Patents Examined by Michael Maskell
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Patent number: 12205810Abstract: An ion guide may comprise a set of plate electrodes, each plate electrode having a plurality of apertures formed therethrough. The set of plate electrodes are spatially arranged such that a relative positioning of each plurality of apertures of a respective plate electrode of the set of plate electrodes and respective adjacent plate electrodes of the set of plate electrodes defines a continuous ion flight path through the respective plurality of apertures of each plate electrode of the set of plate electrodes. The continuous ion flight path has a helical-based and/or spiral-based shape.Type: GrantFiled: July 14, 2023Date of Patent: January 21, 2025Assignee: Thermo Fisher Scientific (Bremen) GmbHInventors: Hamish Stewart, Alexander Wagner, Alexander A. Makarov
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Patent number: 12196740Abstract: The invention relates to a method for classifying a tissue sample obtained from mammary carcinoma. The method comprises determining a stiffness value for each of a plurality of points on said tissue sample, resulting in a stiffness distribution, and assigning said sample to a breast cancer subtype and nodal status based on said stiffness distribution.Type: GrantFiled: June 26, 2023Date of Patent: January 14, 2025Assignee: UNIVERSITÄT BASELInventors: Marija Plodinec, Ellen Obermann, Philipp Oertle, Christian Räz
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Patent number: 12198009Abstract: The disclosure describes aspects of using multiple species in trapped-ion nodes for quantum networking. In an aspect, a quantum networking node is described that includes multiple memory qubits, each memory qubit being based on a 171Yb+ atomic ion, and one or more communication qubits, each communication qubit being based on a 138Ba+ atomic ion. The memory and communication qubits are part of a lattice in an atomic ion trap. In another aspect, a quantum computing system having a modular optical architecture is described that includes multiple quantum networking nodes, each quantum networking node including multiple memory qubits (e.g., based on a 171Yb+ atomic ion) and one or more communication qubits (e.g., based on a 138Ba+ atomic ion). The memory and communication qubits are part of a lattice in an atomic ion trap. The system further includes a photonic entangler coupled to each of the multiple quantum networking nodes.Type: GrantFiled: July 13, 2023Date of Patent: January 14, 2025Assignee: UNIVERSITY OF MARYLAND, COLLEGE PARKInventors: Christopher Monroe, Martin Lichtman, Ismail Volkan Inlek, Clayton Crocker, Ksenia Sosnova
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Patent number: 12198920Abstract: In order to improve the ionization efficiency and ion collection efficiency in an ESI ion source to achieve a higher level of analysis sensitivity while improving the throughput of the analysis, one mode of the present invention provides an ion analyzer equipped with an ion source employing an electrospray ionization method, where the ion source (2) includes: a plurality of capillaries (211-218) configured to spray a supplied liquid sample in the same direction; one or more auxiliary electrodes (23, 231-328) arranged so as to be surrounded by the plurality of capillaries; and a voltage supplier (24) configured to apply, to the plurality of capillaries, a DC high voltage for which the potential of the one or more auxiliary electrodes is used as a reference.Type: GrantFiled: March 17, 2022Date of Patent: January 14, 2025Assignee: SHIMADZU CORPORATIONInventors: Masaru Nishiguchi, Akiko Imazu, Osamu Furuhashi
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Patent number: 12198012Abstract: A quantum computing system, method, and computer readable medium involves initializing a state of a resonator-coupled quantum emitter having at least four levels arranged in an N-configuration, the N-configuration having a first ground state, a second ground state, a first excited state and a second excited state. A frequency of a first transition between the first ground state and the first excited state is tuned, a frequency of a second transition between the second ground state and the second excited state is tuned, and a frequency of a third transition between the second ground state and the first excited state is tuned. A plurality of photons are fed at a frequency corresponding to the frequency of the second transition, thereby entangling the plurality of photons to the resonator-coupled quantum emitter.Type: GrantFiled: April 13, 2023Date of Patent: January 14, 2025Assignees: Yeda Research and Development Co. Ltd., Quantum Source Labs Ltd.Inventors: Gil Semo, Ziv Aqua, Oded Melamed, Dan Charash, Serge Rosenblum, Barak Dayan
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Patent number: 12198917Abstract: Peak determination is executed with respect to the mass spectrum of a sample to generate a peak list. For each of the plurality of peaks contained in the peak list, a Kendrick mass (KM) of a designated monomer is calculated. An RKM is calculated, the RKM being a fractional part of a value obtained by dividing the KM by the integer mass of the monomer, or a remainder of dividing a nominal Kendrick mass (NKM) by the integer mass of the monomer. A plurality of peaks contained in the peak list and satisfying a grouping condition, including the permissible range of the RKM of the starting point peak, are grouped.Type: GrantFiled: June 17, 2022Date of Patent: January 14, 2025Assignee: JOEL Ltd.Inventor: Takaya Satoh
