Patents Examined by Michael Maskell
  • Patent number: 12154774
    Abstract: A mass spectrometer includes an ion source configured to produce ions from a sample; a set of quadrupole rods configured to select ions based on a mass-to-charge ratio; a DC rod driver configured to produce a voltage; a DC rod driver filter configured to filter RF frequency interference; and a controller. The controller is configured to utilize the results of the constrained convex optimization to cause a DC rod drive to produce the DC filter input and provide a required voltage to the set of quadrupole rods, the constrained convex utilizing a impulse response curve of the DC rod driver filter to determine a DC filter input to achieve the required voltage on the set of quadrupole rods; select ions passing through the set of quadrupole rods based on the mass-to-charge ratio; and measure the intensity of the ions.
    Type: Grant
    Filed: November 30, 2021
    Date of Patent: November 26, 2024
    Assignee: Thermo Finnigan LLC
    Inventors: Johnathan W. Smith, Scott T. Quarmby
  • Patent number: 12154779
    Abstract: The invention generally relates to systems and methods for separating ions at about or above atmospheric pressure. In certain embodiments, the invention provides systems that include an ionization source that generates ions and an ion trap. The ion trap is maintained at about or above atmospheric pressure and includes a plurality of electrodes and at least one inlet configured to receive a gas flow and at least one outlet. The system is configured such that a combination of a gas flow and one or more electric fields produced by the electrodes separates the ions based on mass-to-charge ratio and sends the separated ions through the at least one outlet of the ion trap.
    Type: Grant
    Filed: February 10, 2023
    Date of Patent: November 26, 2024
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Dalton Snyder, Amar S. Basu, Wen-Ping Peng
  • Patent number: 12146869
    Abstract: Disclosed are methods, libraries, and samples for quantifying a target analyte in a laboratory sample including the target analyte. The methods typically include the step of estimating the amount of the target analyte in the laboratory sample from mass spectrometric data including signal intensities for the target analyte and one or more internal standards, where the mass spectrometric data are an output of a mass spectrometric analysis of a target sample produced from the laboratory sample and a predetermined amount of the one or more internal standards. The present disclosure also provides a method for analyte quantification. The method comprises adding one or more calibrators to a sample comprising one or more analytes; applying mass spectrometry (MS) to the sample; and using a trained machine learning model to determine an absolute concentration of the one or more analytes.
    Type: Grant
    Filed: July 14, 2023
    Date of Patent: November 19, 2024
    Assignee: MATTERWORKS INC
    Inventors: Timothy Kassis, Jefferson Pruyne, Mark D. Simon, Mimoun Cadosch Delmar Akerman, Jennifer Campbell, Ana Henriques Da Costa, Laura Kolinsky, John M. Geremia
  • Patent number: 12135314
    Abstract: A chromatograph mass spectrometer according to an aspect of the present invention is a chromatograph mass spectrometer including: a chromatograph unit (LC unit 1) configured to separate components in a sample; and a mass spectrometer (MS unit 2) configured to execute mass spectrometry on ions having a specific mass-to-charge ratio derived from a compound for each compound temporally separated by the chromatograph unit, the chromatograph mass spectrometer further including: an analysis condition setting unit (30) configured to allow a user to input a width of a peak on a chromatogram as one of analysis parameters; a data point number storage (311) configured to store information on an appropriate number of data points corresponding to one peak; a sampling time interval calculator (312) configured to calculate a sampling time interval, which is a timing for acquiring data for creating the chromatogram, from the inputted peak width and data point number; and an analysis control unit (32) configured to control an
    Type: Grant
    Filed: June 20, 2019
    Date of Patent: November 5, 2024
    Assignee: SHIMADZU CORPORATION
    Inventor: Kazuma Maeda
  • Patent number: 12130268
    Abstract: An integrated system for liquid separation and electrospray ionization includes an emitter-enabled capillary column including an emitter portion and a column portion; and a retractable protective sleeve for covering and/or supporting the emitter portion along at least a portion of its axis. The protective sleeve is mounted around the emitter-enabled capillary column. The retractable protective sleeve is moveable to an extended position wherein a tip of the emitter portion is covered by the protective sleeve. A resilient member is provided to bias the protective sleeve towards the extended position. The protective sleeve is enclosed and moveable within an outer electrically conductive sheath adapted for insertion within a holder having a high-voltage contact point. The sheath is adapted to contact the high-voltage contact point and provide an electrical connection to enable the emitter-enabled capillary column to receive a high voltage. The sheath has a recess to receive the high-voltage contact point.
