Patents Examined by Michael Maskell
  • Patent number: 11562885
    Abstract: A beamline ion implanter and a method of operating a beamline ion implanter. A method may include performing an ion implantation procedure during a first time period on a first set of substrates, in a process chamber of the ion implanter, and performing a first pressure-control routine during a second time period by: introducing a predetermined gas to reach a predetermined pressure into at least a downstream portion of the beam-line for a second time period. The method may include, after completion of the first pressure-control routine, performing the ion implantation procedure on a second set of substrates during a third time period.
    Type: Grant
    Filed: June 18, 2021
    Date of Patent: January 24, 2023
    Assignee: Applied Materials, Inc.
    Inventors: Thomas Stacy, Jay T. Scheuer, Eric D. Hermanson, Bon-Woong Koo, Tseh-Jen Hsieh
  • Patent number: 11561223
    Abstract: Disclosed is a method of isolating extracellular vesicles and identifying membrane proteins therefrom. The method includes providing human plasma and/or serum; separating lipoproteins and extracellular vesicles from the human plasma and/or serum by a density gradient preparation, collecting the extracellular vesicles from the separated lipoproteins and extracellular vesicles; isolating and purifying the collected extracellular vesicles by using size exclusion chromatography; treating the isolated and purified extracellular vesicles with an aqueous solution to obtain membranes of the extracellular vesicles, wherein the aqueous solution has a pH in a range of 9 to 14; adding salt in a concentration range between 0.5-2.0M to the aqueous solution; isolating the membranes from the treated extracellular vesicles and identifying proteins on the isolated membranes by employing mass spectrometry.
    Type: Grant
    Filed: September 17, 2018
    Date of Patent: January 24, 2023
    Assignee: Exocure Biosciences Inc.
    Inventors: Jan Lotvall, Su Chul Jang, Aleksander Cvjetkovic, Cecilia Lasser
  • Patent number: 11549807
    Abstract: A pattern according to an embodiment includes first and second line patterns, each of the first and second line patterns extends in a direction intersecting a <111> direction and has a side surface, the side surface has at least one {111} crystal plane, the side surface of the first line pattern has a first roughness, and the side surface of the second line pattern has a second roughness larger than the first roughness.
    Type: Grant
    Filed: March 9, 2020
    Date of Patent: January 10, 2023
    Assignee: KIOXIA Corporation
    Inventors: Susumu Iida, Satoshi Tanaka, Takayuki Uchiyama
  • Patent number: 11547770
    Abstract: UV lamp modules for the ultraviolet irradiation of a substrate. The modules include multiple low-pressure mercury lamps, each having a longitudinal axis, located in a waterproof housing having a bottom, a top and a beam exit opening in the bottom which is closed by a beam exit window. To maintain hygiene, homogeneity and compactness, a first airflow zone for the supply of cooling air and a second, separate airflow zone for the discharge of heated cooling air are formed iii the housing. Viewed in a cross-section through the housing perpendicular to the longitudinal axes of the lamps and in a viewing direction from the bottom to the top, the beam exit window, the lamps and the airflow zones are arranged one after the other. The first airflow zone comprises an air supply duct which is equipped with at least one air-guiding mechanism for supplying cooling air to the lamps.
    Type: Grant
    Filed: December 10, 2018
    Date of Patent: January 10, 2023
    Inventors: Johannes Kraft, Silke Schloemp, Jan Winderlich
  • Patent number: 11545348
    Abstract: A measurement section (1) performs a mass spectrometric analysis for each micro area within a measurement area on a sample. A dimension reduction processor (23) performs data processing by non-linear dimension reduction using manifold learning on mass spectrometric data for each micro area, to obtain, for each micro area, a set of data reduced to three dimensions from the dimensions corresponding to the number of mass-to-charge-ratio values. A display color determiner (24) determines a color for each of the points corresponding to the data of the micro areas after the dimension reduction, by arranging those points within a three-dimensional space having three axes representing the three dimensions, with three primary colors respectively assigned to the three axes.
    Type: Grant
    Filed: February 12, 2021
    Date of Patent: January 3, 2023
    Inventor: Shinichi Yamaguchi
  • Patent number: 11531005
    Abstract: The invention generally relates to high-throughput label-free enzymatic bioassays using desorption electrospray ionization-mass spectrometry (DESI-MS).
    Type: Grant
    Filed: June 22, 2022
    Date of Patent: December 20, 2022
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Nicolás M. Morato, Dylan T. Holden
  • Patent number: 11531012
    Abstract: In a chromatograph mass spectrometer having a measurement unit (1) including a chromatograph is combined with a tandem mass spectrometry section capable of an MS/MS analysis, a controller (40) performs chromatograph mass spectrometry by controlling the measurement unit so as to operate the tandem mass spectrometry section to cyclically perform analysis cycles, where each of the analysis cycles includes a first mass spectrometric analysis in which a measurement of ions is performed over a predetermined m/z range and an MS/MS analysis by DIA in which ions included within each of a plurality of windows formed by dividing the m/z range are designated as a precursor ion. A window selector (42, 43) selects, during an execution of an analysis cycle, a window among the plurality of windows for an MS/MS analysis by DDA which is irregularly performed in an ongoing analysis cycle, based on intensity information obtained for each of the plurality of windows from an MS/MS spectrum acquired by the MS/MS analysis by DIA.