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Patent number: 12191111Abstract: The present disclosure provides a technique enabling accurate ascertaining of a charged state of a resist pattern resulting from irradiation of a charged particle beam. The present disclosure provides a charged particle beam system provided with: a charged particle device provided with a charged particle source, deflectors for causing a primary charged particle beam emitted from the charged particle source to be scanned over a sample, an energy discriminator for performing energy discrimination for secondary electrons emitted when the primary charged particle beam has reached the sample, and a detector for detecting secondary electrons which have passed the energy discriminator; and a computer system for generating a scan image on the basis of signal amounts detected by the detector, which fluctuate during scanning of primary charged particles by the deflectors, and storing the scan image into an image storage unit.Type: GrantFiled: May 8, 2019Date of Patent: January 7, 2025Assignee: Hitachi High-Tech CorporationInventors: Fumiya Ishizaka, Daisuke Bizen, Makoto Suzuki
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Patent number: 12191133Abstract: The present invention relates to a method for identifying and/or authenticating a sample, comprising adding at least one chemical compound to the sample, determining a level of the at least one compound after addition to the sample; comparing the level of the at least one compound to a reference level and identifying the sample based on the comparison with the reference sample and the effect of the sample on the level of the at least one compound. The invention further relates to the use of the at least one compound in the method for identifying and/or authenticating a sample. Further, the invention relates to the use of a kit comprising the at least one compound in the inventive method. In addition, the invention relates to a composition comprising the at least one compound. Further, the invention relates to a kit comprising the compositions provided herein, e.g. for calibrating the methods provided herein and/or the instruments employed in the methods provided herein.Type: GrantFiled: May 8, 2020Date of Patent: January 7, 2025Assignee: ORVINUM AGInventors: Frank Jochen Dieterle, Timm Fabian Manfred Hettich, Christian Berchtold, Gotz Schlotterbeck, Markus Ehrat
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Patent number: 12181454Abstract: An integrated system for liquid separation and electrospray ionization includes an emitter-enabled capillary column including an emitter portion and a column portion; and a retractable protective sleeve for covering and/or supporting the emitter portion along at least a portion of its axis. The protective sleeve is mounted around the emitter-enabled capillary column. The retractable protective sleeve is moveable to an extended position wherein a tip of the emitter portion is covered by the protective sleeve. A resilient member is provided to bias the protective sleeve towards the extended position. The protective sleeve is enclosed and moveable within an outer electrically conductive sheath adapted for insertion within a holder having a high-voltage contact point. The sheath is adapted to contact the high-voltage contact point and provide an electrical connection to enable the emitter-enabled capillary column to receive a high voltage. The sheath has a recess to receive the high-voltage contact point.Type: GrantFiled: December 21, 2021Date of Patent: December 31, 2024Assignee: Dionex CorporationInventors: Brandon Howard Robson, Xuefei Sun, Carla Marie Medlin, Shane Bechler
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Patent number: 12181440Abstract: Disclosed is a method of desorbing an adsorbed material by subjecting to energy a diazirine adsorbed on a solid surface or a layer on the solid surface, which causes the diazirine to form a carbene and nitrogen gas; and using the energy of the resultant nitrogen gas to desorb the adsorbed material from the solid surface or a layer on the same. Also disclosed is a method of reacting the resultant carbene with (a) a material in the gas phase proximal to the first solid surface; (b) a material adsorbed on a second solid surface proximal to the first solid surface; or (c) a second solid surface proximal to the first solid surface.Type: GrantFiled: August 5, 2022Date of Patent: December 31, 2024Assignee: Northeastern UniversityInventors: Roger W. Giese, Pushkar Kulkarni
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Patent number: 12183538Abstract: A semiconductor manufacturing apparatus according to the present embodiment includes a stage on which a wafer can be placed. A separator separates a beam of impurities to be introduced into the wafer into an ion component and a neutral component. A controller switches the semiconductor manufacturing apparatus between a first mode and a second mode, where in the first mode, the ion component is introduced into the wafer and in the second mode, the neutral component is introduced into the wafer.Type: GrantFiled: March 4, 2022Date of Patent: December 31, 2024Assignee: Kioxia CorporationInventor: Takayuki Ito
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Patent number: 12176195Abstract: A method of performing mass spectrometry includes obtaining, based on a series of mass spectra of detected ions derived from components eluting from a chromatography column, a plurality of extracted ion chromatograms (XICs), each XIC comprising a plurality of detection points representing detected intensity for a distinct selected m/z as a function of time; detecting, based on the series of mass spectra, precursor ions of each distinct selected m/z of the plurality of XICs; and determining, for each XIC based on a set of detection points of the XIC, a predicted next detection point to be obtained based on a next mass spectrum to be acquired.Type: GrantFiled: January 15, 2024Date of Patent: December 24, 2024Assignee: Thermo Finnigan LLCInventors: Philip M. Remes, Jesse D. Canterbury
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Patent number: 12176199Abstract: The invention relates to an ionization device with an ionization space formed in a container, an inlet system for supplying a gas to be ionized to the ionization space, an electron source having at least one filament for supply of an electron beam to the ionization space, and an outlet system for letting the ionized gas out of the ionization space. Electron optics having at least two electrodes are disposed between the filament and the ionization space.Type: GrantFiled: May 11, 2020Date of Patent: December 24, 2024Assignee: Leybold GmbHInventors: Yessica Brachthaeuser, Thorsten Benter, Marco Thinius, Michel Aliman
