number: 11312935
    Abstract: An object of the present disclosure is to provide a cell culture system, a cell culture environment evaluation device, and a program, capable of performing evaluation of a culture environment without causing an adverse effect on cell culture. An isolator is provided with a culture environment for housing a cell culture vessel having a culture solution containing cells to be cultured placed therein. A sensing unit measures the state of the culture environment and transmits the measurement result of the culture environment to the outside of the isolator. A control device receives the measurement result and performs evaluation in the culture environment based on the measurement result.
    Type: Grant
    Filed: December 26, 2017
    Date of Patent: April 26, 2022
    Assignee: Nihon Kohden Corporation
    Inventors: Hodaka Makino, Wataru Matsuzawa
  • Patent number: 11291995
    Abstract: Selectively vented biological assay devices and methods of performing biological assays with such devices are provided herein. Disclosed devices include (a) a sample receiving cartridge comprising a sample inlet and one or more reaction chambers and (b) a selective venting element having passively tunable porosity. The methods include controlling fluid flow within the subject devices with the selective venting element.
    Type: Grant
    Filed: March 14, 2017
    Date of Patent: April 5, 2022
    Assignee: Lucira Health, Inc.
    Inventors: Debkishore Mitra, Frank B. Myers, III, John Robert Waldeisen, Ivan Krastev Dimov
  • Patent number: 11291968
    Abstract: The invention refers to a reactor and a method respectively for performing, by means of solid reaction members, a biological or chemical transformation, or physical or chemical trapping from, or release of agents to, a fluidic media, and a subsequent cleaning of the reactor, said reactor comprising a vessel (11) in which a transformation device (100) has been mounted. The invention also refers to a reactor kit comprising such reactor. The reactor comprises at least one nozzle (15) arranged on the longitudinal inner wall of the vessel (11). The at least one nozzle (15) is arranged to direct a flow of a cleaning fluid (CF) in a direction towards a longitudinal centre axis (L1) of a flow distributor (1) arranged in the vessel (11).
    Type: Grant
    Filed: April 20, 2017
    Date of Patent: April 5, 2022
    Assignee: SPINCHEM AB
    Inventors: Emil Byström, Lars Eklund, Knut Irgum
  • Patent number: 11286452
    Abstract: A fermentation tank having a first supply or discharge line with a first central opening arranged at the lower end of the fermentation tank for supplying or discharging a product. The fermentation tank also has a second and a third supply or discharge line, each with a centrally arranged opening for supplying or discharging a product, the three openings being arranged at different height levels. Also, a method of fermentation using the fermentation tank.
    Type: Grant
    Filed: October 17, 2016
    Date of Patent: March 29, 2022
    Assignee: KRONES AG
    Inventors: Konrad Müller-Auffermann, Severin Thomandl
  • Patent number: 11286453
    Abstract: Provided is a continuous microalgae culture module, including an outdoor culture unit, a high-density culture unit, a pigment induced unit, and a harvesting unit. A method of culturing microalgae containing macular pigment is also provided, including sequentially culturing microalgae with medium in the outdoor culture unit and the high-density culture unit, producing macular pigment in the pigment induced unit through different light irradiation, and collecting the microalgal biomass containing macular pigment in the harvesting unit.
    Type: Grant
    Filed: November 28, 2018
    Date of Patent: March 29, 2022
    Assignee: National Chiao Tung University
    Inventors: Chih-Sheng Lin, Chiu-Mei Kuo, Yi-Chun Yang, Wen-Xin Zhang
  • Patent number: 11268066
    Abstract: An improved method of culturing cells for cell therapy applications that includes growing desired cells in the presence of antigen-presenting cells and/or feeder cells and with medium volume to surface area ratio of up to 1 ml/cm2 if the growth surface is not comprised of gas permeable material and up to 2 ml/cm2 if the growth surface is comprised of gas permeable material. The desired cells are at a surface density of less than 0.5×106 cells/cm2 at the onset of a production cycle, and the surface density of the desired cells plus the surface density of the antigen presenting cells and/or feeder cells are at least about 1.25×105 cells/cm2.
    Type: Grant
    Filed: November 26, 2019
    Date of Patent: March 8, 2022
    Assignees: Wilson Wolf Manufacturing, Baylor College of Medicine
    Inventors: Juan F. Vera, Cliona M. Rooney, Ann M. Leen, John R. Wilson
  • Patent number: 11268654
    Abstract: Systems and methods for controlling the temperature and pressure of a cryogenic liquid methane storage unit are provided. The disclosed systems and methods generate methane gas from a reservoir of liquid methane stored within the methane storage unit, vent the methane gas through one or more outlet valves connected to the methane storage unit, and generate electric power using the vented methane gas. The generated electric power can then be used to initiating a cooling cycle, which reduces the temperature of said reservoir of liquid methane and reduces the pressure in said methane storage unit. Micro anaerobic digesters and methane storage units may be configured in a networked environment with a central controller that monitors remote units.
