Abstract: A method and system for imaging a sample. The method includes the steps of generating an ultrasonic signal, directing the signal into a sample, which signal is distorted and contains a first order and higher order component signals at first and higher frequencies respectively. The received distorted signal is processed, and an image is formed, and then displayed, from the sum of the first order and second order component signals of the received distorted signal.

Abstract: In a system and a method for the guidance of a catheter with an electrode in an electrophysiological procedure, sequence of images of the catheter and of a resting reference catheter is generated with an X-ray device and stored together with the associated electrographic recordings from the electrodes. A reference image may then be selected from said sequence that corresponds to a desired electrographic pattern. In a next step, the positions of the catheters are localized on the reference image. The position of the reference catheter can be identified with the position of this catheter on an actual image. Thus it is possible to determine on the actual image also a target position for the catheter that corresponds to the position of this catheter on the reference image. The target position may finally be indicated on a monitor to assist the guidance of the catheter to a desired location.

Abstract: A method for measuring a non-linear response from a target using an imaging apparatus includes transmitting a signal towards a region of interest from a transducer at a first amplitude and measuring a first response thereto, and transmitting, from the transducer towards the region of interest, at least one additional signal of the same phase as the first amplitude signal but at one or more different, lower amplitudes and measuring at least one additional response thereto. A difference of a function of the measured additional response or responses from the first response is determined, thereby obtaining a non-linear response of the object of interest, and a representation of the non-linear response is displayed.

Abstract: A method of examining cardiac electromagnetic activity over a heart for diagnosing the cardiac functions of the heart is disclosed. The method may include constructing a phase diagram of electromagnetic signals over a heart by collecting sets of time-dependent magnetic signals, determining the zeroth and the first derivations of each set of the magnetic signals at a given time, and categorizing the zeroth and the first derivations of the magnetic signals in either of the four phases: (+, +), (?, ?), (+, ?), (?, +). The method may also include monitoring a wave propagation of the magnetic signals.

Abstract: The present invention provides methods and systems for evaluating biological materials for the diagnosis of disease, such as gland abnormalities, and the cancerous and precancerous conditions. Nonlinear optical microscopy techniques, such as MP microscopy and harmonic generation microscopy, are used to generate high resolution, three dimensional images of a test tissue, such as a biopsy tissue sample and tissue in whole organisms, that are analyzed, optionally in combination, to detect, identify and characterize tumor-associated collagen signatures. The presence, abundance and extent of histological features and structural motifs comprising tumor-associated collagen signatures may be directly and accurately correlated with the onset and progression of cancer, such as breast cancer. The present methods are capable of providing an accurate and selective diagnosis of cancer, and provide diagnostic information complementary to conventional diagnostic methods.

Abstract: A portable body fat measurement device includes: a light source unit having at least two top view light sources and a guide unit perpendicularly guiding an optical signal generated in the top view light sources to determine a measurement point where body fat is measured; an optical detection unit detecting a scattered optical signal to transform into an electrical signal, the scattered optical signal being generated by a scattering of the optical signal irradiated to the measurement point; and a signal processing unit processing the electrical signal and calculating body fat information, wherein the at least two top view light sources and the optical detection unit are horizontally arranged.

Abstract: A living body inspection apparatus including an oscillation coil which passes an AC current, a detection coil which detects an AC magnetic field generated from the detection coil, an amplification circuit which amplifies a voltage generated by the magnetic field induced by the detection coil, a detecting unit for detecting the output signal of the amplification circuit, a low pass filter to which the output signal of the detecting unit is input, a unit for setting the oscillation coil and detection coil in first and second regions of the living body, a recording unit for recording the output of the low pass filter while the first region and the second region of the living body are moving and a displaying unit for displaying the data recorded in the recording unit or results of analysis of the recorded data.

Abstract: An ultrasound surgical apparatus and associated methods of use enabling relatively pain-free wound debridement is provided. The apparatus is constructed from a tip mechanically coupled to a shaft. The shaft is mechanical coupled to an ultrasound transducer driven by a generator. The ultrasound tip possesses at least one radial surface, a cavity, or some other form of a hollowed out area, within at least one of the radial surfaces, and a cutting member at the opening of the cavity. A method of debriding a wound and/or tissue with the apparatus can be practiced by delivering ultrasonic energy released from the various surfaces of the vibrating tip to the wound and/or tissue prior to and/or while portions of the tip are scrapped across the wound and/or tissue.

Abstract: A method for computer-assisted medical navigation and/or pre-operative treatment planning includes detecting the current position of a patient or a part of a patient's body and the positions of medical treatment devices or treatment-assisting devices. The detected positional data can be assigned to body structure data, in order to jointly use the body structure data in assignment with the positional data, within the context of assisting the treatment. The body structure data can be used which is obtained based on a three-dimensional generic model, where the model is adapted by two-dimensional data linking with patient-characteristic, two-dimensional detection data.

Abstract: Clinical markers are adaptively identified in steered spatial compounding ultrasound imaging. Motion is detected. The use or determination of the clinical marker information adapts to the amount of motion. If sufficient motion is detected, the contribution of clinical marker information may be reduced, the weighting of the clinical marker information relative to the steered compound information is reduced, the acquisition sequence is adjusted for component frames of data, or combinations thereof.

Abstract: The invention relates to a method for locating a medical instrument during an intervention performed on the human body using an X-ray image recording system and an electromagnetic locating system whose systems of coordinates have been or will be mutually registered, with a first item of positional information about the instrument being obtained continuously by means of the locating system and in each case two two-dimensional X-ray images positioned at an angle to each other being intermittently recorded by means of the X-ray image recording system, from which images a second item of positional information about the instrument is determined and compared with the first item of positional information, after which the first item of positional information will be corrected depending on the comparison result taking account of the second item of positional information obtained from the X-ray images.

