Patents Examined by Michael Maskell
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Patent number: 11239068Abstract: Systems and methods for controlling mass filtering of polyatomic ions in an ion beam passing through an inductively coupled plasma mass spectrometer (ICP-MS). Polyatomic ion mass data representative of the exact mass of a polyatomic ion having a target isotope is determined. A control signal is generated based on the determined polyatomic ion mass data and output to an ICP-MS to filter based on mass the polyatomic ions in the ion beam traveling through the ICP-MS to an ion detector.Type: GrantFiled: August 20, 2019Date of Patent: February 1, 2022Assignee: Agilent Technologies, Inc.Inventors: Naoki Sugiyama, Amir Liba, Mark Lee Kelinske, Glenn David Woods
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Patent number: 11232938Abstract: Methods and systems for delivering liquid sample to an ion source and subsequent analysis by mass spectrometry. In accordance with various aspects of the present teachings, MS-based systems and methods are provided in which desorption solvent is used in sampling interface to desorb analyte species from an SPME device that is coupled to an ion source to ionize analyte species desorbed into the desorption solvent for MS analysis (e.g., without a liquid chromatography (LC) column between the sampling interface and the ion source). In various aspects of the methods and systems described herein, configuring the sampling interface can be optimized so as to reduce the fluid volume dead space about the fluid inlet so as to concentrate the one or more analyte species desorbed at optimized conditions from the SPME substrate in a decreased volume of the desorption solvent when the SPME device is inserted into sampling interface.Type: GrantFiled: June 28, 2019Date of Patent: January 25, 2022Assignee: DH Technologies Development Pte. Ltd.Inventors: Don W Arnold, Thomas R Covey, Chang Liu
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Patent number: 11232935Abstract: The compound list stored in identification information memory is populated with theoretical masses associated with a variety of compounds, as well as information such as the type of matrix capable of detecting said compound, potential neutral loss, etc. The adduct ion list, meanwhile, is populated with theoretical masses associated with a variety of adduct ions, as well as other information such as types of matrices capable of producing adducts, etc. When a user specifies a peak on the mass spectrum for a compound search, compound candidate search portion extracts combination candidates based on how well the measured m/z value of the specified peak matches the m/z value for combinations of compounds in the compound list and adduct ions in the adduct ion list, while the type of matrix used during measurement serves as a condition to narrow down the combinations. Display processing portion displays a list of the search results.Type: GrantFiled: September 1, 2016Date of Patent: January 25, 2022Assignee: SHIMADZU CORPORATIONInventors: Masahiro Ikegami, Koretsugu Ogata
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Patent number: 11226309Abstract: Techniques and apparatus for generated predicted collision cross-section (CCS) values based on a hybrid CCS prediction processes are described. In one embodiment, for example, an apparatus may include at least one memory, and logic coupled to the at least one memory. The logic may be configured to implement a predicted CCS process, for example, by receiving analytical information from analysis of a sample using an ion mobility spectrometry instrument, the sample comprising at least one component, generating an approximate molecular model for the component via an approximate molecular modeling process, and generating a predicted CCS value via a computational model based on the approximate molecular model. Other embodiments are described.Type: GrantFiled: April 15, 2020Date of Patent: January 18, 2022Assignee: WATERS TECHNOLOGIES IRELAND LIMITEDInventors: Keith G. Richardson, Hans Vissers
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Patent number: 11223181Abstract: Methods and corresponding apparatus operable to cause an interaction between a drive radiation beam and a medium for generation of emitted radiation by high harmonic generation, the arrangement comprising: an interaction region positioned at an interaction plane and configured to receive the medium; a beam block positioned upstream of the interaction plane at a beam block plane and configured to partially block the drive radiation beam; a beam shaper positioned upstream of the beam block plane at an object plane and configured to control a spatial distribution of the drive radiation beam; and at least one lens positioned upstream of the interaction plane and downstream of the beam block plane, wherein the lens being positioned such that an image of the spatial distribution of the drive radiation beam is formed at the interaction plane.Type: GrantFiled: August 19, 2019Date of Patent: January 11, 2022Assignee: ASML Netherlands B.V.Inventors: Petrus Wilhelmus Smorenburg, Gerrit Jacobus Hendrik Brussaard, David O Dwyer
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Patent number: 11222764Abstract: A charged particle beam device includes: a charged particle source; an optical system which acts on a charged particle beam emitted from the charged particle source; a control unit which controls the optical system; and a storage unit which stores previous setting values of the optical system. The optical system includes a first optical element and a second optical element for controlling a state of the charged particle beam to be incident on the first optical element. The control unit obtains an initial value of a setting value of the second optical element based on previous setting values of the second optical element; and changes a state of the charged particle beam by changing the setting value of the second optical element from the obtained initial value and obtains the setting value of the second optical element based on the change in the state of the charged particle beam.Type: GrantFiled: March 23, 2020Date of Patent: January 11, 2022Assignee: JEOL Ltd.Inventors: Kazuya Yamazaki, Yuko Shimizu, Hirofumi Iijima, Takuma Fukumura, Naoki Hosogi, Tomohiro Nakamichi