    Type: Grant
    Filed: June 26, 2023
    Date of Patent: October 29, 2024
    Assignee: Dionex Corporation
    Inventors: Brandon Howard Robson, Xuefei Sun, Carla Marie Medlin, Shane Bechler
  • Patent number: 12130255
    Abstract: The invention generally relates to high-throughput label-free enzymatic bioassays using desorption electrospray ionization-mass spectrometry (DESI-MS).
    Type: Grant
    Filed: December 20, 2022
    Date of Patent: October 29, 2024
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Nicolás M. Morato, Dylan T. Holden
  • Patent number: 12119085
    Abstract: Systems and methods of predicting a Cannabis chemotype from genetic data include obtaining a training dataset comprising genetic data for at least one mature Cannabis plant, and corresponding chemotype information for the at least one mature Cannabis plant, generating a chemotype prediction model based on the training dataset, the chemotype prediction model being able to predict the chemotype of a mature Cannabis plant, receiving genetic data for a Cannabis seedling, and predicting, via the chemotype prediction model, the chemotype of the Cannabis seedling upon maturation.
    Type: Grant
    Filed: October 5, 2023
    Date of Patent: October 15, 2024
    Assignee: Cannamatrix Inc.
    Inventor: Emanuel Maminakis
  • Patent number: 12111285
    Abstract: First product ion spectrum data is acquired by dissociating a precursor ion derived from a sample component by collision between the precursor ion and an inert gas molecule to generate product ions, and detecting the product ions after separating the product ions according to a mass-to-charge ratio; second product ion spectrum data is acquired by dissociating the precursor ion by a reaction of the precursor ion with hydrogen radicals to generate product ions, and detecting the product ions after separating the product ions according to a mass-to-charge ratio; and a set of product ions having a predetermined mass difference is extracted in the first product ion spectrum data and the second product ion spectrum data.
    Type: Grant
    Filed: November 11, 2019
    Date of Patent: October 8, 2024
    Assignee: SHIMADZU CORPORATION
    Inventors: Hidenori Takahashi, Sadanori Sekiya, Shosei Yamauchi
  • Patent number: 12112933
    Abstract: An imaging mass spectrometer according to one mode of the present invention includes: an analysis execution section (1, 31) configured to perform a mass spectrometric analysis on each of a plurality of measurement points set within a two-dimensional area on a sample, to collect mass spectrum data over a predetermined mass-to-charge-ratio range for each measurement point; a condition memory section (32) configured to store a data matrix creation condition to be used for creation of a data matrix based on the mass spectrum data acquired by the analysis in the analysis execution section; and a data matrix creation section (42) configured to begin, in the middle of an execution of the analysis by the analysis execution section or subsequently to the completion of the analysis, the creation of the data matrix based on mass spectrum data already collected until then, according to the data matrix creation condition stored in the condition memory section.
    Type: Grant
    Filed: August 1, 2019
    Date of Patent: October 8, 2024
    Assignee: SHIMADZU CORPORATION
    Inventor: Kengo Takeshita
  • Patent number: 12100525
    Abstract: An apparatus for supporting spent nuclear fuel including a plurality of wall plates arranged in an intersecting manner to define a basket apparatus extending along a longitudinal axis. The basket apparatus may include a plurality of fuel cells and a plurality of flux traps between adjacent fuel cells. A plurality of reinforcement members may be positioned in the flux traps and may extend between opposing ones of the wall plates that form the flux traps. Each of the wall plates may be a slotted wall plate. The slotted wall plates may be interlocked with one another to form the basket apparatus. Each of the slotted wall plates may include an upper edge, a lower edge, and a plurality of plate slots formed in each of the upper and lower edges. The plate slots of the slotted wall plates may receive intersecting slotted wall plates.