Abstract: A leadless marker for localizing the position of a target within a patient. In one embodiment, the marker includes a casing, a resonating circuit, and a ferromagnetic element. The casing is configured to be positioned at a selected location relative to a target site in the patient; the casing, for example, can be configured to be permanently or semi-permanently implanted into the patient. The resonating circuit has an inductor within the casing comprising a plurality of windings of a conductor, but it does not have external electrical lead lines extending through the casing. The ferromagnetic element is at least partially within the inductor. The ferromagnetic element has a volume such that when the marker is in an imaging magnetic field having a field strength of 1.5 T and a gradient of 3 T/m, then the force exerted on the marker by the imaging magnetic field is not greater than gravitational force exerted on the marker.

Abstract: A three dimensional ultrasound imaging device, having an interpolator that creates up sampled ultrasound image information from a three dimensional ultrasound image information using interpolation; and a memory that stores at least one of the three dimensional ultrasound image information and the up sampled ultrasound image information. The three dimensional ultrasound imaging device can have a probe that sends ultrasound waves, gathers reflected ultrasound waves and creates ultrasound information and a processor that converts the ultrasound information to three dimensional ultrasound image information. The ultrasound imaging device may also have a display that displays the up sampled image information. The three dimensional ultrasound imaging device may use at least one of 2 image to 3 image interpolation, 2 image to 4 image interpolation, 3 image to 4 image interpolation and 3 image to 5 image interpolation.

Abstract: The invention provides a medical guiding system including: a position data calculating device for detecting position and orientation of an ultrasonic endoscope serving as a medical instrument; image storing section for storing medical image data obtained before use of the ultrasonic endoscope; a body position correcting section for correcting at least one of position and direction at least one of viscera and organ in the medical image data, in line with a body position of the subject; and an image configuring section for calculating a position of the ultrasonic endoscope in the medical image data corrected by body position correcting section, based on a position of the ultrasonic endoscope obtained by the position data calculating device.

Abstract: An ultrasound diagnostic apparatus includes a probe 102 that transmits and receives ultrasound waves to/from a subject, transmitting means 120 for supplying a drive signal to the probe 102 for transmitting ultrasound waves, receiving means 122 for receiving and processing a signal output from the probe 102, a displacement calculating unit 105 for measuring displacement of a tissue according to an output signal from an ultrasound transmitting and receiving unit 103, a color DSC 108 for reconstructuring an elasticity image on the basis of the displacement of the tissue, and an image display 112 for displaying the elasticity image. Further, the ultrasound diagnostic apparatus includes setting means 113B for setting a displacement search direction that sets a search direction of the displacement to match a tissue displacement direction for displacing the tissue. The color DSC 108 constructures the elasticity image on the basis of the measurement value of the displacement search direction.

Abstract: An ultrasound-imaging system and method is provided that permits an operator to acquire an image of a volume-of-interest in a time critical fashion, that is capable of referencing the volume rendering to a standard two-dimensional imaging mode, and permits the operator to selectively choose a number of display-mode parameters that result in an operator directed view of the volume-of-interest. The ultrasound-imaging system comprises an input device configured to receive a plurality of imaging parameters and a controller in communication with the input device. The ultrasound-imaging system generates an operator-directed transmit-beam scan sequence in response to the imaging parameters and transmits a spatially modified transmit-beam scan sequence over a portion of the volume-scan range of the ultrasound-imaging system. Moreover, the ultrasound-imaging system provides the flexibility for an operator to direct a plurality of operator-configurable multi-dimensional views.

Abstract: A robot for medical ultrasonic examination has an articulated robot arm with a plurality of arm units (14-16), mounted one on the other to be pivotable, and a computerized system for controlling the movements of the arm, the outermost arm unit being arranged to carry a probe. The outermost arm unit has a carrying member rotatable about a longitudinal axis (IV), and carries a probe holder pivotable about a transverse axis (V) perpendicular to the longitudinal axis (IV). The probe holder has a housing rotatable about the transverse axis, and a holder sleeve rotatable about a longitudinal axis (VI). The three axes (IV, V, VI) intersect at a single point. The probe holder has an opening through which the probe can be inserted from the back and locked in position in the probe holder.

Abstract: Beamforming for N elements in performed in log(N) steps of complexity O(N). The signals measured at each element are treated as a receive beam formed by that element with a beam width equal to the element pattern or the width of the transmit illumination. In each of multiple stages, the number of elements is halved by effectively doubling the pitch. The number of beams formed by each element is doubled by narrowing the beam width by a factor of 2 in sin(?). Since steering and focusing are separated, a single set of delays are applied to each element signal individually prior to the multi-stage beam forming for each finite depth. The data is in a sector format, but by using two beamforming steps, data in a Vector® format is provided.

Abstract: A method for planning a bone implant ascertains a condition of a bone to be treated, and identifies a dysfunctional part of the bone. A free-form area then can be ascertained and registered, wherein the free-form area lies below the dysfunctional part. A control data set then is produced that forms the basis for ablating the bone on the ascertained free-form area.

Abstract: System, method and apparatus wherein a probe employing non-imagining optics is utilized in conjunction with a fluorescing (e.g., nanocrystal) tracer at the body of a patient. Excitation components within the probe working end are utilized to excite the nanocrystals to fluoresce at wavelengths in the near infrared region, such fluorescent energy is homogenized by interacting with involved tissue to provide a uniform fluorescing intensity over the surface of a photo-detector. Initialization and background determination procedures are described along with a technique for determining statistically significant levels of fluorescing activity.