Patents Examined by Michael Maskell
  • Patent number: 11232935
    Abstract: The compound list stored in identification information memory is populated with theoretical masses associated with a variety of compounds, as well as information such as the type of matrix capable of detecting said compound, potential neutral loss, etc. The adduct ion list, meanwhile, is populated with theoretical masses associated with a variety of adduct ions, as well as other information such as types of matrices capable of producing adducts, etc. When a user specifies a peak on the mass spectrum for a compound search, compound candidate search portion extracts combination candidates based on how well the measured m/z value of the specified peak matches the m/z value for combinations of compounds in the compound list and adduct ions in the adduct ion list, while the type of matrix used during measurement serves as a condition to narrow down the combinations. Display processing portion displays a list of the search results.
    Type: Grant
    Filed: September 1, 2016
    Date of Patent: January 25, 2022
    Inventors: Masahiro Ikegami, Koretsugu Ogata
  • Patent number: 11232938
    Abstract: Methods and systems for delivering liquid sample to an ion source and subsequent analysis by mass spectrometry. In accordance with various aspects of the present teachings, MS-based systems and methods are provided in which desorption solvent is used in sampling interface to desorb analyte species from an SPME device that is coupled to an ion source to ionize analyte species desorbed into the desorption solvent for MS analysis (e.g., without a liquid chromatography (LC) column between the sampling interface and the ion source). In various aspects of the methods and systems described herein, configuring the sampling interface can be optimized so as to reduce the fluid volume dead space about the fluid inlet so as to concentrate the one or more analyte species desorbed at optimized conditions from the SPME substrate in a decreased volume of the desorption solvent when the SPME device is inserted into sampling interface.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: January 25, 2022
    Assignee: DH Technologies Development Pte. Ltd.
    Inventors: Don W Arnold, Thomas R Covey, Chang Liu
  • Patent number: 11226309
    Abstract: Techniques and apparatus for generated predicted collision cross-section (CCS) values based on a hybrid CCS prediction processes are described. In one embodiment, for example, an apparatus may include at least one memory, and logic coupled to the at least one memory. The logic may be configured to implement a predicted CCS process, for example, by receiving analytical information from analysis of a sample using an ion mobility spectrometry instrument, the sample comprising at least one component, generating an approximate molecular model for the component via an approximate molecular modeling process, and generating a predicted CCS value via a computational model based on the approximate molecular model. Other embodiments are described.
    Type: Grant
    Filed: April 15, 2020
    Date of Patent: January 18, 2022
    Inventors: Keith G. Richardson, Hans Vissers
  • Patent number: 11223181
    Abstract: Methods and corresponding apparatus operable to cause an interaction between a drive radiation beam and a medium for generation of emitted radiation by high harmonic generation, the arrangement comprising: an interaction region positioned at an interaction plane and configured to receive the medium; a beam block positioned upstream of the interaction plane at a beam block plane and configured to partially block the drive radiation beam; a beam shaper positioned upstream of the beam block plane at an object plane and configured to control a spatial distribution of the drive radiation beam; and at least one lens positioned upstream of the interaction plane and downstream of the beam block plane, wherein the lens being positioned such that an image of the spatial distribution of the drive radiation beam is formed at the interaction plane.
    Type: Grant
    Filed: August 19, 2019
    Date of Patent: January 11, 2022
    Assignee: ASML Netherlands B.V.
    Inventors: Petrus Wilhelmus Smorenburg, Gerrit Jacobus Hendrik Brussaard, David O Dwyer
  • Patent number: 11222764
    Abstract: A charged particle beam device includes: a charged particle source; an optical system which acts on a charged particle beam emitted from the charged particle source; a control unit which controls the optical system; and a storage unit which stores previous setting values of the optical system. The optical system includes a first optical element and a second optical element for controlling a state of the charged particle beam to be incident on the first optical element. The control unit obtains an initial value of a setting value of the second optical element based on previous setting values of the second optical element; and changes a state of the charged particle beam by changing the setting value of the second optical element from the obtained initial value and obtains the setting value of the second optical element based on the change in the state of the charged particle beam.
    Type: Grant
    Filed: March 23, 2020
    Date of Patent: January 11, 2022
    Assignee: JEOL Ltd.
