Abstract: The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compounds—Free-B-ring flavonoids and flavans—for use in the prevention and treatment of diseases and conditions mediated by the COX-2 and 5-LO pathways. The present invention further provides a novel method for simultaneously inhibiting the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) enzymes, and reducing cox-2 mRNA production. Finally, the present invention includes a method for weight loss and blood glucose control. The methods of this invention are comprised of administering to a host in need thereof an effective amount of the composition of this invention together with a pharmaceutically acceptable carrier.

Abstract: A foodstuff of a tablet or capsule, includes: an extract of a plant of genus Salacia; and at least one of calcium carbonate and silicon dioxide in an amount of 1% by mass or more based on the total mass of the tablet or capsule, wherein 50% inhibition concentration (IC50 value) of sucrase is 10 ?g/ml or more and 300 ?g/ml or less.