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Patent number: 12170182Abstract: The present disclosure relates generally to ion implantation, and more particularly, to systems and processes for adjusting a ribbon beam angle of an ion implantation system. An exemplary ion implantation system includes an ion source configured to generate a ribbon beam, a wafer chuck configured to hold a wafer during implantation by the ribbon beam, a dipole magnet disposed between the ion source and the wafer chuck, and a controller. The dipole magnet includes at least two coils configured to adjust a ribbon beam angle of the ribbon beam at one or more locations along a path of the ribbon beam between the ion source and the wafer held in the wafer chuck. The controller is configured to control the ion source, the wafer chuck, and the dipole magnet.Type: GrantFiled: July 2, 2021Date of Patent: December 17, 2024Assignee: Advanced Ion Beam Technology, Inc.Inventors: Zhimin Wan, Chi-ming Huang, Shao-Yu Hu
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Patent number: 12171055Abstract: At a designated range an ultra-short pulse laser beam collapses focusing its power and thereby creating a plasma. A range specific thermal plasma is formed from a pulsed laser configured to produce a pulsed wavefront at a peak power. The peak power of the wavefront exceeds a self-focusing critical power level. An optical wavefront controlling element having one or more optical lens manipulates the pulsed wavefront based on a ratio of the peak power to the self-focusing critical power level, and an atmospheric condition, initiating whole beam collapse at the designated range.Type: GrantFiled: February 15, 2022Date of Patent: December 17, 2024Assignee: APPLIED ENERGETICS, INC.Inventors: Stephen William McCahon, Gregory J. Quarles
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Patent number: 12169204Abstract: The present invention provides rapid, sensitive high-throughput methods and systems for characterizing peptides or proteins using hydrophobic interaction chromatography-coupled native mass spectrometry to improve manufacturing process of biopharmaceutical products, such as identifying impurities during antibody purification, monitoring post-translational modification variants during production, or characterizing drug-to-antibody ratio of antibody-drug conjugates. The separation profiles of the peptides or proteins are generated and compared to identify or qualify the peptides or proteins.Type: GrantFiled: December 4, 2023Date of Patent: December 17, 2024Assignee: Regeneron Pharmaceuticals, Inc.Inventors: Yuetian Yan, Shunhai Wang
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Patent number: 12161769Abstract: A utilitarian highly maneuverable mobile disinfection unit for floors and other horizontal surfaces. A stable steerable self-powered cart is provided with an attached downward-projecting UVC light source. The light source has a parabolic reflector projecting the radiation downward and a peripheral floor brush doubling as a shield against escape of radiation.Type: GrantFiled: May 31, 2022Date of Patent: December 10, 2024Assignee: METRANSPORT, INC.Inventors: William M. Lawson, Jr., Antony S. Wilkie, Jr.
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Patent number: 12165864Abstract: Modules, systems and methods that disinfect surfaces using ultraviolet (UV) light are disclosed. In one aspect, a UV light-emitting module comprises an enclosure comprising a rear wall and a face plate spaced from the rear wall and comprising a light-transmitting aperture. At least one sidewall extends between the rear wall and the face plate, and at least one UV light emitter is within the enclosure. A ventilation opening is located in one or more walls selected from (1) the rear wall and (2) the at least one sidewall.Type: GrantFiled: October 27, 2021Date of Patent: December 10, 2024Assignee: The Boeing CompanyInventors: Jamie J. Childress, Arthur E. Brockschmidt, Jr.
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Patent number: 12154779Abstract: The invention generally relates to systems and methods for separating ions at about or above atmospheric pressure. In certain embodiments, the invention provides systems that include an ionization source that generates ions and an ion trap. The ion trap is maintained at about or above atmospheric pressure and includes a plurality of electrodes and at least one inlet configured to receive a gas flow and at least one outlet. The system is configured such that a combination of a gas flow and one or more electric fields produced by the electrodes separates the ions based on mass-to-charge ratio and sends the separated ions through the at least one outlet of the ion trap.Type: GrantFiled: February 10, 2023Date of Patent: November 26, 2024Assignee: Purdue Research FoundationInventors: Robert Graham Cooks, Dalton Snyder, Amar S. Basu, Wen-Ping Peng
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Patent number: 12154774Abstract: A mass spectrometer includes an ion source configured to produce ions from a sample; a set of quadrupole rods configured to select ions based on a mass-to-charge ratio; a DC rod driver configured to produce a voltage; a DC rod driver filter configured to filter RF frequency interference; and a controller. The controller is configured to utilize the results of the constrained convex optimization to cause a DC rod drive to produce the DC filter input and provide a required voltage to the set of quadrupole rods, the constrained convex utilizing a impulse response curve of the DC rod driver filter to determine a DC filter input to achieve the required voltage on the set of quadrupole rods; select ions passing through the set of quadrupole rods based on the mass-to-charge ratio; and measure the intensity of the ions.Type: GrantFiled: November 30, 2021Date of Patent: November 26, 2024Assignee: Thermo Finnigan LLCInventors: Johnathan W. Smith, Scott T. Quarmby