    Inventors: Kazuya Yamazaki, Yuko Shimizu, Hirofumi Iijima, Takuma Fukumura, Naoki Hosogi, Tomohiro Nakamichi
  • Patent number: 11217438
    Abstract: A method of mass spectrometry or ion mobility spectrometry is disclosed comprising: providing an analyte; supplying a matrix compound to said analyte such that said analyte dissolves in said matrix; forming first droplets of the dissolved analyte; and colliding said first droplets with a collision surface. The use of matrix improves the analyte ion signal.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: January 4, 2022
    Assignee: Micromass UK Limited
    Inventors: Emrys Jones, Tamas Karancsi, Steven Derek Pringle, Julia Balog, Daniel Simon, Lajos Godorhazy, Daniel Szalay, Zoltan Takats
  • Patent number: 11217436
    Abstract: There is provided a method of measuring a mass of an ion species in a mass stream. Where the mass stream is a mass stream emitted from a separation device as a function of a separation parameter, the method comprising: obtaining a mass trace for the ion species, wherein the mass trace comprises a set of intensity peaks, each intensity peak providing a respective measured mass and a respective signal measured by a mass spectrometer; and determining the mass of the ion species as an extrapolation of the measured masses of the set of intensity peaks of the mass trace towards a signal zero.
    Type: Grant
    Filed: November 22, 2019
    Date of Patent: January 4, 2022
    Assignee: Thermo Fisher Scientific (Bremen) GmbH
    Inventor: Hans Pfaff
  • Patent number: 11211150
    Abstract: A preprocessor extracts a plurality of spectra to be processed, from an overall mass spectrum. A simulated spectrum generator having a learned model generates a simulated spectrum having a peak discriminating action, from each mass spectrum. A postprocessor generates a combined simulated spectrum based on the plurality of simulated spectra. A peak filter executes peak discrimination on a peak list using the combined simulated spectrum.
    Type: Grant
    Filed: August 27, 2020
    Date of Patent: December 28, 2021
    Assignee: JEOL Ltd.
    Inventors: Fuminori Uematsu, Takaya Satoh, Masahiko Takei
  • Patent number: 11211236
    Abstract: Real-time search (RTS) for mass spectrometry is described. In one aspect, a mass spectrometer can identify a candidate peptide for a product ion spectrum by searching a mass spectral database. While executing the search of the mass spectral database, a candidate peptide score representing a confidence of a match between the product ion spectrum and a theoretical mass spectrum stored in the mass spectral database is generated. A failing score can be promoted to a passing result based on attributes of the candidate peptide.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: December 28, 2021
    Assignee: Thermo Finnigan LLC
    Inventor: Derek J. Bailey
  • Patent number: 11210065
    Abstract: An item setter sets a plurality of first analysis parameters included in first analysis condition data acquired by an analysis condition data acquirer in a first item that is dependent on characteristics of a first analysis device and a second analysis device, and a second item that is not dependent on the characteristics of the first and second analysis devices. A parameter value converter converts a value of a first analysis parameter of the first item that is set by the item setter into a value of a second analysis parameter corresponding to a second data processing device for the second analysis device, and takes a value of a first analysis parameter of the second item that is set by the item setter as a value of a second analysis parameter as it is.
    Type: Grant
    Filed: September 20, 2018
    Date of Patent: December 28, 2021
    Inventors: Akane Yamamoto, Yoshiki Tainaka
  • Patent number: 11205524
    Abstract: Embodiments of the present disclosure relate to atomic beam collimators and, more particularly, to miniaturized coplanar atomic beam collimators. In some examples, an atomic beam collimator may comprise an atomic channel disposed in a substrate. Additional atomic channels may be provided coplanar with the first atomic channel in the substrate. Some examples include a series of cascaded atomic channels, each cascaded atomic channel separated by a gap. The gaps may reduce the off-flux atoms in the output of the atomic collimator. In some examples, a system may comprise an atomic collimator, an atom source, and/or a microelectromechanical system device. These component can be separate devices or can be incorporated into a common substrate.
    Type: Grant
    Filed: May 17, 2019
    Date of Patent: December 21, 2021
    Assignee: Georgia Tech Research Corporation
    Inventors: Chandra Raman, Farrokh Ayazi
  • Patent number: 11195709
    Abstract: An ambient ionisation source unit (10) is provided comprising: a housing (12) containing a first device (14) for generating analyte material from a surface of a sample to be analysed and a sampling inlet (16) for receiving analyte material liberated from the surface of the sample. The position(s) of the first device and/or sampling inlet is (are) fixed relative to the housing. Thus, the first device and the sampling inlet are integrated into a single unit that can be installed onto the front-end of an ion analysis instrument with minimal or reduced user interaction.
    Type: Grant
    Filed: April 11, 2018
    Date of Patent: December 7, 2021
    Assignee: Micromass UK Limited
    Inventors: Emrys Jones, Steven Derek Pringle, Michael Raymond Morris
  • Patent number: 11189387
    Abstract: A suspension device (10) for at least partially supporting a radioprotection garment (12) worn by an intended user (14), including a harness (34) wearable by the intended user (14) under the radioprotection garment (12), the harness including a harness attachment (38); a support (28) positionable above the intended user (14); an elongated flexible element (30) operatively coupled to the support (28) to be supported thereby; a flexible element attachment (32) secured to the elongated flexible element (30) opposed to the support (28); the harness (34) and flexible element attachment (38) being reversibly attachable to each other.
