Abstract: Regions of tissue having reduced electrical propagation are created in a bladder to affect its electrical or mechanical properties. To create these tissue regions, a tubular device is advanced through the urethra leading to the interior of the bladder, a distal expandable structure of the device is expanded to contact the inner wall of the bladder, and electrodes or other active energy delivery elements of the device are activated to deliver ablation energy. The electrodes or other active energy delivery elements are disposed over the expandable structure which is shaped to conform to the interior of the bladder. The inner wall of the organ is ablated in a predetermined pattern. The same or other electrodes disposed over the expandable structure can used to electrically map the bladder. This map of electrical activity can be used to create the predetermined pattern.

Abstract: Methods, systems and devices for evaluating the integrity of a uterine cavity. A method comprises introducing transcervically a probe into a patient's uterine cavity, providing a flow of a fluid (e.g., CO2) through the probe into the uterine cavity and monitoring the rate of the flow to characterize the uterine cavity as perforated or non-perforated based on a change in the flow rate.

Abstract: A method and system for treating a surgical incision to prevent scarring is disclosed. The system comprising an applicator is configured to protrude a target tissue from one or both sides of a surgical incision into a treatment cavity located in the applicator. The system is further configured to deliver fractional treatment, from energy sources located along the inner walls of the treatment cavity, to an incision edge.

Abstract: Devices, and methods of use thereof, are disclosed for preventing tumor seeding when withdrawing the device along an entry-exit path. Some embodiments of the present invention comprise a method of withdrawing a probe through a tissue via a path that traverses at least some bone tissue, the method including withdrawing the probe through the path, and at least partially concurrently delivering energy in a bipolar manner from the probe to heat a layer of tissue surrounding the probe to a temperature sufficient for thermal coagulation necrosis of cells. The device may be withdrawn incrementally.

Abstract: A surgical operation system includes a US signal output section, an HV signal output section, a probe having a treatment section which has an HV signal applied thereto and vibrates by ultrasound, an HV signal main control section that performs feedback control of the HV signal output section based on the HV signal, a US signal main control section that performs feedback control of the US signal output section based on a US signal, and an HV signal auxiliary control section that controls the HV signal output section based on the US signal, and has a response time shorter than that of the HV signal main control section.

Abstract: A device positionable in a cavity of a bodily organ (e.g., a heart) may discriminate between fluid (e.g., blood) and non-fluid tissue (e.g., wall of heart) to provide information or a mapping indicative of a position and/or orientation of the device in the cavity. Discrimination may be based on flow, or some other characteristic, for example electrical permittivity or force. The device may selectively ablate portions of the non-fluid tissue based on the information or mapping. The device may detect characteristics (e.g., electrical potentials) indicative of whether ablation was successful. The device may include a plurality of transducers, intravascularly guided in an unexpanded configuration and positioned proximate the non-fluid tissue in an expanded configuration. Expansion mechanism may include helical member(s) or inflatable member(s).

Abstract: The present invention relates to the use of electrochemistry to control and generate specific user defined chemical reactions in regions that may be defined by electrode placement and geometry. In one embodiment, the present invention provides a method of shape changing cartilage in a subject through potential-driven electrochemical modification of tissue (PDEMT) or use of a potential-driven electromechanical (EMR) device.

Abstract: A gripping unit includes a supporting section in which at least its entire surface is made of an insulating material, and a swing section swingable about a swing axis relative to the supporting section. The swing section includes a jaw-side facing surface opposed to a treatment section, and a jaw-side electrode section functioning as an electrode when high-frequency energy is transmitted. The support member covers the swing section from a distal direction, both of width directions, and an open direction of the jaw, and the swing section is externally exposed only on the jaw-side facing surface.

Abstract: Aspects of the present disclosure are presented for a surgical instrument for cutting and sealing tissue with a mode selection assembly. The mode selection assembly allows for a user to safely activate or disable a cutting functionality and a sealing functionality through use of electrosurgical energy. In some embodiments, the mode selection assembly allows for a more automated application of the electrosurgical energy and the cutting functionality when applied to a surgical site. The mode selection assembly may also include a knob configured to switch between the aforementioned settings. Various control mechanisms are also disclosed to lock and unlock the cutting element, such as a motorized locking mechanism, a solenoid locking mechanism, a mechanical mechanism and use of a nitinol wire. The inclusion of the mode selection assembly allows for a user to more safely utilize the surgical instrument by intentionally disabling functionality that may otherwise be inadvertently activated.

Abstract: The present invention relates to the field of medical treatment of diseases and disorders, as well as the field of biomedical engineering. Embodiments of the invention relate to the delivery of Irreversible Electroporation (IRE) through the vasculature of organs to treat tumors embedded deep within the tissue or organ, or to decellularize organs to produce a scaffold from existing animal tissue with the existing vasculature intact. In particular, methods of administering non-thermal irreversible electroporation (IRE) in vivo are provided for the treatment of tumors located in vascularized tissues and organs. Embodiments of the invention further provide scaffolds and tissues from natural sources created using IRE ex vivo to remove cellular debris, maximize recellularization potential, and minimize foreign body immune response. The engineered tissues can be used in methods of treating subjects, such as those in need of tissue replacement or augmentation.