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Patent number: 11217438Abstract: A method of mass spectrometry or ion mobility spectrometry is disclosed comprising: providing an analyte; supplying a matrix compound to said analyte such that said analyte dissolves in said matrix; forming first droplets of the dissolved analyte; and colliding said first droplets with a collision surface. The use of matrix improves the analyte ion signal.Type: GrantFiled: March 7, 2016Date of Patent: January 4, 2022Assignee: Micromass UK LimitedInventors: Emrys Jones, Tamas Karancsi, Steven Derek Pringle, Julia Balog, Daniel Simon, Lajos Godorhazy, Daniel Szalay, Zoltan Takats
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Patent number: 11217436Abstract: There is provided a method of measuring a mass of an ion species in a mass stream. Where the mass stream is a mass stream emitted from a separation device as a function of a separation parameter, the method comprising: obtaining a mass trace for the ion species, wherein the mass trace comprises a set of intensity peaks, each intensity peak providing a respective measured mass and a respective signal measured by a mass spectrometer; and determining the mass of the ion species as an extrapolation of the measured masses of the set of intensity peaks of the mass trace towards a signal zero.Type: GrantFiled: November 22, 2019Date of Patent: January 4, 2022Assignee: Thermo Fisher Scientific (Bremen) GmbHInventor: Hans Pfaff
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Patent number: 11211150Abstract: A preprocessor extracts a plurality of spectra to be processed, from an overall mass spectrum. A simulated spectrum generator having a learned model generates a simulated spectrum having a peak discriminating action, from each mass spectrum. A postprocessor generates a combined simulated spectrum based on the plurality of simulated spectra. A peak filter executes peak discrimination on a peak list using the combined simulated spectrum.Type: GrantFiled: August 27, 2020Date of Patent: December 28, 2021Assignee: JEOL Ltd.Inventors: Fuminori Uematsu, Takaya Satoh, Masahiko Takei
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Patent number: 11211236Abstract: Real-time search (RTS) for mass spectrometry is described. In one aspect, a mass spectrometer can identify a candidate peptide for a product ion spectrum by searching a mass spectral database. While executing the search of the mass spectral database, a candidate peptide score representing a confidence of a match between the product ion spectrum and a theoretical mass spectrum stored in the mass spectral database is generated. A failing score can be promoted to a passing result based on attributes of the candidate peptide.Type: GrantFiled: May 30, 2019Date of Patent: December 28, 2021Assignee: Thermo Finnigan LLCInventor: Derek J. Bailey
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Patent number: 11210065Abstract: An item setter sets a plurality of first analysis parameters included in first analysis condition data acquired by an analysis condition data acquirer in a first item that is dependent on characteristics of a first analysis device and a second analysis device, and a second item that is not dependent on the characteristics of the first and second analysis devices. A parameter value converter converts a value of a first analysis parameter of the first item that is set by the item setter into a value of a second analysis parameter corresponding to a second data processing device for the second analysis device, and takes a value of a first analysis parameter of the second item that is set by the item setter as a value of a second analysis parameter as it is.Type: GrantFiled: September 20, 2018Date of Patent: December 28, 2021Assignee: SHIMADZU CORPORATIONInventors: Akane Yamamoto, Yoshiki Tainaka
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Patent number: 11205524Abstract: Embodiments of the present disclosure relate to atomic beam collimators and, more particularly, to miniaturized coplanar atomic beam collimators. In some examples, an atomic beam collimator may comprise an atomic channel disposed in a substrate. Additional atomic channels may be provided coplanar with the first atomic channel in the substrate. Some examples include a series of cascaded atomic channels, each cascaded atomic channel separated by a gap. The gaps may reduce the off-flux atoms in the output of the atomic collimator. In some examples, a system may comprise an atomic collimator, an atom source, and/or a microelectromechanical system device. These component can be separate devices or can be incorporated into a common substrate.Type: GrantFiled: May 17, 2019Date of Patent: December 21, 2021Assignee: Georgia Tech Research CorporationInventors: Chandra Raman, Farrokh Ayazi
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Patent number: 11195709Abstract: An ambient ionisation source unit (10) is provided comprising: a housing (12) containing a first device (14) for generating analyte material from a surface of a sample to be analysed and a sampling inlet (16) for receiving analyte material liberated from the surface of the sample. The position(s) of the first device and/or sampling inlet is (are) fixed relative to the housing. Thus, the first device and the sampling inlet are integrated into a single unit that can be installed onto the front-end of an ion analysis instrument with minimal or reduced user interaction.Type: GrantFiled: April 11, 2018Date of Patent: December 7, 2021Assignee: Micromass UK LimitedInventors: Emrys Jones, Steven Derek Pringle, Michael Raymond Morris