    Type: Grant
    Filed: September 20, 2021
    Date of Patent: December 20, 2022
    Inventors: Kazuma Maeda, Toshiya Matsubara
  • Patent number: 11525833
    Abstract: The present invention provides rapid, sensitive high-throughput methods and systems for characterizing peptides or proteins using hydrophobic interaction chromatography-coupled native mass spectrometry to improve manufacturing process of biopharmaceutical products, such as identifying impurities during antibody purification, monitoring post-translational modification variants during production, or characterizing drug-to-antibody ratio of antibody-drug conjugates. The separation profiles of the peptides or proteins are generated and compared to identify or qualify the peptides or proteins.
    Type: Grant
    Filed: September 27, 2020
    Date of Patent: December 13, 2022
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Yuetian Yan, Shunhai Wang
  • Patent number: 11527396
    Abstract: A multipole with mounting rings arranged on its end faces for mounting the multipole in a mass spectrometer includes two electrode half-shells each having at least two electrodes joinable together by positive-fitting connections on the electrode half-shell longitudinal edges. Each positive-fitting connection includes a fitting and a matching mating fitting, the fitting integrally formed on one electrode half-shell and the mating fitting integrally formed on the other electrode half-shell. Each mounting ring has two mounting ring fittings. One mounting ring fitting can be joined to a mating fitting integrally formed on one of the two electrode half-shells and the other of the two mounting ring fittings can be joined to a mating fitting integrally formed on the other of the two electrode half-shells. Furthermore, a mounting ring for such a multipole has two mounting ring fittings joinable to corresponding mating fittings integrally formed on the electrode half-shells.
    Type: Grant
    Filed: October 21, 2021
    Date of Patent: December 13, 2022
    Assignee: VACUTEC Hochvakuum- & Praezisionstechnik GmbH
    Inventors: Roman Knutas, Carsten Laser
  • Patent number: 11527394
    Abstract: A method of determining one or more interference parameters for a particular peak of an isotopic distribution corresponding to a precursor molecule in MS scan data is provided. The MS scan data comprises a plurality of peaks. Each peak has a mass-to-charge ratio and a relative abundance. The isotopic distribution comprises a subset of the plurality of peaks. The one or more interference parameters comprises a peak purity, pi, for the particular peak. The method comprises determining that there are no interfering peaks relevant to the isotopic distribution and determining that the peak purity, pi, for the particular peak should be a maximum purity value.
    Type: Grant
    Filed: April 28, 2021
    Date of Patent: December 13, 2022
    Assignee: Thermo Fisher Scientific (Bremen) GmbH
    Inventors: Christian Thoeing, Anastassios Giannakopulos
  • Patent number: 11515136
    Abstract: A method of spectrometric analysis comprises obtaining one or more sample spectra for an aerosol, smoke or vapour sample. The one or more sample spectra are subjected to pre-processing and then multivariate and/or library based analysis so as to classify the aerosol, smoke or vapour sample. The results of the analysis are used for various surgical or non-surgical applications.
    Type: Grant
    Filed: September 4, 2020
    Date of Patent: November 29, 2022
    Assignee: Micromass UK Limited
    Inventors: Keith Richardson, Steven Derek Pringle, Julia Balog, Zoltan Takats
  • Patent number: 11508591
    Abstract: An electron source emits an electron beam. The electron beam is received by a beam limiting assembly. The beam limiting assembly has a first beam limiting aperture with a first diameter and a second beam limiting aperture with a second diameter larger than the first diameter. The first beam limiting aperture receives the electron beam. This beam limiting assembly reduces the influence of Coulomb interactions.
    Type: Grant
    Filed: February 8, 2021
    Date of Patent: November 22, 2022
    Assignee: KLA Corporation
    Inventors: Xinrong Jiang, Christopher Sears, Nikolai Chubun, Luca Grella
  • Patent number: 11506644
    Abstract: A first mass spectrum including a fragment ion peak is generated under application of a first ionization method. A second mass spectrum including a molecular ion peak is generated under application of a second ionization method. These mass spectra are synthesized to generate a synthesized mass spectrum. On the synthesized mass spectrum, difference information, such as a mass difference and difference composition, is calculated between the molecular ion peak and the fragment ion peak.
    Type: Grant
    Filed: January 14, 2020
    Date of Patent: November 22, 2022
    Assignee: JEOL Ltd.
