Abstract: In some embodiments, a scientific instrument includes an electron-beam column configured to scan an electron beam across a sample. The electron-beam column includes a beam blanker configured to gate the electron beam in response to a drive signal. The scientific instrument also includes an electron detector configured to measure a flux of transmitted or scattered electrons having interacted with the sample and an electronic controller configured to acquire an image of the sample using values of the flux measured with the electron detector for a plurality of electron-beam scan locations. The electronic controller is further configured to cause the drive signal to have a gating frequency at which the image has a moiré pattern therein.

Abstract: A method of adjusting a position of an electrode within a nebulizer probe of a mass spectrometry device having an open port interface for receiving a sample includes performing a first analysis of the sample at a first analysis condition including a first position of the electrode and a first flow rate. After performing the first analysis, a second analysis of the sample is performed at a second analysis condition including the first position of the electrode and a second flow rate higher than the first flow rate. Thereafter, a third analysis of the sample is performed at a third analysis condition including a second position of the electrode and the second flow rate.

Abstract: Provided is a stage device comprising a stage, a Z-axis motor that magnetically floats the stage, and an X-axis motor that drives, in one axial direction within a plane, the stage floated by the Z-axis motor, wherein: the X-axis motor is provided with an X-axis coil, a pair of X-axis magnets that face each other and that sandwich the X-axis coil in the vertical direction without contacting the X-axis coil, and an X-axis yoke that holds the pair of X-axis magnets; the Z-axis motor is provided with a Z-axis coil, a Z-axis magnet, and a Z-axis yoke that holds the Z-axis magnet; and the Z-axis motor is disposed at a position that is below the X-axis motor such that the magnetic field which has leaked from the Z-axis motor is blocked by the X-axis yoke. Thus, it is possible to suppress magnetic field leakage and to perform high-speed positioning.

Abstract: Systems or techniques are provided for facilitating idle-triggered diagnostics for scientific instruments. In various embodiments, a scientific instrument can comprise a mass spectrometer coupled to a chromatograph. In various aspects, the scientific instrument can determine, via a temperature sensor of the chromatograph or via a clock of the mass spectrometer, whether the scientific instrument is in an idle-time period. In various instances, the scientific instrument can, in response to a determination that the scientific instrument is in the idle-time period, apply one or more electronic control signals to the mass spectrometer or to the chromatograph, measure one or more resultant ion spectra via an ion detector of the mass spectrometer, and determine whether the mass spectrometer or the chromatograph is operating correctly based on the one or more resultant ion spectra.

Abstract: The problem of the present invention is to provide a substrate with high versatility, a method for producing the substrate, and a method for producing a unit cell using the substrate. The problem is solved by providing a substrate comprising a plurality of alkali metal azide spots on a substantially flat surface.

Abstract: A method of analysing a field of a mass spectrometer comprising a mass analyser and a static field mass filter having a first Wien filter and a second Wien filter is provided. The method includes, for each of a plurality of predetermined strengths of one of an electric field or a magnetic field of the first and second Wien filters: setting the one of the electric field or the magnetic field of the first and second Wien filters to the predetermined strength; causing a beam of ions comprising one or more ion species to be injected through the static field mass filter; and measuring, using the mass analyser, a respective intensity of ions of each of the one or more ion species in the beam.

Abstract: A transmission unit of a wireless optical charging system with an adjustable output direction attached to a ceiling of an indoor space according to the present disclosure includes: an optical generation unit that generates laser light; a vertical axis rotation unit that rotates along an axis perpendicular to a floor of the indoor space and transmits the laser light; a horizontal axis rotation unit that rotates while attached to the vertical axis rotation unit, is attached to a plurality of cameras, outputs the transmitted laser light, and rotates an output direction of the laser light and a direction of the plurality of cameras along an axis horizontal to the floor of the indoor space; and a control unit that controls the vertical axis rotation unit and the horizontal axis rotation unit according to rotation angles in vertical and horizontal directions calculated using images captured by the plurality of cameras.

Abstract: An ion implanter may include an ion source, arranged to generate a continuous ion beam, a DC acceleration system, to accelerate the continuous ion beam, as well as an AC linear accelerator to receive the continuous ion beam and to output a bunched ion beam. The ion implanter may also include an energy spreading electrode assembly, to receive the bunched ion beam and to apply an RF voltage between a plurality of electrodes of the energy spreading electrode assembly, along a local direction of propagation of the bunched ion beam.

Abstract: Provided are a structure for particle acceleration and a charged particle beam apparatus, which enable the suppression of electric field concentration occurring near a negative electrode part. The structure for particle acceleration includes: a ceramic body 1 having a through hole 10 formed by an inner wall surface; and a negative electrode 2 and a positive electrode 3 which are arranged, respectively, on one end and the other end of the through hole 10 in the ceramic body. The inner wall surface of the ceramic body 1 is configured such that a first region 22, which is electrically connected with the negative electrode 2, and a second region 23, which is electrically connected with the positive electrode 3, are electrically connected to each other. The surface resistivity of the first region 22 is lower than the surface resistivity of the second region 23.

Abstract: One embodiment of the present disclosure is related to a method for producing a substrate comprising a plurality of tips suitable to be used in scanning probe microscopy (SPM), wherein as a first step, a substrate is produced or provided comprising a plurality of nano-sized tips, preferably arranged in a regular array and spaced apart by nano-sized interspacings. A mask is applied to this substrate, comprising multiple mask portions, wherein each mask portion covers at least one tip, whereafter the substrate is subjected to an etching process relative to the mask portions. After the removal of the mask portions, the method results in the creation of a substrate comprising multiple pedestals having each at least one nanotip on the upper surface thereof and spaced apart at a distance suitable for performing an SPM measurement of a given type.