    Type: Grant
    Filed: February 14, 2018
    Date of Patent: March 8, 2022
    Assignee: Bennamann Services LTD
    Inventors: Christopher Mann, Michael Bennett
  • Patent number: 11268058
    Abstract: Cell culture systems and methods provide improved immunotherapeutic product manufacturing with greater scalability, flexibility, and automation. Cell culture systems are configured with interchangeable cartridges, allowing versatility and scalability. Systems are configured to have multiple connected cell culture chambers, which allows parallel processing of different types of cells. Gas-impermeable cell culture chambers and methods for generating cells in closed systems prevent contamination and user error. Methods for recycling cell culture medium provide additional efficiencies.
    Type: Grant
    Filed: October 20, 2020
    Date of Patent: March 8, 2022
    Assignee: FLASKWORKS, LLC
    Inventors: Shashi K. Murthy, Andrew Kozbial
  • Patent number: 11261417
    Abstract: A bioreaction container including a culture chamber configured to contain a culture solution and a life form in an inner space, the culture chamber having an open upper end; a chamber cover portion coupled to the upper end of the culture chamber, the chamber cover portion having a protruding tube provided on one side thereof so as to communicate with the inner space; a filter cap coupled to the protruding tube in an attachable/detachable manner so as to open/close the protruding tube; a gas introduction portion configured to penetrate the chamber cover portion and to communicate with the inner space so as to supply a predetermined gas into the inner space; and an acidity/basicity adjustment portion installed on the chamber cover portion while containing an adjustment solution that adjusts pH of the culture solution such that the adjustment solution is discharged into the inner space by pneumatic pressure.
    Type: Grant
    Filed: November 7, 2017
    Date of Patent: March 1, 2022
    Assignees: SPL Co., Ltd., E-Cell CD., Ltd., Industry Academy Cooperation Foundation of Sejona University
    Inventors: Sang Oh Heo, Dong Hoon Kim, Doo Hyun Kim, Duk Jae Oh
  • Patent number: 11260393
    Abstract: A digital PCR device using centrifugal force. The present disclosure comprises: sample dish on which a microwell film having formed microwells is mounted; a door unit for inputting a sample while rotating the sample dish, and controlling the temperature of the sample which has been fractionated in the microwells by means of the centrifugal force and thus performing a PCR process; and a scan head unit for reading a fluorescent signal while rotating the sample which has been amplified in the microwells during the PCR process.
    Type: Grant
    Filed: January 4, 2018
    Date of Patent: March 1, 2022
    Inventors: Sung Woon Lee, Ho Chul Nam
  • Patent number: 11253895
    Abstract: Systems and methods for treating contaminated soil and groundwater are contemplated. An aqueous slurry may be formulated from particles of solid-phase organic materials having particle sizes between 0.1 and 100 microns, which serve as organic electron donors which may biodegrade subsurface contaminants. The aqueous slurry is injected into an environmental subsurface at a pressure lower than the fracture pressure of the subsurface, which will result in a more uniform distribution of the slurry throughout the subsurface, rather than concentrated deposition of the solid-phase organic materials at points along the fractures, and will also tend to reduce disruption of the architecture of the soil matrix, increasing the utility of the remediated soil and preventing an increase in the rates of generation and efflux of methane and nitrous oxide from the soil to the atmosphere.
    Type: Grant
    Filed: December 31, 2018
    Date of Patent: February 22, 2022
    Inventors: Kristen A. Thoreson, Scott B. Wilson, John Freim
  • Patent number: 11248251
    Abstract: A biological sterilization indicator for evaluating the effectiveness of a sterilization process includes a cap containing a culture medium, a container containing a concentration of microorganism, and a breakable barrier attached to the cap to encapsulate the culture medium therein. The breakable barrier is formed from a multilayer structure including an aluminum layer and a sealing layer. The biological indicator is configured such that the breakable barrier may be broken at a selected time by engaging the cap and the container at an activated position to introduce the culture medium into the container.
    Type: Grant
    Filed: November 28, 2018
    Date of Patent: February 15, 2022
    Assignee: American Sterilizer Company
    Inventors: Harry Bala, Richard Koszyk, Anthony Fiorello