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Patent number: 11189387Abstract: A suspension device (10) for at least partially supporting a radioprotection garment (12) worn by an intended user (14), including a harness (34) wearable by the intended user (14) under the radioprotection garment (12), the harness including a harness attachment (38); a support (28) positionable above the intended user (14); an elongated flexible element (30) operatively coupled to the support (28) to be supported thereby; a flexible element attachment (32) secured to the elongated flexible element (30) opposed to the support (28); the harness (34) and flexible element attachment (38) being reversibly attachable to each other.Type: GrantFiled: November 18, 2020Date of Patent: November 30, 2021Assignee: NEWTON MEDICAL INC.Inventors: Jean Arsenault, Normand Boiteau
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Patent number: 11189475Abstract: A desolvation unit performs desolvation by heating after a sample solution is turned to sample mist by a nebulizer. A sample gas that contains the desolvated sample mist and a carrier gas is introduced through a sample introduction tube to a plasma torch. An addition unit for adding, to the sample introduction tube, a water-containing gas is provided. The addition unit includes a container that contains ultrapure water, a gas tube for introducing the carrier gas into the ultrapure water to cause bubbling, and a gas tube for adding the water-containing gas, to the sample introduction tube. The plasma torch generates an inductively coupled plasma under the condition that supplied power is set to a range of 550 W to 700 W. Generation of interfering molecule ions due to an element having a high ionization potential is inhibited when an element in a sample ionized by the plasma is analyzed.Type: GrantFiled: December 20, 2018Date of Patent: November 30, 2021Assignee: SHIN-ETSU HANDOTAI CO., LTD.Inventor: Kenji Araki
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Patent number: 11177120Abstract: A mass spectrometry method includes: preparing calibration data for performing calibration on a basis of first data obtained by detecting a chlorobiphenyl in first mass spectrometry of a reference sample of the chlorobiphenyl; acquiring second data obtained by detecting, in second mass spectrometry of a sample, at least one chlorobiphenyl that has a same chlorine number as and is different in kind from the chlorobiphenyl detected in the first mass spectrometry; and calculating a quantitative value for the chlorobiphenyl contained in the sample on a basis of the calibration data and the second data.Type: GrantFiled: April 3, 2019Date of Patent: November 16, 2021Assignee: SHIMADZU CORPORATIONInventor: Riki Kitano
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Patent number: 11164718Abstract: An electron beam detection element according to an exemplary embodiment includes a plurality of unit cells. Each of the plurality of unit cells includes a diode of avalanche multiplication type and a plurality of memories. The diode of avalanche multiplication type is configured to detect an electron beam. The plurality of memories store signals of different frames respectively, each of the signals being output from the diode.Type: GrantFiled: November 2, 2018Date of Patent: November 2, 2021Assignee: Canon Kabushiki KaishaInventor: Yukihiro Kuroda
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Patent number: 11158483Abstract: A charged particle beam deflection device includes a substrate; a plurality of apertures provided in the substrate; a plurality of electrodes deflecting charged particle beams passing through the apertures; a plurality of light-receiving elements controlling voltages applied to the plurality of electrodes; a first optical coupler coupling continuous light to the substrate; a light distributor distributing light coupled by the first optical coupler into a two-dimensional plane; a plurality of modulators performing intensity modulation of light distributed by the light distributor; and a plurality of second optical couplers coupling the modulated light to the light-receiving elements.Type: GrantFiled: September 4, 2020Date of Patent: October 26, 2021Assignee: KABUSHIKI KAISHA TOSHIBAInventors: Kazuya Ohira, Hideto Furuyama
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Patent number: 11152199Abstract: An ion optic assembly includes a set of conductive rods, a first insulator, and a second insulator. The rods are inserted into through-holes of the first insulator, which are arranged about an axis along which the rods are elongated. The rods are then inserted through a bore of the second insulator and become located in notches of the bore, which are arranged about the axis. Accordingly, the first insulator positions one end of the rods at a first distance from the axis, and the second insulator positions the other end of the rods at a second distance from the axis, which may equal to or different from the first distance. The rods contact, and may be spring-biased against, the notches. The assembly may include an electrical contact with fingers spring-biased into contact with the rods. Each insulator may include both through-holes and notches for additional rods.Type: GrantFiled: December 17, 2019Date of Patent: October 19, 2021Assignee: Agilent Technologies, Inc.Inventors: Robert M. Roberts, James L. Bertsch
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Patent number: 11152187Abstract: A method for positioning a specimen in a microscope system includes overserving and/or processing a region of interest (ROI) on the specimen. The microscope system includes: an optical axis; a movable specimen stage for receiving a specimen; a memory apparatus for storing data records that describe the positions of the specimen; and a control apparatus, which can control the movement of the specimen stage with the aid of the stored data records. The method includes: holding a specimen region (ROI) in the first position; storing a first data record, by which the first position is described, wherein the first position is defined as independent position; storing a second data record, by which the second position is described, wherein the second position is linked to the independent position; and calling one of the stored data records such that the specimen stage is moved in such a way that the specimen region is held at the position that is described by the called data record.Type: GrantFiled: May 13, 2019Date of Patent: October 19, 2021Assignee: Carl Zeiss Microscopy GmbHInventor: Josef Biberger