Patents Examined by Michael Maskell
  • Patent number: 11835699
    Abstract: A focusing device for focusing a laser beam in a target area. The focusing device includes a paraboloid mirror configured to widen the laser beam; an ellipsoid mirror or a hyperboloid mirror configured to focus the widened laser beam at a focal position within the target area; and a movement device. The movement device is configured to move the ellipsoid mirror or the hyperboloid mirror relative to the paraboloid mirror, or together with the paraboloid mirror, to change the focal position within the target area.
    Type: Grant
    Filed: November 13, 2020
    Date of Patent: December 5, 2023
    Inventors: Martin Lambert, Tolga Ergin
  • Patent number: 11837436
    Abstract: In one embodiment, a waveform generating device includes a first DA converter converting input data, a controller outputting a first signal having a command value based on the input data, and a second signal having a command value differing by a constant value from the first signal, a second DA converter converting the first signal, a third DA converter converting the second signal, and a combiner combining the output of the first DA converter, the output of the second DA converter, and the output of the third DA converter. When a value of a predetermined first high-order bit of the input data is inverted, the controller changes the command value of the first signal such that a value of the first high-order bit or a second high-order bit different from the first high-order bit is inverted.
    Type: Grant
    Filed: December 27, 2021
    Date of Patent: December 5, 2023
    Assignee: NuFlare Technology, Inc.
    Inventors: Michihiko Ikeda, Akinori Mine, Kuniaki Kawahara
  • Patent number: 11830714
    Abstract: An analysis method includes analyzing a reference sample that contains a predetermined amount of a predetermined component by an analysis device using a chromatograph and obtaining a reference detection value which is a detection value of the predetermined amount of the predetermined component detected by the analysis device, calculating a judgment reference value which is a criterion for judging whether a concentration of a detection subject component in a measurement subject sample is equal to or larger than a reference concentration or equal to or smaller than the reference concentration based on the reference detection value, and analyzing the measurement subject sample by the analysis device and judging that the detection subject component has been detected in a case where a detection value exceeding the judgment reference value is detected in a peak detection time zone corresponding to the detection subject component.
    Type: Grant
    Filed: November 20, 2019
    Date of Patent: November 28, 2023
    Inventors: Yukihiko Kudo, Shinji Sugimoto
  • Patent number: 11823882
    Abstract: A method of mass spectrometry comprising the steps of: providing a library of background ion data including m/z data for multiple background ions in respect of different chromatographic conditions including a change of solvent composition from aqueous (1) to organic (3), chromatographically separating a sample containing analyte components, wherein the chromatographic separation is performed under a chromatographic condition in respect of which background ion data is provided in the library, analysing the sample to obtain sample data comprising m/z values for the sample components as a function of retention time (RT), and calculating one or more error values including ppm error as a function of retention time based on a comparison between background ions identified in the sample data and the library of background ion data. Outliers (4), corrupted measurements and inconsistent measurements at specific retention times are rejected.
    Type: Grant
    Filed: August 30, 2019
    Date of Patent: November 21, 2023
    Assignee: Micromass UK Limited
    Inventor: Martin Raymond Green
  • Patent number: 11808783
    Abstract: Atomic force microscopy apparatus and method that enable observing charge generation transients with nanometer spatial resolution and nanosecond to picosecond time resolution, the timescale relevant for studying photo-generated charges in the world's highest efficiency photovoltaic films. The AFM apparatus includes an AFM, a light source for illumination of a sample operatively coupled to the AFM, a voltage source operatively coupled to the AFM, and a control circuitry operatively coupled to the light source and the voltage source. The AFM apparatus improves the time resolution and enables rapid acquisition of photocapacitance transients in a wide array of solar-energy-harvesting materials.
    Type: Grant
    Filed: October 21, 2021
    Date of Patent: November 7, 2023
    Assignee: Cornell University
    Inventors: John Marohn, Sarah Nathan, Ryan Dwyer
  • Patent number: 11810645
    Abstract: Systems and methods of predicting a Cannabis chemotype from genetic data include obtaining a training dataset comprising genetic data for at least one mature Cannabis plant, and corresponding chemotype information for the at least one mature Cannabis plant, generating a chemotype prediction model based on the training dataset, the chemotype prediction model being able to predict the chemotype of a mature Cannabis plant, receiving genetic data for a Cannabis seedling, and predicting, via the chemotype prediction model, the chemotype of the Cannabis seedling upon maturation.
    Type: Grant
    Filed: July 14, 2023
    Date of Patent: November 7, 2023
    Assignee: Cannamatrix Inc.
    Inventor: Emanuel Maminakis
  • Patent number: 11796504
    Abstract: An apparatus includes multiple levels of ion transport channels, with successive levels coupled by elevator channels. Efficient three dimensional packing provides long path lengths in practical volumes for ion mobility separation with high resolving power. Disclosed elevator configurations provide efficient routing of ion transport channels across levels with low ion loss, enabling ion mobility separation over 100 levels or more. Elevator configurations include (i) opposed traveling waves meeting at an elevator entrance, (ii) external elevator with a wrap-around electrode bank, (iii) external elevator with electrode banks on parallel extension plates, or (iv) elevator operating in surfing mode, in various combinations. Manufacture is aided by printed wiring boards, with interchangeable boards. Assembly with motherboard, spacer block(s), and alignment pins provides efficient distribution of electrode excitations and accurate reproducible positioning.