Abstract: A method of deploying an antenna of an ablation device includes the step of placing an introducing member relative to tissue. The introducing member is disposed on a distal end of a handle member. The method also includes the steps of advancing an antenna distally through the handle member and at least partially through the introducer and rotating the handle member about the longitudinal axis thereof relative to the antenna. The method also includes the step of moving the handle member proximally along the longitudinal axis thereof to retract the introducer proximally relative to the antenna such that the antenna is at least partially deployed relative to the introducer to treat tissue.

Abstract: A device for delivering caloric vestibular stimulation to an individual, includes: (a) an earpiece configured to be at least partially insertable into the ear canal of the individual for delivering a first thermal stimulus; (b) an input unit for receiving a user input indicating efficacy of said first thermal stimulus, and (c) a controller operatively associated with said earpiece and said input unit for: (i) controlling said earpiece to provide said first thermal stimulus, and (ii) receiving a signal corresponding to the user input and generating a control signal to control the earpiece and delivering a subsequent thermal stimulus different from said first thermal stimulus. In some embodiments, each thermal stimulus is an actively controlled time varying waveform stimulus.

Abstract: Apparatus and methods for treating back pain are provided in which electrical stimulation therapy is designed to cause muscle contraction to rehabilitate the muscle, restore neural drive and restore spinal stability. In accordance with one aspect, electrical stimulation is applied through at least one electrode to stimulate efferent motor nerve fibers to cause muscle contraction to facilitate rehabilitation without targeting stimulation of afferent nerve fibers. In accordance with another aspect, a stimulator further includes one or more of a number of additional therapeutic modalities, including a module that provides analgesic stimulation; a module that monitors muscle performance and adjusts the muscle stimulation regime; and/or a module that provides longer term pain relief by selectively and repeatedly ablating nerve fibers.

Abstract: The inventive ablation element comprises an elongated cannula having a proximal end and a distal end. The cannula defines an internal lumen and a cannula axis. A plurality of conductors contained within the lumen, each having a proximal end proximate the proximal end of the cannula, and a distal end proximate the distal end of the cannula. A plurality of ablation stylets each has a proximal end and a distal end, and each coupled to the distal end of a respective conductor, the conductors together with their respective stylets being mounted for axial movement. A trocar point defined proximate the distal end of the cannula. A deflection surface positioned between the trocar point and the proximal end of the cannula, the deflection surface being configured and positioned to deflect at least some of the stylets laterally with respect to the cannula axis in different directions defining an ablation volume.

Abstract: A return electrode monitoring (REM) system for an electrosurgical system is disclosed. The REM system includes circuit components or circuitry for monitoring the magnitude of an interrogation or drive signal, and one or more electrode pads including one or more pairs of split electrode pads. The REM system, while sweeping an interrogation signal over or across a frequency range, monitors the magnitude of the interrogation signal. The REM system determines if there is a frequency shift in the interrogation signal. If there is a frequency shift, the REM system determines the frequency shift and uses it to calculate a reactance value of the impedance. The complex impedance can then be determined. The complex impedance, or at least the reactance value, can be used to determine the capacitive coupling between the patient and pad interface.

Abstract: Example embodiments relate to surgical systems comprising an end-effector assembly and first arm assembly. The end-effector assembly may include a first instrument assembly, which includes a first instrument configurable to move relative to a first axis, and a wrist assembly having a wrist driven portion configurable to be driven so as to move the first instrument relative to a second axis. The first arm assembly may include a first arm assembly joint portion for joining the first arm assembly to a second arm assembly, wrist drive portion configurable to drive the wrist driven portion, and elbow driven portion configurable to be driven so as to move the first arm assembly relative to a third axis. The second arm assembly may include an elbow drive assembly having a first integrated motor and elbow drive portion controllable by the first integrated motor to drive the elbow driven portion.

Abstract: A branch of an instrument comprising a metal part, which is embodied in one piece seamlessly, which comprises the electrode support as well as the electrode plate and connection webs. Preferably, this metal part is produced in an additive production method, for example selective laser melting (SLM). The branches are suitable for instruments for open surgery as well as for laparoscopic and flexible endoscopic instruments.

Abstract: Provided herein are methods, systems, and devices for increasing heat shock protein expression and treating conditions for which increased heat shock protein expression is expected to be beneficial using thermal ablation.

Abstract: The present disclosure relates to electrosurgical instruments for use in sealing various tissues. The instrument includes a housing having a shaft attached thereto and an end effector assembly attached to a distal end of the shaft, wherein the end effector assembly includes first and second jaw members attached thereto. The jaw members are movable relative to one another from a first position for approximating tissue to at least one additional position for grasping tissue therebetween. The jaw members have an elastomeric material disposed on an inner facing tissue contacting surface thereof with the elastomeric materials including an electrode disposed therein. The electrodes are offset a distance X relative to one another such that when the jaw members are closed about the tissue and when the electrodes are activated, electrosurgical energy flows through the tissue in a generally coplanar manner relative to the tissue contacting surfaces.

Abstract: A device for delivering caloric vestibular stimulation to an individual, includes: (a) an earpiece configured to be at least partially insertable into the ear canal of the individual for delivering said caloric vestibular stimulation; (b) a power supply operatively associated with said earpiece; and (c) a controller operatively associated with said power supply and said earpiece for configuring said caloric vestibular stimulation as at least a first and second time-varying waveform. Preferably, the waveforms are actively controlled waveforms.