    Inventors: Ayumi Kubo, Masaaki Ubukata
  • Patent number: 11510308
    Abstract: A neutron beam generating device includes a supporting base, an outer shell, a target material, and a first pipe. The outer shell surrounds a rotating axis, rotatable engages the supporting base, and has a first opening. The target material is disposed in the outer shell. The first pipe extends from the first opening of the outer shell along the rotating axis to the target material. The first pipe is configured to transmit an ion beam to bombard the target material to generate a neutron beam.
    Type: Grant
    Filed: May 4, 2020
    Date of Patent: November 22, 2022
    Inventors: Jyi-Tyan Yeh, Yen-Wan Hsueh Liu, Zhen-Fan You
  • Patent number: 11493487
    Abstract: A method for determining a quantity of an analyte in a liquid sample, comprises: adding a known quantity of an internal standard comprising an isotopically labeled version of the analyte to the sample; (b) providing a continuous stream of the sample having the internal standard to an inlet of a Liquid Chromatography Mass Spectrometry (LCMS) system; and repeatedly performing the steps of: performing a data-independent analysis of the precursor ion species using a mass analyzer, whereby mass spectra of a plurality of fragment-ion species are acquired; calculating one or more degree-of-matching scores that relate to either a number of ions of the internal standard that overlap between results of the data-independent analysis and tabulated mass spectral data of the internal standard; and performing quantitative tandem mass spectrometric analyses of the internal standard and the analyte if each of the degree-of-matching scores meets a respective degree-of-matching condition.
    Type: Grant
    Filed: April 23, 2020
    Date of Patent: November 8, 2022
    Assignee: Thermo Finnigan LLC
    Inventors: Philip M. Remes, David A. Sarracino, Sebastien F. Gallien
  • Patent number: 11485784
    Abstract: This disclosure relates to systems and methods that identify, predict, and rank immunogenic T-cell epitopes. In particular, this disclosure identifies epitopes that arose from disease-associated mutations, wherein the epitopes are predicted to elicit immune response from T cells. Specifically, this disclosure simultaneously considers peptide-level information, including MHC Class I and II presentation, helper and cytotoxic T cell response and sample-level information, including mutation clonality and MHC allele dosage. In some embodiment, the systems and methods are used for personalized treatment of cancers.
    Type: Grant
    Filed: March 31, 2018
    Date of Patent: November 1, 2022
    Inventors: Pei-Jia Yang, Jen-Hao Cheng, Ying-Ja Chen, Shu-Jen Chen, Hua-Chien Chen
  • Patent number: 11482405
    Abstract: A mass spectrometry device that is provided with an ionization unit and ionizes, by the ionization unit, a sample separated by a separation column, subjects the sample to mass separation and detect ions obtained in the mass separation, includes: a gas introduction unit that introduces a first gas obtained by vaporizing a liquid into the ionization unit using a second gas, wherein: the ionization unit ionizes the sample by reacting ions obtained by ionizing the first gas with the sample.
    Type: Grant
    Filed: March 8, 2019
    Date of Patent: October 25, 2022
    Inventor: Riki Kitano
  • Patent number: 11474072
    Abstract: An apparatus and a method of data independent combined ion mobility and mass spectroscopy analysis includes introducing precursor ions into an ion mobility spectrometer (IMS), sequentially releasing precursor ions from said IMS according to their ion mobility, introducing said released precursor ions into a mass filter, fragmenting the precursor ions transmitted through said mass filter to generate fragment ions, and carrying out a mass spectroscopy measurement on said fragment ions. The IMS and mass filter are controlled in a synchronized manner to carry out a plurality of IM scans, wherein adjacent mass windows in said IM scan that are associated with consecutive mass spectroscopy measurements of fragment ions overlap, such that precursor ions transmitted through said mass filter during said IM scan are located in at least one continuous scan region in an m/z-IM plane which extends in a generally diagonal direction in said m/z-IM plane.
    Type: Grant
    Filed: July 30, 2021
    Date of Patent: October 18, 2022
    Assignee: Bruker Daltonics GmbH & Co. KG
    Inventor: Stefan Tenzer
  • Patent number: 11474084
    Abstract: In a mass spectrometry apparatus, an electric field is applied to an injected specimen to ionize the specimen, and mass spectrometry of the specimen is performed. In an emitter which ionizes the specimen, a flashing process to increase a temperature of the emitter is repeatedly performed at a short-time interval during an injection period of the specimen. A flashing current controller controls a flashing current value to be applied to the emitter to increase, in a long term, a flashing temperature which the emitter reaches in the flashing process.
    Type: Grant
    Filed: November 20, 2019
    Date of Patent: October 18, 2022
    Assignee: JEOL Ltd.
    Inventor: Masaaki Ubukata
  • Patent number: 11476105
    Abstract: A method of transferring neutral gaseous material includes the steps of passing heated gas through flow tube in a central gas stream; and permeating a chemical dopant inward to the central gas stream through walls of the flow tube.
    Type: Grant
    Filed: March 19, 2021
    Date of Patent: October 18, 2022
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Graham Asher Newsome, Kevin John Johnson, Michael Paul Malito