    Type: Grant
    Filed: August 11, 2021
    Date of Patent: October 24, 2023
    Assignee: Battelle Memorial Institute
    Inventors: Yehia M. Ibrahim, Adam L. Hollerbach, Ailin Li
  • Patent number: 11791144
    Abstract: An optimization control system may receive mass spectra of ions emitted from an ionization emitter toward an inlet of a mass spectrometer and control, based on the mass spectra, an automated motion system to adjust a position of the emitter relative to the inlet.
    Type: Grant
    Filed: March 10, 2021
    Date of Patent: October 17, 2023
    Assignee: Thermo Finnigan LLC
    Inventors: Bennett S. Kalafut, Joshua A. Silveira, Abhishek Joshi, Eloy R. Wouters
  • Patent number: 11791147
    Abstract: The invention relates to a mass spectrometer for analysing a gas by mass spectrometry, comprising: a controllable inlet system for pulsed feeding of the gas to be analysed from a process region outside the mass spectrometer into an ionisation region, an ionisation device for ionising the gas to be analysed in the ionisation region, an ion transfer device for transferring the ionised gas from a ionisation region via an ion transfer region into an analysis region, and an analyser for detecting the ionised gas in the analysis region. The invention further relates to an associated method for mass spectrometrically analysing a gas.
    Type: Grant
    Filed: August 12, 2019
    Date of Patent: October 17, 2023
    Assignee: Leybold GmbH
    Inventors: Anthony Hin Yiu Chung, Thorsten Benter, Michel Aliman, Rudiger Reuter, Yessica Brachthaeuser
  • Patent number: 11784034
    Abstract: A method for analyzing secondary ion mass spectrum data representing respective secondary ion counts for a range of masses at a given mass resolution. The mass spectrum data is obtained by Secondary Ion Mass Spectrometry, SIMS. Automatic quantification of the ion species and/or cluster ions detected in the analyzed spectrum data is provided.
    Type: Grant
    Filed: December 23, 2019
    Date of Patent: October 10, 2023
    Inventors: Patrick Philipp, Tom Wirtz
  • Patent number: 11781980
    Abstract: The present invention relates to methods for diagnosing Respiratory Distress Syndrome of newborn.
    Type: Grant
    Filed: October 5, 2018
    Date of Patent: October 10, 2023
    Assignee: Sime Diagnostics Ltd.
    Inventors: Peter Schousboe, Henrik Verder
  • Patent number: 11776801
    Abstract: Inductively coupled plasma (ICP) analyzers use an ICP torch to generate a plasma in which a sample is atomized an ionized. Analysis of the atomic ions can be performed by atomic analysis, such as mass spectrometry (MS) or atomic emission spectrometry (AES). Particle based ICP analysis includes analysis of particles such as cells, beads, or laser ablation plumes, by atomizing and ionizing particles in an ICP torch followed by atomic analysis. In mass cytometry, mass tags of particles are analyzed by mass spectrometry, such as by ICP-MS. Systems and methods of the subject application include one or more of: a demountable ICP torch holder assembly, an external ignition device; an ICP load coil comprising an annular fin, particle suspension sample introduction fluidics, and ICP analyzers thereof.
    Type: Grant
    Filed: September 9, 2021
    Date of Patent: October 3, 2023
    Inventors: Alexander Loboda, Raymond Jong, Michael Sullivan, Serguei Vorobiev, Robert Rotenberg, Emil D. Stratulativ, Maxim Voronov, Mark Armstrong
  • Patent number: 11769655
    Abstract: A method of performing targeted multiplexed mass spectrometry includes performing, at a mass spectrometer, a targeted MS3 analysis of an isobaric tag-labeled target analyte included in a multiplex sample eluting from a column. The targeted MS3 analysis is performed during an acquisition segment scheduled based on an expected retention time of the isobaric tag-labeled target analyte. The method further includes performing, during the acquisition segment, a plurality of MS2 analyses of product ions derived from components included in the multiplex sample and eluting from the column. The method further includes determining, based on MS3 mass spectra acquired by the targeted MS3 analysis and MS2 mass spectra acquired by the plurality of MS2 analyses, a relative quantity of the isobaric tag-labeled target analyte in the multiplex sample.