    Type: Grant
    Filed: June 29, 2023
    Date of Patent: September 24, 2024
    Inventors: Krishna P. Singh, P. Stefan Anton
  • Patent number: 12092608
    Abstract: An ion analysis device 1 configured to generate and analyze product ions from precursor ions derived from a sample component includes: a reaction chamber 132 into which the precursor ions are introduced; a radical emitter 134 made of a predetermined kind of metal and disposed in the reaction chamber or a space communicating with the reaction chamber, at least a part of a surface of the radical emitter being oxidized or nitrided; a heating unit 20 configured to heat the radical emitter to a predetermined temperature; and separation detection units 135 and 136 configured to separate and detect, according to at least one of a mass-to-charge ratio and an ion mobility, product ions generated from the precursor ions by a reaction with radicals emitted from the radical emitter heated to the predetermined temperature.
    Type: Grant
    Filed: March 12, 2020
    Date of Patent: September 17, 2024
    Assignee: SHIMADZU CORPORATION
    Inventor: Hidenori Takahashi
  • Patent number: 12087565
    Abstract: An object of the invention is to provide a mass spectrometer capable of preventing a sample from remaining inside an ion source container for a long time. In the mass spectrometer according to the invention, in addition to a first gas used for ionizing an ion source, a second gas flowing toward an exhaust unit along an inner wall of the ion source container is supplied inside the ion source container (see FIG. 1).
    Type: Grant
    Filed: July 10, 2019
    Date of Patent: September 10, 2024
    Assignee: Hitachi High-Tech Corporation
    Inventors: Kouji Ishiguro, Kiyomi Yoshinari
  • Patent number: 12087568
    Abstract: Inductively coupled plasma (ICP) analyzers use an ICP torch to generate a plasma in which a sample is atomized an ionized. Analysis of the atomic ions can be performed by atomic analysis, such as mass spectrometry (MS) or atomic emission spectrometry (AES). Particle based ICP analysis includes analysis of particles such as cells, beads, or laser ablation plumes, by atomizing and ionizing particles in an ICP torch followed by atomic analysis. In mass cytometry, mass tags of particles are analyzed by mass spectrometry, such as by ICP-MS. Systems and methods of the subject application include one or more of: a demountable ICP torch holder assembly, an external ignition device; an ICP load coil comprising an annular fin, particle suspension sample introduction fluidics, and ICP analyzers thereof.
    Type: Grant
    Filed: August 28, 2023
    Date of Patent: September 10, 2024
    Assignee: STANDARD BIOTOOLS CANADA INC.
    Inventors: Alexander Loboda, Raymond Jong, Michael Sullivan, Serguei Vorobiev, Robert Rotenberg, Emil D. Stratulativ, Maxim Voronov, Mark Armstrong
  • Patent number: 12085689
    Abstract: A system for passively monitoring territory proximate to or at restrictive boundaries for tunnels, the system comprising a plurality of muon sensors, a data network in communication with each muon sensor, a power network in electrical communication with each muon sensor, and a data analysis unit, the data analysis unit in communication with each muon sensor via the data network, the data analysis unit comprising a memory and a processor, the memory configured to instruct the processor to analyse data from the plurality of muon detectors to identify and locate a new or emerging tunnel. A method of locating tunnels is also provided.
    Type: Grant
    Filed: April 3, 2020
    Date of Patent: September 10, 2024
    Assignee: IDEON TECHNOLOGIES INC.