Abstract: A collimator includes a collimator cover formed from a material with low radiation attenuation, and a plurality of septa formed from a radiation attenuating material. The collimator cover includes a base plate, a first side plate extending from the base plate, and a second, opposing side plate extending from the base plate. The first side plate has a plurality of first slots defined therein and the second side plate has a plurality of second slots defined therein. Each septum includes a first end retained in one first slot of the plurality of first slots and a second end retained in one corresponding second slot of the plurality of second slots.

Abstract: Provided is a charged particle beam device that can impart a function of an energy filter to even a small BSE detector. The charged particle beam device includes a fluorescent substance that converts charged particles generated by irradiation of a sample with a charged particle beam into light; a detector that detects the light emitted from the fluorescent substance; a light guide element for guiding the light from the fluorescent substance to the detector; a light amount adjuster that adjusts the amount of light that is received by the detector through the fluorescent substance and the light guide element; and a control unit that controls the light amount adjuster.

Abstract: A method of analysing a sample comprises analysing a sample in a first mode of operation so as to produce a spatially resolved data set representative of the sample, and analysing the data set so as to identify one or more regions of the sample. For each of one or more identified regions of the sample, a tandem mass spectrometry (MS/MS) data set is produced for that region by determining a path through the region, and analysing the sample along the path using Desorption Electrospray Ionisation (“DESI”) in a tandem mass spectrometry (MS/MS) mode of operation.

Abstract: A method of evacuating a liquid sample from an open port interface (OPI) via a pressure drop includes applying the pressure drop to a transport liquid. This application generates a plurality of bubbles in the transport liquid during evacuation of the transport liquid from the OPI via a transfer conduit. The liquid sample is separated from a subsequent liquid sample by at least one of the generated bubbles.

Abstract: The present invention provides methods and systems using gas-phase separation with mass spectrometry analysis instead of liquid chromatography, thereby enabling faster peptide, proteome, and multi-omic analysis. Also provided are improved methods and software for data independent acquisition. One embodiment referred to as Direct Infusion-Shotgun Proteome Analysis (DI-SPA) used with data-independent acquisition mass spectrometry (DIA-MS), resulted in targeted quantification of over 500 proteins within minutes of MS data collection (˜3.5 proteins/second). Enabling fast, unbiased protein and proteome quantification without liquid chromatography, DI-SPA offers a new approach to boosting throughput critical to drug and biomarker discovery studies that require analysis of thousands of proteomes. This invention is also able to perform complex multi-omic analysis of proteomes, lipidomes, and metabolomes on a single platform.

Abstract: A mode of a chromatograph mass spectrometer configured to collect chromatograph mass spectrometry data by repeatedly performing MS analysis and MS/MS analysis or only MS/MS analysis according to a predetermined condition in the mass spectrometer unit on a sample containing a compound separated by a chromatograph unit; a scatter diagram creation section (45) configured to create, based on the data collected by the measurement unit, a scatter diagram in which a retention time and a mass-to-charge ratio of precursor ions are set to axes orthogonal to each other and positions or ranges of the precursor ions from which MS/MS spectra are acquired are plotted; a spectrum creation unit (46) configured to create MS/MS spectra corresponding to the precursor ions indicated on the scatter diagram; and a display processing unit (48) configured to display the scatter diagram and the MS/MS spectra together on a screen of a display unit.

Abstract: Methods for acquiring mass spectral data of a sample across at least a portion of an m/z range comprise receiving mass spectral data across the m/z range and partitioning the m/z range into one or more sets of m/z sub-ranges, each set comprising one or more m/z sub-ranges, by dividing the m/z range into a plurality of m/z bins, determining an indication of ion abundance for each m/z bin, based on the mass spectral data, and forming an m/z sub-range of the one or more sets of m/z sub-ranges by assigning m/z bins having ion abundances that correspond to at least a threshold degree to the formed m/z sub-range. A mass analysis is performed on the sample for each set of m/z sub-ranges, thereby acquiring one or more partial mass spectral data sets.

Abstract: Ion mobility spectrometers are uniquely sensitive chemical detectors used in a variety of application spaces. Chemical dopants are commonly used with these instruments to improve sensitive and selectivity of detected species. A dopant source with a wicking filament approach to control emission of a chemical dopant in a small format is disclosed herein. This is demonstrated for several dopants used with IMS detectors and initial performance parameters (e.g., emission rate, emission lifetime, emission concentration control) have been investigated. The dopant source can be used in other chemical ionization systems.

Abstract: A method of separating a sample of ions according to their ion mobilities is provided. The method comprises receiving the sample of ions into a drift tube; applying a first electric field component within the drift tube so as to cause the sample of ions to move along a path within the drift tube, whereby the sample of ions separates along the path; and applying a second electric field component within the drift tube. The first and second electric field components have a combined electric field strength to modify the ion mobility of at least a portion of the sample of ions and to increase the separation of at least a portion of the sample of ions along the path The second electric field component substantially does not cause a net change in the velocity of the sample of ions perpendicular to the path. An apparatus for separating a sample of ions according to their ion mobilities is also provided.

Abstract: There are provided a light guide, an electron ray detector, and a charged particle device that can improve light guiding efficiency of light generated in response to incidence of a detection ray. The electron ray detector includes: a light guide member extending in one direction; a first fluorescent substance layer provided on one end portion side of the light guide member and generating primary fluorescent light in response to incidence of a detection ray; a second fluorescent substance layer extending from one end to the other end of the light guide member and generating secondary fluorescent light in response to incidence of the primary fluorescent light; and a detection unit provided on the other end portion side of the light guide member and optically coupled to the light guide member.