    Type: Grant
    Filed: October 5, 2021
    Date of Patent: September 26, 2023
    Assignee: Thermo Finnigan LLC
    Inventor: Philip M. Remes
  • Patent number: 11764044
    Abstract: A method for deconvoluting measured mass spectrometry data, the method comprising: receiving measured mass spectrometry data representing at least two molecular moieties each having a respective isotopic pattern, wherein at least two of said isotopic patterns overlap; iteratively filling a set of mass channels to produce an approximated version of the mass spectrometry data, said iterative filling comprising a number of iterations, each iteration comprising filling one or more of the mass channels with a chunk of intensity data according to the isotopic pattern of a respective one of the two or more molecular moieties selected for said iteration; terminating said iterative filling when a fitness criterion is met indicating a fit of the approximated version of the mass spectrometry data to the measured mass spectrometry data; and determining the amount of each molecular moiety that produced the measured mass spectrometry data based on the total amount of fills according to the respective isotopic pattern of sa
    Type: Grant
    Filed: March 25, 2022
    Date of Patent: September 19, 2023
    Inventors: Frank Berg, Robert Malek, Kai Fritzemeier
  • Patent number: 11764048
    Abstract: A method of analysis using mass spectrometry and/or ion mobility spectrometry is disclosed. The method comprises: using a first device to generate smoke, aerosol or vapour from a target comprising or consisting of a microbial population; mass analysing and/or ion mobility analysing said smoke, aerosol or vapour, or ions derived therefrom, in order to obtain spectrometric data; and analysing said spectrometric data in order to analyse said microbial population.
    Type: Grant
    Filed: January 3, 2023
    Date of Patent: September 19, 2023
    Assignee: Micromass UK Limited
    Inventors: Zoltán Takáts, Frances Bolt, Tamás Karancsi, Emrys Jones, Keith Richardson, Lajos Godorhazy, Daniel Szalay, Julia Balog, Steven Derek Pringle, Daniel Simon
  • Patent number: 11764049
    Abstract: Exemplary embodiments may deploy a valve that introduces a sample of a calibrant coaxially with flow exiting a source of a mobile phase flow, such as a liquid chromatography (LC) column, on a path to an ion source for the mass spectrometer (MS). The valve may be positioned remotely on a branch that has a junction with the path leading form the source of the mobile phase flow to the ion source. Alternatively, the valve may be positioned in line on the flow path from the source of the mobile phase flow to the ion source of the MS. A novel five port valve design may be employed. With this valve design, a first position of the valve allows a sample loop for the calibrant to be filled. In a second position, the calibrant is added coaxially to the flow from the source of the mobile phase to the MS. In a third position of the valve, diversion of or infusion to a post-source flow is enabled.
    Type: Grant
    Filed: April 14, 2021
    Date of Patent: September 19, 2023
    Assignee: Waters Technologies Corporation
    Inventors: Michael O. Fogwill, Joseph D. Michienzi, Sylvain Gilles Cormier
  • Patent number: 11754536
    Abstract: Disclosed are methods, libraries, and samples for quantifying a target analyte in a laboratory sample including the target analyte. The methods typically include the step of estimating the amount of the target analyte in the laboratory sample from mass spectrometric data including signal intensities for the target analyte and one or more internal standards, where the mass spectrometric data are an output of a mass spectrometric analysis of a target sample produced from the laboratory sample and a predetermined amount of the one or more internal standards. The present disclosure also provides a method for analyte quantification. The method comprises adding one or more calibrators to a sample comprising one or more analytes; applying mass spectrometry (MS) to the sample; and using a trained machine learning model to determine an absolute concentration of the one or more analytes.
    Type: Grant
    Filed: September 7, 2022
    Date of Patent: September 12, 2023
    Inventors: Timothy Kassis, Jefferson Pruyne, Mark D. Simon, Mimoun Cadosch Delmar Akerman, Jennifer Campbell, Ana Henriques Da Costa, Laura Kolinsky, John M. Geremia
  • Patent number: 11754526
    Abstract: A method of evaluating an analysis device that is capable of detecting each of a plurality of compounds included in a sample includes introducing the sample including a first compound into the analysis device for measurement and detecting the first compound and at least one reaction product derived from the first compound, and acquiring information representing whether the analysis device is in a suitable state for an analysis based on an intensity of the detected first compound and an intensity of each of the detected at least one reaction product, and a relative response factor in regard to each of the first compound and the at least one reaction product.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: September 12, 2023
    Inventor: Yukihiko Kudo
  • Patent number: 11749501
    Abstract: An ion implantation apparatus includes a transfer device that transfers a wafer, a support device that supports the wafer at an implantation position, and a control device that controls the ion implantation apparatus to perform chain implantation processing on the wafer, and that controls the transfer device or the support device according to warpage information of the wafer.
    Type: Grant
    Filed: September 8, 2021
    Date of Patent: September 5, 2023
    Inventors: Jian Wang, Shinsuke Inoue, Yuta Iwanami, Takashi Sakamoto, Weijiang Zhao
  • Patent number: 11749516
    Abstract: An ion guide may comprise a set of plate electrodes, each plate electrode having a plurality of apertures formed therethrough. The set of plate electrodes are spatially arranged such that a relative positioning of each plurality of apertures of a respective plate electrode of the set of plate electrodes and respective adjacent plate electrodes of the set of plate electrodes defines a continuous ion flight path through the respective plurality of apertures of each plate electrode of the set of plate electrodes. The continuous ion flight path has a helical-based and/or spiral-based shape.
    Type: Grant
    Filed: May 31, 2022
    Date of Patent: September 5, 2023
    Assignee: Thermo Fisher Scientific (Bremen) GmbH
    Inventors: Hamish Stewart, Alexander Wagner, Alexander A. Makarov