    Inventor: Douglas William Schouten
  • Patent number: 12078611
    Abstract: A gas analyzing apparatus includes: an ionization device that generates an ion flow of a sample gas; an analyzer that analyzes the ion flow supplied from the ionization device; a first ion path that non-linearly guides the ion flow from the ionization device to an inlet of the analyzer; and a blocking device for intermittently blocking and releasing, using an electric field or a magnetic field, the ion flow on at least part of a path of the ion flow through the first ion path to a mass filter of the analyzer. It is possible to perform measurement in a state where the ion flow is blocked and measurement in a state where the ion flow is not blocked.
    Type: Grant
    Filed: January 25, 2022
    Date of Patent: September 3, 2024
    Assignee: ATONARP INC.
    Inventor: Naoki Takahashi
  • Patent number: 12077806
    Abstract: The invention relates to a method for the spectrometric characterization of microorganisms, comprising: providing a test microorganism; acquiring spectrometric measurement data from the test microorganism under potential exposure to variance that is not based on taxonomic classification; selecting a classifier which is trained to determine the identity of a microorganism on a second taxonomic level; and applying the classifier to the measurement data in order to determine the identity of the test microorganism on the second taxonomic level, wherein the classifier is variance-conditioned in such a way that it largely or completely masks out the effect of variance in the characterization of the test microorganism on the second taxonomic level.
    Type: Grant
    Filed: April 19, 2023
    Date of Patent: September 3, 2024
    Inventor: Norman Mauder
  • Patent number: 12080540
    Abstract: A mass spectrometer is disclosed comprising a rotatable isolation valve 1 having a curved, spherical, cylindrical or concave portion. At least a portion of an ion guide 2 is positioned so as to extend within a swept volume of the isolation valve 1 enabling the ion guide 2 to be positioned close to a second downstream ion guide 3 and for ions to be transmitted from the first 2 ion guide to the second ion guide 3 with high ion transmission efficiency.
    Type: Grant
    Filed: September 7, 2022
    Date of Patent: September 3, 2024
    Assignee: Micromass UK Limited
    Inventors: Paul Murray, Mark Towers, Andrew Whatley, Matthew Henderson, Philippa Hart, Emmanuelle Claude, Richard Jarrold, Jeff Brown, Steve Brace, Edward Scott
  • Patent number: 12072351
    Abstract: A new integrated III-V/silicon Atomic Force Microscopy (AFM) active optical probe integrates a III-V semiconductor laser source and a silicon cantilever AFM probe into a robust easy-to-use single III-V/silicon chip to enable AFM measurements, optical imaging, and spectroscopy at the nanoscale.
    Type: Grant
    Filed: November 20, 2020
    Date of Patent: August 27, 2024
    Assignee: ACTOPROBE LLC
    Inventors: Alexander A. Ukhanov, Gennady A Smolyakov, Fei Hung Chu
  • Patent number: 12068148
    Abstract: The invention generally relates to mass spectrometers that utilize ionic wind and methods of use thereof.
    Type: Grant
    Filed: April 4, 2023
    Date of Patent: August 20, 2024
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Brett M. Marsh
  • Patent number: 12061136
    Abstract: A measuring apparatus includes an input to receive an aerosol sample, a modifier unit to provide a modified sample by removing particles of the aerosol sample, and a sensor unit to measure a spectral profile by detecting molecules of the gas phase of the modified sample, wherein the spectral profile is a mobility spectrum or a mass spectrometer spectrum, the modifier unit is arranged to generate a corona discharge, to form charged particles by charging particles of the aerosol sample with the corona discharge, and to provide the modified sample by removing the charged particles with an electric field, the particle removal efficiency of the modifier unit has a cutoff size to prevent propagation of particles larger than the cutoff size to the sensor unit, and the cutoff size is in the range of 1 nm to 20 nm.
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: August 13, 2024
    Assignee: Olfactomics Oy
    Inventors: Antti Roine, Markus Karjalainen, Niku Oksala, Anton Kontunen, Sampo Saari