    Type: Grant
    Filed: November 18, 2020
    Date of Patent: November 30, 2021
    Inventors: Jean Arsenault, Normand Boiteau
  • Patent number: 11189475
    Abstract: A desolvation unit performs desolvation by heating after a sample solution is turned to sample mist by a nebulizer. A sample gas that contains the desolvated sample mist and a carrier gas is introduced through a sample introduction tube to a plasma torch. An addition unit for adding, to the sample introduction tube, a water-containing gas is provided. The addition unit includes a container that contains ultrapure water, a gas tube for introducing the carrier gas into the ultrapure water to cause bubbling, and a gas tube for adding the water-containing gas, to the sample introduction tube. The plasma torch generates an inductively coupled plasma under the condition that supplied power is set to a range of 550 W to 700 W. Generation of interfering molecule ions due to an element having a high ionization potential is inhibited when an element in a sample ionized by the plasma is analyzed.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: November 30, 2021
    Inventor: Kenji Araki
  • Patent number: 11177120
    Abstract: A mass spectrometry method includes: preparing calibration data for performing calibration on a basis of first data obtained by detecting a chlorobiphenyl in first mass spectrometry of a reference sample of the chlorobiphenyl; acquiring second data obtained by detecting, in second mass spectrometry of a sample, at least one chlorobiphenyl that has a same chlorine number as and is different in kind from the chlorobiphenyl detected in the first mass spectrometry; and calculating a quantitative value for the chlorobiphenyl contained in the sample on a basis of the calibration data and the second data.
    Type: Grant
    Filed: April 3, 2019
    Date of Patent: November 16, 2021
    Inventor: Riki Kitano
  • Patent number: 11164718
    Abstract: An electron beam detection element according to an exemplary embodiment includes a plurality of unit cells. Each of the plurality of unit cells includes a diode of avalanche multiplication type and a plurality of memories. The diode of avalanche multiplication type is configured to detect an electron beam. The plurality of memories store signals of different frames respectively, each of the signals being output from the diode.
    Type: Grant
    Filed: November 2, 2018
    Date of Patent: November 2, 2021
    Assignee: Canon Kabushiki Kaisha
    Inventor: Yukihiro Kuroda
  • Patent number: 11158483
    Abstract: A charged particle beam deflection device includes a substrate; a plurality of apertures provided in the substrate; a plurality of electrodes deflecting charged particle beams passing through the apertures; a plurality of light-receiving elements controlling voltages applied to the plurality of electrodes; a first optical coupler coupling continuous light to the substrate; a light distributor distributing light coupled by the first optical coupler into a two-dimensional plane; a plurality of modulators performing intensity modulation of light distributed by the light distributor; and a plurality of second optical couplers coupling the modulated light to the light-receiving elements.
    Type: Grant
    Filed: September 4, 2020
    Date of Patent: October 26, 2021
    Inventors: Kazuya Ohira, Hideto Furuyama
  • Patent number: 11152187
    Abstract: A method for positioning a specimen in a microscope system includes overserving and/or processing a region of interest (ROI) on the specimen. The microscope system includes: an optical axis; a movable specimen stage for receiving a specimen; a memory apparatus for storing data records that describe the positions of the specimen; and a control apparatus, which can control the movement of the specimen stage with the aid of the stored data records. The method includes: holding a specimen region (ROI) in the first position; storing a first data record, by which the first position is described, wherein the first position is defined as independent position; storing a second data record, by which the second position is described, wherein the second position is linked to the independent position; and calling one of the stored data records such that the specimen stage is moved in such a way that the specimen region is held at the position that is described by the called data record.
    Type: Grant
    Filed: May 13, 2019
    Date of Patent: October 19, 2021
    Assignee: Carl Zeiss Microscopy GmbH
    Inventor: Josef Biberger
  • Patent number: 11152200
    Abstract: An interface device, for providing a fluidic interface between a sample separation device and a mass spectrometer, includes an emitter capillary and a plurality of sample capillaries. The sample capillaries are movably arranged within the emitter capillary for transferring fluidic sample from the sample separation device to the mass spectrometer.
    Type: Grant
    Filed: January 30, 2020
    Date of Patent: October 19, 2021
    Assignee: Agilent Technologies, Inc.
    Inventor: Hans-Peter Zimmermann
  • Patent number: 11150249
    Abstract: A microorganism identification method utilizing mass spectrometry is provided. More specifically, a method for identifying a phylotype of Cutibacterium acnes utilizing mass spectrometry is provided. The method includes a) a step for reading out a m/z value of a peak derived from a marker protein on a mass spectrum which is obtained by mass spectrometry of a sample containing microorganisms; and b) a step for judging whether the sample contains Cutibacterium acnes (C. acnes) based on the m/z value.
    Type: Grant
    Filed: February 26, 2020
    Date of Patent: October 19, 2021
    Inventor: Kanae Teramoto